Kathleen M. Loomes, MD

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Kathleen M. Loomes, MD, is a pediatric gastroenterologist in the Division of Gastroenterology, Hepatology and Nutrition at Children's Hospital of Philadelphia. She is Co-Director of the Fred and Suzanne Biesecker Pediatric Liver Center and a leader in the Liver Transplant Program.

Areas of Expertise: Pediatric liver disease, Alagille syndrome, Biliary atresia, Liver transplantation, Cornelia de Lange syndrome
Locations: Main Hospital

Phone: 866-543-5487

Background

Dr. Loomes is an attending physician with the Division of Gastroenterology, Hepatology and Nutrition and holds the Fred and Suzanne Biesecker Endowed Chair in Pediatric Liver Disease at Children's Hospital of Philadelphia.

Dr. Loomes’ primary research interest is in the genetics of liver and bile duct development. Following the identification of Jag1 as the disease gene for Alagille syndrome, a multisystem developmental disorder with bile duct paucity as a major feature, the Notch signaling pathway has been implicated in bile duct development. 

In order to understand the roles of the members of this pathway in bile duct development, Dr. Loomes and her laboratory members have taken a dual approach.  They utilize multiple mouse mutant models within the Notch signaling pathway to elucidate genetic interactions and to study bile duct development in detail. 

In addition, they have generated a bipotential mouse hepatoblast cell line, capable of differentiation into hepatocytes or biliary epithelial cells. Through the manipulation of expression of regulatory genes in this in vitro system, they will be able to shed light on signaling mechanisms for bile duct differentiation.

Education and Training

Medical School

MD - University of Texas Southwestern Medical School, Dallas, TX

Residency

Pediatrics - Johns Hopkins Hospital, Baltimore, MD

Fellowship

Gastroenterology, Hepatology and Nutrition (clinical and research) - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Gastroenterology
Pediatric Transplant Hepatology
Pediatrics

Titles and Academic Titles

Attending Physician

Director of Research Training, Gastroenterology and Hepatology Fellowship Training Program

Co-Director, Fred and Suzanne Biesecker Pediatric Liver Center

Fred and Suzanne Biesecker Endowed Chair in Pediatric Liver Disease

Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Research Interests

Pediatric liver disease
Biliary atresia
Alagille syndrome
Pediatric acute liver failure

Publications

Papers

2019

Berauer John-Paul, Mezina Anya I, Okou David T, Sabo Aniko, Muzny Donna M, Gibbs Richard A, Hegde Madhuri R, Chopra Pankaj, Cutler David J, Perlmutter David H, Bull Laura N, Thompson Richard J, Loomes Kathleen M, Spinner Nancy B, Rajagopalan Ramakrishnan, Guthery Stephen L, Moore Barry, Yandell Mark, Harpavat Sanjiv, Magee John C, Kamath Binita M, Molleston Jean P, Bezerra Jorge A, Murray Karen F, Alonso Estella M, Rosenthal Philip, Squires Robert H, Wang Kasper S, Finegold Milton J, Russo Pierre, Sherker Averell H, Sokol Ronald J, Karpen Saul J: Identification of Polycystic Kidney Disease 1 Like 1 Gene Variants in Children With Biliary Atresia Splenic Malformation Syndrome. Hepatology (Baltimore, Md.) Jan 2019.

Loomes Kathleen M, Spino Cathie, Goodrich Nathan P, Hangartner Thomas N, Marker Amanda E, Heubi James E, Kamath Binita M, Shneider Benjamin L, Rosenthal Philip, Hertel Paula M, Karpen Saul J, Molleston Jean P, Murray Karen F, Schwarz Kathleen B, Squires Robert H, Teckman Jeffrey, Turmelle Yumirle P, Alonso Estella M, Sherker Averell H, Magee John C, Sokol Ronald J: Bone Density in Children With Chronic Liver Disease Correlates With Growth and Cholestasis. Hepatology (Baltimore, Md.) 69(1): 245-257, Jan 2019.

Mack Cara L, Spino Cathie, Alonso Estella M, Bezerra Jorge A, Moore Jeffrey, Goodhue Catherine, Ng Vicky L, Karpen Saul J, Venkat Veena, Loomes Kathleen M, Wang Kasper, Sherker Averell H, Magee John C, Sokol Ronald J: A Phase I/IIa Trial of Intravenous Immunoglobulin Following Portoenterostomy in Biliary Atresia. Journal of pediatric gastroenterology and nutrition 68(4): 495-501, Apr 2019.

