Colin Hawkes, MD, PhD

Colin Hawkes, MD, PhD
Colin Hawkes, MD, PhD, is an attending physician in the Division of Endocrinology and Diabetes and Clinical Director of the Diabetes Center at Children's Hospital of Philadelphia.

Areas of Expertise: Endocrine late effects of cancer and its treatment, Growth hormone deficiency, Disorders of growth and puberty, Type 1 Diabetes
Locations: Buerger Center for Advanced Pediatric Care; Specialty Care & Surgery Center, King of Prussia

Background

Dr. Hawkes trained in pediatrics in Ireland prior to completing fellowship in pediatric endocrinology at Children’s Hospital of Philadelphia. He was appointed as an attending physician in 2015.

His primary research is focused on the evaluation of children with short stature and disorders of growth and puberty. Dr. Hawkes has published over 50 peer-reviewed articles and book chapters, and many of these are related to evaluating growth in children. His doctoral thesis was entitled “Refining the evaluation of growth and the growth hormone / insulin-like growth factor-I axis in children,” and he was awarded his PhD in 2018 for this work. Dr. Hawkes also specializes in the endocrine late effects of cancer treatment and treats many patients with these complications.

Dr. Hawkes also has a clinical and research interest in type 1 diabetes. He has a Master's Degree in education and his work in this area is focused on integrating smartphones to patient education in type 1 diabetes. He has also developed a number of educational smartphone applications for parents, children and healthcare providers. He is currently leading an initiative to integrate community health workers to the diabetes multidisciplinary team, and he is developing novel interventions to improve patient outcomes in type 1 diabetes.

In addition, Dr. Hawkes holds a number of leadership positions in pediatric endocrinology. He is a member and chair of a number of subcommittees of the Pediatric Endocrine Society, and is also member of the editorial board for the Journal of Clinical Endocrinology and Metabolism.

Education and Training

Medical School

PhD in Pediatrics – University College Cork, Ireland

MB BCh BAO, MD – University College Cork, Ireland

 

Residency

Pediatrics - Royal College of Physicians, Dublin, Ireland

Fellowship

Pediatric Endocrinology - The Children’s Hospital of Philadelphia, Philadelphia, PA

Board Certification

CCST Pediatrics (Ireland)
MRCPCH Pediatrics (United Kingdom)
MRCPI Pediatrics (Ireland)
Pediatrics

Graduate Degree

Masters in Teaching and Learning in Higher Education – University College Cork, Ireland

Titles and Academic Titles

Attending Physician

Clinical Director, Diabetes Center

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Research Interests

Evaluation of children with short stature

Type 1 diabetes

Publications

Papers

2019

Hawkes CP, Grimberg A, Kenny LC, Kiely M, O'B Hourihane J, Irvine AD, Sikora K, Larsen JA, Wu Z, Reitz RE, McPhaul MJ, Argon Y, Zemel BS, Murray DM. The relationship between IGF-I and –II concentrations and body composition at birth and over the first 2 months. Pediatr Res. 2019 Feb 11. doi: 10.1038/s41390-019-0331-x. [Epub ahead of print]

Roy SM, Fields DA, Mitchell JA, Hawkes CP, Kelly A, Wu GD, DeRusso PA, Elovitz MA, Ford E, Drigo D, Zemel BS, McCormack SE. Body mass index is a better indicator of body composition than weight-for-length at age 1 month. J Pediatr. 2019 Jan;204:77-83.e1. doi: 10.1016/j.jpeds.2018.08.007. Epub 2018 Sep 26.

Hawkes CP, Lado JL, Givler S, De Leon DD. The effect of continuous intravenous glucagon on glucose requirements in infants with congenital hyperinsulinism. JIMD Rep. 2019;45:45-50. doi: 10.1007/8904_2018_140. Epub 2018 Oct 12.

McGrath N, Hawkes CP, Mayne P, Murphy N. Optimal timing of repeat newborn screening for congenital hypothyroidism in preterm infants to detect delayed TSH elevation and decompensated congenital hypothyroidism. J Pediatr. 2019 Feb;205:77-82. doi: 10.1016/j.jpeds.2018.09.044. Epub 2018 Oct 24.

