Lisa Nowoslawski Akhtar, MD, PhD

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Lisa Nowoslawski Akhtar, MD, PhD, is an attending physician in the Division of Infectious Diseases at Children's Hospital of Philadelphia.

Areas of Expertise: Central nervous system infections, Neonatal herpes simplex virus infection
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - University of Alabama at Birmingham, Birmingham, AL

Residency

Pediatrics - Children’s Hospital of Philadelphia, Philadelphia, PA

Fellowship

Pediatric Infectious Diseases - Children’s Hospital of Philadelphia, PA

Board Certification

General Pediatrics
Pediatric Infectious Diseases

Graduate Degree

PhD in Neurovirology - University of Alabama at Birmingham, Birmingham, AL

Titles and Academic Titles

Attending Physician

Instructor, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

Viral genetic determinants of neonatal HSV disease

Publications

Papers

2017

Reyes ED, Kulej K, Pancholi NJ, Akhtar LN, Avgousti DC, Bricker D, Koniski SA, Seeholzer SH, Isaacs SN, Garcia BA, and Weitzman MD.  Identifying host factors associated with nascent DNA during virus infection.  Molecular and Cellular Proteomics. 2017 Dec; 16(12): 2079-2097.

2011

Huff KR, Akhtar LN, Fox AL, Cannon JA, Smith PD, and Smythies LE.  Extracellular matrix-associated cytokines regulate CD4+ effector T-cell responses in human intestinal mucosa.  Mucosal Immunology.  2011 Jul; 4(4):  420-427. 

2010

Akhtar LN and Benveniste EN.  Viral exploitation of host SOCS protein functions.  Journal of Virology.  2010 Mar; 85(5):  1912-1921.

Akhtar LN, Qin H, Muldowney MT, Yanagisawa LL, Kutsch O, Clements JE, and Benveniste EN.  SOCS3 inhibits antiviral IFN-β signaling to enhance HIV-1 replication in macrophages.  Journal of Immunology.  2010 Aug; 185(4): 2393-2404.

2009

Baker BJ, Akhtar LN, and Benveniste EN.  SOCS1 and SOCS3 in the control of CNS immunity.  Trends in Immunology.  2009 Aug; 30(8): 392-400.

2008

Nozell S, Laver T, Moseley D, Nowoslawski L, DeVos M, Atkinson GP, Harrison K, Nabors LB, and Benveniste EN.  The ING4 tumor suppressor attenuates NF-κB activity at the promoters of target genes.  Molecular and Cellular Biology.  2008 Nov; 28(21): 6632-6645.

2005

Nowoslawski L, Klocke BJ, and Roth KA.  Molecular regulation of acute ethanol-induced neuron apoptosis.  Journal of Neuropathology and Experimental Neurology.  2005 June; 64(6): 490-497.

Chiesa R, Piccardo P, Dossena S, Nowoslawski L, Roth KA, Ghetti B, and Harris DA.  Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease.  Proceedings of the National Academy of Sciences USA.  2005 Jan 4; 102(1): 238-243.

Books

Chapters

Benveniste EN, Akhtar LN, and Baker BJ.  Mechanisms of neurotoxicity by HIV-1 and cellular immune products:  Astrocyte immunobiology.  In HE Gendelman, IP Everall, HS Fox, I Grant, SA Lipton, and S Swindells (Ed.), The Neurology of AIDS, 3rd Edition.  New York, NY.  Oxford University Press, 2011.

Posters and Presentations

2018

Akhtar LN, Della Fera AN, Bowen CD, Renner DW, Pandey U, Peauroi EM, Kimberlin DW, Prichard MN, Whitley RJ, Szpara ML, and Weitzman MD.  Genotypic and phenotypic diversity within the neonatal HSV-2 population. St. Jude/Pediatric Infectious Diseases Society Pediatric Infectious Diseases Research Conference, March 2018.

Akhtar LN, Della Fera AN, Bowen CD, Renner DW, Pandey U, Peauroi EM, Kimberlin DW, Prichard MN, Whitley RJ, Szpara ML, and Weitzman MD.  Neurovirulence determinants of neonatal HSV disease. Pediatric Scientist Development Program (PSDP) Annual Meeting / Association of Medical School Pediatric Department Chairs (AMSPDC), March 2018.

Akhtar LN, Della Fera AN, Bowen CD, Renner DW, Pandey U, Peauroi EM, Kimberlin DW, Prichard MN, Whitley RJ, Szpara ML, and Weitzman MD.  Investigation of viral virulence determinants in neonatal HSV encephalitis. University of Pennsylvania Neurovirology Seminar Series, February 2018.