Gilbert Melissa A, Bauer Robert C, Rajagopalan Ramakrishnan, Grochowski Christopher M, Chao Grace, McEldrew Deborah, Nassur James A, Rand Elizabeth B, Krock Bryan L, Kamath Binita M, Krantz Ian D, Piccoli David A, Loomes Kathleen M, Spinner Nancy B: Alagille syndrome mutation update: Comprehensive overview of JAG1 and NOTCH2 mutation frequencies and insight into missense variant classification. Human mutation Jul 2019.

Ng Vicky Lee, Mazariegos George V, Kelly Beau, Horslen Simon, McDiarmid Sue V, Magee John C, Loomes Kathleen M, Fischer Ryan T, Sundaram Shikha S, Lai Jennifer C, Te Helen S, Bucuvalas John C: Barriers to ideal outcomes after pediatric liver transplantation. Pediatric transplantation 23(6): e13537, Sep 2019.

2018

Chapin Catherine A, Burn Thomas, Meijome Tomas, Loomes Kathleen M, Melin-Aldana Hector, Kreiger Portia A, Whitington Peter F, Behrens Edward M, Alonso Estella M: Indeterminate pediatric acute liver failure is uniquely characterized by a CD103+CD8+ T-cell infiltrate. Hepatology  68(3): 1087-1100, Mar 2018 Notes: In Press.

Mitchell E, Loomes KM, Squires RH, Goldberg D: Variability in Acceptance of Organ Offers by Pediatric Liver Transplant Centers and its Impact on Waitlist Mortality. Liver Transplantation 24(6): 803-09, June 2018.

Alonso Estella M, Ye Wen, Hawthorne Kieran, Venkat Veena, Loomes Kathleen M, Mack Cara L, Hertel Paula M, Karpen Saul J, Kerkar Nanda, Molleston Jean P, Murray Karen F, Romero Rene, Rosenthal Philip, Schwarz Kathleen B, Shneider Benjamin L, Suchy Frederick J, Turmelle Yumirle P, Wang Kasper S, Sherker Averell H, Sokol Ronald J, Bezerra Jorge A, Magee John C: Impact of Steroid Therapy on Early Growth in Infants with Biliary Atresia: The Multicenter Steroids in Biliary Atresia Randomized Trial. The Journal of pediatrics 202: 179-185.e4, 11 2018.

Chen Ying, Gilbert Melissa A, Grochowski Christopher M, McEldrew Deborah, Llewellyn Jessica, Waisbourd-Zinman Orith, Hakonarson Hakon, Bailey-Wilson Joan E, Russo Pierre, Wells Rebecca G, Loomes Kathleen M, Spinner Nancy B, Devoto Marcella: A genome-wide association study identifies a susceptibility locus for biliary atresia on 2p16.1 within the gene EFEMP1. PLoS genetics 14(8): e1007532, 08 2018.

Shneider BL, Spino C, Kamath BM, Magee JC, Bass LM, Setchell KD, Miethke A, Molleston JP, Mack CL, Squires RH, Murray KF, Loomes KM, Rosenthal P, Karpen SJ, Leung DH, Guthery SL, Thomas D, Sherker AH, Sokol RJ, for the Childhood Liver Disease Research Network (ChiLDReN): Placebo-controlled randomized trial of an intestinal bile salt transport inhibitor for pruritus in Alagille syndrome.  Hepatology Communications 2018 Notes: In Press.

Sorensen LG, Neighbors K, Hardison RM, Loomes KM, Varni JW, Ng VL, Squires RH, Alonso EM for the Pediatric Acute Liver Failure Study Group: Health Related Quality of Life and Neurocognitive Outcomes in the First Year after Pediatric Acute Liver Failure. Journal of Pediatrics 2018 Notes: In Press.

2017

Shneider BL, Moore J, Kerkar N, Magee JC, Ye W, Karpen SJ, Kamath BM, Molleston JP, Bezerra JA, Murray KF, Loomes KM, Whitington PF, Rosenthal P, Squires RH, Guthery SL, Arnon R, Schwarz KB, Turmelle YP, Sherker AH, Sokol RJ for the Childhood Liver Disease Research Network: Initial assessment of the infant with neonatal cholestasis - is this biliary atresia? PLOS One 12(5): e017627, May 2017.

