Kathryn Lypen

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Kathryn Lypen is a clinical research associate in the Division of Plastic and Reconstructive Surgery at Children's Hospital of Philadelphia.

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)


Kathryn Lypen, MPH, has over twelve years of professional experience related to various pediatric and adolescent-focused research and evaluation projects. Ms. Lypen has a strong interest in global health and clinical research designed to improve the health and wellbeing of children worldwide. Ms. Lypen has been involved with research and/or fieldwork in Kenya, South Africa, Tanzania, the United States, Zambia and Zimbabwe. In various roles she has managed both quantitative and qualitative data, developed monitoring and evaluation tools, written technical reports, clinical research protocols, and delivered training curriculum for various audiences.

Ms. Lypen currently works at the Children’s Hospital of Philadelphia for the Division of Plastic and Reconstructive Surgery as a Clinical Research Associate II where she is responsible for providing scientific and technical leadership in the coordination, design and conduct of research in clinical practice, with special emphasis on pediatric plastic surgery outcomes.

Education and Training

Undergraduate Degree

BS - University of Michigan, Ann Arbor, Michigan

Graduate Degree

MPH - University of Michigan School of Public Health, Ann Arbor, Michigan 

Titles and Academic Titles

Clinical Research Associate

Departments and Services

Selected Publications


Site-Randomized Controlled Trial of a Combined Cognitive Behavioral Therapy and a Medication Management Algorithm for Treatment of Depression Among Youth Living with HIV in the United States. Brown LK, Chernoff M, Kennard BD, Emslie GJ, Lypen K, Buisson S, Weinberg A, Whiteley LB, Traite S, Krotje C, Harriff L, Townley E, Bunch A, Purswani M, Shaw R, Spector SA, Agwu A, Shapiro DE, IMPAACT 2002 team. JAIDS Journal of Acquired Immune Deficiency Syndromes. 2021 Aug 30. Published ahead of print. DOI: 10.1097/QAI.0000000000002790.

Etravirine in treatment-experienced HIV-1 infected children 1-<6 years of age. Macbrayne CE, Rutstein, RM, Wiznia AA, Graham B, Alvero CG, Fairlie Lee, Lypen K, George KH, Townley E, Moye J, Costello DG, Reding CA, Barroso Hofer C, Crauwels HM, Woot de Trixhe X, Tambuyzer L, Vanveggel S, Opsomer M, Kiser JJ, and the IMPAACT P1090 Protocol Team. AIDS. 2021 Jul 15; 35(9):1413-1421. DOI: 10.1097/QAD.0000000000002902. PMID: 33831904


Tenofovir diphosphate concentrations in dried blood spots from pregnant and postpartum adolescent and young women receiving daily observed pre-exposure prophylaxis in sub-Saharan Africa. Stranix-Chibanda L, Anderson PL, Kacanek D, Hosek S, Huang S, Nematadzira TG, Taulo F, Korutaro V, Nakabiito C, Masenya M, Lypen K, Brown E, Ibrahim ME, Yager J, Wiesner L, Johnston B, Amico KR, Rooney JF, Chakhtoura N, Spiegel HML, Chi BH, IMPAACT 2009 Team. Clinical Infectious Diseases. 2020 Dec 20: ciaa1872. DOI: 10.1093/cid/ciaa1872. PMID: 33341883


'Know that You are not Alone.’ Influences of Social Support on Youth Newly Diagnosed with HIV in Kibera, Kenya: A Qualitative Study Informing Intervention Development. Lockwood NM, Lypen K, Shalabi F, Kumar M, Ngugi E, Harper GW. Int J Environ Res Public Health. 2019; 16(5). pii: E775. DOI: 10.3390/ijerph16050775. PMID: 30836611


‘When we are together I feel at home.’ Types and sources of social support among youth newly diagnosed with HIV in Kenya: implications for intervention. Lypen KD, Lockwood NM, Shalabi F, Harper GW, Ngugi E. African Journal of AIDS Research. 2015; 14(3): 275-284. DOI: 10.2989/16085906.2015.1082145. PMID: 26439602




Pharmacokinetics and Safety of Dispersible and Immediate Release FDC Abacavir/ Dolutegravir/ Lamivudine in Children with HIV Weighing ≥14 kg: Preliminary Results from IMPAACT 2019. Brooks KM, Kiser JJ, Samson P, Rani Y, Ward S, Cressey TR, Cassim H, Deville JG, Masheto GR, Ponatshego PL, Coletti A, Lypen K, Mustich I, Heckman B, Lojacono M, Bowman R, Yin D, Townley E, Majji S, Acosta EP, Buchanan AM, Brothers CH, Chandasana H, Rabie H, Flynn P, on behalf of the IMPAACT 2019 Team. Presented at the International Workshop on HIV Pediatrics, Virtual, July 2021 and the 11th International AIDS Society on HIV Science, Virtual, July 2021.

Directly Observed Therapy (DOT) Can Be Implemented Successfully in Research Settings to Evaluate PrEP PK among Pregnant and Postpartum Adolescents and Young Women in Africa. Brown E, Stranix-Chibanda L, Johnston B, Huang S, Kacanek D, Mungate L, Sango A, Mambiya S, Longwe Mwenda W, Korutaro V, Nanyunja S, Kibalama Ssemambo P, Ssekasi Miwanda A, Kowo H, Nelwamondo S, Spiegel H, Anderson P, Chi B, Lypen K. Presented at the 4th HIV Research for Prevention Conference, Virtual, January 2021.


Site-randomized controlled trial of a combined cognitive behavioral therapy and a medication management algorithm for treatment of depression among youth living with HIV in the United States. Brown L, Chernoff M, Kennard B, Emslie G, Shapiro D, Lypen K, Buisson S, Weinberg A, Whiteley L, Traite, S, Krotje C, Harriff L, Townley E, IMPAACT 2002 Team. Presented at the 23rd International AIDS Conference, Virtual, July 2020.

TFV-DP in DBS for Pregnant/Postpartum Adolescent and Young Women on PrEP in Africa. Anderson P, Stranix-Chibanda L., Huang S, Hosek S, Kacanek D, Nematadzira T, Taulo F, Korutaro V, Nakabiito C, Masenya M, Lypen K, Chakhtoura N, Spiegel H, Chi B, IMPAACT 2009 Team. Presented at the Conference on Retroviruses and Opportunistic Infections (CROI), Virtual, March 2020.