Michele Lambert, MD

Michele Lambert, MD

Michele Lambert, MD, is medical director of the Clinical Coagulation Laboratory and an attending physician in the Division of Hematology at The Children's Hospital of Philadelphia.

Areas of Expertise: Congenital platelet disorders, General hematology
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

Michele Lambert, MD, is the medical director of the Clinical Coagulation Laboratory with a special interest in inherited and acquired platelet disorders and the interplay between genetic disorders and hematologic disease. Her clinical and research focus has been on the diagnosis and management of platelet related bleeding disorders.

Education and Training

Medical School

MD - University of Medicine and Dentistry of New Jersey, Newark, NJ

Internship

Pediatrics - St. Christopher's Hospital for Children, Philadelphia, PA

Residency

Pediatrics (Chief Resident) - St. Christopher's Hospital for Children, Philadelphia, PA

Fellowship

Pediatric Hematology/Oncology - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

American Board of Pediatrics
American Board of Pediatrics/Hematology-Oncology

Undergraduate Degree

BS in Biology - Rensselaer Polytechnic Institute, Troy, NY

Graduate Degree

MTR - University of Pennsylvania, Philadelphia, PA

Titles and Academic Titles

Attending Physician

Medical Director, Clinical Coagulation Laboratory

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Publications

Papers

2016

Turro E, Greene D, Wijgaerts A, Thys C, Lentaigne C, Bariana T, Westbury S, Kelly AM, Selleslag D, Stephens JC, Papadia S, Simeoni I, Penkett CJ, Ashford S, Attwood AP, Austin S, Bakchoul T, Collins P, Deevi SVV, Favier R, Kostadima M, Lambert MP, Mathias M, Millar CM, Peerlink K, Perry DJ, Schulman S, Whitehorn D, Wittevrongel C, DeMaeyer M, Rendon A, Gomez K, Erber WN, Mumford AD, Nurden P, Stirrups K, Bradley JR, Raymond FL, Laffan MA, Van Geet, C, Richardson S, Freson, K, Ouwehand WH: A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies. Science translational medicine 8(328):328ra30-328ra30. March 2016. PMID: 26936507.

Neunert CN, Despotovic JM, Bennett CM, Lambert MP, Grace RE on behalf of the Pediatric ITP Consortium of North America: Thrombopoietin Receptor Agonist Use in Children: Data from the Pediatric ITP Consortium of North America ICON2 Study. Pediatric Blood and Cancer Epub: March 2016.

Stritt S, Nurden P, Favier R, Favier M, Ferioli S, Gotru S, van Eeuwijk JMM, Schulze H, Nurden A, Lambert MP, Turro E, Burger-Stritt S, Matsushita M, Mittermeier L, Ballerini P, Zierler S, Laffan M, Chubanov V, Gudermann T, Nieswandt T, Braun A: Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture. Nature Communications. Nature Communications 7:11097. March 2016. PMID: 27020697.

Witmer C, Lambert MP, O’Brien S, Neunert C. Multicenter Cohort Study Comparing US Management of Inpatient Pediatric Immune Thrombocytopenia to Current Treatment Guidelines. Pediatric Blood and Cancer. Epub. February 2016. PMID: 26929009.

Stritt S, Nurden P, Turro E, Greene D, Jansen SB, Westbury SK, Petersen R, Astle WJ, Marlin S, Bariana TK, Kostadima M, Lentaigne C, Maiwald S, Papadia S, Kelly AM, Stephens JC, Penkett CJ, Ashford S, Tuna S, Austin S, Bakchoul T, Collins P, Favier R, Lambert MP, Mathias M, Millar CM, Mapeta R, Perry DJ, Schulman S, Simeoni I, Thys C, Consortium Bridge-Bpd, Gomez K, Erber WN, Stirrups K, Rendon A, Bradley JR, van Geet C, Raymond FL, Laffan MA, Nurden AT, Nieswandt B, Richardson S, Freson K, Ouwehand WH, Mumford AD: A gain-of-function variant in DIAPH1 causes dominant macrothrombocytopenia and hearing loss. Blood Epub, Feb 2016. PMID: 26912466.

