Alexandre Arkader, MD
Areas of expertise: Benign and malignant bone and soft tissue tumors, Complex trauma/pediatric fractures, Leg length discrepancy/angular deformities, Limb salvage surgery, Sarcomas, Limb deformity, Musculoskeletal tumors, Limb lengthening, Pediatric orthopaedic surgery
About Alexandre Arkader
Alexandre Arkader, MD, is a board-certified attending surgeon who specializes in treating children with bone tumors. He works with the Orthopedics Center and the Cancer Center at Children’s Hospital of Philadelphia.
Dr. Arkader is one of a handful of surgeons in the country with formal training in both pediatric orthopedics and orthopedic oncology. Additionally, he has a special interest in treating complex limb deformities, expertise in external fixation methods and other minimally invasive techniques for limb preservation and correction.
“The minute I started my orthopedic residency, I knew I’d go into peds ortho; I just love caring for children,” Dr. Arkader says. “The thought about taking care of oncology patients only came to me during my fellowship at CHOP Orthopedics. The combination of both subspecialties – orthopedics and orthopedic oncology – lead to my desire to treat children with benign and malignant bone and soft tissue tumors, as well as perform limb salvage and reconstruction procedures for children with congenital and acquired conditions.”
“The ability to create such a positive impact in the care of these children, the possibility of combining all the principles in pediatric orthopedic care and oncological principles to achieve the best outcome possible for the affected child is both challenging and inspiring,” Dr. Arkader adds.
Dr. Arkader joined CHOP after eight years at the Children’s Hospital of Los Angeles (CHLA) and Keck School of Medicine of USC. At CHLA, Dr. Arkader served as the Director of the Bone and Soft Tissue Tumor program, the Orthopedic Trauma Program, and the International Fellowship at the Children’s Orthopedic Center at CHLA.
Dr. Arkader earned his medical degree from F.T.E. Souza Marques in Rio de Janeiro, Brazil. He completed an internship in international medicine at the Hospital Santa Casa de Misericordia, and a residency in orthopedic surgery at the Hospital de Traumatologia-Ortopedia in Rio de Janeiro, Brazil.
In 2003, Dr. Arkader came to the United States to further his professional training. He completed a fellowship in pediatric orthopedics at Children’s Hospital of Philadelphia, and a second fellowship in musculoskeletal oncology at Memorial Sloan-Kettering Cancer Center in New York, NY.
Along with his clinical work, Dr. Arkader is also an active researcher. He’s published more than 80 peer-reviewed articles, many of which focused on musculoskeletal oncology and benign bone tumors, an area in which CHOP is a national leader in both experience and volume of patients successfully treated.
“We are 100% focused on pediatric care,” Dr. Arkader says. “I’m proud to work here with a team that is fully dedicated to achieving the best outcomes possible for all of our patients.”
Dr. Arkader has served as a national authority for numerous textbook chapters on pediatric musculoskeletal tumors. He has lectured in innumerous national and international meetings, and leads a biannual pediatric orthopedic course in South America. He participates in several study groups focused on research related to trauma and musculoskeletal infections and is an active reviewer for several medical journals. In addition, Dr. Arkader is a member of several national and international professional organizations including the Pediatric Orthopedic Society of North America, the American Academy of Orthopaedic Surgeons, the Musculoskeletal Tumor Society and the Children's Oncology Group.
