Alexandre Arkader, MD

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Alexandre Arkader, MD, is an attending surgeon in the Division of Orthopaedics and Division of Oncology at Children's Hospital of Philadelphia, specializing in the treatment of bone and soft tissue tumors.

Areas of Expertise: Benign and malignant bone and soft tissue tumors, Complex trauma/pediatric fractures, Leg length discrepancy/angular deformities, Limb salvage surgery, Sarcomas, Limb deformity, Musculoskeletal tumors, Limb lengthening, Pediatric orthopaedic surgery
Locations: Main Hospital; Buerger Center for Advanced Pediatric Care; Specialty Care, King of Prussia; Middleman Family Pavilion

Appointments, Referrals and Video Visits: 215-590-1527

Background

Alexandre Arkader, MD, is a board-certified attending surgeon who specializes in treating children with bone tumors. He works with the Division of Orthopaedics and the Cancer Center at Children’s Hospital of Philadelphia.

Dr. Arkader is one of a handful of surgeons in the country with formal training in both pediatric orthopaedics and orthopaedic oncology. Additionally, he has a special interest in treating complex limb deformities, expertise in external fixation methods and other minimally invasive techniques for limb preservation and correction.

“The minute I started my orthopedic residency, I knew I’d go into peds ortho; I just love caring for children,” Dr. Arkader says. “The thought about taking care of oncology patients only came to me during my fellowship at CHOP Orthopaedics. The combination of both subspecialties – orthopaedics and orthopaedic oncology – lead to my desire to treat children with benign and malignant bone and soft tissue tumors, as well as perform limb salvage and reconstruction procedures for children with congenital and acquired conditions.”

“The ability to create such a positive impact in the care of these children, the possibility of combining all the principles in pediatric orthopaedic care and oncological principles to achieve the best outcome possible for the affected child is both challenging and inspiring,” Dr. Arkader adds.

Dr. Arkader joined CHOP after eight years at the Children’s Hospital of Los Angeles (CHLA) and Keck School of Medicine of USC. At CHLA, Dr. Arkader served as the Director of the Bone and Soft Tissue Tumor program, the Orthopedic Trauma Program, and the International Fellowship at the Children’s Orthopedic Center at CHLA.

Dr. Arkader earned his medical degree from F.T.E. Souza Marques in Rio de Janeiro, Brazil. He completed an internship in international medicine at the Hospital Santa Casa de Misericordia, and a residency in orthopedic surgery at the Hospital de Traumatologia-Ortopedia in Rio de Janeiro, Brazil.

In 2003, Dr. Arkader came to the United States to further his professional training. He completed a fellowship in pediatric orthopedics at Children’s Hospital of Philadelphia, and a second fellowship in musculoskeletal oncology at Memorial Sloan-Kettering Cancer Center in New York, NY.

Along with his clinical work, Dr. Arkader is also an active researcher. He’s published more than 80 peer-reviewed articles, many of which focused on musculoskeletal oncology and benign bone tumors, an area in which CHOP is a national leader in both experience and volume of patients successfully treated.

“We are 100% focused on pediatric care,” Dr. Arkader says. “I’m proud to work here with a team that is fully dedicated to achieving the best outcomes possible for all of our patients.”

Dr. Arkader has served as a national authority for numerous textbook chapters on pediatric musculoskeletal tumors. He has lectured in innumerous national and international meetings, and leads a biannual pediatric orthopedic course in South America. He participates in several study groups focused on research related to trauma and musculoskeletal infections and is an active reviewer for several medical journals. In addition, Dr. Arkader is a member of several national and international professional organizations including the Pediatric Orthopedic Society of North America, the American Academy of Orthopaedic Surgeons, the Musculoskeletal Tumor Society and the Children's Oncology Group.