Bride KL, Vincent T, Smith-Whitley K, Lambert MP, Bleesing JJ, Seif AE, Manno CS, Casper J, Grupp SA, Teachey DT. Sirolimus is effective in relapsed/refractory autoimmune cytopenias: results of a prospective multi-institutional trial. Blood. 2016 Jan 7;127(1):17-28

2014

Sullivan SK, Mills JA, Koukouritaki SB, Vo KK, Lyde RB, Paluru P, Zhao G, Zhai L, Sullivan LM, Wang Y, Kishore S, Gharaibeh EZ, Lambert MP, Wilcox DA, French DL, Poncz M, Gadue P.: High-level transgene expression in induced pluripotent stem cell-derived megakaryocytes: correction of Glanzmann thrombasthenia. Blood. 123(5): 753-7, Jan 2014. PMCID: PMC3907760

 

Abstracts

2016

Lambert MP, Kwiatkowski J: Iron Deficiency is a significant complication of Eltrombopag Treatment for ITP in Pediatric Patients Thrombosis and Hemostasis Societies of North America Meeting, Chicago, IL. Platform Presentation, April 2016.

Romasko EJ, Devkota B, Jayaraman V, Jairam S, Scarano MI, Biswas S, Thom CS, Dulik MC, Conlin LK, Spinner NB, Krantz ID, Lambert MP: Utility and Limitations of Exome Sequencing in the Diagnosis of Pediatric Platelet Disease Annual Clinical Genetics Meeting, Tampa, FL. Poster Presentation, March 2016.

2014

Ben J. Samelson-Jones, Michele P. Lambert: Use of Recombinant Factor VIIa (rVIIa) in Glanzmann's Thrombasthenia: A Systematic Review of the Literature. American Society of Hematology/Oncology Annual Meeting, Chicago, IL April 2014.

2013

Ingmar Bruns, MD, Daniel Lucas, PhD, Sandra Pinho, PhD, Jalal Ahmed, Michele P Lambert, MD, Christoph Scheiermann, PhD, Yuya Kunisaki, MD, PhD, Mortimer Poncz, MD and Paul S. Frenette, MD: Megakaryocytes Regulate Hematopoietic Stem Cell Quiescence Via PF4 Secretion. American Society of Hematology Plenary Session December 2013.

David T. Teachey, MD, TIffaney Vincent, Kim Smith-Whitley, MD, Michele P Lambert, MD, Alix E. Seif, MD, MPH, James T. Casper, MD and Stephan A Grupp, MD, PhD: Targeting mTOR Signaling Leads To Complete and Durable Responses In Children With Multi-Lineage Autoimmune Cytopenias, Including ALPS, SLE, Evans and CVID. American Society of Hematology, Oral Presentation December 2013.

Corinna L. Schultz, MD and Michele P Lambert, MD: Influence Of Updated ASH Guidelines On Practice Patterns In Management Of Newly Diagnosed Childhood ITP, 2007-2012. American Society of Hematology, Oral Presentation December 2013.

Cassie N. Kline, MD; Richard Hodinka, MD; Michele P. Lambert, MD: Investigating correlation between common upper respiratory and gastrointestinal viral infections and Idiopathic Thrombocytopenic Purpura. American Society of Pediatric Hematology/Oncology annual meeting; Poster presentation Apr 2013.

2012

Michele P. Lambert, Donna McDonald-McGinn, Elaine Zakai: Hematologic Manifestations of 22qDS. 22qDeletion Syndrome meeting, Lake Buena Vista, FL July 2012.

Xiao L, Poncz M, Lambert MP: Platelet Factor 4 (PF4) causes cell cycle arrest in megakaryocytes by inactivating CDC2 (CDK1) and CDK2 Gordon Research Conference on Hemostasis March 2012.

