Amanda Ackermann, MD, PhD

Amanda Ackermann, MD, PhD

Amanda Ackermann, MD, PhD, is an attending physician in the Division of Endocrinology and Diabetes at Children's Hospital of Philadelphia.

Areas of Expertise: Diabetes, Hyperinsulinism, Hypoglycemia
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD, Medical Scientist Training Program, Vanderbilt University Medical Center, Nashville, TN

Residency

Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

Fellowship

Pediatric Endocrinology - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Endocrinology
Pediatrics

Graduate Degree

PhD, Molecular Physiology and Biophysics, Vanderbilt University Medical

Center, Nashville, TN

Titles and Academic Titles

Attending Physician

Associate Program Director, Pediatric Endocrinology Fellowship Program

Assistant Professor, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Research Interests

Diabetes
Congenital hyperinsulinism
Islet biology
Genetics

Publications

Papers

2017

Wong, S.Y., Gadomski, T., van Scherpenzeel, M., Honzik, T., Hansikova, H., Holmefjord, K.S.B., Mork, M., Bowling, F., Skykut-Cegielska, J., Koch, D., Hertecant, J., Preston, G., Jaeken, J., Peeters, N., Perez, S., Nguyen, D.D., Crivelly, K., Emmerzaal, T., Gibson, K.M., Raymond, K., AbuBakar, N., Foulquier, F., Poschet, G., Ackermann, A.M., He, M., Lefeber, D.J., Thiel, C., Kozicz, T., and Morava, E.: Oral D-galactose supplementation in PGM1-CDG. Genetics in Medicine 19(11): 1226-1235, 2017. PMCID: PMC5675745

Li, C., Ackermann, A.M., Patel, P., Chen, P., Boodhansingh, K.E., Givler, S., Bhatti, T.R., Liu, C., Schug, J., Doliba, N., Matschinsky, F.M., Nissim, I., Kaestner, K.H., Naji, A., Adzick, N.S., Stanley, C.A., and De León, D.D.: Functional and metabolic evaluation of islets from infants with hyperinsulinism due to loss of function mutations of ATP-dependent potassium channels. Diabetes 66(7): 1901-1913, July 2017. PMCID: PMC5482088

Ackermann, A.M. and Levine, M.A.: Compound heterozygous mutations in COL1A1 associated with an atypical form of type I osteogenesis imperfecta. American Journal of Medical Genetics Part A 173(7): 1907-1912, July 2017.

van der Meulen, T., Mawla, A., DiGruccio, M.R., Adams, M.W., Nies, V., Dólleman, S., Liu, S., Ackermann, A.M., Cáceres, E., Hunter, A.E., Kaestner, K.H., Donaldson, C.J., and Huising, M.O.: Virgin beta cells persist throughout life at a neogenic niche within pancreatic islets. Cell Metabolism 25(4): 911-926, April 2017.

Ackermann, A.M., Zhang, J., Heller, A., Briker, A., and Kaestner, K.H.: High-fidelity Glucagon-CreER mouse line generated by CRISPR-Cas9 assisted gene targeting. Molecular Metabolism 6(3): 236-244, January 2017. PMCID: PMC5323890

2016

Wong SY, Beamer LJ, Gadomski T, Honzik T, Mohamed M, Wortmann SB, Brocke Holmefjord KS, Mork M, Bowling F, Sykut-Cegielska J, Koch D, Ackermann A, Stanley CA, Rymen D, Zeharia A, Al-Sayed M, Marquardt T, Jaeken J, Lefeber D, Conrad DF, Kozicz T, Morava E. Defining the phenotype and assessing severity in phosphoglucomutase-1 deficiency. J Pediatr. 2016 Aug;175:130-136.e8. doi: 10.1016/j.jpeds.2016.04.021. Epub 2016 May 17.

Ackermann AM, Wang P, Schug J, Naji A, Kaestner KH. Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes. Mol Metab. 2016 Jan 11;5(3):233-44.

Wong, S.Y., Beamer, L.J., Gadomski, T., Honzik, T., Mohamed, M., Wortmann, S.B., Brocke Holmefjord, K.S., Mork, M., Bowling, F., Skykut-Cegielska, J., Koch, D., Ackermann, A., Stanley, C.A., Rymen, D., Zeharia, A., Al-Sayed, M., Marquardt, T., Jaeken, J., Lefeber, D., Conrad, D.F., Kozicz, T., and Morava, E. 2016. Defining the phenotype and assessing severity in phosphoglucomutase-1 deficiency. The Journal of Pediatrics. E-pub ahead of print. PMID: 27206562.