Education and Training

Medical School

MD - Fundação Técnico-Educacional Souza Marques, Rio de Janeiro, Brazil

Internship

Internal Medicine - Hospital Santa Casa da Misericórdia, Rio de Janeiro, Brazil

Residency

Orthopaedic Surgery - Hospital de Traumatologia-Ortopedia (National Institute of Orthopaedics and Traumatology - Federal Research Institute), Rio de Janeiro, Brazil

Fellowship

Pediatric Orthopaedics - Children’s Hospital of Philadelphia, Philadelphia, PA

Musculoskeletal Oncology - Memorial Sloan-Kettering Cancer Center, New York, NY

Board Certification

Orthopaedic Surgery – American Board of Orthopaedic Surgery

Titles and Academic Titles

Attending Surgeon

Conditions Treated

Departments and Services

Publications

Books

Chapters

2020

Arkader A, Weber K; Bone and Soft-Tissue Tumors. In: Lovell and Winter’s Pediatric Orthopaedics, 8th Edition. Wolters Kluwer/ Lippincott Williams & Wilkins, Philadelphia, (editors:), 2020.

Moore S, Johnson S, Arkader A, Schoenecker J; Diagnostically Directed Examination for Inflammatory, Infectious and Neoplastic Conditions. In: Musculoskeletal Infections Physical Examination for Pediatric and Adolescent Musculoskeletal Disorders:  A media-enhanced guide for diagnosis and next steps (editors: Noonan K, Kocher M), 2020.

Misaghi A, Schoenecker J, Arkader A; Physeal Injuries. In: Green’s Skeletal Trauma in Children, 6th Edition. Elsevier Saunders, Philadelphia, (editors: Mencio GA; Swiontkowski MF), 2020 in preparation.

Misaghi A, Arkader A; Operative Management of Unicameral Bone Cyst, Aneurysmal Bone Cyst, and Nonossifying Fibroma. In: Operative Techniques in Orthopedic Surgery (editors: Flynn JF, Sankar WN, Wiesel SA), 3rd edition, 2020 in preparation.

Thacker MM, Arkader A; Benign and Malignant Musculoskeletal Neoplasms. In: Orthopaedic Knowledge Update: Pediatrics 6. ICL 70. American Academy of Orthopaedic Surgeons, 2020 in preparation

Arkader A, Boriani S; Management of Spine Tumors in the Growing Spine. In: The Growing Spine 3rd Ed., 2020 in preparation.

2019

Baldwin K, Shah A, Wells L, Arkader A; Common Fractures. In: Nelson Textbook of Pediatrics (editors Kliegman, St Geme, Blum, Shah, Tasker, Wilson), 21st edition, pages 3662-70, 2019.

Arkader A, Schwend R; Pathologic Fractures and Non-accidental Trauma. In: Rockwood and Wilkins’ Fractures in Children, 9th Edition, Wolters Kluwer/ Lippincott Williams & Wilkins, Philadelphia, (editors: Skaggs D; Flynn JM; Waters PM), chapter 6, 2019.

2017

Woodward C, Arkader A, Cahill PJ; Sacral Aneurysmal Bone Cyst. In: Pediatric Orthopedic Trauma Case Atlas (editors Iobst C and Frick SL), Springer, 2017.

Posters and Presentations

2021

Nguyen MK, Arkader A, Kaplan SL, Guariento A, Hong S, Moore ZR, Nguyen JC. Radiographic characterization of acute scaphoid fractures in children under 11 years of age. Pediatric Radiology (in press), 2021.

Baghdadi S, Harwood K, Arkader A, Lawrence T. “Open reduction of medial epicondyle fractures in children and adolescents: supine versus prone position”. J Pediatr Orthop (in press), 2021.

2020

Magdaleno C, Arkader A, Goodarzian F, Marachelian A; Premature epiphyseal growth plate arrest after isotretinoin therapy for High Risk Neuroblastoma (HR-NBL)-A Case Series and Review of the Literature. Pediatric Blood & Cancer Aug;67(8):e28236, 2020.

Tolchin D, et al.; De Novo SOX6 Variants Cause a Neurodevelopmental Syndrome Associated with Attention-Deficit/Hyperactivity Disorder, Craniosynostosis and Osteochondromas. Am J Hum Genet 2020 Jun 4;106(6):830-845, 2020.

Grigoriu E, Dormans JP, Arkader A; Primary Aneurismal Bone Cyst of the Spine in Children: Updated Outcomes of a Modern Surgical Technique. International Journal of Spine Surgery Aug;14(4):615-622, 2020.

Shah R, Miller D, Mahmoud M, Arkader A; Simultaneous Bilateral Femur Fractures in Children: A Case Series from a Pediatric Level I Trauma Center and Review of the Literature. Iowa Orthop J. 2020;40(1):167-171.