Wang KS, Tiao G, Bass LM, Hertel PM, Mogul D, Kerkar N, Clifton M, Azen C, Bull L, Rosenthal P, Stewart D, Superina R, Arnon R, Bozic M, Brandt ML, Dillon PA, Fecteau A, Iyer K, Kamath B, Karpen S, Karrer F, Loomes KM, Mack C, Mattei P, Miethke A, Soltys K, Turmelle YP, West K, Zagory J, Goodhue C, Shneider B, the Childhood Liver Disease Research Network (ChiLDReN): Analysis of surgical interruption of the enterohepatic circulation as a treatment for pediatric cholestasis. Hepatology 65(5): 1645-1654, May 2017.

Tsai EA, Gilbert MA, Grochowski CM, Underkoffler LA, Meng H, Zhang X, Wang MM, Shitaye H, Hankenson KD, Piccoli D, Lin H, Kamath BM, Devoto M, Spinner NB, Loomes KM: THBS2 is a Candidate Modifier of Liver Disease Severity in Alagille Syndrome. Cellular and Molecular Gastroenterology and Hepatology Special Edition 2(5): 59-69, July 2017.

Ng VL, Sorensen LG, Alonso EM, Fredericks EM, Wen Y, Moore J, Karpen SJ, Shneider BL, Molleston JP, Bezerra JA, Murray KF, Loomes KM, Rosenthal P, Squires RH, Wang K, Arnon R, Schwarz KB, Turmelle YP, Haber BH, Sherker AH, Magee JC, Sokol RJ, the Childhood Liver Disease Research Network (ChiLDReN): Neurodevelopmental Outcome of Young Children with Biliary Atresia and Native Liver:  Results from the ChiLDReN Study. Journal of Pediatrics 2017 Notes: In Press.

Youngstrom DW, Senos dos Santos R, Zondervan RL, Brodeur JD, Lints AL, Young DR, Mitchell TL, Moore ME, Myers MH, Tseng WJ, Loomes KM, Hankenson KD.: Intraoperative delivery of the Notch ligand Jagged-1 regenerates appendicular and craniofacial bone defects. NPJ Regenerative Medicine 2(32): doi: 10.1038, Dec 2017 Notes: ecollection 2017.

2016

Wang KS, Tiao G, Bass LM, Hertel PM, Mogul D, Kerkar N, Clifton M, Azen C, Bull L, Rosenthal P, Stewart D, Superina R, Arnon R, Bozic M, Brandt ML, Dillon PA, Fecteau A, Iyer K, Kamath B, Karpen S, Karrer F, Loomes KM, Mack C, Mattei P, Miethke A, Soltys K, Turmelle YP, West K, Zagory J, Goodhue C, Shneider B, the Childhood Liver Disease Research Network (ChiLDReN): Analysis of surgical interruption of the enterohepatic circulation as a treatment for pediatric cholestasis. Hepatology. 2016 Dec 27. doi: 10.1002/hep.29019. [Epub ahead of print]

Zamora R, Vodovotz Y, Mi Q, Barclay D, Yin J, Horslen S, Rudnick D, Loomes KM, Squires RH.: Data-driven modeling for precision medicine in pediatric acute liver failure. Molecular Medicine 2016.

Wang Kasper S, Tiao Greg, Bass Lee M, Hertel Paula M, Mogul Douglas, Kerkar Nanda, Clifton Matthew, Azen Colleen, Bull Laura, Rosenthal Philip, Stewart Dylan, Superina Riccardo, Arnon Ronen, Bozic Molly, Brandt Mary L, Dillon Patrick A, Fecteau Annie, Iyer Kishore, Kamath Binita, Karpen Saul, Karrer Frederick, Loomes Kathleen M, Mack Cara, Mattei Peter, Miethke Alexander, Soltys Kyle, Turmelle Yumirle P, West Karen, Zagory Jessica, Goodhue Cat, Shneider Benjamin L: Analysis of surgical interruption of the enterohepatic circulation as a treatment for pediatric cholestasis. Hepatology (Baltimore, Md.) Dec 2016.