Books

Chapters

2018

Ackermann, A.M. and De León, D.D. (2018) Chapter 47: Congenital Hyperinsulinism. Manual of Endocrinology and Metabolism, 5th Ed. Lavin, N. (ed.). Wolters Kluwer, Page: 656-664.

2017

Ferrara, C.T., Ackermann, A.M., and Palladino, A.A. (2017) Section F: Endocrinology: Diabetes Mellitus and Hyperglycemia. Comprehensive Pediatric Hospital Medicine, 2nd Ed. Zaoutis, L.B. and Chiang, V.W. (eds.). McGraw-Hill, Page: 317-320.

2016

Ferrara CT, Ackermann AM, and Palladino AA.  (2016) Endocrinology.  In: Shah SS, Zaoutis LB, Catallozzi M, and Frank G, eds. The Philadelphia Guide: Inpatient Pediatrics, 2nd Ed.  Philadelphia, PA: Mosby Elsevier, McGraw-Hill.

2013

Ferrara CT and Misfeldt AA.  (2013)  Endocrinology:  Diabetes Mellitus and Hyperglycemia.  In:  Zaoutis LB and Chiang VW, eds.  Comprehensive Pediatric Hospital Medicine, 2nd Ed.  Philadelphia, PA:  Mosby Elsevier, McGraw-Hill.

Ferrara CT, Misfeldt AA, and Palladino AA.  (2013)  Endocrinology.  In:    Shah SS, Zaoutis LB, Catallozzi M, and Frank G, eds.  The Philadelphia Guide: Inpatient Pediatrics, 2nd Ed.  Philadelphia, PA:  Mosby Elsevier, McGraw-Hill.

Posters and Presentations

2018

Ackermann, A.M., Gao, L., Lim, H.W., Wang, Z., Schug, J., Won, K.J., Voight, B.F., Naji, A., and Kaestner, K.H.: Transcriptomic and epigenomic changes in human pancreatic alpha and beta cells associated with type 2 diabetes. Epigenomics of Diabetes and Other Metabolic Diseases Gordon Research Conference, Hong Kong, China, May 28, 2018. Poster presentation.

Ackermann, A.M., Gao, L., Lim, H.W., Wang, Z., Schug, J., Won, K.J., Voight, B.F., Naji, A., and Kaestner, K.H.: Transcriptomic and epigenomic changes in human pancreatic alpha and beta cells associated with type 2 diabetes. Human Islet Research Network Annual Investigator Meeting, Washington, DC, May 9, 2018. Poster presentation.

Mackarey, A., Moss, N.M., Briker, A., Ackermann, A.M.*, and Kaestner, K.H.*: Understanding the role of KDM6A in beta cell differentiation, maturation, and function. 44th Annual Eastern-Atlantic Student Research Forum at University of Miami, FL, February 20, 2018. Poster presentation.

2017

Vajravelu, M.E., Kilberg, M., Lord, K., Gaines, S., Lavelle, J., Jacobstein, C., Mirth, M., and Ackermann, A.M.: Reducing time to treatment of diabetic ketoacidosis in the emergency department setting. 10th International Meeting of Pediatric Endocrinology, Washington, DC, September 14, 2017. Poster presentation.

Ackermann, A.M., Li, C., Lord, K., Boodhansingh, K.E., Kalish, K.M., Bhatti, T.R., States, L., Adzick, N.S., Stanley, C.A., De León, D.D.: Severe hyperinsulinism in infants with Beckwith-Wiedemann Syndrome and heterozygous KATP channel mutations: more than focal or diffuse disease. 10th International Meeting of Pediatric Endocrinology, Washington, DC, September 14, 2017. Poster presentation.

Ackermann, A.M. Fixing the gene mutations in beta cells that cause hyperinsulinism. Congenital Hyperinsulinism Family Conference, Galloway, NJ, July 15,2017. Oral presentation.

Ackermann, A.M. Epigenomic signatures in islet development. American Diabetes Association 77th Scientific Sessions, San Diego, CA, June 11, 2017. Oral presentation.

Vajravelu, M.E., Lord, K., Gaines, S., Jacobstein, C., Lavelle, J., Patel, N., Orenstein, M., Palladino, A.A., Kelley, J., and Ackermann, A.M.: Reducing time to treatment of diabetic ketoacidosis in the emergency department setting. The Endocrine Society's 99th Annual Meeting, Orlando, FL, April 2, 2017. Poster presentation.

