Matthew Gillespie, MD

Matthew Gillespie, MD

Matthew Gillespie, MD, is an attending cardiologist In the Cardiac Center at Children's Hospital of Philadelphia with expertise in interventional cardiology and transcatheter treatment of heart disease.

Areas of Expertise: Interventional cardiology, Transcatheter treatment of heart disease
Locations: Main Campus
Phone: 215-590-4040

Education and Training

Medical School

MD - Temple University School of Medicine, Philadelphia, PA

Internship

Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

Residency

Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

Fellowship

Interventional Cardiology - The Children's Hospital of Philadelphia, Philadelphia, PA
Pediatric Cardiology - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Cardiology
Pediatrics

Titles and Academic Titles

Attending Cardiologist

Associate Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2018

Athar M. Qureshi, Neha Bansal, Doff B. McElhinney, Younes Boudjemline, Tom J. Forbes, Nicola Maschietto, Shabana Shahanawaz,  John P. Cheatham,  Richard Krasuski,  Luke Lamers, Massimo Chessa,  Brian H. Morray,  Bryan H. Goldstein,  Cory V. Noel Yunfei Wang, Matthew J. Gillespie, : Branch Pulmonary Artery Valve Implantation Reduces Pulmonary Regurgitation and Improves Right Ventricular Size/Function in Patients with Large Right Ventricular Outflow Tracts. JACC, Cardiovascular Interventions in press 2018.

2017

Stephan J. Wu, Tacy Downing, Christopher Mascio, Matthew J. Gillespie, Yoav Dori, Jonathan J. Rome Andrew C. Glatz: Reintervention Burden and Vessel Growth After Surgical Reimplantation of a Pulmonary Artery During Childhood. Pediatr Cardiol Nov 2017.

Mozumdar Namrita, Burke Edmund, Schweizer Melissa, Gillespie Matthew J, Dori Yoav, Narayan Hari K, Rome Jonathan J, Glatz Andrew C: A Comparison of Anterograde Versus Retrograde Approaches for Neonatal Balloon Aortic Valvuloplasty. Pediatric cardiology Nov 2017.

O'Byrne Michael L, Shinohara Russell T, Grant Elena K, Kanter Joshua P, Gillespie Matthew J, Dori Yoav, Rome Jonathan J, Glatz Andrew C: Increasing propensity to pursue operative closure of atrial septal defects following changes in the instructions for use of the Amplatzer Septal Occluder device: An observational study using data from the Pediatric Health Information Systems database. American heart journal 192: 85-97, Oct 2017.

Whiteside Wendy, Tretter Justin T, Aboulhosn Jamil, Aldoss Osamah, Armstrong Aimee K, Bocks Martin L, Gillespie Matthew J, Jones Thomas K, Martin Mary Hunt, Meadows Jeffrey J, Metcalf Christina M, Turner Mariel E, Zellers Thomas, Goldstein Bryan H: Acute and Midterm Outcomes of Transcatheter Pulmonary Valve Replacement for Treatment of Dysfunctional Left Ventricular Outflow Tract Conduits in Patients With Aortopulmonary Transposition and a Systemic Right Ventricle. Circulation. Cardiovascular interventions 10(9), Sep 2017.

Downing Tacy E, Allen Kiona Y, Goldberg David J, Rogers Lindsay S, Ravishankar Chitra, Rychik Jack, Fuller Stephanie, Montenegro Lisa M, Steven James M, Gillespie Matthew J, Rome Jonathan J, Spray Thomas L, Nicolson Susan C, Gaynor J William, Glatz Andrew C: Surgical and Catheter-Based Reinterventions Are Common in Long-Term Survivors of the Fontan Operation. Circulation. Cardiovascular interventions 10(9), Sep 2017.

Bergersen Lisa, Benson Lee N, Gillespie Matthew J, Cheatham Sharon L, Crean Andrew M, Hor Kan N, Horlick Eric M, Lung Te-Hsin, McHenry Brian T, Osten Mark D, Powell Andrew J, Cheatham John P: Harmony Feasibility Trial: Acute and Short-Term Outcomes With a Self-Expanding Transcatheter Pulmonary Valve. JACC. Cardiovascular interventions 10(17): 1763-1773, Sep 2017.

