Hong Lin, PhD

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Hong Lin, PhD, is a neurology researcher with the Division of Neurology at Children's Hospital of Philadelphia.

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Fellowship

Postdoctoral Fellow in Molecular Neurobiology - Institute of Basic Medical Science, Beijing, China
Postdoctoral Fellow in Neuropharmacology and Neuropathology - University of Pennsylvania School of Medicine, Philadelphia, PA

Graduate Degree

PhD in Physiology - Peking Union Medical College, Beijing, China
MD in Physiology - Peking Union Medical College, Beijing, China

Titles and Academic Titles

Neurology Researcher

Departments and Services

Publications

Papers

2017

Lin H, Magrané J., Rattelle A.J., Stepanova A., Galkin A., Clark E.M., Dong Y-N., Halawani S.W. and Lynch D.R Early cerebellar deficits in mitochondrial biogenesis and respiratory chain complexes in the KIKO mouse model of Friedreich ataxia. Disease Models and Mechanisms, in press, 2017

2016

Lin H., Jacobi A.A., Anderson S.A. and Lynch D.R. D-serine and serine racemase are associated with PSD-95 and glutamatergic synapse stability. Frontier in Cellular Neuroscience, 10:34, 2016.

2014

Lin H., Hsu F-C., Baumann B.H., Coulter D.A., Anderson S.A. and Lynch D.R. Cortical parvalbumin GABAergic deficits with α7 nicotinic acetylcholine receptor deletion: Implications for schizophrenia. Molecular and Cellular Neuroscience, 61:163-175, 2014.

Lin H., Hsu F-C., Baumann B.H., Coulter D.A. and Lynch D.R. Cortical synaptic NMDA receptor deficits in α7 nicotinic acetylcholine receptor gene deletion models: Implication for neuropsychiatric diseases. Neurobiology of Disease, 63:129-140, 2014.

2013

Zhu H., Bhattacharyya B., Lin H., and Gomez C.M. Skeletal muscle calpain acts through nitric oxide neural microRNAs to regulate acetylcholine release in motor nerve terminals. Journal of Neuroscience, 33: 7308-7324, 2013.

2011

Zhu H., Bhattacharyya B., Lin H., and Gomez C.M. IP3R1 receptors amplify physiological and pathological synaptic calcium signals. Journal of Neuroscience, 31:15269-15283, 2011.

2010

Lin H., Vicini S., Hsu F-C., Doshi S., Takano H., Coulter D.A. and Lynch D.R. Axonal α7 nicotinic ACh receptors modulate presynaptic NMDAR expression and structural plasticity of glutamatergic presynaptic boutons during early synaptic development. Proceedings of the National Academy of Sciences of the United States of America, 107: 16661-16666, 2010.

2008

Lim Y., Lim S.T., Tomar A., Gardel M., Bernard-Trifilo J.A., Chen X.L., Uryu S.A., Canete-Soler R., Zhai J., Lin H., Schlaepfer W.W., Nalbant P., Bokoch G., Ilic D., Waterman-Storer C., and Schlaepfer D.D. PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility. Journal of Cell Biology, 180:187-203, 2008.

2007

Zhai J., Lin H. Julien J-P. and Schlaepfer W.W. Disruption of neurofilament network with aggregation of light neurofilament protein: A common pathway leading to motor neuron degeneration due to Charcot-Marie-Tooth disease-linked mutations in NFL and HSPB1. Human Molecular Genetics, 16:3103-3116, 2007.

2005

Zhai J., Lin H., Canete-Soler R. and Schlaepfer W.W. HoxB2 binds mutant SOD1 and is altered in transgenic model of ALS. Human Molecular Genetics, 14:2629-2640, 2005.

Lin H., Zhai J., and Schlaepfer W.W. RNA-binding protein is involved in aggregation of light neurofilament protein and is implicated in the pathogenesis of motor neuron degeneration. Human Molecular Genetics, 14:3643-3659, 2005.

2004

Lin H., Zhai J., Canete-Soler R. and Schlaepfer W.W. 3' untranslated region in a light neurofilament (NF-L) mRNA triggers aggregation of NF-L and mutant superoxide dismutase 1 proteins in neuronal cells. Journal of Neuroscience, 17: 2716-2726, 2004.

2003

Lin H., Zhai J., Nie Z, Wu J, Meinkoth J.L., Schlaepfer W.W. and Canete-Soler R. Neurofilament RNA causes neurodegeneration with accumulation of ubiquitinated aggregates in cultured motor neurons. Journal of Neuropathology and Experimental Neurology, 62: 936-950, 2003.

