Jennifer Heim, MD
Locations: Main Building
About Jennifer Heim, MD
Titles
Attending Physician
Awards and Honors
2018 Residency Safety and Quality Award Co-Recipient; American Academy of Neurology (AAN)
2018, Child Neurology Chief Resident Service Award, 2017-2018; Barrow Neurological Institute at Phoenix Children’s Hospital, Phoenix, AZ
2013, International Health Elective Month; Department of Neurology, Clinica Santa Maria/Universidad de Chile, Santiago, Chile; Sponsor: Pablo Reyes-Sanchez, MD
2010, Global Health Fund, Selected Participant; Loyola University Chicago Stritch School of Medicine, Community Health and Service Summer Project, Pendelton County, WV, Organizer: Alicia Kurtz, MD
Education & training
Undergraduate Degree
BA in Biology - University of Pennsylvania, College of Arts & Sciences, Philadelphia, PA
Medical Degree
MD - Loyola University Chicago, Stritch School of Medicine, Maywood, IL
Residency
Child Neurology - Barrow Neurological Institute at Phoenix Children’s Hospital, Phoenix, AZ
Fellowship
Pediatric Movement Disorders - Barrow Neurological Institute at Phoenix Children’s Hospital, Phoenix, AZ
Additional Training
2021, Hammersmith Infant Neurological Examination (HINE) and Hammersmith Neonatal Neurological Examination (HNNE) Training and Certifications, Cerebral Palsy Foundation
2018-2020, Deep Brain Stimulation for Pediatric Movement Disorders; Supervising Physicians: Michael Kruer, MD (Neurology); Francisco Ponce, MD (Neurosurgery), Barrow Neurological Institute, Phoenix, AZ
2018-2020, Intrathecal Baclofen Pump Management, Supervising Physician: Michael Kruer, MD (Neurology), Barrow Neurological Institute, Phoenix, AZ
2019-2020, Botulinum Toxin (Botox) Injection for Spasticity, Supervising Physician: Cristina Kwasnica, MD (Neuro-rehabilitation) Children’s Rehabilitative Services, Dignity Medical Group, Phoenix, AZ
Publications
Publications
2024
Norton BY, Liu J, Lewis SA, Magee H, Kruer TN, Dinh R, Bakhtiari S, Nordlie SH, Shetty S, Heim J, Nishiyama Y, Arango J, Johnson D, Seabrooke L, Shub M, Rosenberg R, Shusterman M, Wisniewski S, Cooper B, Rothwell E, Fahey MC, Shrader MW, Lennon N, Oleszek J, Pierce W, Fleming H, Belthur M, Tinto J, Noritz G, Glader L, Steffan K, Walker W, Grenard D, Aravamuthan B, Bjornson K, Joseph M, Gross P, Kruer MC; Cerebral Palsy Research Network. Development and validation of a stakeholder-driven, self-contained electronic informed consent platform for trio-based genomic research studies. medRxiv [Preprint]. 2024 May 3:2024.05.01.24306461. doi: 10.1101/2024.05.01.24306461. PMID: 39040210 Free PMC article. Preprint.
Hashem Almousa, Sara A Lewis, Somayeh Bakhtiari, Sandra Hinz Nordlie, Alex Pagnozzi, Helen Magee, Stephanie Efthymiou, Jennifer A Heim, Patricia Cornejo, Maha S Zaki, Najwa Anwar, Shazia Maqbool, Fatima Rahman, Derek E Neilson, Anusha Vemuri, Sheng Chih Jin, Xiao-Ru Yang, Abolfazl Heidari, Koen van Gassen, Aurélien Trimouille, Christel Thauvin-Robinet, James Liu, Ange-Line Bruel, Hoda Tomoum, Mennatallah O Shata, Mais O Hashem, Mehran Beiraghi Toosi, Ehsan Ghayoor Karimiani, Gözde Yeşil, Lokesh Lingappa, Debangana Baruah, Farnoosh Ebrahimzadeh, Julien Van-Gils, Laurence Faivre, Mina Zamani, Hamid Galehdari, Saeid Sadeghian, Gholamreza Shariati, Rahema Mohammad, Jasper van der Smagt, Alya Qari, John B Vincent, A Micheil Innes, Ali Dursun, R Köksal Özgül, Halil Tuna Akar, Kaya Bilguvar, Cyril Mignot, Boris Keren, Claudia Raveli, Lydie Burglen, Alexandra Afenjar, Laura Donker Kaat, Marjon van Slegtenhorst, Fowzan Alkuraya, Henry Houlden, Sergio Padilla-Lopez, Reza Maroofian, Michael Sacher, Michael C Kruer, TRAPPC6B biallelic variants cause a neurodevelopmental disorder with TRAPP II and trafficking disruptions, Brain, Volume 147, Issue 1, January 2024, Pages 311–324.