Lin H, Zoll B, Russo P, Spinner NB, Loomes KM: A challenging Case of Focal Extrahepatic Duct Obstruction/Hypoplasia in Alagille Syndrome. Journal of Pediatric Gastroenterology and Nutrition Dec 2016 Notes: E-pub ahead of print.

Cofer Zenobia C, Cui Shuang, EauClaire Steven F, Kim Cecilia, Tobias John W, Hakonarson Hakon, Loomes Kathleen M, Matthews Randolph P: Methylation Microarray Studies Highlight PDGFA Expression as a Factor in Biliary Atresia. PloS one 11(3): e0151521, 2016.

Zamora R, Vodovotz Y, Mi Q, Barclay D, Yin J, Horslen S, Rudnick D, Loomes KM, Squires RH: Data-Driven Modeling for Precision Medicine in Pediatric Acute Liver Failure. Molecular medicine (Cambridge, Mass.) 22, Nov 2016 Notes: Epub ahead of print.

Youngstrom DW, Dishowitz MI, Bales CB, Carr E, Mutyaba PL, Kozloff KM, Shitaye H, Hankenson KD, Loomes KM: Jagged1 expression by osteoblast-lineage cells regulates trabecular bone mass and periosteal expansion in mice. Bone 91: 64-74, October 2016 Notes: doi: 10.1016/j.bone.2016.07.006.

Tsai Ellen A, Gilbert Melissa A, Grochowski Christopher M, Underkoffler Lara A, Meng He, Zhang Xiaojie, Wang Michael M, Shitaye Hailu, Hankenson Kurt D, Piccoli David, Lin Henry, Kamath Binita M, Devoto Marcella, Spinner Nancy B, Loomes Kathleen M: THBS2 Is a Candidate Modifier of Liver Disease Severity in Alagille Syndrome. Cellular and molecular gastroenterology and hepatology 2(5): 663-675.e2, Sep 2016.

Ng VL, Li R, Loomes KM, Leonis MA, Rudnick DA, Belle SH, Squires RH, for the Pediatric Acute Liver Failure Study Group (PALFSG): Outcomes of Children With and Without Hepatic Encephalopathy from the Pediatric Acute Liver Failure (PALF) Study Group. Journal of Pediatric Gastroenterology and Nutrition 63(3): 357-364, September 2016.

Tang V, Cofer ZC, Cui S, Sapp V, Loomes KM, Matthews RP: Loss of a Candidate Biliary Atresia Susceptibility Gene, add3a, Causes Biliary Developmental Defects in Zebrafish. J Pediatr Gastroenterol Nutr August 2016.

Narkewicz MR, Horslen S, Belle SH, Rudnick DA, Ng VL, Rosenthal P, Romero R, Loomes KM, Zhang S, Hardison RM, Squires RH; Pediatric Acute Liver Failure Study Group: Prevalence and Significance of Autoantibodies in Children with Acute Liver Failure. J Pediatr Gastroenterol Nutr August 2016.

January Kathleen, J Conway Laura, Deardorff Matthew, Harrington Ann, Krantz Ian D, Loomes Kathleen, Pipan Mary, Noon Sarah E: Benefits and limitations of a multidisciplinary approach to individualized management of Cornelia de Lange syndrome and related diagnoses. American journal of medical genetics. Part C, Seminars in medical genetics May 2016.

Rajagopalan Ramakrishnan, Grochowski Christopher M, Gilbert Melissa A, Falsey Alexandra M, Coleman Karlene, Romero Rene, Loomes Kathleen M, Piccoli David A, Devoto Marcella, Spinner Nancy B: Compound heterozygous mutations in NEK8 in siblings with end-stage renal disease with hepatic and cardiac anomalies. American journal of medical genetics. Part A 170(3): 750-3, Mar 2016.

Patel Jyoti K, Loomes Kathleen M, Goldberg David J, Mercer-Rosa Laura, Dodds Kathryn, Rychik Jack: Early Impact of Fontan Operation on Enteric Protein Loss. The Annals of thoracic surgery 101(3): 1025-30, Mar 2016.