Gillespie Matthew J, Benson Lee N, Bergersen Lisa, Bacha Emile A, Cheatham Sharon L, Crean Andrew M, Eicken Andreas, Ewert Peter, Geva Tal, Hellenbrand William E, Hor Kan N, Horlick Eric M, Jones Thomas K, Mayer John, McHenry Brian T, Osten Mark D, Powell Andrew J, Zahn Evan M, Cheatham John P: Patient Selection Process for the Harmony Transcatheter Pulmonary Valve Early Feasibility Study. The American journal of cardiology Jul 2017.

2016

Schoonbeek Rosanne C, Takebayashi Satoshi, Aoki Chikashi, Shimaoka Toru, Harris Matthew A, Fu Gregory L, Kim Timothy S, Dori Yoav, McGarvey Jeremy, Litt Harold, Bouma Wobbe, Zsido Gerald, Glatz Andrew C, Rome Jonathan J, Gorman Robert C, Gorman Joseph H, Gillespie Matthew J: Implantation of the Medtronic Harmony Transcatheter Pulmonary Valve Improves Right Ventricular Size and Function in an Ovine Model of Postoperative Chronic Pulmonary Insufficiency. Circulation. Cardiovascular interventions 9(10), Oct 2016.

Wijdh-den Hamer Inez J, Bouma Wobbe, Lai Eric K, Levack Melissa M, Shang Eric K, Pouch Alison M, Eperjesi Thomas J, Plappert Theodore J, Yushkevich Paul A, Hung Judy, Mariani Massimo A, Khabbaz Kamal R, Gleason Thomas G, Mahmood Feroze, Acker Michael A, Woo Y Joseph, Cheung Albert T, Gillespie Matthew J, Jackson Benjamin M, Gorman Joseph H, Gorman Robert C: The value of preoperative 3-dimensional over 2-dimensional valve analysis in predicting recurrent ischemic mitral regurgitation after mitral annuloplasty. The Journal of thoracic and cardiovascular surgery 152(3): 847-59, Sep 2016.

O'Byrne Michael L, Gillespie Matthew J, Kennedy Kevin F, Dori Yoav, Rome Jonathan J, Glatz Andrew C: The influence of deficient retro-aortic rim on technical success and early adverse events following device closure of secundum atrial septal defects: An Analysis of the IMPACT Registry(®). Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions May 2016.

Pierce Eric L, Siefert Andrew W, Paul Deborah M, Wells Sarah K, Bloodworth Charles H, Takebayashi Satoshi, Aoki Chikashi, Jensen Morten O, Gillespie Matthew J, Gorman Robert C, Gorman Joseph H, Yoganathan Ajit P: How Local Annular Force and Collagen Density Govern Mitral Annuloplasty Ring Dehiscence Risk. The Annals of thoracic surgery Apr 2016.

Matthew J. Gillespie, MD, Robert C. Gorman, MD,  Joseph H. Gorman III, MD: Transcatheter Mitral Valve Replacement: Update on New Devices. Journal of Structural Heart Disease. Science International Corp. ISSN 2326-4004, 2(2): 44, April 2016.

Harris Matthew A, Avitabile Catherine M, Fu Gregory L, Kim Daniel W, Kim Timothy S, Gillespie Matthew J, Keller Marc S, Fogel Mark A, Whitehead Kevin K: Accuracy and Internal Consistency of Cardiac Magnetic Resonance Imaging in Measuring Branch Pulmonary Artery Flows in Patients With Conotruncal Anomalies and Branch Pulmonary Artery Stents. The American journal of cardiology 117(7): 1160-6, Apr 2016.

Dori Yoav, Keller Marc S, Rome Jonathan J, Gillespie Matthew J, Glatz Andrew C, Dodds Kathryn, Goldberg David J, Goldfarb Samuel, Rychik Jack, Itkin Maxim: Percutaneous Lymphatic Embolization of Abnormal Pulmonary Lymphatic Flow as Treatment of Plastic Bronchitis in Patients With Congenital Heart Disease. Circulation 133(12): 1160-70, Feb 2016.