Lambert MP, Xiao L, Meng R, Marks M, Poncz M: Alpha-granule protein recycling during megakaryopoiesis: Platelet factor 4 (PF4) is taken up by megakaryocytes (Megs) through a lipoprotein receptor related protein-1 (LRP1) dependent process and is available for release by stimulated Megs Platelets 2012; 7th International Platelet Symposium March 2012.

Books

Chapters

2013

Lambert, MP, Poncz, M: Inherited Thrombocytopenias. Platelets. Michelson, AD (eds.). Elsevier Science, 2nd edition; 3rd edition: 985-998, 2007, 2013.

2012

Lambert, M: Autoimmune Hemolytic Anemia. The 5-Minute Pediatric Consult. Schwartz, MW, Bell, LM, Bingham, PM, Chung, EK, Friedman, DF, Tanel, RE, Mamula, P, Loomes, KM and Mascarenhas, M (eds.). Lippincott, Williams & Wilkins, 5th edition, 2008, 2012.

Lambert, M: Glucose-6 Phosphate Dehydrogenase Deficiency. The 5-Minute Pediatric Consult. Schwartz, MW, Bell, LM, Bingham, PM, Chung, EK, Friedman, DF, Tanel, RE, Mamula, P, Loomes, KM and Mascarenhas, M (eds.). Lippincott, Williams & Wilkins, 5th edition, 2008, 2012.

Lambert, MP: Anemia of Chronic Disease. The 5-Minute Pediatric Consult. Schwartz, MW, Bell, LM, Bingham, PM, Chung, EK, Friedman, DF, Tanel, RE, Mamula, P, Loomes, KM and Mascarenhas, M (eds.). Lippincott, Williams & Wilkins, 5th edition, 2008, 2012.

Lambert, MP: Hereditary Spherocytosis. The 5-Minute Pediatric Consult. Schwartz, MW, Bell, LM, Bingham, PM, Chung, EK, Friedman, DF, Tanel, RE, Mamula, P, Loomes, KM and Mascarenhas, M (eds.). Lippincott, Williams & Wilkins, 5th edition, 2008, 2012.

Awards and Honors

2011, International Society on Thrombosis and Haemostasis New Investigator Travel Award
2009, International Society of Thrombosis and Haemostasis Young Investigator Travel Award
2006, American Society of Pediatric Hematology/Oncology Young Investigator Travel Award
2005, American Society of Hematology Young Investigator Travel Award
1998, UMDNJ-NJMS Alumni Association Award in honor of Dr. Franklin Behrle
1997, UMDNJ-NJMS Alumni Association Scholarship
1985-1998, UMDNJ-NJMS Joseph Muscarelli Memorial Scholarship
1995, Alpha Epsilon Delta - Premedical honor society

Editorial and Academic Positions

Editorial positions

2009-present, Pediatric Blood and Cancer, Ad Hoc Reviewer
2009-present, Blood, Ad Hoc Reviewer

Academic and institutional committees

2008-2012, Member IRB-C, The Children's Hospital of Philadelphia

Leadership and Memberships

Memberships in Professional Organizations

2007-present, International Society of Thrombosis and Haemostasis
2014, NIH/NHLBI (Grant Reviewer; Microfluidic Assays SBIR/STTR)
2011-present, Society for Pediatric Research/Pediatric Academic Society
2008-present, Platelet Disorder Support Association
2008-present, Cornelia De Lange Foundation, Member Medical Advisory Board
2007-present, American Society of Pediatric Hematology/Oncology
2007-present, American Society of Hematology
1999-present, American Medical Association

Institutional and Academic Committees

Co-chair, ISTH Scientific Subcommittee on Genomics of Rare Bleeding Disorders
Co-chair, Interventional Subcommittee of the Operations Committee of the Pediatric Immune Thrombocytopenia Consortium of North America
Medical Advisory Board, Platelet Disorder