Michael S. Leibowitz, MD, PhD

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Michael S. Leibowitz, MD, PhD, is an attending physician with the Cancer Center and the Blood and Marrow Transplant Program at Children's Hospital of Philadelphia.

Locations: Main Hospital

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - University of Pittsburgh, Pittsburgh, PA


Pediatrics - Children’s Hospital Colorado, Aurora, CO


Pediatrics - Children’s Hospital Colorado, Aurora, CO


Hematology/Oncology - Children’s Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatrics – American Board of Pediatrics

Graduate Degree

PhD in Immunology - University of Pittsburgh, Pittsburgh, PA

Titles and Academic Titles

Attending Physician

Instructor of Oncology, Perelman School of Medicine at the University of Pennsylvania

Departments and Services




Leibowitz M, Wolfe H, Flynn, A, Waanders A, Burlingam C, Aumaier B, Friedman D, Lambert Michele.  Standardization of prophylactic transfusion dosing in a pediatric oncology population: a quality improvement project.  Transfusion. 2018 Sep 27: 1-5. PubMed PMID 30264395.


Leibowitz MS, Srivastava RM, Andrade Filho PA, Egloff AM, Wang L, Seethala RR, Ferrone S and Ferris RL.  SHP2 is overexpressed and inhibits pSTAT1-mediated APM component expression, T-cell attracting chemokine secretion, and CTL recognition in head and neck cancer cells.  Clin Cancer Res. 2013 Feb 15;19(4):798-808.  PubMed PMID: 23368316. 


Leibowitz MS, Andrade Filho PA, Ferrone S, Ferris RL. Deficiency of activated STAT1 in head and neck cancer cells mediates TAP1-dependent escape from cytotoxic T lymphocytes. Cancer Immunol Immunother. 2011 Apr;60(4):525-535.  PubMed PMID: 21207025. 


Sen M, Tosca PJ, Zwayer C, Ryan MJ, Johnson JD, Knostman KA, Giclas PC, Peggins JO, Tomaszewski JE, McMurray TP, Li C, Leibowitz MS, Ferris RL, Gooding WE, Thomas SM, Johnson DE, Grandis JR. Lack of toxicity of a STAT3 decoy oligonucleotide. Cancer Chemother Pharmacol. 2009 May;63(6):983-95.  PubMed PMID:  18766340.


Wesa AK, Herrem CJ, Mandic M, Taylor JL, Vasquez C, Kawabe M, Tatsumi T, Leibowitz MS, Finke JH, Bukowski RM, Bruckheimer E, Kinch MS, Storkus WJ. Enhancement in specific CD8+ T cell recognition of EphA2+ tumors in vitro and in vivo after treatment with ligand agonists. J Immunol. 2008 Dec 1;181(11):7721-7.  PubMed PMID: 19017961.


Couch ME, Ferris RL, Brennan JA, Koch WM, Jaffee EM, Leibowitz MS, Nepom GT, Erlich HA, Sidransky D. Alteration of cellular and humoral immunity by mutant p53 protein and processed mutant peptide in head and neck cancer. Clin Cancer Res. 2007 Dec 1;13(23):7199-206.  PubMed PMID: 18056201.

Domchek SM, Recio A, Mick R, Clark CE, Carpenter EL, Fox KR, DeMichele A, Schuchter LM, Leibowitz MS, Wexler MH, Vance BA, Beatty GL, Veloso E, Feldman MD, Vonderheide RH. Telomerase-specific T-cell immunity in breast cancer: effect of vaccination on tumor immunosurveillance. Cancer Res. 2007 Nov 1;67(21):10546-55.  PubMed PMID: 17974999.


Delong P, Carrol RG, Henry AC, Tanaka T, Ahmad S, Leibowitz MS, Sterman DH, June CH, Albelda SM, Vonderheide RH.  Regulatory T cells and cytokines in malignant pleural effusions secondary to mesothelioma and carcinoma.  Cancer Biol Ther. 2005 Mar 4;(3):342-6.  PubMed PMID:  15846066.

Posters and Presentations

Invited Lectures


Leibowitz MS. "Chimeric antigen receptor immunotherapy targeting fibroblast activation protein in lung cancer".  Pulmonology Research Conference, University of Pennsylvania Department of Allergy, Pulmonology and Critical Care. May, 2017.

Awards and Honors

2018 St. Baldrick's Foundation Scholar Award Funded by David’s Warriors
2018 Alex Lemonade Stand Young Investigator Award, Co-funded by the Sebastian Strong Foundation
2010, AACR Dr. Axel Ullrich Scholar-in-Training Award
2005, American Society of Hematology Trainee Award
2002, Bowdoin College, cum laude with honors in Biology
1999-2002, Sarah and James Bowdoin Scholar

Leadership and Memberships

Memberships in Professional Organizations

2015-present, Children's Oncology Group
2012-present, American Academy of Pediatrics
2010-present, American Association for Cancer Research