Education and Training
Postdoctoral Fellow, Cell and Developmental Biology – Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
Postdoctoral Fellow, Mitochondrial Medicine – Children's Hospital of Philadelphia, Philadelphia, PA
Bachelor’s Degree in Biology - University of Calabria, Italy
PhD in Animal Biology - University of Calabria, Italy
Master’s Degree in Biology (molecular pathology) - University of Calabria, Italy
Titles and Academic Titles
Research Assistant Professor
Departments and Services
Electron microscopy and live-cell imaging
Excitation contraction coupling
Skeletal and cardiac muscle diseases
Mitochondria morphology and dynamics
Video-tracking analysis of amphibians affected by neurotoxic pesticides impairing neuromuscular system
Lavorato M, Iyer V R, Dewight W, Cupo R R, Debattisti V, Gomez L, De la Fuente S, Zhao Y-T, Valdivia H H, Hajnóczky G, Franzini-Armstrong C. Increased mitochondrial nanotunneling activity, induced by calcium imbalance, affects intermitochondrial matrix exchanges. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E849-E858. doi: 10.1073/pnas.1617788113. Epub 2017 Jan 17.
Perni S, Lavorato M, Beam KG. De novo reconstitution reveals the proteins required for skeletal muscle voltage-induced Ca2+ release. Proc Natl Acad Sci USA 114 (52), 13822-13827. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13822-13827. doi: 10.1073/pnas.1716461115. Epub 2017 Dec 11.
Lavorato M, Gupta P K, Hopkins P M, Franzini-Armstrong C.Skeletal muscle microalterations in patients carrying Malignant Hyperthermia-related mutations of the e-c coupling machinery. Eur J Transl Myol. 2016 Sep 15;26(4):6105. doi: 10.4081/ejtm.2016.6105. eCollection 2016 Sep 15.
Linsley J W, Hsu I-U, Groomc L, Yarotskyy V, Lavorato M, Horstick E J , Linsley D, Wang W, Franzini-Armstrong C, Dirksen R T, Kuwada J Y, 2016. Congenital myopathy results from misregulation of a muscle Ca2+ channel by mutant Stac3. Proc Natl Acad Sci USA, 114(2): E228–E236.
Lavorato M, Taiqin H, Iyer V R, Perni S, Meissner G, and Franzini-Armstrong C, 2015. Dyad content is reduced in cardiac myocytes of mice with impaired calmodulin regulation of RyR2. J Muscle Res Cell Motil. 36(2):205-14.
Lavorato M, Bernabò I, Crescente A, Denoël M, Tripepi, Brunelli E, 2013. Endosulfan Effects on Rana dalmatina Tadpoles: Quantitative Developmental and Behavioural Analysis. Arch Environ Contam Toxicol. 2013 Feb;64(2):253-62. doi: 10.1007/s00244-012-9819-7. Epub 2012 Oct 13.
Lavorato M. Mitochondria fission in fatigued muscle. Gordon Research Seminar and Gordon Conference, Muscle: Excitation-Contraction Coupling, 2017. Les Diablerets, Switzerland.
Lavorato M, Iyer V. R, Franzini-Armstrong C. A convenient alternative view of muscle membranes. Gordon Conference, Muscle: Excitation-Contraction Coupling, 2017. Les Diablerets, Switzerland.
Madan A, Viswanathan M C, Lavorato M, Schmidt W, Ochala J, Cammarato A, 2017. ACTA1-Related Nemaline Myopathy Mutations Engender a Range of Structural and Functional Phenotypes in Drosophila Indirect Flight Muscles. Biophys J, 112 (3) p182a.
Iyer V R, Monfredi O, Maltsev V, Lavorato M; Stern M, Franzini-Armstrong C, 2016. SR Contribution to Calcium Cycling in Sino-Atrial Node Cells: As seen from Nanoscale Electron Microscopy and Numerical Modeling. Biophys J 110, 359a.