2016

Ackermann, A.M. (May 1, 2016) Interesting presentation of pituitary mass. Pediatric Academic Societies’ Annual Meeting, Baltimore, MD.

Ackermann, A.M. (March 17, 2016) Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes. Keystone Symposia Conference - Islet Biology: From Cell Birth to Death, Keystone, CO.

2015

Ackermann AM. (August 17, 2015) Diabetes mellitus in children and adolescents, Crozer Pediatric Residency Program, Chester, PA.

Ackermann AM. (June 10, 2015) Endocrine emergencies. The Children’s Hospital of Philadelphia Pediatric Residency Program, Philadelphia, PA.

Ackermann AM, Bramswig N, Zhang J, and Kaestner KH. (June 3, 2015) Epigenetic reprogramming of pancreatic alpha cells to beta cells. European Society for Pediatric Endocrinology’s Science School, Annecy, France.

Ackermann, A.M., Li, C., Freeze, H.H., Ficicioglu, C., Kaestner, K.H., and Stanley, C.A. (April 25, 2015) Hypoglycemia due to lower threshold of glucose-stimulated insulin secretion in phosphoglucomutase-1 deficiency. Pediatric Academic Societies’ Annual Meeting, San Diego, CA.

Ackermann, A.M. and Rustico S. (March 24, 2015) Diabetes Mellitus in Children and Adolescents, Crozer Pediatric Residency Program, Chester, PA.

Ackermann, A.M., Li, C., Freeze, H.H., Ficicioglu, C., KaestnerHypoglycemia due to lower threshold of glucose.,K.H., and Stanley, C.A. (March 21, 2015) Hypoglycemia due to lower threshold of glucose-stimulated insulin secretion in phosphoglucomutase 1 deficiency. Eastern Society for Pediatric Research Annual Meeting, Philadelphia, PA.

Ackermann, A.M., Li, C., Freeze, H.H., Ficicioglu, C., Kaestner, K.H., and Stanley, C.A. (January 30, 2015) Hypoglycemia due to lower threshold of glucose-stimulated insulin secretion in phosphoglucomutase-1 deficiency. Endocrine Fellows Foundation Research Meeting, San Antonio, TX.

Awards and Honors

2014-2016, Juvenile Diabetes Research Foundation Postdoctoral Fellowship Award
2013-2014, Medical Genetics T32 Trainee, The Children’s Hospital of Philadelphia
2013, Pediatric Endocrine Society Research Fellowship Award
2015, Young Investigator Trainee Award, Eastern Society for Pediatric Research
2015, Outstanding Poster Award, Joint Meeting of the Islet Study Group & Beta Cell Workshop, Jerusalem, Israel
2013, 2015 & 2016 - Pediatric Endocrine Society Travel Award
2010, Richard B. Johnston Jr. Award in Pediatrics, Vanderbilt University
2010, Oscar B. Crofford Award for Diabetes/Endocrine Research, Vanderbilt Univ.
2008, Graduate Student Scholar in Diabetes, Vanderbilt University
2007, Keystone Symposia Scholarship
2002 - 2010, Canby Robinson Scholarship, merit-based, Vanderbilt University
2002, Magna cum laude, Southwestern University
2002, Phi Beta Kappa
1998 - 2002, National Merit Scholarship

Editorial and Academic Positions

Editorial Positions

2018 - present, Scientific Reports, ad hoc reviewer
2018 - present, Clinical Diabetes, ad hoc reviewer
2017 - present, Diabetes, ad hoc reviewer
2017 - present, Molecular Metabolism, ad hoc reviewer
2016 - present, Journal of Bone and Mineral Metabolism, ad hoc reviewer

Academic and Institutional Committees

2018 - present, Research Trainee Advisory Committee, Children’s Hospital of Philadelphia
2015 - present, Scientific Review Committee, The Children’s Hospital of Philadelphia

Leadership and Memberships

Memberships in professional organizations

National

2016 - present, American Association for the Advancement of Science
2014 - present, Endocrine Society
2012 - present, Society for Pediatric Research
2012 - present, Philadelphia Endocrine Society
2012 - present, Pediatric Endocrine Society
2014 - present, Research Advisory Council, Pediatric Endocrine Society
2010 - present, American Academy of Pediatrics

Local

2012 - present, Philadelphia Endocrine Society