David R. Jobes, MD

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David R. Jobes, MD, is a senior anesthesiologist in the Division of Cardiothoracic Anesthesiology with expertise delivering anesthesia to patients undergoing cardiac or thoracic surgery.

Areas of Expertise: Adults with congenital heart disease, Cardiac anesthesia including major vascular and thoracic anesthesia, Clinical investigation, Coagulation management and blood conservation strategies in cardiac surgery, Neuroprotective strategies, Outcomes research
Locations: Main Hospital
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

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Education and Training

Medical School

MD - Hahnemann University School of Medicine, Philadelphia, PA

Internship

Transitional Internship - Hamot Medical Center, Erie, PA

Residency

Anesthesia - The Hospital of the University of Pennsylvania, Philadelphia, PA

Fellowship

Cardiothoracic Anesthesia - Hospital of the University of Pennsylvania, Philadelphia, PA

Board Certification

Anesthesiology

Titles and Academic Titles

Attending Anesthesiologist

Emeritus Professor CE of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Publications

Papers

2015

Kilbaugh, T. J., Himebauch, A. S., Zaoutis, T., Jobes, D., Greeley, W. J., Nicolson, S. C., Zuppa, A. F. : A pilot and feasibility study of the plasma and tissue pharmacokinetics of cefazolin in an immature porcine model of pediatric cardiac surgery. Paediatric Anesthesia 25(11): 1111-9, November 2015.

Jobes DR, Sesok-Pizzini D, Friedman D: Reduced transfusion requirement using fresh whole blood in pediatric cardiac surgery. Annals of Thoracic Surgery 99(5): 1706-11, May 2015.

2014

Kilbaugh T, Himebauch A, Berkowitz D, Zaoutis T, Jobes DR, Greeley W, Fox E, Nicolson SC, Zuppa AF: Plasma and tissue pharmacokinetics of cefazolin in an immature porcine model of pediatric cardiac surgery.  Journal of Pediatric Infectious Disease Society 2014.

Jobes DR, Sesok-Pizzini D, Friedman D: Reduced blood donor exposure in patients under 2 years of age having surgery for congenital heart disease: review of a 15 year experience. Journal of Thoracic and Cardiovascular Surgery 2014.

2013

Stricker Paul A, Lin Elaina E, Fiadjoe John E, Sussman Emily M, Pruitt Eric Y, Zhao Huaqing, Jobes David R: Evaluation of central venous pressure monitoring in children undergoing craniofacial reconstruction surgery. Anesthesia and analgesia 116(2): 411-9, Feb 2013.

2012

Nathan AT, Jobes DR: In Response: Normal Tp-e values in Children. Anesthe Analg 114(1): 240, 2012.

Stricker Paul A, Lin Elaina E, Fiadjoe John E, Sussman Emily M, Jobes David R: Absence of tachycardia during hypotension in children undergoing craniofacial reconstruction surgery. Anesthesia and analgesia 115(1): 139-46, Jul 2012.

Stricker Paul A, Fiadjoe John E, Jobes David R: Factors influencing blood loss and allogeneic blood transfusion practice in craniosynostosis surgery. Paediatric anaesthesia 22(3): 298-9, Mar 2012.

2011

Stricker Paul A, Fiadjoe John E, Davis Amanda R, Sussman Emily, Burgess Beverly J, Ciampa Brian, Mendelsohn Jared, Bartlett Scott P, Sesok-Pizzini Deborah A, Jobes David R: Reconstituted blood reduces blood donor exposures in children undergoing craniofacial reconstruction surgery. Paediatric anaesthesia 21 ( 1 ): 54- 61, Jan 2011.

2010

Kim G.G., El Rouby S., Thompson J., Gupta A., Williams J., Jobes D.R.: Point of care micro-coagulation tests in a normal pediatric population. J Thromb Thrombolysis 29(4): 429-36, May 2010.

Stricker P, Shaw T, Desouza D, Hernandez S, Bartlett S, Sesok-Pizzini D, Jobes D: Blood loss, Replacement, and Associated Morbidity in Children Undergoing Craniofacial Surgery. Paediatr Anaesth 20(2): 150-9, Feb 2010.