Titles
Attending Surgeon
Certifications
Orthopaedic Surgery – American Board of Orthopaedic Surgery
Awards and Honors
2017 Top Docs Award from Southern Jersey Magazine (peer indication)
2017-2022, Philadelphia Magazine's Top Doctors in Orthopedic Surgery
2016-2021 Best Doctors® award (peer indication)
Leadership and Memberships
Memberships in Professional Organizations
International
2018-present, Sociedad Argentina de Ortopedia y Traumatologia Infantil
2015-present, Sociedad Colombiana de Cirurgia Ortopedica y Traumatologia
2011-present, Sociedad Chilena de Ortopedia y Traumatología
National
2012-present, Musculoskeletal Tumor Society
2010-present, Children’s Oncology Group
Editorial and Academic Positions
Editorial Positions
2019-present, Editor, tumors section, JPOSNA
2018-present Reviewer, Journal of Children’s Orthopaedics
2018-present Reviewer, Journal of Pediatric Orthopaedics B
2018-present Reviewer, BMC Musculoskeletal Disorders
2018-present Reviewer JBJS Essential Surgical Techniques
Education & training
Medical Degree
MD - Fundação Técnico-Educacional Souza Marques, Rio de Janeiro, Brazil
Internship
Internal Medicine - Hospital Santa Casa da Misericórdia, Rio de Janeiro, Brazil
Residency
Orthopedic Surgery - Hospital de Traumatologia-Ortopedia (National Institute of Orthopaedics and Traumatology - Federal Research Institute), Rio de Janeiro, Brazil
Fellowship
Pediatric Orthopedics - Children’s Hospital of Philadelphia, Philadelphia, PA
Musculoskeletal Oncology - Memorial Sloan-Kettering Cancer Center, New York, NY
Publications
Publications
2023
Gaballah M, Worede F, Alexander C, Arkader A, Cahill AM, Acord MR. Novel method to biopsy aneurysmal bone cysts in children. Skeletal Radiol. 2023 May 16. doi: 10.1007/s00256-023-04360-1. Epub ahead of print. PMID: 37191930.
2022
Heyer J, Anari JB, Baldwin K, Arkader A. Standardizing a Postoperative Protocol for Supracondylar Humerus Fractures J Pediatr Orthop, 2022 Feb 1;42(2):e103-e108.
Baghdadi S, Mahmoud M, Flynn JM, Arkader A. Unplanned Return to the Operating Room (UpROR) After Pediatric Diaphyseal Femoral Fractures. J Pediatr Orthop, 2022 Feb 1;42(2):e120-e125.
Baskar D, Hosseinzadeh P, Mosca V, Bouchard M, Aroojis A, Arkader A, Cidambi E, Denning J, Eastwood D, Gantsoudes G, Kelly DM, Kishta W, Masquijo J, May C, Milbrandt T, Nichols LR, Frick S. Dynamic Supination in Congenital Clubfoot: A Modified Delphi Panel Approach to Standardizing Definitions and Indications for Treatment. J Pediatr Orthop. 2022 Feb 18.
Masquijo JJ, Sanchez Ortiz M, Ponzone A, Fernández Korosec L, Arkader A. Fractures of the lateral condyle of the humerus associated with elbow dislocation in children. A systematic review of the literature. Rev Esp Cir Ortop Traumatol 2022 Mar-Apr;66(2):95-104.
Hussaini SH, Gaballah M, Baghdadi S, Arkader A, Williams BA, Sze RW, Nguyen JC. Pediatric musculoskeletal pathologies: are there differences in triage of diagnoses and preferences for communication between radiology and orthopedics? Skeletal Radiol. 2022 Apr;51(4):863-871.
Nguyen JC, Baghdadi S, Pogoriler J, Guariento A, Rajapakse CS, Arkader A. Pediatric Osteosarcoma: Correlation of Imaging Findings with Histopathologic Features, Treatment, and Outcome. Radiographics 2022 Jul-Aug;42(4):1196-1213.
Huang K, Houlihan N, Arkader A, Flynn JM, Williams BA. Early Knee Range of Motion Following Operative Treatment for Tibial Tubercle Avulsion Fractures Is Safe. J Pediatr Orthop. 2022 Aug 15.
Ponzone A, Korosec LF, Arkader A, Masquijo J. Manejo de la fractura del cóndilo lateral del húmero asociada a luxación del codo en niños. Un estudio multicéntrico. Temas Libres 2022 Nov 11.
