Ulf H. Beier, MD

Medical School

Dr. med. - Christian, Albrechts, University of Kiel, Kiel, Germany

Internship

Pediatrics - University of Illinois at Chicago, Chicago, IL

Residency

Pediatrics - University of Illinois at Chicago, Chicago, IL (Chief Resident)

Fellowship

Pediatric Nephrology - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Nephrology
Pediatrics

Papers

2019

Liu Y, Bao C, Wang L, Han R, Beier UH, Akimova T, Dent SYR, Hancock WW. GCN5 and PCAF have complementary roles in Foxp3+ T-regulatory cells and their dual loss leads to lethal autoimmunity. Cancers (Basel), April 2019.

Singhal S, Stadanlick J, Annunziata MJ, Rao AS, Bhojnagarwala PS, O'Brien S, Moon EK, Cantu E, Danet-Desnoyers G, Ra HJ, Litzky L, Akimova T, Beier UH, Hancock WW, Albelda SM, Eruslanov EB. Human tumor-associated monocytes/macrophages and their regulation of T cell responses in early-stage lung cancer. Science Translational Medicine 11(), February 2019.

Lieber Arnon D, Beier Ulf H, Xiao Haiyan, Wilkins Benjamin J, Jiao Jing, Li Xinmin S, Schugar Rebecca C, Strauch Christopher M, Wang Zeneng, Brown J Mark, Hazen Stanley L, Bokulich Nicholas A, Ruggles Kelly V, Akimova Tatiana, Hancock Wayne W, Blaser Martin J. Loss of HDAC6 alters gut microbiota and worsens obesity. FASEB journal 33(1): 1098-1109, Jan 2019.

2018

Lieber, A.D., U.H. Beier, H. Xiao, B.J. Wilkins, J. Jiao, X.S. Li, R.C. Schugar, C.M. Strauch, Z. Wang, J.M. Brown, S.L. Hazen, N.A. Bokulich, K.V. Ruggles, T. Akimova, W.W. Hancock and M.J. Blaser, Loss of HDAC6 alters gut microbiota and worsens obesity. FASEB J, 2018: p. fj201701586R.

Wang, L., U.H. Beier, T. Akimova, S. Dahiya, R. Han, A. Samanta, M.H. Levine and W.W. Hancock, Histone/protein deacetylase inhibitor therapy for enhancement of Foxp3+ T-regulatory cell function post-transplantation. Am J Transplant, 2018.

Negorev, D., U.H. Beier, T. Zhang, J.G. Quatromoni, P. Bhojnagarwala, S.M. Albelda, S. Singhal, E. Eruslanov, F.W. Lohoff, M.H. Levine, J.M. Diamond, J.D. Christie, W.W. Hancock and T. Akimova, Human neutrophils can mimic myeloid-derived suppressor cells (PMN-MDSC) and suppress microbead or lectin-induced T cell proliferation through artefactual mechanisms. Sci Rep, 2018. 8(1): p. 3135.

Beier, U.H., Apoptotic Regulatory T Cells Retain Suppressive Function through Adenosine. Cell Metab, 2018. 27(1): p. 5-7.

Mandapathil M, Beier UH, Graefe H, Kröger B, Hedderich J, Maune S, Meyer JE. Differential chemokine expression patterns in tonsillar disease.. Acta Otorhinolaryngol Ital. 38(): 316-322, August 2018.

2017

Angelin, A., L. Gil-de-Gomez, S. Dahiya, J. Jiao, L. Guo, M.H. Levine, Z. Wang, W.J. Quinn, 3rd, P.K. Kopinski, L. Wang, T. Akimova, Y. Liu, T.R. Bhatti, R. Han, B.L. Laskin, J.A. Baur, I.A. Blair, D.C. Wallace, W.W. Hancock and U.H. Beier, Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments. Cell Metab, 2017. 25(6): p. 1282-1293 e7.

Huang, J., L. Wang, S. Dahiya, U.H. Beier, R. Han, A. Samanta, J. Bergman, E.M. Sotomayor, E. Seto, A.P. Kozikowski and W.W. Hancock, Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function. Sci Rep, 2017. 7(1): p. 8626.

Akimova, T., T. Zhang, D. Negorev, S. Singhal, J. Stadanlick, A. Rao, M. Annunziata, M.H. Levine, U.H. Beier, J.M. Diamond, J.D. Christie, S.M. Albelda, E.B. Eruslanov and W.W. Hancock, Human lung tumor FOXP3+ Tregs upregulate four "Treg-locking" transcription factors. JCI Insight, 2017. 2(16).

Laskin, B.L., J. Jiao, H.J. Baluarte, S. Amaral, S.L. Furth, T. Akimova, W.W. Hancock, M.H. Levine, P.P. Reese and U.H. Beier, The Effects of Tacrolimus on T-Cell Proliferation Are Short-Lived: A Pilot Analysis of Immune Function Testing. Transplant Direct, 2017. 3(8): p. e199.