2018

McGrath N, Hawkes CP, McDonnell CM, Cody D, O’Connell SM, Mayne P, Murphy N. Incidence of congenital hypothyroidism over 37 years in Ireland. Pediatrics. 2018 Oct;142(4). pii: e20181199. doi: 10.1542/peds.2018-1199.

McGrath N, Hawkes CP, Mayne P, Murphy NP. Permanent decompensated congenital hypothyroidism in newborns with whole-blood thyroid-stimulating hormone concentrations between 8 and 10 mU/L: The case for lowering the threshold. Horm Res Paediatr. 2018;89(4):265-270. doi: 10.1159/000488288. Epub 2018 May 25.

Samuels SL, Surrey LF, Hawkes CP, Amberge M, Mostoufi-Moab S, Langer JE, Adzick NS, Kazahaya K, Bhatti T, Baloch Z, LiVolsi VA, Bauer AJ. Characteristics of follicular variant papillary thyroid carcinoma in a pediatric cohort. J Clin Endocrinol Metab. 2018 Apr 1;103(4):1639-1648. doi: 10.1210/jc.2017-02454.

Hawkes CP, Murray DM, Kenny LC, Kiely M, O'B Hourihane J, Irvine AD, Wu Z, Argon Y, Reitz RE, McPhaul MJ, Grimberg A. Correlation of insulin-like growth factor-I and –II concentrations at birth measured by mass spectrometry and growth from birth to two months. Horm Res Paediatr. 2018;89(2):122-131. doi: 10.1159/000486035. Epub 2018 Jan 18.

Kilberg MJ, Rasooly IR, Bauer AJ, Hawkes CP. Newborn screening in the US can miss persistent mild hypothyroidism. J Pediatr. 2018 Jan;192:204-208. doi: 10.1016/j.jpeds.2017.09.003.

Samuels SL, Surrey LF, Hawkes CP, Amberge M, Mostoufi-Moab S, Langer JE, Adzick NS, Kazahaya K, Bhatti T, Baloch Z, LiVolsi BA, Bauer AJ: Characteristics of follicular variant papillary thyroid carcinoma in a pediatric cohort. Journal of Clinical Endocrinology and Metabolism 103:1639-1648, 2018.

2017

Mavinkurve M, McGrath N, Johnston N, Moloney S, Murphy NP, Hawkes CP. Oral administration of diluted nasal desmopressin in managing neonatal central diabetes insipidus. J Pediatr Endocrinol Metab. 2017 May 24;30(6):623-628. doi: 10.1515/jpem-2017-0051.

Hawkes CP, Li D, Hakonarson H, Meyers KE, Thummel K, Levine MA. CYP3A4 induction by Rifampin: An alternative pathway for vitamin D inactivation in patients with CYP24A1 mutations. J Clin Endocrinol Metab. 2017 May 1;102(5):1440-1446. doi: 10.1210/jc.2016-4048.

Harrison VS, Rustico S, Palladino AP, Ferrara C, Hawkes CP. Glargine co-administration with intravenous insulin in pediatric diabetic ketoacidosis is safe and facilitates transition to a subcutaneous regimen. Pediatr Diabetes. 2017 Dec;18(8):742-748. doi: 10.1111/pedi.12462. Epub 2016 Nov 3.

2016

Hawkes CP, Dzata VE, Grimberg A, Deleon DD. Adding glucagon stimulated GH testing to the diagnostic fast increases the detection of GH-sufficient children. Hormone Research in Paediatrics. 2016;85(4):265-72.

Hawkes CP, Adzick NS, Palladino AA, DeLeon DD. Late presentation of fulminant necrotizing enterocolitis in a child with hyperinsulinism on octreotide therapy. Hormone Research in Paediatrics. 2016 Feb.

Marzec M, Hawkes CP, Eletto D, Boyle S, Rosenfeld R, Hwa V, Wit JM, van Duyvenvoorde HA, Oosdijk W, Losekoot M, Pedersen OB, Have CT, Yeap BB, Altzmon G, Grimberg A, Argon Y. A human variant of glucose-regulated protein 94 that inefficiently supports IGF production. Endocrinology. 2016 May;157(5):1914-28.

2015

Hawkes CP, Grimberg A. Insulin-like growth factor-I is a marker for the nutritional state. Pediatric Endocrinology Reviews Dec 2015;13(2):465-477.