Azoury S, Erdman D, Kovack S, Levin SL, Arkader A, Weber K, Othman S, Innocenti M, Sergesketter A, Nguyen J, Bringman B. Long-term Outcomes Following Free Vascularized Fibula Physeal Transfer for Proximal Humerus Oncologic Reconstruction in Children: An International Multi-Institutional Study". Plastic and Reconstructive Surgery 2022, Dec, (10.1097).
2021
Baghdadi S, Harwood K, Arkader A, Lawrence T. “Open reduction of medial epicondyle fractures in children and adolescents: supine versus prone position”. J Pediatr Orthop May-Jun 01;41(5):273-278, 2021.
Hart CM, Alswang J, Bram J, Kim ST, Arkader A, Silva M. Operative Versus Nonoperative Management of Acute Pediatric Monteggia Injuries With Complete Ulna Fractures. J Pediatr Orthop Jun 2, 2021(online ahead of print).
Farkas AB, Baghdadi S, Arkader A, Nguyen MK, Venkatesh TP, Srinivasan AS, Nguyen JC. Magnetic resonance imaging findings of synovial sarcoma in children: location-dependent differences. Pediatr Radiol 2021 Jul 28 (52, 2539-48).
Nguyen MK, Arkader A, Kaplan SL, Guariento A, Hong S, Moore ZR, Nguyen JC. Radiographic characterization of acute scaphoid fractures in children under 11 years of age. Pediatric Radiology Aug;51(9):1690-1695, 2021.
Baghdadi S, Nguyen JC, Arkader A. Nonossifying Fibroma of the Distal Tibia: Predictors of Fracture and Management Algorithm. J Pediatr Orthop Sep 1;41(8):e671-679, 2021.
Nguyen JC, Davis KW, Arkader A, Guariento A, Sze A, Hong S, Jaramillo D. Pre-treatment MRI of leukaemia and lymphoma in children: are there differences in marrow replacement patterns on T1-weighted images? Eur Radiol Oct; 31(10):7992-8000, 2021.
Denning JR, Gohel S, Arkader A. Open Reduction and Internal Screw Fixation of Transitional Ankle Fractures in Adolescents. JBJS Essent Surg Tech. 2021 Dec 22;11(4):e19.00070. doi: 10.2106/JBJS.ST.19.00070. eCollection 2021 Oct-Dec.
Nguyen J, Arkader A, Willliams B, Sze R, Gaballah M, Baghdadi s, Hussaini S. Pediatric musculoskeletal pathologies: Are there differences in triage of diagnoses and preferences for communication between radiology and orthopedics? Skeletal Radiology, Dec 4, 2021
Othman S, Azoury SC, Bauder A, Arkader A, Kovach SJ. Targeted muscle reinnervation in the pediatric population. Orthoplastic Surgery, 2021, Dec 9 (31-33).
Masquijo J, Ortiz MS, Ponzone A, Korosec LF, Arkader A. Fracturas del cóndilo lateral del húmero asociadas aluxación de codo en ni˜nos. Una revisión sistemática dela literatura. Revista Española de Cirugía Ortopédica y Traumatología (online ahead of print).
LaValva S.M., Rogers B.H., Arkader A. and Shah A.S. Are Junior Residents Competent at Closed Reduction and Casting of Distal Radius Fractures in Children? Iowa Orthop J, 41(1):39-46, 2021.
2020
Tolchin D, et al.; De Novo SOX6 Variants Cause a Neurodevelopmental Syndrome Associated with Attention-Deficit/Hyperactivity Disorder, Craniosynostosis and Osteochondromas. Am J Hum Genet 2020 Jun 4;106(6):830-845, 2020.
McCullough MC, Arkader A, Ariani R, Lightdale-Miric N, Tolo V, Stevanovic M; Surgical Outcomes, Complications, and Long-Term Functionality for Free Vascularized Fibula Grafts in the Pediatric Population: A 17-Year Experience and Systematic Review of the Literature. J Reconstr Microsurg Jun;36(5):386-396, 2020.