Jiao, J., R. Han, W.W. Hancock and U.H. Beier, Proximity Ligation Assay to Quantify Foxp3 Acetylation in Regulatory T Cells. Methods Mol Biol, 2017. 1510: p. 287-293.

2016

Levine, M.H., Z. Wang, H. Xiao, J. Jiao, L. Wang, T.R. Bhatti, W.W. Hancock and U.H. Beier, Targeting Sirtuin-1 prolongs murine renal allograft survival and function. Kidney Int, 2016. 89(5): p. 1016-26.

Wang, L., S. Kumar, S. Dahiya, F. Wang, J. Wu, K. Newick, R. Han, A. Samanta, U.H. Beier, T. Akimova, T.R. Bhatti, B. Nicholson, M.P. Kodrasov, S. Agarwal, D.E. Sterner, W. Gu, J. Weinstock, T.R. Butt, S.M. Albelda and W.W. Hancock, Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3+ T-regulatory Cell Function and Promotes Antitumor Immunity. EBioMedicine, 2016. 13: p. 99-112.

Laskin, B.L., H.K. Singh, U.H. Beier, T. Moatz, S.L. Furth, N. Bunin, D. Witte, J. Goebel, S.M. Davies, C. Dandoy, S. Jodele and V. Nickeleit, The Noninvasive Urinary Polyomavirus Haufen Test Predicts BK Virus Nephropathy in Children After Hematopoietic Cell Transplantation: A Pilot Study. Transplantation, 2016. 100(10): p. e81-7.

Xiao, H., J. Jiao, L. Wang, S. O'Brien, K. Newick, L.C. Wang, E. Falkensammer, Y. Liu, R. Han, V. Kapoor, F.K. Hansen, T. Kurz, W.W. Hancock and U.H. Beier, HDAC5 controls the functions of Foxp3(+) T-regulatory and CD8(+) T cells. Int J Cancer, 2016. 138(10): p. 2477-86.

Akimova, T., M.H. Levine, U.H. Beier and W.W. Hancock, Standardization, Evaluation, and Area-Under-Curve Analysis of Human and Murine Treg Suppressive Function. Methods Mol Biol, 2016. 1371: p. 43-78.

2015

Beier, U.H., A. Angelin, T. Akimova, L. Wang, Y. Liu, H. Xiao, M.A. Koike, S.A. Hancock, T.R. Bhatti, R. Han, J. Jiao, S.C. Veasey, C.A. Sims, J.A. Baur, D.C. Wallace and W.W. Hancock, Essential role of mitochondrial energy metabolism in Foxp3(+) T-regulatory cell function and allograft survival. FASEB J, 2015. 29(6): p. 2315-26.

Wang, L., Y. Liu, R. Han, U.H. Beier, T.R. Bhatti, T. Akimova, M.I. Greene, S.W. Hiebert and W.W. Hancock, FOXP3(+) regulatory T cell development and function require histone/protein deacetylase 3. J Clin Invest, 2015. 125(8): p. 3304.

2014

Akimova, T., H. Xiao, Y. Liu, T.R. Bhatti, J. Jiao, E. Eruslanov, S. Singhal, L. Wang, R. Han, K. Zacharia, W.W. Hancock and U.H. Beier, Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells. Mucosal Immunol, 2014. 7(5): p. 1209-20.

Liu, Y., L. Wang, R. Han, U.H. Beier, T. Akimova, T. Bhatti, H. Xiao, P.A. Cole, P.K. Brindle and W.W. Hancock, Two histone/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T-regulatory cell development and function. Mol Cell Biol, 2014. 34(21): p. 3993-4007.

2013

Liu, Y., L. Wang, J. Predina, R. Han, U.H. Beier, L.C. Wang, V. Kapoor, T.R. Bhatti, T. Akimova, S. Singhal, P.K. Brindle, P.A. Cole, S.M. Albelda and W.W. Hancock, Inhibition of p300 impairs Foxp3(+) T regulatory cell function and promotes antitumor immunity. Nat Med, 2013. 19(9): p. 1173-7.

Wang, L., Y. Liu, R. Han, U.H. Beier, R.M. Thomas, A.D. Wells and W.W. Hancock, Mbd2 promotes foxp3 demethylation and T-regulatory-cell function. Mol Cell Biol, 2013. 33(20): p. 4106-15.

Wang, L., Y. Liu, U.H. Beier, R. Han, T.R. Bhatti, T. Akimova and W.W. Hancock, Foxp3+ T-regulatory cells require DNA methyltransferase 1 expression to prevent development of lethal autoimmunity. Blood, 2013. 121(18): p. 3631-9.

2012

Beier, U.H., L. Wang, R. Han, T. Akimova, Y. Liu and W.W. Hancock, Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms. Sci Signal, 2012. 5(229): p. ra45.

Beier, U.H., L. Wang and W.W. Hancock, Combination of isoform-selective histone/protein deacetylase inhibitors improves Foxp3+ T-regulatory cell function. Cell Cycle, 2012. 11(18): p. 3351-2.