Nicolson S, Montenegro L, Cohen M, O'Neill D, Calfin D, Jones L, Jobes D.: A Comparison of the Efficacy and Safety of Chloral Hydrate versus Inhaled Anesthesia for Sedating Infants and Toddlers for Transthoracic Echocardiograms. Journal of the American Society of Echocardiography 23( 1 ): 38-42, Jan 2010.

Jobes DR, Wolfe Y, O"Neill D, Calder J, Jones L, Sesok-Pizzini D, Zheng XL: Toward a definition of "fresh" whole blood: an in vitro characterization of coagulation properties in refrigerated whole blood for transfusion. Transfusion 51(1): 43-51, Jan 2010.

2009

Raffini L, Schwed A, Zheng X, Tanzer M, Nicolson S, Gaynor J, Jobes D: Thromboelastography in patients post-Fontan compared to healthy children. Pediatr Card April 2009.

2008

Augoustides J, Szeto W, Kohl B, Cowie D, Hoo A, Gambone A, Jobes D: Prolonged Mechanical Ventilation After Aortic Arch Repair Requiring Deep Hypothermic Circulatory Arrest: incidence, Effect on Outcome, and Clinical Predictors. The Open Anesthesiology Journal 2008.

Augoustides JG, Watcha SM, Pochettino A, Jobes DR: Early tracheal extubation in adults undergoing single-lung transplantation for chronic obstructive pulmonary disease: pilot evaluation of perioperative outcome. Interact Cardiovasc Thorac Surg 7(5): 755-820, Oct 2008.

Ganesh Arjunan, Jobes David R: Ultrasound-guided catheterization of the internal jugular vein. Anesthesiology 108(6): 1155-6; author reply 1156-7, Jun 2002.

2007

Seifert H, Howard D, Silber J, Jobes D: Females are at increased risk of death during hospitalization for pediatric cardiac surgery. J. Thoracic Cardiovasc Surgerv 133: 668-675, 2007.

Pochettino A, Augoustides J, Kowalchuck D, Watcha S, Cowie D, Jobes D: Cardiopulmonary Bypass for Lung Transplantation in Cystic Fibrosis: Pilot Evaluation of Perioperative Outcome. J Cardiothor Vase Anesth. 21: 208-211, 2007.

Pochettino Alberto, Augoustides John GT, Kowalchuk Deborah A, Watcha Sam M, Cowie Doreen, Jobes David R: Cardiopulmonary bypass for lung transplan1ation in cystic fibrosis: pilot evaluation of perioperative outcome. Journal of cardiothoracic and vascular anesthesia 21(2): 208-11, Apr 2007.

2006

Augoustides, Pochettino A, Ochroch EA, Cowie D, Weiner J, Gambone AJ, Pinchasic D, Bavaria JE, Jobes DR.: Renal Dysfunction after Thoracic Aonic Surgery Requiring Deep Hypothermic Circulatory Arrest: definition, incidence, and clinical predictors. J Cardiothor Vase Anesth. 20: 673-677, 2006.

2005

Levy RJ, Stem WB, Minger KI, Montenegro LM, Ravishankar C, Rome JJ, Nicolson SC, Jobes DR: Evaluation of Tissue Saturation as a Noninvasive Measure of Mixed Venous Saturation in Children. Ped Crit Care Med 6: 671-675, 2005.

Augoustides JG, Raman S, Pochettino A, Ochroch AE, Savino JS, Bavaria JE, Jobes DR: Bleeding and Blood Product Utilization in Adults Undergoing Elective Aortic Root Replacement: The impact of Antifibrinolytic Exposure and Aortic Root Prothesis. Annals of Cardiac Anaesthesia 8: 125-132, 2005.