Nguyen JC, Nguyen MK, Arkader A, Guariento A, Sze A, Moore ZR, Chang B; Age dependent changes in pediatric scaphoid fracture pattern on radiograph. Skeletal Radiol Dec;49(12):2011-2018 2020.

Arkader A, Williams A, Binitie O, Thacker MM, Farfalli GL; Pediatric Chondroblastoma and the Need for Lung Staging at Presentation J Pediatr Orthop. Oct;40(9):e894-e897 2020

Magee L, Mahmoud M, Baldwin K, Talwar D, Gandhi J, Arkader A; Characteristics and Hospital Costs of Spica Cast Treatment of Non-accidental-related Diaphyseal Femoral Fractures in Children Before Walking Age. J Pediatr Orthop Nov/Dec;40(10):e932-e935. 2020

LaValva S.M., Rogers B.H., Arkader A. and Shah A.S. Risk Factors for Failed Closed Reduction of Pediatric Distal Radius Fractures. Journal of Hand Surgery Global Online (in press), 2020.

Misaghi A., Mahmoud M.A., Arkader A. and Baldwin K.D. Fracture Characteristics Predict Suboptimal Alignment in Preschool Femoral Shaft Fractures Treated with Spica Casting: A Retrospective Chart review. Current Orthopaedic Practice, 31(4), pp.379-384.

Nguyen J.C., Biko D.M., Nguyen M.K., Othman S., Weber K.L., Ganley T.J. and Arkader A. Magnetic Resonance Imaging Features of Intra-Articular Tenosynovial Giant Cell Tumor In Children. Pediatric Radiology, pp.1-9, 2020.

Al-Mahdi W, Ibrahim MM, Spiegel DA, Arkader A, Nance M, Baldwin K; Is Systemic Inflammatory Response Syndrome Relevant to Pulmonary Complications and Mortality in Multiply Injured Children? J Pediatr Orthop. 2020 Jan;40(1):1-7.

Adams A, Mahmmoud M, Wells L, Flynn J, Arkader A; Physeal Fractures of the Distal Femur: Is More Surgery Better? J Pediatr Orthop B. 2020 Jan;29(1):40-46

Shabtai L, Lightdale-Miric N, Rounds A, Arkader A, Pace JL; Incidence, risk factors and outcomes of avascular necrosis occurring after humeral lateral condyle fractures. J Pediatr Orthop B. 2020 Mar;29(2):145-148.

Meza BC, Obana KK, Talathi NS, Shah AS, Lightdale-Miric N, Arkader A; Predicting Radial Head Instability in Multiple Hereditary Exostoses (MHE): A Multicenter Analysis of Risk Factors. J Pediatr Orthop. 2020 Jan 27 (Epub ahead of print)

Whitlock PW, Salari KF, Blumstein G, Zhang B, Arkader A, Choi PD; Reliability and normative values of common adult radiographic parameters for hip preservation in the developing pelvis. J Hip Preservation Surgery 2019 in press

McCullough MC, Arkader A, Ariani R, Lightdale-Miric N, Tolo V, Stevanovic M; Surgical Outcomes, Complications, and Long-Term Functionality for Free Vascularized Fibula Grafts in the Pediatric Population: A 17-Year Experience and Systematic Review of the Literature. J Reconstr Microsurg Jun;36(5):386-396, 2020.

2019

Anari JB, Arkader A, Spiegel DA, Baldwin KD; Approaching Unusual Pediatric Distal Humerus Fracture Patterns. J Am Acad Orthop Surg. 2019 May 1;27(9):301-311.

Arkader A, Schur M, Refakis C, Capraro A, Woon R, Choi P; Unicortical Fixation is Sufficient for Surgical Treatment of Tibial Tubercle Avulsion Fractures in Children. J Pediatr Orthop. 2019 Jan;39(1):e18-e22.

Refakis CA, Arkader A, Baldwin KD, Spiegel DA, Sankar WN; Predicting Periarticular Infection in Children With Septic Arthritis of the Hip: Regionally Derived Criteria May Not Apply to All Populations. J Pediatr Orthop. 2019 May/Jun;39(5):268-274.