Eric L. Pierce, Andrew W. Seifert, Deborah M Paul, Sarah K Wells, Charles Bloodworth, Satoshi Takebayashi, Chikashi Aoki, Morten O Jensen, Matthew J. Gillespie, Robert C. Gorman, Joseph H. Gorman III, Ajit P. Yoganathan: How Local Annular Force and Collagen Density Govern Mitral Annuloplasty Ring Dehiscence Risk. The Annals of thoracic surgery Jan 2016.

O'Byrne ML, Rome N, Santamaria RW, Hallbergson A, Glatz AC, Dori Y, Gillespie MJ, Goldfarb S, Haas AR, Rome JJ. Intra-procedural Bronchoscopy to Prevent Bronchial Compression During Pulmonary Artery Stent Angioplasty. Pediatr Cardiol. 2016 Mar;37(3):433-41. doi: 10.1007/s00246-015-1296-0. Epub 2015 Nov 6.

2012

Patel AR, Farrell P, Harris M, Gaynor JW, Gillespie MJ. Acquired ventricular septal aneurysm in a patient with pulmonary atresia with intact ventricular septum. Cardiol Young. 2012 Apr;22(2):227-9. Epub 2011 Aug 25. Cited in PubMed; PMID 21864450.

Kondo N, Shuto T, McGarvey JR, Koomalsingh KJ, Takebe M, Gorman RC, et al. Melody valve-in-ring procedure for mitral valve replacement: feasibility in four annuloplasty types. Ann Thorac Surg. 2012 Mar;93(3):783-8. Cited in PubMed; PMID 22364973.

Schwartz MC, Rome JJ, Gillespie MJ, Whitehead K, Harris MA, Fogel MA, et al. Relation of left ventricular end diastolic pressure to right ventricular end diastolic volume after operative treatment of tetralogy of Fallot. Am J Cardiol. 2012 Feb 1;109(3):417-22. Epub 2011 Nov 11. Cited in PubMed; PMID 22078963.

Glatz AC, Rome JJ, Small AJ, Gillespie MJ, Dori Y, Harris MA, et al. Systemic to pulmonary collateral flow as measured by cardiac magnetic resonance imaging is associated with acute post-Fontan clinical outcomes. Circ Cardiovasc Imaging. Epub 2012 Jan 6. Cited in PubMed; PMID 22228054.

2011

Hicks JD, Donsante A, Pierson TM, Gillespie MJ, Chou DE, Kaler SG. Increased frequency of congenital heart defects in Menkes disease. Clin Dysmorphol. Epub 2011 Nov 29. Cited in PubMed; PMID 22134099.

Shuto T, Kondo N, Dori Y, Koomalsingh KJ, Glatz AC, Rome JJ, et al. Percutaneous transvenous Melody valve-in-ring procedure for mitral valve replacement. J Am Coll Cardiol. 2011 Dec 6;58(24):2475-80. Cited in PubMed; PMID 22133846.

Vergnat M, Jackson BM, Cheung AT, Weiss SJ, Ratcliffe SJ, Gillespie MJ, et al. Saddle-shape annuloplasty increases mitral leaflet coaptation after repair for flail posterior leaflet. Ann Thorac Surg. 2011 Sep;92(3):797-803. Epub 2011 Jul 30. Cited in PubMed; PMID 21803330.

Gillespie MJ, Dori Y, Harris MA, Sathanandam S, Glatz AC, Rome JJ. Bilateral branch pulmonary artery melody valve implantation for treatment of complex right ventricular outflow tract dysfunction in a high-risk patient. Circ Cardiovasc Interv. 2011 Aug;4(4):e21-3. Cited in PubMed; PMID 21846891. No abstract available.