Augoustides JG, Floyd, TF, McGarvey ML, Ochroch EA, Pochettino A, Fulford S, Gambone AJ, Weiner J, Raman S, Savino JS, Bavaria JE, Jobes DR: Major Clinical Outcomes in Adults Undergoing Thoracic Aortic Surgery Requiring Deep Hypothermic Circulatory Arrest: Quantification of Organ-Based Perioperative Outcome and Detection of Opportunities for Perioperative Intervention. J Cardiothor Vase Anesth. 19: 446-452, 2005.

Augoustides JG., Lakshrninarayana S, Ochroch AE., Gambone AJ.,Weiner J, Pinchasik D, Kowalchuk D, JobesD: Randomized Controlled Clinical Trial of Real-Time Needle-Guided Ultrasound for Internal Jugular Venous Cannulation in a Large University Anesthesia Department. Page: 310-315, June 2005.

2004

Howard D, Silber J, Jobes D: Do regulations limiting medical residents' work hours. L Gen Intern Med Page: 1-7, 2004.

2003

Seifert HA, Jobes DR, Ten Have T, Kimmel SE, Montenegro LM, Steven JM, Nicolson SC, and Strom BL: Adverse Events After Protamine Administration Following Cardiopulmonary Bypass in Infants and Children Anesth Analg 97: 383-389, 2003.

2002

Augoustides JG, Diaz D, Weiner J, Clarke C, Jobes DR: Current Practice of Internal jugular Venous Cannulation in a University Anesthesia Department: influence of operator experience on cannulation success and arterial injury J Cardiothor Vase Anesth. 16 (5): 561-566, 2002.

Augoustides JG, Jobes DR, Diaz D, Weiner J:J : Safe Internal Jugular Vein Cannulation. Cardiothorac. Cardiothorac Vase Anesth 16 (2): 262-263, April 2002.

2000

Traber KB, Allison SR, Jobes DR: Ultrasound-assisted Jugular Venous Cannulation: A Survey of Training and Use in an Academic Center and Impact Post­graduation. Am. J. Anesthesia. Clinical Anesthesia 2000.

Mahle WT, Clancy RR, Moss EM, Gerdes M, Jobes OR: Wernovsky G: Neurodevelopmental outcome and lifestyle assessment in school-aged and adolescent children with hypoplastic left heart syndrome. Pediatrics, 105 (5): 1082-1089, May 2000.

1999

Zucker ML, Jobes C, Siegel M, Jobes, DR, LaDuca FM: Activated Clotting Time (ACT) testing: Analysis of Reproducibility. J Extra Corpor Technol. Sep: 31 (3): 130-134, 1999.

1998

Gottschalk AG, Smith DS, Jobes DR, Kennedy SK, Lally S, Noble K, Grugan K, Seifert H, Malkowitcz K, Gutsche BB, Wein A: A randomized study of preemptive analgesia in recovery from radical suprapubic prostatectomy. JAMA 279 (14): 1076-1082, 1998.

1996

Tobias M, Pilla M, Rogers C, Jobes D: Lidocaine inhibition of coagulation; implications for epidural blood patch. Anesthesia and Analgesia 82: 766-779, 1996.

1995

26. Jobes DR, Shaffer W, Aitken GL: Increased accuracy and precision of heparin and protamine dosing reduces blood loss and transfusion in primary cardiac surgical patients. J Thorac Cardiovasc Surg. 110: 36-45, 1995.

1994

Stayer S, Steven JM, Nicolson SC, Jobes DR, Norwood W, Stanley C, Baumgart S: Metabolic effects of surface cooling neonates prior to cardiac surgery. Anesth Analg, 79: 834-839, 1994.

Nicolson SC, Steven JM, Kurth D, Krucylak K, Jobes DR: Anesthesia for noncardiac surgery in infants with hypoplastic left heart syndrome following Hemi-Fontan operation. J Cardiothor and Vase Anes. 8: 334-336, 1994.

1993

Reynolds LM, Nicolson SC, Steven JM, Escobar A, McGonigle M, Jobes DR: Influence of sensor site location on pulse oximetry kinetics in children. Anesth Analg 76: 751-754, 1993.