Grigoriu E, Dormans JP, Arkader A; Primary Aneurismal Bone Cyst of the Spine in Children: Updated Outcomes of a Modern Surgical Technique. International Journal of Spine Surgery Aug;14(4):615-622, 2020.
Magdaleno C, Arkader A, Goodarzian F, Marachelian A; Premature epiphyseal growth plate arrest after isotretinoin therapy for High Risk Neuroblastoma (HR-NBL)-A Case Series and Review of the Literature. Pediatric Blood & Cancer Aug;67(8):e28236, 2020.
Arkader A, Williams A, Binitie O, Thacker MM, Farfalli GL; Pediatric Chondroblastoma and the Need for Lung Staging at Presentation J Pediatr Orthop. Oct;40(9):e894-e897 2020
Magee L, Mahmoud M, Baldwin K, Talwar D, Gandhi J, Arkader A; Characteristics and Hospital Costs of Spica Cast Treatment of Non-accidental-related Diaphyseal Femoral Fractures in Children Before Walking Age. J Pediatr Orthop Nov/Dec;40(10):e932-e935. 2020
Nguyen JC, Nguyen MK, Arkader A, Guariento A, Sze A, Moore ZR, Chang B; Age dependent changes in pediatric scaphoid fracture pattern on radiograph. Skeletal Radiol Dec;49(12):2011-2018 2020.
Nguyen J.C., Biko D.M., Nguyen M.K., Othman S., Weber K.L., Ganley T.J. and Arkader A. Magnetic Resonance Imaging Features of Intra-Articular Tenosynovial Giant Cell Tumor In Children. Pediatric Radiology, pp.1-9, 2020.
Misaghi A., Mahmoud M.A., Arkader A. and Baldwin K.D. Fracture Characteristics Predict Suboptimal Alignment in Preschool Femoral Shaft Fractures Treated with Spica Casting: A Retrospective Chart review. Current Orthopaedic Practice, 31(4), pp.379-384.
LaValva S.M., Rogers B.H., Arkader A. and Shah A.S. Risk Factors for Failed Closed Reduction of Pediatric Distal Radius Fractures. Journal of Hand Surgery Global Online (in press), 2020.
Shah R, Miller D, Mahmoud M, Arkader A; Simultaneous Bilateral Femur Fractures in Children: A Case Series from a Pediatric Level I Trauma Center and Review of the Literature. Iowa Orthop J. 2020;40(1):167-171.
Lectures by Invitation
2022
“Fraturas do supracondilianas e côndilo lateral”. International Guest at the XIV Congresso Brasileiro de Ortopedia Pediátrica/ X Congreso de La Sociedad Latinoamericana de Ortopedia Y Traumatologia Infantil, Santos, Brazil, May 2022.
“Fraturas de Tornozelo”. International Guest at the XIV Congresso Brasileiro de Ortopedia Pediátrica/ X Congreso de La Sociedad Latinoamericana de Ortopedia Y Traumatologia Infantil, Santos, Brazil, May 2022.
“Fraturas Patológicas”. International Guest at the XIV Congresso Brasileiro de Ortopedia Pediátrica/ X Congreso de La Sociedad Latinoamericana de Ortopedia Y Traumatologia Infantil, Santos, Brazil, May 2022.
“Crescimento Guiado para Correção de Deformidades do Joelho”. International Guest at the XIV Congresso Brasileiro de Ortopedia Pediátrica/ X Congreso de La Sociedad Latinoamericana de Ortopedia Y Traumatologia Infantil, Santos, Brazil, May 2022.
“Pathologic Fractures”. New Zealand Orthopaedic Association COE On Call Paediatric Orthopaedics, Queenstown, August 2022.