Lavorato M, Ramesh V I, Zhao Y-T, Valdivia H H, Franzini-Armstrong C, 2016. Electron tomography of mitochondrial nanotunnels in a CPVT model with RyR2 loss-of-function mutation. Biophys J 110, 367a.
Lavorato M, Schmidt W, Viswanathan M C, Ochala J, Franzini-Armstrong C, Cammarato A, 2015. The actin F352S nemaline myopathy mutation disrupts indirect flight muscle structure and function in Drosophila. Biophys J 110, 128a.
Iyer V R, Lavorato M, Zhao Y-T, Valdivia H H, Franzini-Armstrong C, 2015. Mitochondrial abnormalities in a mouse CPVT model with RyR2 loss-of-function mutation. Biophys J 108, 132a.
Beqollari D, Romberg CF, Feng W, Lopez JR, Lavorato M, Perni S, Hopkins PM, Franzini-Armstrong C, Pessah IN, Allen PD, Beam KG, Bannister RA, 2015. Calcium channel dysfunction in a mutant mouse model of malignant hyperthermia (CaV1.1 R174W). Biophys J 108, 504a.
Iyer V R*, Lavorato M*, Zhao YT, Valdivia H., Franzini-Armstrong C. Ultrastructural cardiac alterations resulting from cardiac RyR2 mutations with opposite functions. * contributed equally. Gordon Conference: Muscle: Excitation-Contraction Coupling, 2015, Sunday River in Newry ME United States.
Posters and Presentations
Lavorato M. Gordon Research Conference and Gordon Research Seminar. Muscle: Excitation -Contraction Coupling. Les Diablerets, Switzerland. Selected talk, two posters’ presenter.
Lavorato M. 60th Biophysical Society Annual Meeting. Selected talk and poster presenter.
Lavorato M. Biomedical Postdoctoral research symposium, University of Pennsylvania, Philadelphia, PA. Poster presenter.
Lavorato M. Gordon Conference: Muscle: Excitation-Contraction Coupling, 2015, Sunday River in Newry ME United States. Selected talk and poster presenter.
Lavorato M. 59th Biophysical Society Annual Meeting, Baltimore, Maryland (poster presenter).
Lavorato M. Biomedical Postdoctoral research symposium. Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Poster presenter.
Lavorato M. Mitochondrial nanotunnels in a CPVT model with RyR2 loss-of-function mutation. The ISHR-Latin American Section-Sponsored Symposia during the XXIV Congreso Argentino de Hipertensión, Mendoza, Argentina.
Lavorato M. Invited speaker: Strange mitochondrial behavior. Friendly or not? At the Mitocare, Jefferson University, Philadelphia PA
Awards and Honors
2017, FEBS Journal Poster Prize at the GRC on Muscle: Excitation-Contraction Coupling, Les Diablerets, Switzerland
2010-2011, Two International Mobility Fellowships for PhD students, Department of Environmental Sciences, Behavioral Biology Unit, University of Liège (Belgium)
2009, Bonino Pulejo Foundation Fellowship, Messina, Italy
Leadership and Memberships
Memberships in Professional Organizations
2012-present, Biophysical Society
Patient Experience Ratings
About the Patient Experience Rating System
The Patient Experience Rating is an average of all responses to the care provider related questions shown above from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.
Responses are measured on a scale of 1 to 5 with 5 being the best score.
We are committed to true transparency. However, to ensure the comments are fair and correctly attributed, we review each one before posting to the website. We exclude entire comments that disclose patient's protected health information, are off-topic, or include other confidential or inappropriate content. Comments will appear on provider bios only if providers have a minimum number of comments.
Comments are shared internally for education purposes to ensure that we are doing our very best for the patients and families for whom we are privileged to care.
The comments are submitted by patients and families and reflect their views and opinions. The comments are not endorsed by and do not reflect the views of Children’s Hospital of Philadelphia.