2015

Kamath BM, Chen Z, Romero R, Fredericks EM, Alonso EM, Arnon R, Heubi J, Hertel PM, Karpen SJ, Loomes KM, Murray KF, Rosenthal P, Schwarz KB, Subbarao G, Teckman JH, Turmelle YP, Wang KS, Sherker AH, Sokol RJ, Magee JC: Quality of Life and Its Determinants in a Multicenter Cohort of Children with Alagille Syndrome. The Journal of Pediatrics 167(2): 390-396.e3, Aug 2015.

Mouzaki M, Bass LM, Sokol RJ, Piccoli DA, Quammie C, Loomes KM, Heubi JE, Hertel PM, Scheenstra R, Furuya K, Kutsch E, Spinner NB, Robbins KN, Venkat V, Rosenthal P, Beyene J, Baker Ar, Kamath BM: Early Life Predictive Markers of Liver Disease Outcome in an International, Multi-Center Cohort of Children with Alagille Syndrome. Liver international: official journal of the International Association for the Study of the Liver Jul 2015.

Tsai EA, Grochowski CM, Falsey AM, Rajagopalan R, Wendel D, Devoto M, Krantz ID, Loomes KM, Spinner NB: Heterozygous Deletion of FOXA2 Segregates with Disease in a Family with Heterotaxy, Panhypopituitarism, and Biliary Atresia. Human Mutation 36(6), June 2015.

Grochowski CM, Rajagopalan R, Falsey AM, Loomes KM, Piccoli DA, Krantz ID, Devoto M, Spinner B: Exome sequencing reveals compound heterozygous mutations in ATP8B1 in a JAG1/NOTCH2 mutation-negative patient with clinically diagnosed Alagille syndrome. American Journal of Medical Genetics 167A(4): 891-3, Mar 2015.

Teckman JH, Rosenthal P, Abel R, Bass LM, Michail S, Murray KF, Rudnick DA, Thomas DW, Spino C, Arnon R, Hertel PM, Heubi J, Kamath BM, Karnsakul W, Loomes KM, Magee JC, Molleston JP, Romero R, Shneider BL, Sherker AH, Sokol RJ: Baseline Analysis of a Young Alpha-1-AT Deficiency Liver Disease Cohort Reveals Frequent Portal Hypertension. Journal of Pediatric Gastroenterology and Nutrition 61(1): 94-101, Feb 2015.

2014

Venkat VL, Shneider BL, Magee JC, Turmelle Y, Arnon R, Bezerra JA, Hertel PM, Karpen SJ, Kerkar N, Loomes KM, Molleston J, Murray KF, Ng VL, Raghunathan T, Rosenthal P, Schwartz K, Sherker AH, Sokol RJ, Teckman J, Wang K, Whitington PF, Heubi JE: Total serum bilirubin predicts fat-soluble vitamin deficiency better than serum bile acids in infants with biliary atresia. Journal of Pediatric Gastroenterology and Nutrition 59(6): 702-7, Dec 2014.

Bezerra JA, Spino C, Magee JC, Shneider BL, Rosenthal P, Wang KS, Erlichman J, Haber B, Hertel P M, Karpen SJ, Kerkar N, Loomes KM, Molleston JP, Murray KF, Romero R, Schwarz KB, Shepherd R, Suchy FJ, Turmelle YP, Whitington PF, Moore J, Sherker AH, Robuck PR, Sokol RJ: Use of corticosteroids after hepatoportoenterostomy for bile drainage in infants with biliary atresia: the START randomized clinical trial. JAMA 311(17): 1750-9, May 2014.

Tsai EA, Grochowski CM, Loomes KM, Bessho K, Hakonarson H, Bezerra JA, Russo PA, Haber BA, Spinner NB, Devoto M: Replication of a GWAS signal in a Caucasian population implicates ADD3 in susceptibility to biliary atresia. Human Genetics 133(2), Feb 2014.

2013

Underkoffler LA, Carr E, Nelson A, Ryan MJ, Schulz R, Loomes KM: Microarray Data Reveal Relationship between Jag1 and Ddr1 in mouse liver. PLOS One 8(12): e84383, December 2013.

Tsai Ellen A, Grochowski Christopher M, Loomes Kathleen M, Bessho Kazuhiko, Hakonarson Hakon, Bezerra Jorge A, Russo Pierre A, Haber Barbara A, Spinner Nancy B, Devoto Marcella: Replication of a GWAS signal in a Caucasian population implicates ADD3 in susceptibility to biliary atresia. Human genetics Oct 2013.