2023
Lewis SA, Shetty S, Gamble S, Heim J, Zhao N, Stitt G, Pankratz M, Mangum T, Marku I, Rosenberg RB, Wilfong AA, Fahey MC, Kim S, Myers SJ, Appavu B, Kruer MC. Intrathecal magnesium delivery for Mg++-insensitive NMDA receptor activity due to GRIN1 mutation. Orphanet J Rare Dis. 2023 Aug 3;18(1):225.
2022
Sussman BL, Wyckoff SN, Heim J, Wilfong AA, Adelson PD, Kruer MC, Gonzalez MJ, Boerwinkle VL. Resting State Functional MRI Effective Connectivity in Movement Disorders Helpful? A Focused Review Across Lifespan and Disease. Front Neurol. 2022 Apr 14;13:847834. doi: 10.3389/fneur.2022.847834. eCollection 2022. PMID: 35493815
2021
Sotirios Keros MD, PhD, Jennifer Heim MD, Wejdan Hakami MD, Efrat Zohar-Dayan MD, Bruria Ben-Zeev MD, Zach Grinspan MD, MS, Michael C. Kruer MD, Andrea L. Meredith PhD, Lisdexamfetamine Therapy in Paroxysmal Non-kinesigenic Dyskinesia Associated with the KCNMA1-N999S Variant; Mov Disord Clin Pract. 11 December 2021
Sara Lewis, Somayeh Bakhtiari, Jennifer Heim, Patricia Cornejo, James Liu, Aris Huang, Andrew Musmacker, Sheng Chih Jin, Kaya Bilguvar, Sergio R. Padilla-Lopez, Michael C. Kruer; Mutation in ZDHHC15 Leads to Hypotonic Cerebral Palsy, Autism, Epilepsy, and Intellectual Disability; Neurol Genet. Aug 2021, 7 (4) e602; DOI: 10.1212/NXG.0000000000000602
Bhatia P, Heim J, Cornejo P, Kane L, Santiago J, Kruer MC. Opsoclonus-myoclonus-ataxia syndrome in children. J Neurol. 2021 Mar 29. doi: 10.1007/s00415-021-10536-3. PMID: 33779841.
2020
Steel, D., Heim, J., Kruer, M.C., Sanchis‐Juan, A., Raymond, L.F., Eunson, P. and Kurian, M.A. (2020), Biallelic mutations of TBC1D24 in exercise‐induced paroxysmal dystonia. Mov Disord. January 2020.
Heim J, Vemuri A, Lewis S, Guida B, Troester M, Keros S, Meredith A, Kruer MC. Cataplexy in Patients Harboring the KCNMA1 p.N999S Mutation. Mov Disord Clin Pract. 2020 Aug 21;7(7):861-862.
