Ulf H. Beier, MD, is an Assistant Professor of Pediatrics at Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania. Dr. Beier graduated from medical school in Germany (University of Kiel). He completed his Pediatric residency training at the University of Illinois at Chicago, where he also served as Chief resident. Subsequently, he joined CHOP as a Nephrology Fellow in 2008.
Following his fellowship, Dr. Beier stayed on as faculty at Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania. During his clinical training and time as faculty at the Children’s Hospital of Philadelphia, Dr. Beier became interested in the immune biology of transplantation, and started working in the laboratory of Wayne W. Hancock. There, he studied the biology of the histone/protein deacetylase Sirtuin-1 in T cell function.
Subsequently, Dr. Beier developed an independent research interest in T cell metabolism and the immunosuppressive tumor microenvironment. He observed that regulatory T cells are metabolically well adapted to low-glucose, high L-lactate environments (Cell Metabolism 2017). Cancers can be very adept at evading the immune response by creating a metabolic environment favoring pro-tolerant conditions. Dr. Beier aims to learn from cancer to develop new approaches to therapeutic immunosuppression derived from the mechanisms of how cancer metabolism evades anti-tumor immunity. His research is funded by the American Society of Nephrology, the Laffey McHugh foundation, and the National Institutes of Health.
Education and Training
Dr. med. - Christian, Albrechts, University of Kiel, Kiel, Germany
Pediatrics - University of Illinois at Chicago, Chicago, IL
Pediatrics - University of Illinois at Chicago, Chicago, IL (Chief Resident)
Pediatric Nephrology - The Children's Hospital of Philadelphia, Philadelphia, PA
Titles and Academic Titles
Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Departments and Services
Targeting sirtuin-1 to enhance foxp3+ regulatory T-cell function
HDAC9 and mitochondrial biology
Liu Y, Bao C, Wang L, Han R, Beier UH, Akimova T, Dent SYR, Hancock WW. GCN5 and PCAF have complementary roles in Foxp3+ T-regulatory cells and their dual loss leads to lethal autoimmunity. Cancers (Basel), April 2019.
Singhal S, Stadanlick J, Annunziata MJ, Rao AS, Bhojnagarwala PS, O'Brien S, Moon EK, Cantu E, Danet-Desnoyers G, Ra HJ, Litzky L, Akimova T, Beier UH, Hancock WW, Albelda SM, Eruslanov EB. Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer. Science Translational Medicine 11(), February 2019.
Lieber Arnon D, Beier Ulf H, Xiao Haiyan, Wilkins Benjamin J, Jiao Jing, Li Xinmin S, Schugar Rebecca C, Strauch Christopher M, Wang Zeneng, Brown J Mark, Hazen Stanley L, Bokulich Nicholas A, Ruggles Kelly V, Akimova Tatiana, Hancock Wayne W, Blaser Martin J. Loss of HDAC6 alters gut microbiota and worsens obesity. FASEB journal 33(1): 1098-1109, Jan 2019.
Lieber, A.D., U.H. Beier, H. Xiao, B.J. Wilkins, J. Jiao, X.S. Li, R.C. Schugar, C.M. Strauch, Z. Wang, J.M. Brown, S.L. Hazen, N.A. Bokulich, K.V. Ruggles, T. Akimova, W.W. Hancock and M.J. Blaser, Loss of HDAC6 alters gut microbiota and worsens obesity. FASEB J, 2018: p. fj201701586R.
Wang, L., U.H. Beier, T. Akimova, S. Dahiya, R. Han, A. Samanta, M.H. Levine and W.W. Hancock, Histone/protein deacetylase inhibitor therapy for enhancement of Foxp3+ T-regulatory cell function post-transplantation. Am J Transplant, 2018.
Negorev, D., U.H. Beier, T. Zhang, J.G. Quatromoni, P. Bhojnagarwala, S.M. Albelda, S. Singhal, E. Eruslanov, F.W. Lohoff, M.H. Levine, J.M. Diamond, J.D. Christie, W.W. Hancock and T. Akimova, Human neutrophils can mimic myeloid-derived suppressor cells (PMN-MDSC) and suppress microbead or lectin-induced T cell proliferation through artefactual mechanisms. Sci Rep, 2018. 8(1): p. 3135.
Beier, U.H., Apoptotic Regulatory T Cells Retain Suppressive Function through Adenosine. Cell Metab, 2018. 27(1): p. 5-7.