Leonard Laura D, Chao Grace, Baker Alastair, Loomes Kathleen, Spinner Nancy B: Clinical utility gene card for: Alagille Syndrome (ALGS). European journal of human genetics : EJHG Jul 2013.

Leonis Mike A, Alonso Estella M, Im Kelly, Belle Steven H, Squires Robert H: Chronic acetaminophen exposure in pediatric acute liver failure. Pediatrics 131(3): e740-6, Mar 2013.

2012

Clark Dinah M, Sherer Ilana, Deardorff Matthew A, Byrne Janice L B, Loomes Kathleen M, Nowaczyk Malgorzata J M, Jackson Laird G, Krantz Ian D: Identification of a prenatal profile of Cornelia de Lange syndrome (CdLS): a review of 53 CdLS pregnancies. American journal of medical genetics. Part A 158A(8): 1848-56, Aug 2012.

Lin Henry C, Le Hoang Phuc, Hutchinson Anne, Chao Grace, Gerfen Jennifer, Loomes Kathleen M, Krantz Ian, Kamath Binita M, Spinner Nancy B: Alagille syndrome in a Vietnamese cohort: mutation analysis and assessment of facial features. American journal of medical genetics. Part A 158A(5): 1005-13, May 2012.

Humphreys Ryan, Zheng Wei, Prince Lawrence S, Qu Xianghu, Brown Christopher, Loomes Kathleen, Huppert Stacey S, Baldwin Scott, Goudy Steven: Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients. Human molecular genetics 21(6): 1374-83, Mar 2012.

Kamath Binita Maya, Bauer Robert C, Loomes Kathleen M, Chao Grace, Gerfen Jennifer, Hutchinson Anne, Hardikar Winita, Hirschfield Gideon, Jara Paloma, Krantz Ian D, Lapunzina Pablo, Leonard Laura, Ling Simon, Ng Vicky Lee, Hoang Phuc Le, Piccoli David A, Spinner Nancy Bettina: NOTCH2 mutations in Alagille syndrome. Journal of medical genetics 49(2): 138-44, Feb 2012.

Kamath Binita M, Podkameni Gisele, Hutchinson Anne L, Leonard Laura D, Gerfen Jennifer, Krantz Ian D, Piccoli David A, Spinner Nancy B, Loomes Kathleen M, Meyers Kevin: Renal anomalies in Alagille syndrome: a disease-defining feature. American journal of medical genetics. Part A 158A(1): 85-9, Jan 2012.

2011

Schrier Samantha A, Sherer Ilana, Deardorff Matthew A, Clark Dinah, Audette Lynn, Gillis Lynette, Kline Antonie D, Ernst Linda, Loomes Kathleen, Krantz Ian D, Jackson Laird G: Causes of death and autopsy findings in a large study cohort of individuals with Cornelia de Lange syndrome and review of the literature. American journal of medical genetics. Part A 155A(12): 3007-24, Dec 2011.

2010

Bales CB, Kamath BM, Munoz PS, Nguyen A, Piccoli DA, Spinner NB, et al. Pathologic lower extremity fractures in children with Alagille syndrome. J Pediatr Gastroenterol Nutr. 2010 Jul;51(1):66-70. Cited in PubMed; PMID 20453673.

Kamath BM, Loomes KM, Piccoli DA. Medical management of Alagille syndrome. J Pediatr Gastroenterol Nutr. 2010 Jun;50(6):580-6. Cited in PubMed; PMID 20479679.

Bauer RC, Laney AO, Smith R, Gerfen J, Morrissette JJ, Woyciechowski S, et al. Jagged1 (JAG1) mutations in patients with tetralogy of Fallot or pulmonic stenosis. Hum Mutat. 2010 May;31(5):594-601. Cited in PubMed; PMID 20437614. 

2009

Colletti RB, Baldassano RN, Milov DE, Margolis PA, Bousvaros A, Crandall WV, et al. Variation in care in pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2009 Sep;49(3):297-303. Cited in PubMed; PMID 19590456.

High FA, Jain R, Stoller JZ, Antonucci NB, Lu MM, Loomes KM, et al. Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development. J Clin Invest. 2009 Jul;119(7):1986-96. doi: 10.1172/JCI38922. Epub 2009 Jun 8. Cited in PubMed; PMCID: PMC2701882.

