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Research Studies

Relapsed and Refractory Neuroblastoma Research Studies

Recruitment Status

Study categories

Clinical trial phase

22CT012: GPC2 CAR T Cell Trial

The purpose of this study is to test an experimental approach called cell therapy for neuroblastoma or retinoblastoma. This study will take a patient's own white blood cells (T cells) and change them to turn against the cancer. These cells are an experimental treatment and have not been approved by the FDA. CAR T cells have been used to treat other cancers, but GPC2 CAR T cells have not been administered to human patients prior to this clinical trial.

If they choose to participate in this study, active participation will last approximately 12 months. Participants will also be asked to sign consent to a separate long term follow-up protocol to monitor their health for up to 15 years after their last GPC2 CAR T treatment.

This study will assess the safety and effectiveness of GPC2 CAR T cells. Overall, approximately 45 subjects will be enrolled on this study.

Phase: Phase I

Actively recruiting: Yes

Category: Adults, Children

Conditions: Retinoblastoma (Eye Cancer in Children), Relapsed and Refractory Neuroblastoma

Lutetium Lu177 Edotreotide in Somatostatin Receptor-positive Tumors

This study involves taking a study drug called Lutetium Lu 177 Edotreotide. The overall goal of this study is to see if the study drug is safe in adolescent subjects with a SomatoSTatin Receptor positive (SSTR-positive) solid tumor or lymphoma that is recurrent or that has progressed under one or more previous treatments, and which cannot be completely removed by surgery.

Phase: Phase I

Actively recruiting: Yes

Category: Children

Conditions: Relapsed and Refractory Neuroblastoma, Ewing sarcoma, Hepatoblastoma (liver cancer), Osteosarcoma (bone cancer in children), Rhabdomyosarcoma, Soft tissue sarcomas, Wilms Tumor (Kidney Tumor)

PEEL-224 in Solid Tumors

This study enrolls patients with refractory, progressive, or relapsed solid tumors. The purpose of this study is to find out whether a drug called PEEL-224 ("the study drug") is safe and effective when given as monotherapy (a drug given by itself) and as part of a combination therapy together with other chemotherapy drugs.

Phase: Phase I, Phase II

Actively recruiting: Yes

Category: Adults, Children

Conditions: Ewing sarcoma, Hepatoblastoma (liver cancer), Relapsed and Refractory Neuroblastoma, Osteosarcoma (bone cancer in children), Rhabdomyosarcoma, Soft tissue sarcomas, Wilms Tumor (Kidney Tumor)

PHOX2B CAR T-Cells for Relapsed Neuroblastoma

The purpose of this study is to test an experimental approach called cell therapy for neuroblastoma. This study will take a patient's own white blood cells (T cells) and change them to turn against the cancer. CART cells have been used to treat other cancers, but PHOX2B CART cells have not been administered to human patients prior to this clinical trial. Participants will be given PHOX2B cells via an IV and then monitored for up to 12 months.

Participants will also be asked to sign consent to a separate long term follow-up protocol to monitor their health for up to 15 years after their last PHOX2B CART treatment.

Phase: Phase I

Actively recruiting: Yes

Category: Adults, Children

Conditions: Relapsed and Refractory Neuroblastoma

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