Marcus G. Davey, PhD

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Marcus G. Davey, PhD, is a Senior Research Investigator with the Center for Fetal Research at Children's Hospital of Philadelphia, an extension of CHOP's Center for Fetal Diagnosis & Treatment.

Locations: Main Hospital
Phone: 1-800-468-8376

Background

Marcus Davey, PhD, is a Developmental Physiologist and Senior Research Investigator in the Center for Fetal Research, the research extension of the Center for Fetal Diagnosis & Treatment at Children's Hospital of Philadelphia (CHOP). He also serves as Adjunct Associate Professor of Surgery at the Perelman School of Medicine at the University of Pennsylvania.

Dr. Davey earned his BS (Honors) at the Monash School of Medicine in Melbourne, Australia, completing his honors thesis on respiratory control following preterm birth. He received his PhD from the Department of Physiology at Monash University in Melbourne, Australia. During his doctoral studies, he established a neonatal pulmonary function laboratory to evaluate prenatal therapies for human disease, including severe lung hypoplasia and prematurity of birth. In 1998, Dr. Davey was the recipient of the PSANZ Young Investigator Award. 

Tackling Extreme Prematurity

Marcus Davey, researcher, in the lab

CHOP researchers design a unique womb-like, fluid-filled environment to bridge critical time from mother’s womb to outside world.

Since joining Children’s Hospital of Philadelphia in 1999, Dr. Davey has been part of a team working on cutting-edge studies aimed at treating a wide variety of genetic disorders before birth. His post-doctoral work has centered on prenatal surgical and genetic therapies for lung development disorders, with a focus on the biology of the lung and conditions such as bronchopulmonary dysplasia, congenital diaphragmatic hernia and pulmonary hypertension. Dr. Davey’s research focus extends to areas of pediatric respiratory and pulmonary issues and pediatric surgery. He is well published, with authorship on over 40 peer reviewed research publications.

Dr. Davey’s extensive research has explored the safety and efficacy of fetal therapies with the potential to improve respiratory function and lung development. He studies the impact of prematurity on lung development and how in utero treatments such as tracheal occlusion affect respiratory function and lung growth.

Since 2013, Dr. Davey has served as co-investigator and “lead-tinkerer” on the study of an extra-uterine support device being tested in CHOP’s Center for Fetal Research. With perseverance, innovation and a unique bioengineering skillset, he co-developed a unique womb-like, fluid-filled environment to provide prolonged (up to four weeks) physiologic support for extreme prematurity. He is study director on an FDA Early Feasibility Animal Trial to evaluate clinical translation of this groundbreaking technology.

Education and Training

Fellowship

Postdoctoral Research Fellow - Institute for Surgical Science, Children’s Hospital of Philadelphia, Philadelphia, PA

Undergraduate Degree

BSci Honors Program - School of Medicine, Monash University, Melbourne, Australia
BSci - Monash University, Melbourne, Australia

Graduate Degree

PhD - Monash University, Melbourne, Australia

Titles and Academic Titles

Senior Research Investigator

Developmental Physiologist

Adjunct Associate Professor, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

Neonatal pulmonary function

Prenatal surgical and genetic therapies for lung development disorders

Impact of prematurity on lung development

Publications

Papers

2019

Ozawa K, Davey MG, Tian Z, Hornick MA, Mejaddam AY, McGovern PE, Flake AW, Rychik J. Fetal echocardiographic assessment of the cardiovascular impact of prolonged support in the EXTrauterine Environment for Neonatal Development (EXTEND) system. [Published online ahead of print April 15, 2019] Ultrasound Obstet Gynecol.

Rossidis AC, Angelin A, Lawrence KM, Baumgarten HD, Kim AG, Mejaddam AY, Coons BE, Hartman HA, Hwang G, Monos S, Peranteau WH, Davey MG, Murdock D, Wallace DC, Flake AW. Premature Lambs Exhibit Normal Mitochondrial Respiration after Long-Term Extrauterine Support. Fetal Diagn Ther. 2019 Mar 12;:1-7. PMID: 30861524 

Mejaddam AY, Hornick MA, McGovern PE, Baumgarten HD, Lawrence KM, Rossidis AC, Hwang G, Young K, Abdulmalik O, Partridge EA, Peranteau WH, Davey MG, Flake AW. Erythropoietin Prevents Anemia and Transfusions in Extremely Premature Lambs Supported by an EXTrauterine Environment for Neonatal Development (EXTEND). Fetal Diagn Ther. 2019 Jan 31;:1-7. PMID: 30703769 

Lawrence KM, McGovern PE, Mejaddam A, Rossidis AC, Baumgarten H, Kim A, Grinspan JB, Licht DJ, Didier RA, Vossough A, Radaelli E, Rychik J, Song L, Peranteau WH, Davey MG, Flake AW, Gaynor JW. Chronic intrauterine hypoxia alters neurodevelopment in fetal sheep. J Thorac Cardiovasc Surg. 2019 Jan 11;. PMID: 30745051 

2018

Lawrence KM, Hennessy-Strahs S, McGovern PE, Mejaddam AY, Rossidis AC, Baumgarten HD, Bansal E, Villeda M, Han J, Gou Z, Zhao S, Rychik J, Peranteau WH, Davey MG, Flake AW, Gaynor JW, Bartoli CR. Fetal hypoxemia causes abnormal myocardial development in a preterm ex utero fetal ovine model. JCI Insight. 2018;3(24).