Golson ML, Le Lay J, Gao N, Brämswig N, Loomes KM, Oakey R, et al. Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas. Mech Dev. 2009 Aug-Sep;126(8-9):687-99. Epub 2009 Jun 6. Cited in PubMed; PMCID: PMC2728177.

Golson ML, Loomes KM, Oakey R, Kaestner KH. Ductal malformation and pancreatitis in mice caused by conditional Jag1 deletion. Gastroenterology. 2009 May;136(5):1761-71.e1. Epub 2009 Jan 23. Cited in PubMed; PMID 19208348.

Aitken JF, Loomes KM, Scott DW, Reddy S, Phillips AR, Prijic G, et al. Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic mice.  Diabetes. 2010 Jan;59(1):161-71. Epub 2009 Sep 30.

Abstracts

2016

Chapin C, Meijome T, Loomes KM, Melin-Aldana H, Russo P, Kreiger P, Whitington PF, Behrens EM, Alonso EM.  Indeterminate Pediatric Acute Liver Failure is Characterized by Dense Polyclonal CD8+ Hepatic Infiltration. Hepatology 64(1): 143A, October  2016.

Alonso EM, Ye W, Hawthorne K, Venkat VL, Loomes KM, Mack CL, Hertel PM, Karpen SJ, Kerkar N, Molleston JP, Murray KF, Romero R, Rosenthal P, Schwarz KB, Shneider B, Suchy FJ, Turmelle YP, Wang KS, Whitington PF, Sherker AH, Sokol RJ, Bezerra JA, Magee JC.: Impact of Steroid Therapy on Early Growth in Infants with Biliary Atresia. Hepatology 64(1): 43A, October  2016.

2015

Ng VL, Sorensen LG, Alonso EM, Fredericks EM, Ye W, Karpen SJ, Shneider B, Bezerra JA, Molleston JP, Murray KF, Rosenthal P, Wang KS, Loomes KM, Hertel PM, Kerkar N, Schwarz KB, Turmelle YP, Haber BA, Sherker AH, Magee JC, Sokol RJ: Neurodevelopmental Outcomes in Patients with Biliary Atresia and Native Liver at Ages 1 and 2 Years:  Results from ChiLDReN. Hepatology 62(1): 277A, October  2015.

Loomes KM, Spino C, Goodrich NP, Hangartner TN, Marker AE, Heubi JE, Kamath BM, Shneider B, Rosenthal P, Hertel PM, Karpen SJ, Kerkar N, Molleston JP, Murray KF, Schwarz KB, Teckman J, Turmelle YP, Whitington PF, Sherker AH, Magee JC, Sokol RJ.: DXA Bone Density in Alagille Syndrome Correlates with Fracture History and Degree of Cholestasis. Hepatology 62(1): 1034A, October 2015.

Loomes KM, Rajagopalan R, Grochowski C, Chen Y, Gilbert M, Lin HC, Devoto M, Spinner NB: Exome Sequencing and de novo Mutation Analysis Reveal a Highly Connected Gene Network in Isolated Biliary Atresia. Hepatology 62(1): 1034A, October  2015.

2014

Wang KS, Shneider BL, Azen CG, Arnon R, Bass LM, Bozic MA, Brandt ML, Clifton MS, Dillon PA, Fecteau A, Hertel PM, Hirose S, Iyer K, Kamath BM, Karpen SJ, Karrer FM, Kerkar N, Loomes KM, Mack C, Mattei P, Miethke AG, Mogul D, Rosenthal P, Soltys KA, Superina R, Stewart D, Tiao G, Turmelle YP, West K.: Analysis of surgical interruption of the enterohepatic circulation as a treatment for pediatric cholestasis:  a retrospective, multi-institutional study. Hepatology 60(1): 523A, October  2014.

Underkoffler LA, McComb EK, Dutton J, Nelson A, Loomes KM, Ryan MJ: Jag1+/- Rfng+/- murine livers show aberrant differentiation of Sox9 progenitors by 1 week of age. Hepatology 60(1): 968A, October  2014.

Underkoffler LA, McComb EK, Dutton J, Nelson A, Loomes KM, Ryan MJ: Microarray analysis of laser-captured portal tracts of Jag1+/- Rfng+/- liver reveals possible sub-population of hepatic progenitors. Hepatology 60(1): 967A, October  2014.