Hawkes CP, Mavinkurve M, Fallon M, Grimberg A, Cody D. Serial GH measurement after intravenous catheter placement alone can detect levels above stimulation test thresholds in children. J Clin Endocrinol Metab. 2015 Nov;100(11):4357-63.

Hawkes CP, Schnellbacher S, Singh RJ, Levine MA. 25-hydroxyvitamin D can interfere with a common assay for 1,25-dihydroxyvitamin D in vitamin D intoxication. J Clin Endocrinol Metab. 2015 Aug;100(8):2883-9.

2014

Coss KP, Hawkes CP, Crushell E, Adamczyk B, Saldova R, Knerr I, Monavari AA, Rudd PM, Treacy EP. IgG N-glycan abnormalities in children with Galactosaemia. Journal of Proteomic Research. 2014;13(2):385-94.

O’Brien N, Hawkes CP, Murphy NP. Is the UK type 1 diabetes tariff applicable in an Irish setting. Irish Medical Journal. 2014 Jul;107(7):204-207.

Scully D, Hawkes CP, Murphy NP. Difficulties associated with diabetes management during the junior certificate academic examinations. Irish Medical Journal. 2014 May;107(5):154-156.

McGlacken-Byrne SM, Hawkes CP, Flanagan E, Ellard S, McDonnell CM, Murphy NP. The Evolving Course of HNF4a Hyperinsulinaemic Hypoglycaemia – A Case Series. Diabetes Medicine 2014. Jan;31(1):e1-5.

Hawkes CP, McDarby V, Cody D. Fear of hypoglycaemia amongst parents of children with type 1 diabetes. J Paediatr Child Health. 2014 Aug;50(8):639-42.

Hawkes CP, Murphy NP. Paediatric Type 1 Diabetes in Ireland. Results of the first national audit. Irish Medical Journal. 2014 Apr;107(4):102-104.

Hawkes CP, Levine MA. Ketotic Hypercalcemia: A case series and description of a novel entity. J Clin Endocrinol Metab. 2014 May;99(5):1531-6.

Books

Chapters

2015

Hawkes CP, Katz LL. Growth Factor Regulation of Fetal Growth. In: Fetal and Neonatal Physiology. 5th Ed. Elsevier/Saunders; 2015.

Hawkes CP, Stanley CA. Pathophysiology of Neonatal Hypoglycemia. In: Fetal and Neonatal Physiology. 5th Ed. Elsevier/Saunders; 2015.

Posters and Presentations

2014

Hawkes CP, Hindmarsh PC, Murphy NP, McCarthy M, O’Riordan SMP. Parent and child feedback on the first educational smartphone application (Pumps4Kids) for pediatric insulin pump starts. American Pediatric Society / Society for Pediatric Research. Vancouver, May 2014

Hawkes CP, Dzata VE, Grimberg A, DeLeon DD. Integrating growth hormone testing with hypoglycaemia investigation. American Pediatric Society / Society for Pediatric Research. Vancouver, May 2014

McDarby V, O’Brien F, Hawkes CP, Cody D. The relationship between paediatric parenting stress and HbA1c, insulin regimen and recency of diagnosis in parents of children with T1DM. International Society for Paediatric and Adolescent Diabetes, Toronto 2014.

2013

Hawkes CP, Hindmarsh PC, Murphy NP, McCarthy M, O’Riordan SM. The development of a smartphone application to supplement insulin pump education in children. European Society for Paediatric Endocrinology Joint Meeting, Milan, Nov 2013

Awards and Honors

2015, Pediatric Endocrine Society: Fellows’ Ethics Award

2014, Patient-Oriented Research Award, The Children's Hospital of Philadelphia Research Poster Day

2013, Patient-Oriented Research Award, The Children's Hospital of Philadelphia Research Poster Day

2013, Biomnis Innovation in Healthcare Award, Ireland

2011, Irish Paediatric Society Annual Research Award

2009, Irish Perinatal Society Annual Research Award

Leadership and Memberships

Memberships in professional organizations

International

European Society for Paediatric Endocrinology

National

Eastern Pediatric Endocrinology Society

Endocrine Society

Pediatric Academic Society

Pediatric Endocrine Society

- Publications Committee