Mandapathil M, Beier UH, Graefe H, Kröger B, Hedderich J, Maune S, Meyer JE. Differential chemokine expression patterns in tonsillar disease.. Acta Otorhinolaryngol Ital. 38(): 316-322, August 2018.
Angelin, A., L. Gil-de-Gomez, S. Dahiya, J. Jiao, L. Guo, M.H. Levine, Z. Wang, W.J. Quinn, 3rd, P.K. Kopinski, L. Wang, T. Akimova, Y. Liu, T.R. Bhatti, R. Han, B.L. Laskin, J.A. Baur, I.A. Blair, D.C. Wallace, W.W. Hancock and U.H. Beier, Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments. Cell Metab, 2017. 25(6): p. 1282-1293 e7.
Huang, J., L. Wang, S. Dahiya, U.H. Beier, R. Han, A. Samanta, J. Bergman, E.M. Sotomayor, E. Seto, A.P. Kozikowski and W.W. Hancock, Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function. Sci Rep, 2017. 7(1): p. 8626.
Akimova, T., T. Zhang, D. Negorev, S. Singhal, J. Stadanlick, A. Rao, M. Annunziata, M.H. Levine, U.H. Beier, J.M. Diamond, J.D. Christie, S.M. Albelda, E.B. Eruslanov and W.W. Hancock, Human lung tumor FOXP3+ Tregs upregulate four "Treg-locking" transcription factors. JCI Insight, 2017. 2(16).
Laskin, B.L., J. Jiao, H.J. Baluarte, S. Amaral, S.L. Furth, T. Akimova, W.W. Hancock, M.H. Levine, P.P. Reese and U.H. Beier, The Effects of Tacrolimus on T-Cell Proliferation Are Short-Lived: A Pilot Analysis of Immune Function Testing. Transplant Direct, 2017. 3(8): p. e199.
Jiao, J., R. Han, W.W. Hancock and U.H. Beier, Proximity Ligation Assay to Quantify Foxp3 Acetylation in Regulatory T Cells. Methods Mol Biol, 2017. 1510: p. 287-293.
Levine, M.H., Z. Wang, H. Xiao, J. Jiao, L. Wang, T.R. Bhatti, W.W. Hancock and U.H. Beier, Targeting Sirtuin-1 prolongs murine renal allograft survival and function. Kidney Int, 2016. 89(5): p. 1016-26.
Wang, L., S. Kumar, S. Dahiya, F. Wang, J. Wu, K. Newick, R. Han, A. Samanta, U.H. Beier, T. Akimova, T.R. Bhatti, B. Nicholson, M.P. Kodrasov, S. Agarwal, D.E. Sterner, W. Gu, J. Weinstock, T.R. Butt, S.M. Albelda and W.W. Hancock, Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3+ T-regulatory Cell Function and Promotes Antitumor Immunity. EBioMedicine, 2016. 13: p. 99-112.
Laskin, B.L., H.K. Singh, U.H. Beier, T. Moatz, S.L. Furth, N. Bunin, D. Witte, J. Goebel, S.M. Davies, C. Dandoy, S. Jodele and V. Nickeleit, The Noninvasive Urinary Polyomavirus Haufen Test Predicts BK Virus Nephropathy in Children After Hematopoietic Cell Transplantation: A Pilot Study. Transplantation, 2016. 100(10): p. e81-7.
Xiao, H., J. Jiao, L. Wang, S. O'Brien, K. Newick, L.C. Wang, E. Falkensammer, Y. Liu, R. Han, V. Kapoor, F.K. Hansen, T. Kurz, W.W. Hancock and U.H. Beier, HDAC5 controls the functions of Foxp3(+) T-regulatory and CD8(+) T cells. Int J Cancer, 2016. 138(10): p. 2477-86.
Akimova, T., M.H. Levine, U.H. Beier and W.W. Hancock, Standardization, Evaluation, and Area-Under-Curve Analysis of Human and Murine Treg Suppressive Function. Methods Mol Biol, 2016. 1371: p. 43-78.
Beier, U.H., A. Angelin, T. Akimova, L. Wang, Y. Liu, H. Xiao, M.A. Koike, S.A. Hancock, T.R. Bhatti, R. Han, J. Jiao, S.C. Veasey, C.A. Sims, J.A. Baur, D.C. Wallace and W.W. Hancock, Essential role of mitochondrial energy metabolism in Foxp3(+) T-regulatory cell function and allograft survival. FASEB J, 2015. 29(6): p. 2315-26.
