Lawrence W. Brown, MD

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Lawrence Brown, MD, is a pediatric neurologist in the Division of Neurology at Children's Hospital of Philadelphia

Areas of Expertise: Behavioral disorders in pediatric neurology (especially Tourette syndrome and complex ADHD), Pediatric epilepsy, Pediatric sleep disorders
Locations: Main Hospital; Specialty Care & Surgery Center, King of Prussia; Buerger Center for Advanced Pediatric Care

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

Lawrence W. Brown, MD, is a pediatric neurologist at Children’s Hospital of Philadelphia (CHOP) and Director of the Pediatric Neuropsychiatry Program at CHOP. He specializes in epilepsy and sleep disorders as well as behavioral disorders, including Tourette syndrome and complex attention deficit hyperactivity disorder (ADHD).

Dr. Brown was drawn to neurology because of his deep interest in child development and the desire to help children challenged by neurodevelopmental disorders.

“I have always been fascinated by the miracle of childhood as we develop language, personality, talents and independence,” he says. “I have always been equally fascinated by the challenges that occur on the way.”

His philosophy of care centers around giving children the care and resources they need to reach the full extent of their capabilities.

“I want families to know that their team of clinicians and researchers will not only treat symptoms, but take a comprehensive approach to help their child achieve his or her potential,” he says.

Along with his work at CHOP, Dr. Brown is an Associate Professor of Neurology and Pediatrics at the Perelman School of Medicine at the University of Pennsylvania.

Dr. Brown points to breakthroughs in understanding the genetic roots of brain disorders as holding promise for future treatments, while noting that other factors must be considered as well.

“It is an exciting time with daily advances in neurogenetics and the opportunity for a new level of possibilities for previously untreatable disorders,” he says. “At the same time we need to address the social determinants of neurologic health.”

In addition to his clinical role, Dr. Brown is a researcher focusing on the medical transition to adulthood and the genetic basis of Tourette syndrome.

Education and Training

Medical School

MD - New York University School of Medicine, New York, NY

Internship

Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

Residency

Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

Fellowship

Pediatric Neurology - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Neurology
Pediatrics
Sleep Medicine

Titles and Academic Titles

Attending Physician

Director, Pediatric Neuropsychiatry Program

Associate Professor of Neurology and Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

Drug trials in pediatric epilepsy and Tourette syndrome
Pharmacokinetic studies in pediatrics
Sleep in neurodevelopmental disabilities

Publications

Papers

2018

Abdulkadir M, Londono D, Gordon D, Fernandez TV, Brown LW, Cheon KA, Coffey BJ, Elzerman L, Fremer C, Fründt O, Garcia-Delgar B, Gilbert DL, Grice DE, Hedderly T, Heyman I, Hong HJ, Huyser C, Ibanez-Gomez L, Jakubovski E, Kim YK, Kim YS, Koh YJ, Kook S, Kuperman S, Leventhal B, Ludolph AG, Madruga-Garrido M, Maras A, Mir P, Morer A, Müller-Vahl K, Münchau A, Murphy TL, Plessen KJ, Roessner V, Shin EY, Song DH, Song J, Tübing J, van den Ban E, Visscher F, Wanderer S, Woods M, Zinner SH, King RA, Tischfield JA, Heiman GA, Hoekstra PJ, Dietrich A. Investigation of previously implicated genetic variants in chronic tic disorders: a transmission disequilibrium test approach. European Archives of Psychiatry and Clinical Neuroscience. 2018 Apr;268(3):301-316.

2016

Abdulkadir M, Tischfield JA, King RA, Fernandez TV, Brown LW, Cheon KA, Coffey BJ, de Bruijn SF, Elzerman L, Garcia-Delgar B, Gilbert DL, Grice DE, Hagstrøm J, Hedderly T, Heyman I, Hong HJ, Huyser C, Ibanez-Gomez L, Kim YK, Kim YS, Koh YJ, Kook S, Kuperman S, Lamerz A, Leventhal B, Ludolph AG, Madruga-Garrido M, Maras A, Messchendorp MD, Mir P, Morer A, Münchau A, Murphy TL, Openneer TJ, Plessen KJ, Rath JJ, Roessner V, Fründt O, Shin EY, Sival DA, Song DH, Song J, Stolte AM, Tübing J, van den Ban E, Visscher F, Wanderer S, Woods M, Zinner SH, State MW, Heiman GA, Hoekstra PJ, Dietrich A. Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder. Journal of Psychiatric Research. 2016 Nov;82:126-35.

Brown LW, Camfield P, Capers M, Cascino G, Ciccarelli M, de Gusmao CM, Downs SM, Majnemer A, Miller AB, SanInocencio C, Schultz R, Tilton A, Winokur A, Zupanc M. The neurologist's role in supporting transition to adult health care: A consensus statement. Neurology. 2016 Aug 23;87(8):835-40.