Banka P, Sleeper LA, Atz AM, Cowley CG, Gallagheher D, Gillespie MJ, et al. Practice variability and outcomes of coil embolization of aortopulmonary collaterals before Fontan completion: a report from the Pediatric Heart Network Fontan Cross-Sectional Study. Am Heart J. 2011 Jul;162(1):125-30. Cited in PubMed; PMID 21742098.

Harris MA, Whitehead KK, Gillespie MJ, Liu TY, Cosulich MT, Shin DC, et al. Differential branch pulmonary artery regurgitant fraction is a function of differential pulmonary arterial anatomy and pulmonary vascular resistance. JACC Cardiovasc Imaging. 2011 May;4(5):506-13. Cited in PubMed; PMID 21565739.

Dori Y, Sarmiento M, Glatz AC, Gillespie MJ, Jones VM, Harris MA, et al.  X-ray magnetic resonance fusion to internal markers and utility in congenital heart disease catheterization. Circ Cardiovasc Imaging. 2011 Jul;4(4):415-24. Epub 2011 May 2. Cited in PubMed; PMID 21536785.

O'Connor MJ, Ravishankar C, Ballweg JA, Gillespie MJ, Gaynor JW, Tabbutt S, et al. Early systemic-to-pulmonary artery shunt intervention in neonates with congenital heart disease. J Thorac Cardiovasc Surg. 2011 Jul;142(1):106-12. Epub 2011 Jan 26. Cited in PubMed; PMID 21272898.

Robb JD, Harris MA, Minakawa M, Rodriguez E, Koomalsingh KJ, Shuto T, et al. Melody valve implantation into the branch pulmonary arteries for treatment of pulmonary insufficiency in an ovine model of right ventricular outflow tract dysfunction following tetralogy of Fallot repair. Circ Cardiovasc Interv. 2011 Feb 1;4(1):80-7. Epub 2011 Jan 4. Cited in PubMed; PMID 21205938.

2010

Glatz AC, Zhu X, Gillespie MJ, Hanna BD, Rome JJ. Use of angiographic CT imaging in the cardiac catheterization laboratory for congenital heart disease. JACC Cardiovasc Imaging. 2010 Nov;3(11):1149-57. Cited in PubMed; PMID 21071003.

Matsuzaki K, Morita M, Hamamoto H, Noma M, Robb JD, Gillespie MJ, et al. Elimination of ischemic mitral regurgitation does not alter long-term left ventricular remodeling in the ovine model. Ann Thorac Surg. 2010 Sep;90(3):788-94. Cited in PubMed; PMCID: PMC3079348.

Schwartz M, Glatz AC, Rome JJ, Gillespie MJ. The Amplatzer vascular plug and Amplatzer vascular plug II for vascular occlusion procedures in 50 patients with congenital cardiovascular disease. Catheter Cardiovasc Interv. 2010 Sep 1;76(3):411-7. Cited in PubMed; PMID 20552654.

Abstracts

2016

Matthew J. Gillespie, Brian McHenry, Emile Bacha, Peter Ewert, Tal Geva, Kan Hor, Evan Zahn, Lee Benson, Lisa Bergersen, John P.Cheatham,: "Patient Selection Process for The Medtronic Native Transcatheter Pulmonary Valve Early Feasibility Study" Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions  May 2016.

John P. Cheatham, Lisa Bergersen, Matthew J. Gillespie, Brian McHenry, Lee Benson: Initial Results From The early Feasibility Study of The Medtronic Native Outflow Tract Transcatheter Pulmonary Valve. JACC Apr 2016.

Books

Chapters

2017

Matthew C. Schwartz MD, Andrew C. Glatz MD, Matthew J. Gillespie MD: Valvular Insufficiency and Heart Failure. Heart Failure in the Child and Young Adult: From Bench to Bedside. John Jeffries MD,  Joseph W. Rossano MD, Anthony C. Chang MD MBA, MPH, Jeffrey A. Towbin MD, Robert E. Shaddy MD (eds.). Elsevier, Dec 2017.

