Rachel M. Hurley, MD, PhD
Locations: Buerger Center for Advanced Pediatric Care
About Rachel M. Hurley, MD, PhD
Titles
Attending Physician
Instructor, Perelman School of Medicine at the University of Pennsylvania
Certifications
Pediatrics – American Board of Pediatrics
Awards and Honors
2025, Conquer Cancer Young Investigator Award. American Society of Clinical Oncology (ASCO)
2025, Rally Foundation for Childhood Cancer Research Postdoctoral and Clinical Research Fellow Grant
2025, Selected for the Children's Hospital of Philadelphia Resident & Fellows Grand Rounds Lectureship
2024, Brigid Levenlhal Special Merit Award. American Society of Clinical Oncology (ASCO) 2024 Annual Meeting
2024-present Marlene Shiomchik Fellowship in Cancer Research, Abramson Cancer Center, University of Pennsylvania
2023, Selected participant in AACR Molecular Biology in Clinical Oncology Workshop
2023, William Pottash Fellow Teacher of the Year. Children’s Hospital of Philadelphia
2019, Abstract Award Winner, 29^^ Annual Interdisciplinary Breast Cancer Conference
2019, Hematology/Oncology Medical Student Research Travel Award Scholarship
2017-2018, Minnesota Ovarian Cancer Alliance Ovarian Cancer Research Training Grant
2015, Travel Award: Mayo Clinic-Karolinska Institutet 21'*' Annual Scientific Meeting
2013-2020, Mayo Bonner M.D./Ph.D. Scholar. Mayo Clinic
2012, Mayo Quality Fellow, Bronze Certification: Mayo Clinic
2011, Augustana Covenant Award for Excellence
2011, Summa Cum Laude. Augustana University
2010, Barry M. Goldwater Scholarship Honorable Mention
2009, American Chemical Society Student Affiliates Leadership Award
2009, American Chemical Society POLEYED Organic Award
2009-2010, YT Johnson Pre-Medical Scholarship. Augustana University
2008, CRC Press Chemistry Achievement Award
2008, Sioux Valley Section American Chemical Society Poster Competition Winner
2008, 2009, Beta Beta Beta Biology Honor Society
2008, 2009, South Dakota BRIN Summer Undergraduate Research Fellowship
2007-2011, South Dakota Opportunities Scholar
2007-2011, Augustana Chemistry Trustee’s Fellowship
2007-2011, Augustana Distinguished Scholar
2007-2011, CIVITAS Honors Program, Augustana University
Leadership and Memberships
2022-present, American Society of Hematology
2022-present, Children’s Oncology Group
2018-present, American Society of Clinical Oncology
2018-present, American Academy of Pediatrics
2013-present, American Association for Cancer Research
2011-present, American Medical Association
Editorial and Academic Positions
Editorial Positions
Ad Hoc Reviewer, JCO Precision Oncology
Academic and Institutional Committees
Fellow Representative, Pediatric Hematology Oncology Fellowship Committee Leadership
Education & training
Undergraduate Degree
BA in AC Chemistry, Biology - Augustana University (formerly Augustana College), Sioux Falls, SD
Graduate Degree
PhD in Molecular Pharmacology & Experimental Therapeutics - Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN
Medical Degree
MD - Mayo Clinic Alix School of Medicine, Rochester, MN
Residency
Pediatrics, Accelerated Research Pathway - Children’s Hospital of Philadelphia, Philadelphia, PA
Fellowship
Pediatric Hematology/Oncology - Children’s Hospital of Philadelphia, Philadelphia, PA (Chief Fellow)
Publications
Publications
2025
Hurley, R.M.; Wagner, J.M.; Kanakkanthara, A.; Schneider, P.A.; Macon. E.P.; Heinzen, E.P.; Warpman Berglund, U.; Sanjiv. K.; Hou, X.: Becker. M.A.; Mauer, M.J.; Swisher, E.M.; Larson, M.; Oberg, A.L.: Weroha, S.J.; Helieday. T.: Kaufmann, S.H.; Wahner Hendrickson. Mitotic MTHl Inhibitor Karonudib Kills Epithelial Ovarian Cancer Independent of Platinum Sensitivity. Experimental Hematology & Oncology. 2025; 14:88. McGchee, C.D.*; Meng. X.W.*: Wu, X.*; Correia, C.*; Vcnkatachalam. A.*; Flatten. K.S.; Peterson. K.L.; Patel, A.G.: Rossman, O.K.: Wong. C.; Hurley, R.M.; Wagner, J.M.; Schneider, P.A.; Dai. H.; Poirier, G.G.; Wahner Hendrickson. A.E.; Swisher. E.M.; Pandey, A.: Li, H.; Kaufmann, S.H. Codon Specific Readthrough as a Mechanism of BRCA2 Restoration in Acquired PARP Inhibitor and Chemotherapy Resistance. Nucleic Acid Research. Accepted for publication.
