Dr. Alexandra Borst is an Assistant Professor of Pediatrics in the Division of Hematology and Associate Clinical Director of the Comprehensive Vascular Anomalies Program at the Children’s Hospital of Philadelphia. She completed medical school at Columbia University, pediatrics residency at CHOP, and fellowship in pediatric hematology-oncology at Duke University. Prior to joining faculty at CHOP in 2021, she previously directed the vascular anomalies program at Vanderbilt and was an active member of the hemostasis and thrombosis center (HTC) there. Dr. Borst’s clinical and academic interests are in non-malignant hematology and vascular anomalies. She sees patients in the CHOP HTC and is working to build a comprehensive clinical and research program for hereditary hemorrhagic telangiectasia (HHT) and establish CHOP as a pediatric HHT center of excellence.
Education and Training
MD - Columbia University College of Physicians & Surgeons, New York, NY
Pediatrics - Children’s Hospital of Philadelphia, Philadelphia, PA
Clinical/Research Fellow, Pediatric Hematology & Oncology - Duke University Medical Center, Durham, NC
Hematology – American Board of Internal MedicinePediatrics – American Board of Pediatrics
Titles and Academic Titles
Associate Clinical Director, Comprehensive Vascular Anomalies Program
Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Departments and Services
Means M, Whitehead M, Borst AJ, Cristancho A. Neonatal medullary venous thrombosis and hemorrhage from protein C deficiency. Neuropediatrics. 2023 Feb. DOI: 10.1055/a-2041-3461. PMID: 36822225.
Schievink WI, Maya MM, Borst AJ. Adolescent Headache Due to Congenital Pelvic/Sacral Vascular Malformation. Ann Neurol. 2023 Mar 30. doi: 10.1002/ana.26651. Epub ahead of print. PMID: 36995356.
Grenier JM, Borst AJ, Sheppard SE, Snyder KM, Li D, Surrey LF, Al-Ibraheemi A, Weber DR, Treat JR, Smith CL, Laje P, Dori Y, Adams DM, Acord M, Srinivasan AS. Pathogenic variants in PIK3CA are associated with clinical phenotypes of kaposiform lymphangiomatosis, generalized lymphatic anomaly, and central conducting lymphatic anomaly. Pediatr Blood Cancer. 2023 May 17:e30419. doi: 10.1002/pbc.30419. Epub ahead of print. PMID: 37194624.
Ahlers CG, Lan M, Schoenecker JG, Borst AJ. Blood Loss and Transfusion in a Pediatric Scoliosis Surgery Cohort in the Antifibrinolytic Era. J Pediatr Hematol Oncol. 2022 Apr 1;44(3):e701-e706. doi: 10.1097/MPH.0000000000002351. PMID: 34654764; PMCID: PMC8957516.
Goldenberg NA, Kittelson JM, Abshire TC, et al. for the Kids-DOTT Trial Investigators (including Borst, AJ) and the ATLAS Group. Effect of Anticoagulant Therapy for 6 Weeks vs 3 Months on Recurrence and Bleeding Events in Patients Younger Than 21 Years of Age With Provoked Venous Thromboembolism: The Kids-DOTT Randomized Clinical Trial. JAMA. 2022;327(2):129-137. doi:10.1001/jama.2021.23182
Snyder EJ, Sarma A, Borst AJ, Tekes A. Lymphatic Anomalies in Children: Update on Imaging Diagnosis, Genetics, and Treatment. AJR Am J Roentgenol. 2022 Jun;218(6):1089-1101. doi: 10.2214/AJR.21.27200. Epub 2022 Jan 19. PMID: 35043669.
Gibson BHY, Duvernay MT, McKeithan LJ, Benvenuti TA, Warhoover TA, Martus JE, Mencio GA, Emerson BR, Moore-Lotridge SN, Borst AJ, Schoenecker JG. Variable Response to Antifibrinolytics Correlates with Blood-loss and Transfusion in Posterior Spinal Fusion. Spine Deform. 2022 Jul;10(4):841-851. doi: 10.1007/s43390-022-00489-6. Epub 2022 Mar 5. Erratum in: Spine Deform. 2022 Apr 13;: PMID: 35247191; PMCID: PMC9891390.