2015

Michael L. O'Byrne MD MSCE, Matthew J. Gillespie MD: Pulmonary Insufficiency - Melody Valve Transcatheter Pulmonary Valve Therapy for the Dysfunctional Right Ventricular Outflow Tract. Catheter Based Valve and Aortic Surgery. Gorav AIawadi MD, Irving L. Kron MD (eds.). Springer, 1(1): 267-281, Dec 2015.

2013

Matthew J. Gillespie MD and Jonathan J. Rome MD: Hemodynamic Assessment and Transcatheter Therapy for Congenital Heart Disease. Mastery of Cardiothoracic Surgery. Larry R. Kaiser MD, Irvin L. Kron MD, and Thomas L. Spray MD (eds.). Lippincott - Raven, 3rd edition, Dec 2013.

2012

Shyam K. Sathanandam MD, Stephanie Fuller MD, and Matthew J. Gillespie MD: Evaluation and Therapy: Neonatal Critical Heart Disease. Pediatric Practice: Cardiology. Marie M. Gleason MD, Jack Rychik MD, and Robert Shaddy MD (eds.). May 2012.

2006

Gillespie MJ, Schneider H, Rome JJ. The use of cardiac catheterization to diagnose and treat heart disease in pediatric patients. In: Vetter VL, editor. The requisites in pediatrics - pediatric cardiology.  Philadelphia: Elsevier Mosby; 2006.  p. 195 - 221.

Posters and Presentations

Invited Lectures

2018

Gillespie MJ. "What to Expect Over the Next Decade: Transcatheter Heart Valves = Plastics!", Cardiology 2018, Scottsdale, AZ. Feb, 2018.

Gillespie MJ. "Future Innovations and Applications in the Catheterization Lab", Cardiology 2018, Scottsdale, AZ. Feb, 2018.

2017

Gillespie MJ. "Diagnostic Cardiac Catheterization in Congenital Heart Disease", SCAI Fall Fellows Course 2017, Las Vegas, NV. Dec, 2017.

Gillespie MJ. "Debate: The Gore Cardioform Septal Occluder is Superior to the Amplatzer Septal Occluder" Pro, SCAI Fall Fellows Course 2017, Las Vegas, NV. Dec, 2017.

Gillespie MJ. "Pulmonary Arteriovenous Malformations and Veno-venous Collaterals", SCAI Fall Fellows Course 2017, Las Vegas, NV. Dec, 2017.

Gillespie MJ. "PDA Stenting: Which Cases to Start With?", SCAI Fall Fellows 2017, Las Vegas, NV. Dec, 2017.

Gillespie MJ. "Interventions Outside of The Heart", SCAI Fall Fellows Course 2017, Las Vegas NV. Dec, 2017.

Gillespie MJ. "Harmony TPV Screening Process and Case Examples", SCAI Fall Fellows 2017, Las Vegas, NV. Dec, 2017.

Gillespie MJ. "Early Experience Using the ADO II AS Device for PDA closure in Premature Infants" Abbott/St Jude Investigators WEBEX Meeting. Aug, 2017.

Gillespie MJ. "Securing Ideas: How to File for Patents", SCAI Scientific Sessions 2017, New Orleans, LA. May, 2017.

Gillespie MJ. "Physician Perspective on the Novel Gore Cardioform ASD Occluder", Gore ASSURED Investigator Meeting, Dallas, TX. Feb, 2017.

Gillespie MJ. "Use of Intraprocedural  Bronchoscopy to Assess for Airway Compression During Interventions", PICS-AICS 2017, Miami, FL. Jan, 2017.

2016

Gillespie MJ. "The Great ASD Debate: Why Using the St Jude Amplatzer Septal Occluder Device is Better than Using the Gore Device(s)", SCAI Fall Fellows Course, 2016, Las Vegas. Dec, 2016.

Gillespie MJ. "Postoperative BADNESS: Cardiac Catheterization in an Acute Postoperative Patient with Low Cardiac Output of Unclear Etiology", SCAI Fall Fellows Course 2016, Las Vegas, NV. Dec, 2016.

Gillespie MJ. "Cardiac Catheterization Pre-Glenn and  Pre-Fontan: Setting the Stage for Successful Surgery" SCAI Fall Fellows Course 2016, Las Vegas, NV. Dec, 2016.