2024
Oberg, A.L.; Heinzen. E.P.; Hou, X.; Al Hilli, M.M.; Hurley, R.M.; Wahner-Hendrickson, A.E.; Goergen. K.M; Larson, M.C.; Eckel-Passow, J.E.; Maurer. M.J.; Kaufmann. S.H.; Haluska, P.; Weroha, S.J. Statistical analysis of comparative tumor growth repeated measures experiments in the patient derived xenograft (PDX) selling: experience in ovarian cancer. Scientific Reports. 2024 Apr 13;I l(l):8076.
2022
Manzo, J.: Puhalla. S.; Pahuja. S.; Ding, 1".: Lin, Y.; Applcman, L.: Tawbi, H.: Stoller, R.; Lee. JJ.; Diergaarde, B.: Kiesel, B.F.; Yu, J.; Tan, A.R.; Belani, C.P.; Chew, if; Garcia, A.A.; Morgan. R..I.; Wahncr Hendrickson, A.E.; Visscher, D.W.; Hurley, R.M.; Kaufmann, S.IL; Swisher, E.M.: Oesterreich. S.: Katz. T.; Ji, J.; Zhang, Y.; Parchment, R.B.; Chen, A.: Duan, W.: Giranda. V.; Shepherd. S.P.: Ivy. S.P. Chu. E.; Bcumcr. J.H.. ETCnM-8282 Study Team. A phase 1 and pharmacodynamic study of chronically-dosed, single-agent veliparib (ABT- 888) in patients with BRCAl- or BRCA2- mutated cancer or platinum-refractory ovarian or triple-negative breast cancer. Cancer Chemotherapy and Pharmacology. 2022; 89:721-735.
2021
Hurley, R.M.*; McGehee, C.D.*; Nesic, K. Correia, C.; Weiskittel. T.M.: Kelly. R.L.; Venkatachalam. A.: Hou, X.; Pathoulas. N.M.: Meng, X.W.; Kondrashova. O.; Harrell. M.I.: Radke, M.R.; Schneider, P.A.: Flatten, K.S.; Peterson. K.L.; Becker. M.A.; Dobrovic, A.; Lin, K.K.: Harding, T.C.; Ross, C.A.; Wagner, J.M.; Wakefield, M.; Scott, C.; Haluska, P.; Wahner Hendrickson. A.E.; Karnitz, L.M.; Swisher, E.M.: Li, H.; Weroha. S.J.; Kaufman, S.H. Characterization of a RAD51C-Silenced High Grade Serous Ovarian Cancer Model During PARP Inhibitor Resistance Development. Nucleic Acids Research Cancer. 2021 3(3): zcab028.
Nesic. K.; Kondrashova, O.; Hurley, R.; McGehee, C.; Vandenberg. C.J.; I lo, G.Y.: Lieschke. E.; Dali. G.V.; Bound, N.; Shield-Artin, K.; Radke. M.R.; Musafer. A.; Chai, Z.Q.; Reza Eftekhariyan Ghamsar, M.; Harrcl. M.I.; Kee, D.: Olesen. I.; McNally. O.M.: Traficante. N.; Dc Faxio, A.; Bowtell. D.D.L.; Swisher, E.M.; Weroha. J.; Nones, K.; Waddell. N.; Kaufmann, S.l I.: Dobrovic, A.; Wakefield. M.J; Scott. C.L. Acquired RADS IC promoter methylation loss causes PARP inhibitor resistance in high grade serous ovarian carcinoma. Cancer Research. 2021;8l(18): 4709-4722.
Wahner-fJendrickson. A.E.; Visscher, D.W.; Hou. X.; Goergen, K.M.: Atikinson, FI.J.; Beito, T.G.; Negron. V.; Lingle, W.L.; Bruzek, A.K.; Hurley, R.M.: Wagner, .I.M.: Flatten, K.S.; Rachel M. Hurley. MD, PhD 6 Peterson, K.L; Schneider, P.A.; Larson, M.C.; Maurer, M.J.; Kalli, K.R.; Oberg, A.L.; Weroha. S.J.: Kaufmann. S.K. ClIFR and Paclitaxel Sensitivity of Ovarian Cancer. Cancers. 2021; 13(23):6043.
Abstracts (includes Posters and Scientific Presentations)
2025
Derry, A.; Gutstein. L.; Huang, K.; Long, A.; Holloman. M.; Zhou. Z.; Xu, F.; Hurley, R.; Crane, J.; Laetsch, T.: Li, M. Prognostic factors for pediatric osteosarcoma. American College of Medical Genetics (ACMG) Annual Clinical Genetics Meeting (Poster), March 2025.