2017

Akhtar LN, Della Fera AN, Bowen CD, Renner DW, Pandey U, Peauroi EM, Kimberlin DW, Prichard MN, Whitley RJ, Szpara ML, and Weitzman MD.  The neonatal HSV-2 population contains genotypic and phenotypic diversity. 3rd Philadelphia-Wide Neurovirology and Neuroimmunology Symposium, September 2017.

Akhtar LN, Della Fera AN, Bowen CD, Renner DW, Pandey U, Peauroi EM, Kimberlin DW, Prichard MN, Whitley RJ, Szpara ML, and Weitzman MD.  Investigation of viral virulence determinants of invasive neonatal HSV disease. St. Jude/Pediatric Infectious Diseases Society Pediatric Infectious Diseases Research Conference, March 2017.

Akhtar LN, Della Fera AN, Bowen CD, Renner DW, Pandey U, Peauroi EM, Kimberlin DW, Prichard MN, Whitley RJ, Szpara ML, and Weitzman MD.  Investigation of viral virulence determinants of invasive neonatal HSV disease. St. Jude/Pediatric Infectious Diseases Society Pediatric Infectious Diseases Research Conference, 2017.

Akhtar LN, Bowen CD, Renner DW, Peauroi EM, Della Fera AN, Kimberlin DW, Prichard MN, Whitley RJ, Szpara ML, and Weitzman MW.  Investigation of viral virulence determinants of invasive neonatal HSV disease. Pediatric Scientist Development Program (PSDP) Annual Meeting / Association of Medical School Pediatric Department Chairs (AMSPDC), 2017.

Akhtar LN, Della Fera AN, Bowen CD, Renner DW, Pandey U, Peauroi EM, Kimberlin DW, Prichard MN, Whitley RJ, Szpara ML, Weitzman MD. Investigation of viral virulence determinants of invasive neonatal HSV disease. Children's Hospital of Philadelphia Research Poster Day, 2017.

2016

Reyes ED, Kulej K, Akhtar LN, Avgousti DC, Koniski S, Seeholzer SH, Weitzman MD.  Identifying host factors on viral genomes reveals targets of early viral proteins.  Children’s Hospital of Philadelphia Research Poster Day, 2016.

Reyes ED, Kulej K, Avgousti DC, Akhtar LN, Bricker D, Pancholi N, Koniski S, Garcia BA, and Weitzman MD.  Identifying host factors associated with replicating viral DNA. US Human Proteome Organization (HUPO) Annual Conference, 2016.

Reyes ED, Kulej K, Avgousti DC, Akhtar LN, Bricker D, Pancholi N, Koniski S, Garcia BA, and Weitzman MD: Identifying host factors associated with replicating viral DNA. American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry and Allied Topics, 2016.

Awards and Honors

2015, NIH/NICHD Pediatric Scientist Development Program, K12 Career Development Award

2011, MD awarded magna cum laude from the University of Alabama School of Medicine (UASOM)

2011, Glasgow-Rubin Citation for Academic Achievement, UASOM

2009, NIH/NINDS Ruth L. Kirschstein National Research Service Award, F30 Individual Fellowship

2009, UASOM Medical Student Research Day, First Place Poster in HIV/AIDS

2008, UASOM Medical Student Research Day, First Place Poster in HIV/AIDS

2007, Alpha Omega Alpha (AOA) Honor Medical Society (selected in junior year), UASOM

2007, NIH/NIAID Ruth L. Kirschstein National Research Service Award, T32 Training Grant

2007, UASOM Medical Student Research Day, First Place Oral Presentation

2007, Pathology Honor Society of the Association of Pathology Chairs

2006, Stuart Graves Award for Pathology, UASOM

2005, McGraw Hill/LANGE Medical Student Award, UASOM

2005, UASOM Medical Student Research Day, Second Place Oral Presentation

2003, BS awarded suma cum laude from the University of Alabama at Birmingham (UAB)

2003, Dean’s Award: School of Natural Sciences and Mathematics, UAB

2003, Rhodes Scholarship Nominee, UAB

2003, National Collegiate Athletic Association (NCAA) Post Graduate Scholarship

2003, NCAA Woman of the Year Nominee, UAB

2003, Conference USA Post Graduate Scholarship

2003, Conference USA Scholar Athlete of the Year

2003, Mervyn Goldstein Memorial Scholarship, UAB

2003, Women’s Top Female Athlete Grade Point Average Award, UAB

Editorial and Academic Positions

Academic and Institutional Committees

Leader, CHOP Bacterial Meningitis Diagnosis and Management Pathway
CHOP Infectious Diseases Education Committee

Leadership and Memberships

Memberships in Professional Organizations

2016-present, American Society for Microbiology
2014-present, Pediatric Infectious Diseases Society
2014-present, Infectious Diseases Society of America
2011-present, American Academy of Pediatrics