Gillespie MJ. "Transcatheter Pulmonary Valve Replacement: The Melody Valve and Beyond.  Where Have We Been and Where are We Going?", SCAI Fall Fellows 2016, Las Vegas, NV. Dec, 2016.

Gillespie MJ. "Embolization Therapy: Treatment of Pulmonary AVMs and Veno-Venous Collaterals in Congenital Heart Disease", SCAI Fall Fellows Course 2016, Las Vegas, NV. Dec, 2016.

Gillespie MJ. "Transcather Pulmonary Valve Replacement Using The Melody Valve: Indications, Techniques, and Current Outcomes", SCAI Fall Fellows Course, 2016, Las Vegas. Dec, 2016.

Gillespie MJ. "PDA Stenting: When and How", SCAI Fall Fellows Course 2016, Las Vegas. Dec, 2016.

Gillespie MJ. "Creating a New Device: Navigating The Pathway", PICES-SCAI 2016 Scientific Sessions, Orlando, FL. May, 2016.

Gillespie MJ. "I Have an Idea - What Should I Do?", SCAI 2016 Scientific Sessions, Orlando, FL. May, 2016.

Gillespie MJ. "Retrieval of Embolized Devices", Procedural and Advanced Imaging Animal Lab For Congenital and Structural Heart Defects, Minneapolis, MN. May, 2016.

Gillespie MJ. "Indications for ASD Closure in Pediatrics and Adults", Procedural and Advanced Imaging ANimal Lab For Congenital and Structural Heart Defects, Minneapolis, MN. May, 2016.

Gillespie MJ. "Complications of ASD Closure - Procedural and Post-Procedural", Procedural and Advanced Imaging ANimal Lab For Congenital and Structural Heart Defects, Minneapolis, MN. May, 2016.

Gillespie MJ. "Percutaneous Heart Valve Replacemnet: What's Next for Pulmpnary and Mitral Valves?" Grand Rounds, The Cardiac Center at The Children's Hospital of Philadelphia. Mar, 2016.

Awards and Honors

2017, Biomedical Device of the Year 2016-17,Penn Center for Innovation, University of Pennsylvania

2016, "Best of the Best Abstract" Award, SCAI Scientific Sessions 2016

2013, "Most Important Papers in Congenital Heart Disease"  / Circulation: Cardiovascular Interventions Editor's Choice (Circ Cardiovasc Interv. 2011 Feb 1;4(1):80-7)

2013, "Most Important Papers in Congenital Heart Disease"  / Circulation: Cardiovascular Interventions Editor's Choice (Circ Cardiovasc Interv. 2012 Dec;5(6):862-70)

2012, Fellow, Society for Cardiovascular Angiography and Interventions

2010, Smart Heart Award, The Children's Heart Foundation

2009-2011, Beginning Grant In Aid, American Heart Association

2007-2008, Foerderer-Murray Award

1998-present, Alpha Omega Alpha, Medical Honor Society

Editorial and Academic Positions

Editorial positions

2013-present, Editorial Board, The Journal of Structural heart Disease

Reviewer

2011-present, Journal of Clinical and Experimental Medicine
2010-present, Journal of the American College of Cardiology
2010-present, American Heart Journal
2010-present, The American Journal of Cardiology
2009-present, Circulation: Cardiovascular Interventions
2008-present, Circulation
2007-present, Congenital Heart Disease: Clinical Studies from Fetus to Adulthood
2005-present, Catheterization and Cardiovascular Interventions
2005-present, Pediatric Cardiology

Academic committees

2012-present, CTSA Consortium Child Health Oversight Committee (CC-CHOC), Pediatric Therapeutics Development Committee
2007-present, Pediatric Cardiology Fellowship Committee

Leadership and Memberships

2005-present, Society Cardiac Angiography and Intervention
 - 2015-present, Mentor, "Emerging Leaders in Medicine Committee"
 - 2014-present, Executive Committee Member, Congenital Heart Disease Council
2005-present, American Heart Association
2001-present, American College of Cardiology