Hancock, W.W., T. Akimova, U.H. Beier, Y. Liu and L. Wang, HDAC inhibitor therapy in autoimmunity and transplantation. Ann Rheum Dis, 2012. 71 Suppl 2: p. i46-54.

Liu, Y., L. Wang, R. Han, U.H. Beier and W.W. Hancock, Two lysines in the forkhead domain of foxp3 are key to T regulatory cell function. PLoS One, 2012. 7(1): p. e29035.

Akimova, T., U.H. Beier, Y. Liu, L. Wang and W.W. Hancock, Histone/protein deacetylases and T-cell immune responses. Blood, 2012. 119(11): p. 2443-51.

2011

Beier, U.H., L. Wang, T.R. Bhatti, Y. Liu, R. Han, G. Ge and W.W. Hancock, Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival. Mol Cell Biol, 2011. 31(5): p. 1022-9.

Akimova, T., U.H. Beier, L. Wang, M.H. Levine and W.W. Hancock, Helios expression is a marker of T cell activation and proliferation. PLoS One, 2011. 6(8): p. e24226.

Beier, U.H., T. Akimova, Y. Liu, L. Wang and W.W. Hancock, Histone/protein deacetylases control Foxp3 expression and the heat shock response of T-regulatory cells. Curr Opin Immunol, 2011. 23(5): p. 670-8.

de Zoeten, E.F., L. Wang, K. Butler, U.H. Beier, T. Akimova, H. Sai, J.E. Bradner, R. Mazitschek, A.P. Kozikowski, P. Matthias and W.W. Hancock, Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. Mol Cell Biol, 2011. 31(10): p. 2066-78.

Abstracts

2018

Laskin B, Seif A, Bunin N, Wang Y, Beier U, Altrich M, Jodele S, Daives S, Denburg M. BK viremia is common in children after allogeneic hematopoietic cell transplant. Biol Blood Marrow Transplant, 2018.

Books

2011

Beier UH, Copelovitch L. Disorders of the renal & urologic systems: congenital anomalies of the kidney & urologic system. In: Florin TA, Ludwig S, editors. Netter's pediatrics. Amsterdam (The Netherlands): Elsevier; 2011. p. 408-13.

2006

Ruiz CE, Beier UH. Small intestinal submucosa: a new generation of valve replacement. In: Hijazi ZM, Ruiz CE, Bonhoeffer P, Feldmann L, editors. Transcatheter valve repair. London: Martin Dunitz & Parthenon Publishing, Taylor & Francis Medical Books; 2006. p. 75-7.

Posters and Presentations

2019

Hancock WW, Zhang T, Beier UH, Samanta A, Han R, Wang L, Jiao J, Diamond JM, Wilkes DS, Lederer DJ, Simmons RA, Christie JD, Akimova T. Obesity Induced Il-18 Production Impairs Foxp3+ Treg Function and Increases Risk Of Primary Graft Dysfunction In Lung Transplant Recipient. Am J Transplant, 2019. presented at American Transplant Congress 2019, Boston, MA.

Akimova T, Zhang T, Beier UH, Samanta A, Han R, Wang L, Jiao J, Diamond JM, Wilkes DS, Lederer DJ, Simmons RA, Christie JD, Hancock WW. Obesity Leads to Increased IL-18, Treg Impairment and Increased Risk of PGD. The Journal of Heart and Lung Transplantation, 2019. International Society for Heart and Lung Transplantation (ISHLT), April 2019, Orlando, FL.

Salmon E, Ehlayel AM, Welsh SS, Boyer DL, Polsky TG, Hewlett JL, Beier UH. Vecuronium Induced Pseudohypernatremia: A Case Report. Oral presentation given by a collaborator at the Reseal Research Institute 2019, New Orleans, LA, 2019. Renal Research Institute, 21st International Conference on Dialysis: Advances in Kidney Disease, January 2019, New Orleans, LA.

2018

Beier UH, Cully MD, Siska PJ, Jiao J, TeSlaa T, Quinn 3rd WJ, Hancock WW, Baur JA, Rabinowitz JD, Renner K, Kreutz M. Fatty acid depletion is a reversible cause of kynurenine induced T cell apoptosis. J Immunol, 2019. Immunology 2018, San Diego, CA, podium and poster presentation.

Angelin A, Gil-de-Gómez L, Dahiya S, Jiao J, Guo L, Levine MH, Wang Z, Quin  W, Kopinski PK, Wang L, Baur JA, Blair IA, Hancock WW, Wallace DC, Beier UH. Foxp3 increase oxidative phosphorylation and NAD oxidation, adapting  regulatory T cells to low glucose high lactate environments. Oral research presentation given by a collaborator, Targeting Mitochondrial 2018, Berlin, Germany, 2018. Targeting Mitochondria, October 2018, Berlin, Germany, oral presentation.