Didier RA, Sridharan A, Lawrence K, Coleman BG, Davey MG, Flake AW. Contrast-Enhanced Ultrasound in Extracorporeal Support: In Vitro Studies and Initial Experience and Safety Data in the Extreme Premature Fetal Lamb Maintained by the Extrauterine Environment for Neonatal Development. J Ultrasound Med. 2018 Dec 17;. PMID: 30560564 

Rossidis AC, Baumgarten HD, Lawrence KM, McGovern PE, Mejaddam AY, Li H, Hwang G, Young K, Peranteau WH, Davey MG, Gaynor JW, Flake AW. Chronically Hypoxic Fetal Lambs Supported by an Extra-Uterine Device Exhibit Mitochondrial Dysfunction and Elevations of Hypoxia Inducible Factor 1-Alpha. Fetal Diagn Ther. 2018 Jun 28; 1-8. [Epub ahead of print]

Partridge EA, Davey MG, Hornick M, Dysart KC, Olive A, Caskey R, Connelly JT, Hedrick HL, Peranteau WH, Flake AW. Pumpless arteriovenous extracorporeal membrane oxygenation: A novel mode of respiratory support in a lamb model of congenital diaphragmatic hernia. J Pediatr Surg. 2018 Mar 9;. [Epub ahead of print] PMID: 29605270 

2017

Burgos CM, Davey MG, Riley JS, Jia H, Flake AW, Peranteau WH. Lung function and pulmonary artery blood flow following prenatal maternal retinoic acid and imatinib in the nitrofen model of congenital diaphragmatic hernia. J Pediatr Surg. 2018 Sep;53(9):1681-1687. Epub 2017 Dec 19.

Partridge EA, Davey MG, Hornick MA, McGovern PE,  Mejaddam AY, Vrecenak JD, Mesas-Burgos C, Olive A, Caskey RC, Weiland TR, Han J, Schupper AJ, Connelly JT, Dysart KC, Rychik J, Hedrick HL, Peranteau WH, Flake AW. Corrigendum: An extra-uterine system to physiologically support the extreme premature lamb. Nat Commun. 2017 May 23;8:15794. Doi: 10.1038/ncomms15794.

Emily A. Partridge, Marcus G. Davey, Matthew A. Hornick, Patrick E. McGovern, Ali Y. Mejaddam, Jesse D. Vrecenak, Carmen Mesas-Burgos, Aliza Olive, Robert C. Caskey, Theodore R. Weiland III, Jiancheng Han, James T. Connelly, Kevin C. Dysart, Alexander J. Schupper, Jack Rychik, Holly L. Hedrick, William H. Peranteau, and Alan W. Flake. “An extra-uterine physiologic support system for the extreme premature lamb.” Nature Communications. Published online April 25, 2017.

Davey MG, Riley JS, Andrews A, Tyminski A, Limberis M, Pogoriler JE, Partridge E, Olive A, Hedrick HL, Flake AW, Peranteau WH. Induction of Immune Tolerance to Foreign Protein via Adeno-Associated Viral Vector Gene Transfer in Mid-Gestation Fetal Sheep. PLoS One. 2017 Jan 31;12(1):e0171132. doi: 10.1371/journal.pone.0171132. eCollection 2017.

2016

McClain LE, Davey MG, Zoltick PW, Limberis MP, Flake AW, Peranteau WH. Vector serotype screening for use in ovine perinatal lung gene therapy. J Pediatr Surg. 2016 Jun;51(6):879-84. doi: 10.1016/j.jpedsurg.2016.02.048. Epub 2016 Mar 3.

Mesas Burgos C, Pearson EG, Davey MG, Riley J, Jia H, Laje P, Mayer J, Flake AW, Peranteau WH. Improved pulmonary function in the nitrofen model of congenital diaphragmatic hernia following prenatal maternal dexamethasone and/or sildenafil. Pediatr Res. 2016 Oct;80(4):577-85. doi: 10.1038/pr.2016.127. Epub 2016 Jul 4. PMID: 27376883.

Watanabe M, Li H, Kim AG, Weilerstein A, Radu A, Davey MG, Loukogeorgakis S, Snachez MD, Sumita K, Falke AW. Complete tissue coverage achieved by scaffold-based tissue engineering in the fetal sheep model of Myelomeningocele. Biomaterials. 2016 Jan;76:133-43. doi: 10.1016/j.biomaterials.2015.10.051. Epub 2015 Oct 23.

Posters and Presentations

Lectures by Invitation

2017

Davey M. Medical Fluid Bags. Keynote Plenary Presentation; 2017 Oct; Boston, MA

Davey M. National Association of Neonatal Nurses; 2017 Oct; Providence, RI

2016

Davey M. Keynote Plenary Presentation. International Society of Ultrasound in Obstetrics and Gynecology, Rome, Italy

Awards and Honors

2007, Young Investigator Award. International Fetal Maternal Medicine Society, Aruba

2005, Foederer Research Award. Children's Hospital of Philadelphia, PA 

2003, The William Maul Measey endowed Fellowship in Fetal Surgery

1998, Young Investigator Award, presented at the annual conference of the Perinatal Society of Australia and New Zealand, Alice Springs, Australia.

1996, John Reed Research Award, presented at the annual conference of the Thoracic Society of Australia and New Zealand (Jointly awarded with Prof. R. Harding), Perth, Australia

Editorial and Academic Positions

Editorial Positions

Reviewer

American Journal of Respiratory Care and Critical Care Medicine

American Journal of Respiratory Cell and Molecular Biology   

Journal of Applied Physiology

Journal of Pediatric Research

Journal of Pediatric Pulmonology

Journal of Pediatric Surgery

Journal of Reproduction, Fertility and Development

Experimental Lung Research

Pediatric Pulmonary

Pediatric Research

Book Review

2005, Basic Statistics for Nursing & Health Professions (Plichta et al.), Wolters-Kluwer

Leadership and Memberships

IACUC Member, Children’s Hospital Research Institute, Philadelphia, PA