Adams AJ, Baldwin KD, Arkader A, Sankar WN; Assessing the Need for Common Perioperative Laboratory Tests in Pediatric Patients With Femoral Shaft Fractures. J Pediatr Orthop. 2019 Jul;39(6):e456-e461.

Godfrey J, Choi PD, Shabtai L, Nossov SB, Williams A, Lindberg AW, Silva S, Caird MS, Schur MD, Arkader A; Management of Pediatric Type I Open Fractures in the Emergency Department or Operating Room: A Multi-Center Perspective.  J Pediatr Orthop. 2019 Aug;39(7):372-376.

2018

Harris LH, Arkader A, Broom A, Flynn JM, Yellin J, Whitlock P, Miller A, Sawyer J, Roaten J, Skaggs DL, Choi PD; Pulseless Supracondylar Humerus Fracture with Anterior Interosseous Nerve or Median Nerve Injury – An Absolute Indication for Open Reduction? J Pediatr Orthop. 2018 Aug 4. 

Pace JL, Arkader A, Sousa T, Broom AM, Shabtai L; Incidence, Risk Factors, and Definition for Nonunion in Pediatric Lateral Condyle Fractures. J Pediatr Orthop. 2018 May/Jun;38(5):e257-e261.

Invited Lectures

International
2021

“10 Tumores Osseos Benignos em +/- 30 minutos”. Guest lecturer at the 2nd Curso Interdisciplinar de Ortopedia Pediatrica, Brazilian Pediatric Orthopedic Society, virtual course. July 20th, 2021.

“Cistos Osseos: U versus A”. Guest lecturer at the OrtoCurso EAD de Oncologia Ortopédica, Brazil (virtual course). July 31st, 2021.

2020

“Pathologic Fractures of the Proximal Femur”. Webinar for the 56th Sociedad Chilena de Ortopedia Y Traumatologia congreso (1st online). November 20th, 2020.

“Fraturas Patológicas do Fêmur Proximal”. Webinar for SLAOTI (Sociedad Latinoamericana de Ortopedia Y Traumatologia Infantil) and SBOP (Brazilian Pediatric Orthopedic Society). July 2020. Brazil.

“Avaliação e Manejo das Fraturas Patológicas nas Crianças”. Webinar for Faculdade de Ciências Médicas Santa Casa de São Paulo. August 6, 2020, São Paulo, Brazil.

“Manejo de Fracturas Patológicas de Fémur Proximal en Niños”. Webinar for Sociedad Venezuelana de Ortopedia Infantil. August 7, 2020, Venezuela.

“Fraturas do Condilo Lateral do Umero”. Webinar for SLAOTI (Sociedad Latinoamericana de Ortopedia Y Traumatologia Infantil) and SBOP (Brazilian Pediatric Orthopedic Society). October 2020. Brazil.

“Crecimiento Guiado: trucos Y tecnicas”. Webinar for SLAOTI (Sociedad Latinoamericana de Ortopedia Y Traumatologia Infantil). November 3rd, 2020.

“Pediatric Bone Tumors”. Round table discussion for the 1st Online Meeting of SBOT (Brazilian Pediatric Orthopedic Society). November 11th, 2020.

“Growth Plate Bar Resection”. Webinar for the 56th Sociedad Chilena de Ortopedia Y Traumatologia congreso (1st online). November 20th, 2020.

2019

“Pathologic Fractures in Children”. XI TROIA Congresso Brasileiro de Trauma Ortopedico Pediatrico. June 2019, Manaus, Brazil

“The Treatment of Growth Arrest”. XI TROIA Congresso Brasileiro de Trauma Ortopedico Pediatrico. June 2019, Manaus, Brazil

“Fractures of the Lateral Humerus Condyle – Complications”. XI TROIA Congresso Brasileiro de Trauma Ortopédico Pediátrico. June 2019, Manaus, Brazil.