Hurley, R.M.; Guo, L.; Barkauskas, D.A.; Yu, L.; Chen, Y.L.; Gutstein, L.; Hawkins, D.: Scharschmidt. T.; Skapek, S.X.; Spunt. S.L.; Wang, D.; Weiss. A.R.; Xu, L.; Laetsch. T.W. CINSARC score as a prognostic genomic signature in pediatric non-rhabdomyosarcoma soft tissue sarcoma. NHGRI Research Training: and Career Development Annual Meeting (Poster), April 2025.
Hurley, R.M.: Huang, K.; Gutstein. L.: Segers, B.; Caradonio, O.: Maple, E.; Rivera, D.: Robinson. J.: Szepessy, A.: Bastianelli. W.; Crane. J.; Laetsch. T. Evaluating Front-Line Therapy Accordance with Current Synovial Sarcoma Guidelines. Connective Tissue Oncology Society (CTOS) 2025 Annual Meeting (Poster), November 2025.
Huang, K.; Gutstein. L.; Segers, B.; Caradonio. O.; Maple, E.; Rivera. D.: Robinson, J.; Szepessy, A.: Bastianelli, W.; Crane. J.: Laetsch, 1'.; Hurley, R.M. Describing the Characteri-stics and Treatment of Synovial Sarcoma in the Recurrent Setting. Connective J'issue Oncology Society (CTOS) 2025 Annual Meeting (Poster), November 2025.
2024
Hurley, R.M.; Kaufman, R.; Wilson, E.; Levine, E.; Surrey, L.; Grohar. P. I'he Role of Trabectedin in Multiply-Relapsed Ewing Sarcoma. NHGRI Research Training and Career Development Annual Meeting (Poster). April 2024.
Hurley, R.M.; Guo, L,; Barkauskas, D.A.; Yu. L.; Chen, Y.L.; Giitstein. L.: Hawkins, D.S.; Scharschmidt. T.; Skapek, S.K.; Spunt, S.L.; Wang. D.; Weiss. A.R.; Xu, L.; Laetsch, T.W. CINSARC score use in pediatric non-rhabdomyosarcoma soft tissue sarcoma (NRSTS) in the Children’s Oncology Group (COG) studies ARST0332 and ARST132I. American Society of Clinical Oncology tASCO) Annual Meeting (Oral), June 2024.
Hurley, R.M.; Gutstein. L.; Segers, B.; Caradonio, O.; Maple. E.; Rivera, D.; Robinson, J.: Bastianelli. W.; Huang, K.; Crane, J.; Laetsch. T. Synovial Sarcoma Registry and Biospecimen Repository (SSRBR): Describing the Cohort and Survival Outcomes to Date. Connective Tissue Oncology Society (CTOS) 2024 Annual Meeting (Poster), November 2024.
2023
Vcnkatachalam, A.: Correia, C.; Mcgehee. C.; Finstuen-Magro. S.; Schneider. P.A.; Hurley, R.; Peterson. K.L.; l lcinzen, E.; Larson, M.C.; Hou, X.; Oberg. A.L.; Weroha, S.; Kaufmann, S.H. Impact of dexamethasone on chemotherapy response in ovarian cancer. AACR Special Conference on Ovarian Cancer (Poster), October 2023.
Lectures by Invitation
2025
Hurley, R.M. 11 March 2025 “Moving Forward: The Impact of Patient Registries & Basic Science," The Synovial Sarcoma Foundation’s Synovial Sarcoma Virtual Conference.
2024
Hurley, R.M. June 2024 “CINSARC score use in pediatric non-rhabdomyosarcoma soft tissue sarcoma in the Children's Oncology Group studies ARST0332 and ARST1321,” American Society of Clinical Oncology Annual Meeting; Chicago.
Editorials, Reviews, Chapters
2025
Vacil. J.R.; Struble, S.L; Hurley, R.; Tipps. J.; Surrey. L.; Finn, L.; Balls, F.M.; Lactsch, T.W.: Mendenhall. S.D. Infantile Fibrosarcoma of the Hand: Case Report of a Limb-Sparing Treatment with Modern Targeted Oral Chemotherapy and Surgical Resection. Journal of Hand Surgery Global Online. Submitted, Under Review.
2024
Hurley, R.M.*; Turn, C.* Solid Tumors. Book Chapter in Nelson Pediatrics Board Review. 2e. 2024: Elsevier. In press.
2021
Wyatt, K.D.; Kohorst. M.A.; Coon, L.M.; Hurley, R.M.; van Dorland, H.A.: Arndt, C.A.S. Hereditary' Thrombotic Thrombocytopenic Purpura in a 9-Month Old: Diagnosing and Managing an Ultra-rare Disorder. J Pediatr Hematol Oncol. 2021 May I ;43(4):e577-e579.
2015
Fatcmi. Y.*; Hurley, R.*: Grant. C.; Henrichson, T.; Ghosh. K. Challenges in the evaluation and treatment of giant intraductal breast papillomas. Clinical Case Reports. 3(1);7-10. 2015.