Heim J, Vemuri A, Salih M, Kruer MC; Clinical Child Neurology, Movement Disorders in Childhood (Book chapter, published 2020)
Jin SC, Lewis SA, Bakhtiari S, Zeng X, Sierant MC, Shetty S, Nordlie SM, Elie A, Corbett MA, Norton BY, van Eyk CL, Haider S, Guida BS, Magee H, Liu J, Pastore S, Vincent JB, Brunstrom-Hernandez J, Papavasileiou A, Fahey MC, Berry JG, Harper K, Zhou C, Zhang J, Li B, Zhao H, Heim J, Webber DL, Frank MSB, Xia L, Xu Y, Zhu D, Zhang B, Sheth AH, Knight JR, Castaldi C, Tikhonova IR, López-Giráldez F, Keren B, Whalen S, Buratti J, Doummar D, Cho M, Retterer K, Millan F, Wang Y, Waugh JL, Rodan L, Cohen JS, Fatemi A, Lin AE, Phillips JP, Feyma T, MacLennan SC, Vaughan S, Crompton KE, Reid SM, Reddihough DS, Shang Q, Gao C, Novak I, Badawi N, Wilson YA, McIntyre SJ, Mane SM, Wang X, Amor DJ, Zarnescu DC, Lu Q, Xing Q, Zhu C, Bilguvar K, Padilla-Lopez S, Lifton RP, Gecz J, MacLennan AH, Kruer MC. Mutations disrupting neuritogenesis genes confer risk for cerebral palsy. Nat Genet. 2020 Oct;52(10):1046-1056. doi: 10.1038/s41588-020-0695-1. Epub 2020 Sep 28. Erratum in: Nat Genet. 2021 Jan 11
2019
JR Bowers, M Valentine, V Harrison, VY Fofanov, J Gillece, J Delisle, B Patton, J Schupp, K Sheridan, D Lemmer, S Ostdiek, HK Bains, J Heim, T Sylvester, S Prasai, M Kretschmer, N Fowle, K Komatsu, S Brady, S Robinson, K Fitzpatrick, GA Ostovar, E Alsop, E Hutchins, K Jensen, P Keim, DM Engelthaler. Genomic Analyses of Acute Flaccid Myelitis Cases among a Cluster in Arizona Provide Further Evidence of Enterovirus D68 Role. mBio Jan 2019, 10 (1) e02262-18
2016
Iverson SA, Ostdiek S, Prasai S, Engelthaler D, Kretschmer M; Fowle N; Tokhie H; Routh J; Sejvar J; Ayers T; Bowers J; Brady S; Rogers S; Nix WA; Komatsu K; Sunenshine R; AFM Investigation Team Notes from the Field: Cluster of Acute Flaccid Myelitis in Five Pediatric Patients — Maricopa County, Arizona, 2016. MMWR Morb Mortal Wkly Rep 2017;66:758–760.
Abstracts (includes Posters and Scientific Presentations)
2024
Clinical Improvement with lamotrigine in patient with SGCE-associated myoclonus dystonia syndrome - J. Heim (Phoenix, United States), 8th International Symposium on Paediatric Movement Disorders (02/2024) Barcelona, Spain (Platform video presentation, February 2024)
2020
Heim J, Lewis S, Vanatta L, Zhao N, Kruer MC. P27 - Combination of chelation therapy and low-manganese diet in a patient with SLC39A14-associated hypermanganesemia and dystonia. 1st International Symposium on Genetic Syndromes with Movement Disorders and Epilepsy (February 2020). Barcelona, Spain. (Poster presentation, 2020)
2019
Heim J, Vemuri A, Lewis SA, Meredith A, Keros S, Kruer MC. Drop attacks in patients with KCNMA1 p.N999S heterozygous de novo mutations. 6th Annual Symposium on Paediatric Movement Disorders (02/2019), Barcelona, Spain (Platform video presentation, February 2019)
2018
Bakhtiari S, Tafakhori A, Jin SC, Zeng X, Corbett M, Liu J, Heim J, Hockley MH, Norton BY, Magee H, Van Eyk C, Lifton RP, MacLennan AH, Gecz J, Padilla-Lopez S, Bilguvar K, Darvish H, Kruer MC. Cerebral palsy gene discovery based on whole exome sequencing of multiplex, consanguineous families. American Society of Human Genomic Annual Meeting, (Poster Presentation, 2018)
Robers M, Tokhie H, Jacobsen B, Aslam S, Jackson R, Chen E, Heim J, Murthy G, Zigelbaum A, Knievel K, Improving Outcomes in Inpatient Send-Out Studies (P4.003), Neurology Apr 2018, 90 (15 Supplement) P4.003 (Poster Presentation, AAN Annual Meeting 2018)