2018

“Fracturas patológicas del fémur proximal: Desde la evaluación inicial hasta la estabilización”. XXXVIII Congresso Annual Sociedad Argentina de Ortopedia y Traumatologia Infantil. September 2018, Buenos Aires, Argentina

“Osteocondromatosis múltiple hereditaria (OMH)”. XXXVIII Congresso Annual Sociedad Argentina de Ortopedia y Traumatologia Infantil. September 2018, Buenos Aires, Argentina

“Fracturas de femur en pacientes pre-escolares: ¿Necesitamos ser mas agresivos en el tratamiento?”. XXXVIII Congresso Annual Sociedad Argentina de Ortopedia y Traumatologia Infantil. September 2018, Buenos Aires, Argentina

“Infecciones que parecen tumores y viceversa”. XXXVIII Congresso Annual Sociedad Argentina de Ortopedia y Traumatologia Infantil. September 2018, Buenos Aires, Argentina

“Deformidades angulares de rodilla en niños”. XXXVIII Congresso Annual Sociedad Argentina de Ortopedia y Traumatologia Infantil. September 2018, Buenos Aires, Argentina

“Tratamiento de las fracturas de tobillo en niños”. XXXVIII Congresso Annual Sociedad Argentina de Ortopedia y Traumatologia Infantil. September 2018, Buenos Aires, Argentina

2017

“10 Benign Bone Tumors in 20ish Minutes”. International Faculty at the POS/POSNZ combined ASM meeting ICL. August 2017, Queenstown, New Zealand

“Infections that Look Like Tumors and Vice-Versa”. International Faculty at the POS/POSNZ combined ASM meeting ICL. August 2017, Queenstown, New Zealand

“Pathologic Fractures: from Diagnosis to Treatment”. International Faculty at the POS/POSNZ combined ASM annual meeting. August 2017, Queenstown, New Zealand

“Fraturas do Antebraço”. International Faculty at the 5th Combined SLAOTI/POSNA/EPOS meeting. October 2017, São Paulo, SP, Brazil

“Fraturas do Tornozelo”. International Faculty at the 5th Combined SLAOTI/POSNA/EPOS meeting. October 2017, São Paulo, SP, Brazil

“Fraturas do Colo do Rádio”. International Faculty at the 5th Combined SLAOTI/POSNA/EPOS meeting. October 2017, São Paulo, SP, Brazil

“Deformidades Angulares do Joelho”. International Faculty at the 5th Combined SLAOTI/POSNA/EPOS meeting. October 2017, São Paulo, SP, Brazil

“10 Tumores Benígnos em 15 Minutos”. International Faculty at the 5th Combined SLAOTI/POSNA/EPOS meeting. October 2017, São Paulo, SP, Brazil

“Pediatric Ankle Fractures”. International Faculty at the XXXI Congresso Annual Sociedad Mexicana de Ortopedia Pediatrica. November 2017, Puerto Vallarta, Jalisco, Mexico

“Diaphyseal Femur Fractures”. International Faculty at the XXXI Congresso Annual Sociedad Mexicana de Ortopedia Pediatrica. November 2017, Puerto Vallarta, Jalisco, Mexico

“Pediatric Hip Fractures”. International Faculty at the XXXI Congresso Annual Sociedad Mexicana de Ortopedia Pediatrica. November 2017, Puerto Vallarta, Jalisco, Mexico

“Bone Tumors Around the Hip”. International Faculty at the XXXI Congresso Annual Sociedad Mexicana de Ortopedia Pediatrica. November 2017, Puerto Vallarta, Jalisco, Mexico

“Open Fractures in Children”. International Faculty at the XXXI Congresso Annual Sociedad Mexicana de Ortopedia Pediatrica. November 2017, Puerto Vallarta, Jalisco, Mexico

Awards and Honors

2017 Top Docs Award from Southern Jersey Magazine (peer indication)
2017-2022, Philadelphia Magazine's Top Doctors in Orthopaedic Surgery
2016-2021 Best Doctors® award (peer indication)

Editorial and Academic Positions

Editorial Positions

2019-present, Editor, tumors section, JPOSNA

2018-present  Reviewer, Journal of Children’s Orthopaedics

2018-present  Reviewer, Journal of Pediatric Orthopaedics B

2018-present Reviewer, BMC Musculoskeletal Disorders

2018-present Reviewer JBJS Essential Surgical Techniques

Leadership and Memberships

Memberships in Professional Organizations

International

2018-present, Sociedad Argentina de Ortopedia y Traumatologia Infantil

2015-present, Sociedad Colombiana de Cirurgia Ortopedica y Traumatologia

2011-present, Sociedad Chilena de Ortopedia y Traumatología

National

2012-present, Musculoskeletal Tumor Society

2010-present, Children’s Oncology Group