Wang, L., Y. Liu, R. Han, U.H. Beier, T.R. Bhatti, T. Akimova, M.I. Greene, S.W. Hiebert and W.W. Hancock, FOXP3(+) regulatory T cell development and function require histone/protein deacetylase 3. J Clin Invest, 2015. 125(8): p. 3304.
Akimova, T., H. Xiao, Y. Liu, T.R. Bhatti, J. Jiao, E. Eruslanov, S. Singhal, L. Wang, R. Han, K. Zacharia, W.W. Hancock and U.H. Beier, Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells. Mucosal Immunol, 2014. 7(5): p. 1209-20.
Liu, Y., L. Wang, R. Han, U.H. Beier, T. Akimova, T. Bhatti, H. Xiao, P.A. Cole, P.K. Brindle and W.W. Hancock, Two histone/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T-regulatory cell development and function. Mol Cell Biol, 2014. 34(21): p. 3993-4007.
Liu, Y., L. Wang, J. Predina, R. Han, U.H. Beier, L.C. Wang, V. Kapoor, T.R. Bhatti, T. Akimova, S. Singhal, P.K. Brindle, P.A. Cole, S.M. Albelda and W.W. Hancock, Inhibition of p300 impairs Foxp3(+) T regulatory cell function and promotes antitumor immunity. Nat Med, 2013. 19(9): p. 1173-7.
Wang, L., Y. Liu, R. Han, U.H. Beier, R.M. Thomas, A.D. Wells and W.W. Hancock, Mbd2 promotes foxp3 demethylation and T-regulatory-cell function. Mol Cell Biol, 2013. 33(20): p. 4106-15.
Wang, L., Y. Liu, U.H. Beier, R. Han, T.R. Bhatti, T. Akimova and W.W. Hancock, Foxp3+ T-regulatory cells require DNA methyltransferase 1 expression to prevent development of lethal autoimmunity. Blood, 2013. 121(18): p. 3631-9.
Beier, U.H., L. Wang, R. Han, T. Akimova, Y. Liu and W.W. Hancock, Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms. Sci Signal, 2012. 5(229): p. ra45.
Beier, U.H., L. Wang and W.W. Hancock, Combination of isoform-selective histone/protein deacetylase inhibitors improves Foxp3+ T-regulatory cell function. Cell Cycle, 2012. 11(18): p. 3351-2.
Hancock, W.W., T. Akimova, U.H. Beier, Y. Liu and L. Wang, HDAC inhibitor therapy in autoimmunity and transplantation. Ann Rheum Dis, 2012. 71 Suppl 2: p. i46-54.
Liu, Y., L. Wang, R. Han, U.H. Beier and W.W. Hancock, Two lysines in the forkhead domain of foxp3 are key to T regulatory cell function. PLoS One, 2012. 7(1): p. e29035.
Akimova, T., U.H. Beier, Y. Liu, L. Wang and W.W. Hancock, Histone/protein deacetylases and T-cell immune responses. Blood, 2012. 119(11): p. 2443-51.
Beier, U.H., L. Wang, T.R. Bhatti, Y. Liu, R. Han, G. Ge and W.W. Hancock, Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival. Mol Cell Biol, 2011. 31(5): p. 1022-9.
Akimova, T., U.H. Beier, L. Wang, M.H. Levine and W.W. Hancock, Helios expression is a marker of T cell activation and proliferation. PLoS One, 2011. 6(8): p. e24226.
Beier, U.H., T. Akimova, Y. Liu, L. Wang and W.W. Hancock, Histone/protein deacetylases control Foxp3 expression and the heat shock response of T-regulatory cells. Curr Opin Immunol, 2011. 23(5): p. 670-8.
de Zoeten, E.F., L. Wang, K. Butler, U.H. Beier, T. Akimova, H. Sai, J.E. Bradner, R. Mazitschek, A.P. Kozikowski, P. Matthias and W.W. Hancock, Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. Mol Cell Biol, 2011. 31(10): p. 2066-78.
Laskin B, Seif A, Bunin N, Wang Y, Beier U, Altrich M, Jodele S, Daives S, Denburg M. BK viremia is common in children after allogeneic hematopoietic cell transplant. Biol Blood Marrow Transplant, 2018.