2014

Bisker E, McClelland GM, Brown LW, Liu GT. The Long-Term Outcome of Ocular Tics in a Pediatric Neuro-Ophthalmology Practice. J AAPOS (Journal of the American Association for Pediatric Ophthalmology and Strabismus). 2014 Feb;18(1):31-5.

2013

Brown LW, Roach ES. Outgrowing the Child Neurologist: Facing the Challenges of Transition. JAMA Neurology 70: 496-497, 2013.

Prashad P, Brown LW. Brain Tumor Presenting as Somnambulism in an Adolescent. Pediatr Neurol. 2013 Sep;49(3):209-12. Epub 2013 Jul 5.

Books

2017

Camfield, C.S., Camfield, P.R., Brown, L.W.: Transitional care for children with neurological disorders.    Philadelphia: Elsevier. Pp. 1270-1275, 2017. Pediatric Neurology: Principles and Practice, Sixth Edition. Swaiman, K.F., Ashwal, S., Ferriero, D.M., Schor, N.F., et al (eds.). Elsevier, 2017.

2013

Brown LW. Paraplegia. Zorc J, Brown LW, Clark BJ, Manno CS (Eds.). Clinical Handbook of Pediatrics, Fifth Edition. Baltimore: Williams & Wilkins. Pp 614-623, 2013. 2013. 



Brown LW. Vertigo. Zorc J, Brown LW, Clark BJ, Manno CS (Eds.). Clinical Handbook of Pediatrics, Fifth Edition. Baltimore: Williams & Wilkins. Pp 846-855, 2013. 2013. 



Brown LW. Episodic events mimicking seizures in childhood and adolescence. Pediatric Epilepsy. Duchowny M, Cross JH,Arzimanoglou A. (Eds.). McGraw Hill. Pp 162-171, 2013. 

Posters and Presentations

Invited Lectures

2018

Brown LW. "Improved Health Care Transition For Youth With Epilepsy: A Goal For All Providers"; Health Resources and Services Administration; national webinar. May 2018.

2017

Brown LW. The Neurologist's Role in Medical Transition. National Institute of Neurologic Disorders and Stroke 2017 Nonprofit Forum, Bethesda, MD. Sep 2017.

Brown LW. "The Neurologist's Role in Medical Transition". National Institute of Neurologic Disorders and Stroke 2017 Nonprofit Forum, Bethesda, MD. Aug 2017.

Brown LW. Medical Management of Neurobehavioral Issues in Children with NF1. Neurofibromatosis Symposium, Philadelphia, PA. Apr 2017.

Brown LW. Improving Health Care Transition: The Neurologist's Role.  Keynote address, meeting of Coordinating Center for Children and Youth with Epilepsy grantees for American Academy of Pediatrics, Washington, DC. Apr 2017.

Brown LW. Medical Management of Neurobehavioral Issues in Children with NF1. Neurofibromatosis Symposium, Philadelphia, PA. Apr 2017.

Brown LW. Expecting to Transition: Reframing the Journey.  Annual meeting of the Tuberous Sclerosis Alliance, Washington, DC. Mar 2017.

Awards and Honors

  • 2015, Meyer Service Award - Pennsylvania Tourette Syndrome Alliance
  • 2012, Pennsylvania Psychopharmacology Guidelines Workgroup
  • 2012, Donald M. Palatucci Advocacy Leadership Forum, American Academy of Neurology, faculty
  • 2011-2014, Partial University of Pennsylvania Sabbatical to develop advocacy projects for Child Neurology Foundation
  • 2011, Donald M. Palatucci Advocacy Leadership Forum, American Academy of Neurology, mentor
  • 2010, Donald M. Palatucci Advocacy Leadership Forum, American Academy of Neurology, advocate
  • 2001, Fritz E. Dreifuss International Travel Scholar, Epilepsy Foundation of America
  • 2001, Professional mentor, LaSalle University, Academy of Development of Interfaith Leadership
  • 1996, Visiting professor, CHOP-China Exchange Program: Beijing and Shanghai, China
  • 1996, Visiting professor, Sara Hospitals:  Brasilia and Salvador, Brazil

Editorial and Academic Positions

Editorial Positions

1996-present, Editorial Board, Pediatric Neurology

Leadership and Memberships

Memberships in Professional Organizations

  • 2017-present, American Professional Society of ADHD and Related Disorders
    • 2017-present, Board of Directors
  • 1991-present, American Epilepsy Society
  • 1984-present, Sleep Research Society
  • 1973-present, Child Neurology Society
  • 1973-present, American Academy Neurology
  • 1972-present, American Academy of Pediatrics