Reynolds LM, Nicolson SC, Jobes DR, Steven JM, Manno CS: DDAVP does not decrease bleeding after bypass in young children undergoing extensive reparative procedures. J Thor Cardiovasc Surg, l 06: 954-958, December 1993.

1992

Nicolson SC, Jobes DR, Zucker H, et al: Effect of administration or withholding dextrose in prebypass intravenous fluids on intraoperative blood glucose concentrations in infants undergoing cardiac surgery with hypothermic circulatory arrest. J Cardiothoracic Anesth. 6: 316-319, 1992.

Jobes DR, Nicolson SC, Steven JM, Miller M, Jacobs W, Norwood W: Carbon dioxide prevents pulmonary over-circulation in hypoplastic left heart syndrome. Annals of Thoracic Surgery. 54: 150-151, 1992.

1991

Troianos C, Jobes DR, Ellison N: Ultrasound Guided Cannulation of the Internal Jugular Vein: A Prospective, Randomized Study. Anesth Analg. 72: 823-826, 1991.

Manno CS, Hedberg KW, Bunin GR, Kim HC, Nicolson SC, Jobes DR, Schwartz E, Norwood WI: Comparison of the hemostatic effects of fresh whole blood, stored whole blood and components after open heart surgery in children. Blood 77: 930- 936, 1991.

1990

Nicolson SC, Jobes DR, Quinlan JA: Cardiovascular effects of administering Esmolol in the prebypass period to patients anesthetized with sufentanil-pancuronium for myocardial revascularization. J Cardiothoracic Anesth. 4: 55-58, 1990.

1989

Nicolson SC, Jobes DR, Steven JM, Hillyer P, Handrahan N: Evaluation of a user­ operated patient-side blood gas and chemistry monitor in children undergoing cardiac surgery. J Cardiothoracic Anesth. 3: 741-744, 1989.

Nicolson SC, Betts EK, Jobes DR, Christianson LA, Walters JW, Mayes KR, Korevaar WC: Comparison of oral and intramuscular preanesthetic medication for pediatric inpatient surgery. Anesthesiology 71: 8-10, 1989.

1988

Jobes DR, Nicolson SC, Pigott JD, Norwood WI: An enclosed system for continuous postoperative mediastinal aspiration. The Annals of Thoracic Surgery. 45: 101-102, 1988.

Jobes DR, Nicolson SC: Monitoring of arterial hemoglobin oxygen satura-.tion using a tongue sensor. Anesth Analg, 67: 186- I 88, 1988.

1986

Jobes Dr, Nicolson SC: An alternative method to secure an edotracheal tube in infants with midline facial defects. Anesthesiology, 64(5) Page: 643-644, 1986.

1985

Nicolson SC, Sweeney MF, Moore RA, Jobes DR: Comparison of internal and external jugular cannulation of the central circulation in the pediatric patient. Crit Care Med 13: 747-749, 1985.

1983

Lieberman RW, Orkin FK, Schwartz AJ, Jobes DR: Hemodynamic predictors of myocardial ischemia during coronary artery surgery. Anesthesiology 59: 353-355, 1983.

Jobes DR, Schwartz AJ, Greenhaw DE, Stephenson L, Ellison N: Safer jugular vein cannulation: recognition of arterial puncture and preferential use of the external jugular route. Anesthesiology 59: 36-41, 1983.

1982

Schwartz AJ, Jobes DR, Levy WJ, Palermo L, Ellison N: Tntrathoracic vascular catheterization via the external jugular vein. Anesthesiology 52: 400-402, 1982.

1981

Jobes DR, Schwartz AJ, Ellison N, Andrews R, Ruffini RA, Ruffini JJ: Monitoring heparin anticoagulation and its neutralization. Ann Thorac Surg, 31: 161-166, 1981.

1980

Schwartz AJ, Conahan TJ, Jobes DR, Andrews RW, MacVaugh H, Ominsky AJ: Peripheral vascular response to potassium administration during cardiopulmonary bypass. J Thor Cardiovasc Surg, 79: 313-317, 1980.