Beier UH, Copelovitch L. Disorders of the renal & urologic systems: congenital anomalies of the kidney & urologic system. In: Florin TA, Ludwig S, editors. Netter's pediatrics. Amsterdam (The Netherlands): Elsevier; 2011. p. 408-13.
Ruiz CE, Beier UH. Small intestinal submucosa: a new generation of valve replacement. In: Hijazi ZM, Ruiz CE, Bonhoeffer P, Feldmann L, editors. Transcatheter valve repair. London: Martin Dunitz & Parthenon Publishing, Taylor & Francis Medical Books; 2006. p. 75-7.
Posters and Presentations
Hancock WW, Zhang T, Beier UH, Samanta A, Han R, Wang L, Jiao J, Diamond JM, Wilkes DS, Lederer DJ, Simmons RA, Christie JD, Akimova T. Obesity Induced Il-18 Production Impairs Foxp3+ Treg Function and Increases Risk Of Primary Graft Dysfunction In Lung Transplant Recipient. Am J Transplant, 2019. presented at American Transplant Congress 2019, Boston, MA.
Akimova T, Zhang T, Beier UH, Samanta A, Han R, Wang L, Jiao J, Diamond JM, Wilkes DS, Lederer DJ, Simmons RA, Christie JD, Hancock WW. Obesity Leads to Increased IL-18, Treg Impairment and Increased Risk of PGD. The Journal of Heart and Lung Transplantation, 2019. International Society for Heart and Lung Transplantation (ISHLT), April 2019, Orlando, FL.
Salmon E, Ehlayel AM, Welsh SS, Boyer DL, Polsky TG, Hewlett JL, Beier UH. Vecuronium Induced Pseudohypernatremia: A Case Report. Oral presentation given by a collaborator at the Reseal Research Institute 2019, New Orleans, LA, 2019. Renal Research Institute, 21st International Conference on Dialysis: Advances in Kidney Disease, January 2019, New Orleans, LA.
Beier UH, Cully MD, Siska PJ, Jiao J, TeSlaa T, Quinn 3rd WJ, Hancock WW, Baur JA, Rabinowitz JD, Renner K, Kreutz M. Fatty acid depletion is a reversible cause of kynurenine induced T cell apoptosis. J Immunol, 2019. Immunology 2018, San Diego, CA, podium and poster presentation.
Angelin A, Gil-de-Gómez L, Dahiya S, Jiao J, Guo L, Levine MH, Wang Z, Quin W, Kopinski PK, Wang L, Baur JA, Blair IA, Hancock WW, Wallace DC, Beier UH. Foxp3 increase oxidative phosphorylation and NAD oxidation, adapting regulatory T cells to low glucose high lactate environments. Oral research presentation given by a collaborator, Targeting Mitochondrial 2018, Berlin, Germany, 2018. Targeting Mitochondria, October 2018, Berlin, Germany, oral presentation.
Awards and Honors
2017, John Merrill Grant in Transplantation Scholar of the ASN Foundation for Kidney Research
2017, Early Career Faculty Honor Roll, The Children’s Hospital of Philadelphia
2010, Young Investigator Award, American Transplant Congress
2010, Alien of Exceptional Ability, United States Citizenship and Immigration Services
2007, Elected Member, AΩA honor medical society
Editorial and Academic Positions
International Journal of Cancer
American Journal of Transplantation
Scandinavian Journal of Immunology
Trends in Pharmacological Sciences
Journal of Rheumatology
Cellular and Molecular Immunology
Cancer Immunology Research
Archives of Toxicology
Journal of Medical Genetics
Leadership and Memberships
Memberships in Professional Organizations
American Society of Pediatric Nephrology
- 2011-present, Research Committee
American Society of Transplantation
American Society of Nephrology
American Association of Immunologists
Patient Experience Ratings
About the Patient Experience Rating System
The Patient Experience Rating is an average of all responses to the care provider related questions shown above from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.
Responses are measured on a scale of 1 to 5 with 5 being the best score.
We are committed to true transparency. However, to ensure the comments are fair and correctly attributed, we review each one before posting to the website. We exclude entire comments that disclose patient's protected health information, are off-topic, or include other confidential or inappropriate content. Comments will appear on provider bios only if providers have a minimum number of comments.
Comments are shared internally for education purposes to ensure that we are doing our very best for the patients and families for whom we are privileged to care.
The comments are submitted by patients and families and reflect their views and opinions. The comments are not endorsed by and do not reflect the views of Children’s Hospital of Philadelphia.