“Complex open fractures. Management and treatment”. International guest at the Combined Pediatric Orthopaedic Spanish Society (SEOP) and Pediatric Orthopaedic Society of North America (POSNA) trauma meeting (making decisions in pediatrics complex fractures – _Toma de decisiones en fracturas complejas en la edad pediátrica), Madrid, October 2022.
“Proximal femur pathologic fractures. Management”. International guest at the Combined Pediatric Orthopaedic Spanish Society (SEOP) and Pediatric Orthopaedic Society of North America (POSNA) trauma meeting (making decisions in pediatrics complex fractures – _Toma de decisiones en fracturas complejas en la edad pediátrica), Madrid, October 2022.
“Transitional ankle fractures. Management”. International guest at the Combined Pediatric Orthopaedic Spanish Society (SEOP) and Pediatric Orthopaedic Society of North America (POSNA) trauma meeting (making decisions in pediatrics complex fractures – _Toma de decisiones en fracturas complejas en la edad pediátrica), Madrid, October 2022.
“Forearm deformity in MHE”. International guest at the 58th Congress of the Chilean Society of Orthopedic Surgery (SCHOT), Vina del Mar, Chile, October 2022.
“Resection of osteochondromas around the hip”. International guest at the 58th Congress of the Chilean Society of Orthopedic Surgery (SCHOT), Vina del Mar, Chile, October 2022.
“Resection of physeal bars”. International guest at the 58th Congress of the Chilean Society of Orthopedic Surgery (SCHOT), Vina del Mar, Chile, October 2022.
“The good, the bad and the ugly in tumor pathology”. International guest at the 58th Congress of the Chilean Society of Orthopedic Surgery (SCHOT), Vina del Mar, Chile, October 2022.
“Pathologic fractures of the proximal femur”. International guest at the Spanish Pediatric Orthopedic Society (SEOP) Webinar series, online, December 2022.
2021
“10 Tumores Osseos Benignos em +/- 30 minutos”. Guest lecturer at the 2nd Curso Interdisciplinar de Ortopedia Pediatrica, Brazilian Pediatric Orthopedic Society, virtual course. July 20th, 2021.
“Cistos Osseos: U versus A”. Guest lecturer at the OrtoCurso EAD de Oncologia Ortopédica, Brazil (virtual course). July 31st, 2021.
“Proximal Femoral Osteochondroma Excision”. Guest lecturer at the Virtual Combined POSNA SLAOTI SAOTI Meeting. October 15th and 16th 2021.
“Fracturas Pediatricas de Cadera”. Guest lecturer at the Curso Fracturas En El Nino; Departamento de Ortopedia y Traumatologia Pediatrica del Hospita; de Trauma Manuel Giagni, Assuncion, Paraguay. October 29th, 2021.
2020
“Fraturas Patológicas do Fêmur Proximal”. Webinar for SLAOTI (Sociedad Latinoamericana de Ortopedia Y Traumatologia Infantil) and SBOP (Brazilian Pediatric Orthopedic Society). July 2020. Brazil.
“Avaliação e Manejo das Fraturas Patológicas nas Crianças”. Webinar for Faculdade de Ciências Médicas Santa Casa de São Paulo. August 6, 2020, São Paulo, Brazil.
“Manejo de Fracturas Patológicas de Fémur Proximal en Niños”. Webinar for Sociedad Venezuelana de Ortopedia Infantil. August 7, 2020, Venezuela.
“Fraturas do Condilo Lateral do Umero”. Webinar for SLAOTI (Sociedad Latinoamericana de Ortopedia Y Traumatologia Infantil) and SBOP (Brazilian Pediatric Orthopedic Society). October 2020. Brazil.
“Crecimiento Guiado: trucos Y tecnicas”. Webinar for SLAOTI (Sociedad Latinoamericana de Ortopedia Y Traumatologia Infantil). November 3rd, 2020.
“Pediatric Bone Tumors”. Round table discussion for the 1st Online Meeting of SBOT (Brazilian Pediatric Orthopedic Society). November 11th, 2020.