Borst AJ, Nakano TA. Targeting inflammation-induced Kasabach-Merritt phenomenon. Blood. 2022;139(11):1603-1605. doi:10.1182/blood.2022015412
Raghavendran P, Albers SE, Phillips JD, Zarnegar-Lumley S, Borst AJ. Clinical Response to PI3K-α Inhibition in a Cohort of Children and Adults With PIK3CA-Related Overgrowth Spectrum Disorders. Journal of Vascular Anomalies. 2022;3(1):e038. doi:10.1097/JOVA.0000000000000038
Borst AJ, Swerdlin RF, Phillips JD, Hawkins CM, and Briones MA. How We Established a Multidisciplinary Program for Vascular Anomalies. Pediatr Blood Cancer. 2022;69(S3):e28863. doi:10.1002/pbc.28863
Croteau S.E., Wheeler A.P., Khan O., Haley K.M., Borst A.J., Lattimore S., et al. Pharmacokinetic-tailored approach to hemophilia prophylaxis: Medical decision making and outcomes. Res Pract Thromb Haemost 2020; 00: 1– 8. https://doi.org/10.1002/rth2.12305
Borst A.J., Nakano, T.A., Blei, F., Adams, D.M., Duis, J. A Primer on a Comprehensive Genetic Approach to Vascular Anomalies. Front Pediatr. 2020;8:579591.
Borst, A.J., Sudan, D.L., Wang, L.A., Neuss, M.J., Rothman, J.A., Ortel, T.L., 2018. Bleeding and thrombotic complications of pediatric liver transplant. Pediatr Blood Cancer 65, e26955. https://doi.org/10.1002/pbc.26955
Borst, A.J., Tchapyjnikov, D., 2018. B6 and Bleeding: A Case Report of a Novel Vitamin Toxicity. Pediatrics 141, S430–S433. https://doi.org/10.1542/peds.2017-2039
Borst, A.J., Wechsler, D.S., 2017. Transplanting One Problem for Another. Pediatrics 139, e20170542. https://doi.org/10.1542/peds.2017-0542
Tchapyjnikov, D., Borst, A.J., 2017. Immune-related Neurological Symptoms in an Adolescent Patient Receiving the Checkpoint Inhibitor Nivolumab. J. Immunother. 40, 286–288. https://doi.org/10.1097/CJI.0000000000000177
Borst, A.J., States, L.J., Reilly, A.F., Rheingold, S.R., 2013. Determining response and recurrence in pediatric B-cell lymphomas of the bone. Pediatr Blood Cancer 60, 1281–1286. https://doi.org/10.1002/pbc.24523
Posters and Presentations
Borst, AJ, Eng, W, Griffin, M, Ricci, KW, Engel, E, Adams, DM, Dayneka, J, Cohen-Cutler, SJ, Andreoli, SM, Wu, MD, Wheeler, AP, Heym, KM, Crary, SE, Nakano, TA, Schulte, R, Setty, B, McLean, TW, Pahl, KS, Intzes, S, Pateva, I, Teitelbaum, M, Zong, Z, Li, Y, and Jeng, MR. Risk Factors and Treatment Response in Kaposiform Hemangioendothelioma: A Multicenter Cohort Study. Oral abstract: 2023 ASPHO Conference: 2023 May 11. Fort Worth, TX.
Borst, AJ, Eng, W, Griffin, M, Ricci, KW, Engel, E, Adams, DM, Dayneka, J, Cohen-Cutler, SJ, Andreoli, SM, Tucker, E, Wheeler, AP, Heym, KM, Crary, SE, Nakano, TA, Schulte, R, Setty, B, McLean, TW, Pahl, KS, Intzes, S, Pateva, I, Teitelbaum, M, Zong, Z, Li, Y, and Jeng, MR. Treatment Practices and Response Rates in Kaposiform Hemangioendothelioma: A Multicenter Cohort Study. Poster session: 2023 ASPHO Conference: 2023 May 11. Fort Worth, TX.
