Jeffrey Bergelson, MD

Jeffrey Bergelson, MD

Dr. Bergelson is an attending physician in the Division of Infectious Diseases  at Children's Hospital of Philadelphia. He holds the Stanley Plotkin Endowed Chair in Pediatric Infectious Diseases.

Areas of Expertise: Enterovirus entry into cells, Management and treatment of common pediatric infectious diseases, Viral pathogenesis, Virus receptors, Cell biology of virus entry
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - University of Pennsylvania School of Medicine, Philadelphia, PA


University of California, San Francisco, CA


Children's Hospital, Boston, MA

Board Certification

American Board of Pediatrics

Titles and Academic Titles

Attending Physician, Division of Infectious Diseases

Stanley Plotkin Endowed Chair in Pediatric Infectious Diseases

Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

How viruses enter cells to begin infection




Harris KG, Morosky SA, Drummond CG, Patel M, Kim C, Stolz DB, Bergelson JM, Cherry S, Coyne CB. RIP3 Regulates Autophagy and Promotes Coxsackievirus B3 Infection of Intestinal Epithelial Cells. Cell host & microbe. 2015; 18(2):221-32. NIHMSID: NIHMS715934

Pan J, Zhang L, Odenwald MA, Shen L, Turner JR, Bergelson JM. Expression of human decay-accelerating factor on intestinal epithelium of transgenic mice does not facilitate infection by the enteral route. Journal of virology. 2015; 89(8):4311-8.

Pan J, Zhang L, Organtini LJ, Hafenstein S, Bergelson JM. Specificity of coxsackievirus B3 interaction with human, but not murine, decay-accelerating factor: replacement of a single residue within short consensus repeat 2 prevents virus attachment. Journal of virology. 2015; 89(2):1324-8.


Kim C, Bergelson JM. Echovirus 7 entry into polarized caco-2 intestinal epithelial cells involves core components of the autophagy machinery. Journal of virology. 2014; 88(1):434-43.


Krieger SE, Kim C, Zhang L, Marjomaki V, Bergelson JM. Echovirus 1 entry into polarized Caco-2 cells depends on dynamin, cholesterol, and cellular factors associated with macropinocytosis. Journal of virology. 2013; 87(16):8884-95.

Nishimura Y, Lee H, Hafenstein S, Kataoka C, Wakita T, et al. Enterovirus 71 binding to PSGL-1 on leukocytes: VP1-145 acts as a molecular switch to control receptor interaction. PLoS pathogens. 2013; 9(7):e1003511.

Bergelson JM, Coyne CB. Picornavirus entry. Advances in experimental medicine and biology. 2013; 790:24-41.