Richman KA, Jobes DR, Schwalb AJ: Continuous in vivo blood gas determination in man -- reliability and safety of a new device. Anesthesiology 52: 237-240, 1980.

1979

Cote CJ, Jobes DR, Schwartz Ellisom N: Two approaches to cannulation of a child's internal jugular vein. Anesthesiology 50: 371-373, 1979.

1977

Jobes DR, Kennell EM, Bush GC, Mull TD, Lecky JH, Behar MG, Wollman H: Cerebral blood flow and metabolism during morphine-nitrous oxide anesthesia in man. Anesthesiology 47: 16-18, 1977.

1975

Jobes DR, Kennell EM, Bitner RL, Swenson EJ: Effect of morphine-nitrous oxide anesthesia on cerebral autoregulation. Anesthesiology 42: 30-34, 1975.

1974

Johnstone RE, Jobes DR, Smith TC: Reversal of morphine anesthesia with naloxone. Anesthesiology 4 I: 361-367, 1974.

Books

Chapters
2009

Bailey PD, Jobes DR: The patient with Fontan physiology. International Anesthesiology Clinics 2009.

Bailey Philip D, Jobes David R: The Fontan patient. Anesthesiology clinics 27(2):285-    300, Jun 2009.

2007

Montenegro LM, Jobes DR: Complications of Massive Transfusion. In "Complications in Anesthesia" 2nd Edition Saunders, Elsevier  JL Atlee (eds.). 2007.

2006

Steven JM, Marino B, Jobes DR: Hypoplastic Left Heart Syndrome. In "Critical Heart Disease in Infants and Children" Mosby Year Book. DG Nichols   (eds.). 2006.

2005

Montenegro LM, Jobes DR: Complications of Massive Transfusion in Complications in Anesthesiology. WB Saunders Co. Philadelphia Pa.   J. Atlee  (eds.). 2005.

2004

Steven JM, Marino B, Jobes DR: Hypoplastic Left Heart Syndrome. In "Critical Heart Disease in Infants and Children" Mosby Year Book  DG Nichols  (eds.). 2004.

2002

Nicolson SC, Steven JM, Jobes DR: Perioperative management of the child with hypoplastic left heart syndrome. In Critical Heart Disease in Infants and Children, edited by ,  D Nichols, W Greeley, Cameronon DE (eds.). Mosby Yearbook  2nd Edition, 2002.

Nicolson SC, Steven JM, Jobes DR: Anesthetic Considerations for Patients with  Hypoplastic Left Heart Syndrome for Staged Reconstruction Surgery In Hypoplastic Left Heart Syndrome  Futura Publishing Company  HA Hennein, EL Bove (eds.). Page: 49-66, 2002.

1996

Jobes, DR: Managing fluids, electrolytes and blood loss. Dripps: Introduction to Anesthesia. D.E. Longnecker and F.L. Murphy, (eds.). 9th edition W.B. Saunders Co. New York, Page: 170-185, 1996.

1995

Traber K, Jobes DR: Approach to the Bleeding Patient, in Blood: Hemostasis, Transfusion and Alternatives in the Perioperative Period. Blood. C.L. Lake, R. A, Moore (eds.). Raven Press, New York, 1995.

Nicolson SC, Steven JM, Jobes DR: Perioperative management of the child with hypoplastic left heart syndrome. In Critical Heart Disease in Infants and Children. In Critical Heart Disease in Infants and Children, edited by Cameronon DE, Mosby Yearbook. Nichols D, Greeley W, Cameronon DE (eds.). Mosby Yearbook, Page: pp. 863-884, 1995.

Campbell FW, Jobes DR, Ellison N: Anticoagulation and coagulation during cardiac surgery. In The Practice of Cardiac Anesthesia, 2nd edition, edited by FA Hensley and DE Martin, Little Brown and Company, Boston, MA Page: pp. 434-462  1995.

1994

Jobes DR, Ellison N: Hemotherapy: Control of hemostasis and blood replacement. In Principles and Practice of Cardiac Anesthesia Page: 597 - 620, 1994.