Borst, AJ, Hammill, AM, Crary, SE, McLean, TW, Felton, T, and Blatt, J. Barriers to Genetic Testing in Vascular Malformations. Poster session: 2023 ASPHO Conference: 2023 May 12. Fort Worth, TX.
Raghavendran P, Albers SE, Phillips JD, Zarnegar-Lumley S, and Borst AJ. Clinical Response to PI3K-α Inhibition in a Cohort of Children and Adults With PIK3CA-Related Overgrowth Spectrum Disorders. Oral abstract: International Society for the Study of Vascular Anomalies World Congress: 2022 May 13. Vancouver, BC.
Borst, A.J., Bonfield, C.M., Deenadayalan, P.S., Le, C.H., Helmer Sobey, J., and Reddy, S.K. E-aminocaproic acid (EACA) vs. tranexamic acid (TXA) in children undergoing complex cranial vault reconstruction for repair of craniosynostosis. Poster presented at: Society for Pediatric Anesthesia meeting; 2021 Feb 27; Virtual.
Ahlers, C.G., Lan, M.G., Schoenecker, J.G., and Borst, A.J. Worsened outcomes in pediatric neuromuscular scoliosis patients compared to idiopathic scoliosis patients after posterior spinal fusion surgery. Poster session presented at: The Anesthesiology Annual Meeting; 2020 October 3; Virtual.
Duvernay, M., Gibson, B.H.Y., Mckeithan, L., Borst, A.J., and Schoenecker, J.G. Platelet Dysfunction and Persistent Fibrinolysis in Pediatric Scoliosis Surgery Patients Receiving Tranexamic Acid. Blood 2020; 136 (Supplement 1): 26. doi: https://doi.org/10.1182/blood-2020-138730. Oral abstract presentation at: American Society of Hematology Annual Meeting; 2020 Dec 5; Virtual.
Borst, AJ. Lymphatic Anomalies, XXX∘ Argentinian Cardiovascular Surgery Annual Meeting, Virtual. 2021
Borst, AJ. Vascular Anomalies for the Pediatric Hematologist-Oncologist, presentation to the Cumberland Pediatric Foundation, Virtual Continuing Medical Education Program, Brentwood, TN. 2020.
Borst, AJ. Emergencies in Vascular Anomalies, Vanderbilt Life Flight Group Conference, Nashville, TN. 2019.
Awards and Honors
2021, Nominated to the Geoffrey Fleming Academy for Excellence in Education Mentorship Program
2018, Appointed to the Katherine Dodd Faculty Scholars Program
2017, Silber Award, Duke University
2016, ASH Abstract Achievement Award
2015, Accepted to Dr. Craig Kessler’s “Hematology Fellows Consortium”
2010, Alpha Omega Alpha, Columbia University
2010, Glasgow-Rubin Achievement Award, Columbia University
2010, Daniel J. Fink MD Memorial Prize, Columbia University
2005, Kappa Delta Award, Pomona College
2005, Vaile Prize in Biology, Pomona College
2005, Phi Beta Kappa, Pomona College
2005, Magna Cum Laude, Pomona College
Editorial and Academic Positions
Ad Hoc Reviewer
Journal of Pediatric Hematology-Oncology
Journal of Vascular Anomalies
Pediatric Blood and Cancer
Leadership and Memberships
Memberships in Professional Organizations
2020-present, International Society on Thrombosis and Haemostasis
2017-present, International Society for the Study of Vascular Anomalies
2015-present, Hemostasis and Thrombosis Research Society
- 2018-present, VENUS Pediatric Thrombosis Committee
2014-present, American Society of Pediatric Hematology/Oncology
- 2018-present, Vascular Anomalies Special Interest group
- 2018-present, Education and Research Committees
2014-present, American Society of Hematology
Patient Experience Ratings
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