“Growth Plate Bar Resection”. Webinar for the 56th Sociedad Chilena de Ortopedia Y Traumatologia congreso (1st online). November 20th, 2020. “Pathologic Fractures of the Proximal Femur”. Webinar for the 56th Sociedad Chilena de Ortopedia Y Traumatologia congreso (1st online). November 20th, 2020.
Presentation
2021
Lawrence T, Baghdadi S, Arkader A. “Open reduction of medial epicondyle fractures in children and adolescents: supine versus prone position” (podium presentation during the PRiSM 8th Annual Meeting being held virtually January 27-30, 2021)
Guzek, R., Cornell, M., Nguyen, J., Arkader, A. Diffuse Tenosynovial Giant Cell Tumors: Case Series From a Large Pediatric Orthopedic Hospital. ePoster at the 2021 Pediatric Orthopaedic Society of North America (POSNA) Annual Meeting, Dallas, TX.
Talwar, D., Baghdadi, S., Nocka, H., Arkader, A. Psychosocial factors impacting the mental health of the orthopedic workforce due to COVID-19. ePoster at 2021 American Public Health Association Annual Meeting. Denver, CO.
Hart C., Bram, J., Alswang, J., Arkader, A., Silva, M. Unicortical Fixation Appears Sufficient for Open Reduction and Internal Fixation of Tibial Avulsion Fractures in Children: A Multicenter Outcomes Study. Paper presentation at 2021 AAOS Annual Meeting, San Diego, CA, USA.
2020
Arkader A, Williams A, Thacker M, Benitie O, Farfalli G. “Chondroblastoma: Reconsidering the need for lung staging” (Virtual podium at the 2020 Pediatric Orthopaedic Society of North America (POSNA) Annual Meeting)
Misaghi A, Mahmoud M, Arkader A, Baldwin K. “Fracture Characteristics Predict Suboptimal Alignment in Pre School Femur fractures Treated in a Spica Cast” (E-poster at the 2020 Philly Ortho Trauma Symposium)
Editorials, Reviews, Chapters
2022
Arkader A, Boriani S; Management of Spine Tumors in the Growing Spine. In: The Growing Spine: Management of Spinal Disorders in Young Children 3rd Ed., 2022, Pages 411-430.
Mashoura K, Arkader A. Bone Tumors. In: Fundamentals of Pediatric Surgery, 2022, Pages 1101-1112.
2020
Arkader A, Weber K; Bone and Soft-Tissue Tumors. In: Lovell and Winter’s Pediatric Orthopaedics, 8th Edition. Wolters Kluwer/ Lippincott Williams & Wilkins, Philadelphia, (editors:), 2020.
Moore S, Johnson S, Arkader A, Schoenecker J; Diagnostically Directed Examination for Inflammatory, Infectious and Neoplastic Conditions. In: Musculoskeletal Infections Physical Examination for Pediatric and Adolescent Musculoskeletal Disorders: A media-enhanced guide for diagnosis and next steps (editors: Noonan K, Kocher M), 2020.
Misaghi A, Schoenecker J, Arkader A; Physeal Injuries. In: Green’s Skeletal Trauma in Children, 6th Edition. Elsevier Saunders, Philadelphia, (editors: Mencio GA; Swiontkowski MF), 2020 in preparation.
Misaghi A, Arkader A; Operative Management of Unicameral Bone Cyst, Aneurysmal Bone Cyst, and Nonossifying Fibroma. In: Operative Techniques in Orthopedic Surgery (editors: Flynn JF, Sankar WN, Wiesel SA), 3rd edition, 2020 in preparation.
Thacker MM, Arkader A; Benign and Malignant Musculoskeletal Neoplasms. In: Orthopedic Knowledge Update: Pediatrics 6. ICL 70. American Academy of Orthopaedic Surgeons, 2020 in preparation