Zhai J., Lin H., Nie Z., Wu J., Canete-Soler R., Schlaepfer W.W. and Schlaepfer D.D. Direct interaction of focal adhesion kinase with p190RhoGEF. Journal of Biological Chemistry, 278: 24865-24873, 2003.

Maeno-Hikichi Y., Chang S., Matsumura K., Lai M., Lin H., Nakagawa N., Kuroda S. and Zhang J.F. A PKC-ENH-channel complex specifically modulates N-type Ca2+ channels. Nature Neuroscience, 6: 468-475, 2003.

2002

Nie Z., Wu J., Zhai J., Lin H., Ge W., Schlaepfer W.W. and Canete-Soler R. Untranslated element in neurofilament mRNA has neuropahtic effect on motor neurons of transgenic mice. Journal of Neuroscience, 22: 7662-7670, 2002.

Wu J., Zhai J., Lin H., Nie Z, Ge W., Garcia-Bermerjo L., Muschel R.J., Schlaepfer W.W. and Canete-Soler R. Cytoplasmic retension sites in p190RhoGEF confer anti-apoptotic activity to an EGFP-tagged protein. Brain Research Molecular Brain Research, 117: 27-38, 2002.

Ge W., Wu J., Zhai J., Nie Z, Lin H., Schlaepfer W.W. and Canete-Soler R. Binding of p190RhoGEF to a destabilizing element on the light neurofilament mRNA is competed by BC1 RNA. Journal of Biological Chemistry, 277: 42701-42705, 2002.

2001

Zhai J., Lin H., Shamim M., Schlaepfer W.W., Cañete-Soler R. Identification of a novel interaction of 14-3-3 with P190RhoGEF. Journal of Biological Chemistry, 276:41318-24, 2001.

1998

Lin H. and Cai Y. Inducible nitric oxide synthase and hypoxic pulmonary vascular remodeling. Chinese Journal of Tuberculosis and Respiratory Diseases (Article in Chinese), 21:207, 1998.

1997

Lin H., Cai Y., Deng X. Hypoxia induces gene expression of inducible nitric oxide synthase in pulmonary vascular smooth cells. Basic & Clinical Medicine (Article in Chinese), 17:199-203, 1997.

Lin H., Cai Y., Deng X. Hypoxia induces gene expression of inducible nitric oxide synthase in pulmonary vascular smooth cells. Basic & Clinical Medicine (Article in Chinese), 17:199-203, 1997.

Lin H. and Cai Y. Effect of hypoxia on distribution and activity of nitric oxide synthase in rat lung. Acta Academiae Medicinae Sinicae (Article in Chinese), 19:110-115, 1997.

Lin H., Cai Y, Deng X., Cai Q. and Zhou X. Role of endothelial-derived nitric oxide and its synthase during the development of hypoxic pulmonary hypertension in rat. Chinese Journal of Applied Physiology (Article in Chinese), 13: 163-167, 1997.

Books

Chapters

1999

Lin H., Fan M. and Liu D-P. Gene expression and LIM homeobox genes during neuronal development. (Chapter 1) in Developmental Neurobiology edited By Cai and Li, Science Press in China, P1-P31, 1999.

Posters and Presentations

2017

Lin H., Halawani S.M, Malik D.M., Rattelle A.J., Clark E.M., Dong Y-N., Magrané J. and Lynch D.R. Frataxin deficiency impairs IP3R-coupled ER-mitochondrial signaling in cerebellum of Friedreich ataxia mouse models. Poster accepted. Society for Neuroscience 2017 Annual meeting. Washington, DC.

2016

Lin H, Lao-Peregrín C., Clark E.M., Dong Y., Rattelle A.J., Magrané J. and Lynch D.R. Early cerebellar mitochondrial deficits in a frataxin-deficient mouse model of Friedreich’s ataxia. Poster 43.08/L14, Society for Neuroscience 2016 Annual meeting. San Diego, CA.

2015

Lin H., Magrané J. and Lynch D.R. Cerebellar circuit deficits in a frataxin-deficient mouse model of Friedreich’s ataxia. Poster 400.17/F43, Society for Neuroscience 2015 Annual meeting, Chicago, IL.

Awards and Honors

2017, Friedreich Ataxia Research Alliance Research Grant
2010 & 2015, Foerderer Grant for Excellence, Children’s Hospital of Philadelphia
2004, MDA Development Grant, Muscular Dystrophy Association
1997, Distinguished Young Investigator Award, Chinese Society for Physiology
1992, Honored Graduate Student, Beijing Normal University
1988, Honored Undergraduate Student, Beijing Normal University

Leadership and Memberships

Memberships in Professional Organizations

2001-present, Society for Neuroscience