1993

Nicolson SC, Jobes DR: Hypoplastic left heart syndrome. In Pediatric Cardiac Anesthesia, 2: 271-280, 1993.

1991

Ellison N, Campbell F. Jobes D: Postoperative Hemostasis. In Seminars in Thoracic and Cardiovascular Surgery  3: 33 - 38, 1991.

1990

Campbell FW, Jobes DR, Ellison N: Anticoagulation and coagulation during cardiac surgery. In The Practice of Cardiac Anesthesia Page: 546-549, 1990.

1989

Ellison N, Jobes DR: Hemostasis during cardiopulmonary bypass.  In Cardiopulmonary Bypass. Current Concepts and Controversies Page: 99-107, 1989.

1988

Jobes DR, Ellison N: Effective hemostasis in the cardiac surgical patients: Current status.  In Effective Hemostasis in Cardiac Surgery. A Society of Cardiovascular Anesthesiologists Monograph Page: 195 -201, 1988.

Ellison N, Jobes DR, Schwartz AJ: Heparin therapy during cardiac surgery.  In Effective Hemostasis in Cardiac Surgery. A Society of Cardiovascular Anesthesiologists Monograph Page: 1-14, 1988.

1986

Jobes DR, Nicolson SC: Hemodilution, arterial flow rates and cardiopulmonary bypass. In Common Problems in Cardiac Anesthesia 1986.

1985

Nicolson SC, Jobes DR: Anesthesia for PDA ligation in premature infants. In International Anesthesiology Clinics 1985.

1983

Schwartz AJ, Jobes DR, Ellison N: Pharmacology of cardiopulmonary resuscitation. In Cardiac Anesthesia  2, 1983.

1982

Schwartz AJ, Jobes DR: Congenital heart disease - special anesthetic considerations. In Cardiac Anesthesia, edited by TJ Conahan, Addison-Wesley Page: 62 - 91, 1982.

Jobes DR, Gallagher J: Acute normovolemic hemodilution. In International Anesthesiology Clinics 1982.



Jobes DR, Ellison N: Hemostatic mechanisms. TJ Conahan, Addison-Wesley, Page: 287 - 303, 1982.

Ellison NE, Jobes DR, Schwartz AJ: Implications of anticoagulant therapy. In International Anesthesiology Clinics 1982.

Awards and Honors

2007-2016,  The Best Doctors in America

2008,  Citation in " Guide to America's Top Anesthesiologists"

1996-2006,  The Best Doctors in America

1991-1992, Award for Excellence in Teaching

1991-1994, The Best Doctors in America

1963-1967, Krannert Scholarship

Editorial and Academic Positions

Editorial Positions

2012-present, Consultant reviewer to the editorial board of JOAN

2012-present, Consultant reviewer to the editorial board of BJA2012-present, Consultant Reviewer to the Editorial Board, Chest

2012-present, Consultant Reviewer to the Editorial Board, Anesthesiology

2012-present, Consultant Reviewer to the Editorial Board, Cardiothoracic and Vascular Anesthesia

2012-present, Consultant Reviewer to the Editorial Board, Journal of Thoracic and Cardiovascular Surgery

2012-present, Consultant Reviewer to the Editorial Board, Annals of Thoracic Surgery

2010-present, Consultant Reviewer to the Editorial Board of Transfusion Medicine

2000-present, Consultant Reviewer to the Editorial Board, Annals of Internal Medicine

1990-present, Consultant Reviewer to the Editorial Board, Anesthesia and Analgesia

Academic and Institutional Committees

2010-present, Chairman, Transfusion Committee of the ECMS

2010-present, Department of Pediatrics, Division of Cardiology Scholarship Oversight Committee

2008-present, Quality Improvement Committee of the ECMS

2003-present, Director of Clinical Research, Division of Cardiac Anesthesia

2003-present, Chairman, Cardiac Center Research Committee

Leadership and Memberships

Memberships in Professional Organizations

Association of University Anesthetists

Society for Pediatric Anesthesia

Society of Cardiovascular Anesthesiologists

The Congenital Cardiac Anesthesia Society