2011

Kamath BM, Hutchinson A, Bauer R, Gerfen J, Krantz ID, Piccoli DA, et al. NOTCH2 mutations in Alagille syndrome [abstract oral presentation]. International Liver Congress; 2011 Mar 31; Berlin, Germany.

Books

2018

Kamath BM and Loomes KM: Alagille Syndrome:  Pathogenesis and Clinical Management. Book. Springer, 2018.

2013

Zorc JJ, Alpern ER, Brown L, Loomes KM, Clark BJ, Marino BS, Mollen CM, Raffini LJ, Editors: Schwartz's Clinical Handbook of Pediatrics. . Lippincott, Williams and Wilkins, 2013.

Schwartz MW, Bell LM, Bingham PM, Chung EK, Friedman DF, Loomes KM, Mamula P, Mascarenhas MR, Tanel RE (Eds): The 5 Minute Pediatric Consult. 6th Edition. Lippincott Williams and Wilkins, 2013.

2009

Zorc JJ, Alpern ER, Brown LW, Loomes KM, Marino BS, Mollen CJ, et al., editors. Clinical handbook of pediatrics. Philadelphia: Lippincott Williams & Wilkins; 2009.

2008

Schwartz MW, Bell LM, Bingham PM, Chunk EK, Friedman DF, Loomes KM, et al., editors. The 5-minute pediatric consult. Philadelphia: Lippincott Williams & Wilkins; 2008.

Chapters

2016

Emerick KM, Loomes KM: Pediatric Cholestatic Liver Disease with Genetic Etiology. Pediatric Gastrointestinal and Liver Disease, 5th Ed. Wyllie R, Hyams JS, Kay M (eds.). Elsevier, 2016.

2011

Emerick KM and Loomes KM: Pediatric Cholestatic Liver Disease with Genetic Etiology. Pediatric Gastrointestinal and Liver Disease, 4th Ed. Wyllie R, Hyams JS and Kay M (eds.). Philadelphia: Elsevier Mosby Saunders, 2011.

2010

Kamath BM, Loomes KM, Piccoli DA. JAGGED1/NOTCH2 sequence in Alagille syndrome. In: Murray K, Larson AM, editors. Fibrocystic diseases of the liver. New York: Springer-Verlag; 2010.

2008

Ryan MJ, Loomes KM. Congenital hepatic fibrosis. In: Liacouras CA, Piccoli DA, editors. Pediatric gastroenterology: the requisites. Philadelphia: Mosby Elsevier; 2008. p. 253-60.

Franciosi J, Loomes KM. Wilson disease. In: Liacouras CA, Piccoli DA, editors. Pediatric gastroenterology: the requisites. Philadelphia: Mosby Elsevier; 2008. p. 298-304.

Loomes KM. Biliary Atresia. In: Schwartz MW, Bell LM, Bingham PM, Chunk EK, Friedman DF, Loomes KM, et al., editors. The 5-minute pediatric consult. Philadelphia: Lippincott, Williams and Wilkins; 2008. p 104-5.

Loomes KM. Biliary Jaundice. In: Schwartz MW, Bell LM, Bingham PM, Chunk EK, Friedman DF, Loomes KM, et al., editors. The 5-minute pediatric consult. Philadelphia: Lippincott, Williams and Wilkins; 2008. p. 472-3.

2004

Russo P, Loomes KM. Diseases of the intrahepatic biliary tree: paucity of the intrahepatic bile ducts. In: Russo L, Rucchelli E, Piccoli DA, editors. Pathology of pediatric gastrointestinal and liver disease. 2004. p. 220-36.

2002

Loomes KM, Kusumi K, Spinner NB. Notch genes. In: Wiley Encyclopedia of Molecular Medicine. 2002. p. 2287-90.

2001

Loomes KM and Piccoli DA: Metabolic and Infectious Causes of Neonatal Hepatitis  Fetal and Neonatal Secrets. Polin R and Spitzer AR (eds.). Philadelphia:  Hanley and Belfus, 2001.

2000

Loomes KM: Congenital hepatic fibrosis. The 5-Minute Pediatric Consult. Schwartz MW, Bell LM, Bingham PM, Chung EK, Friedman DF and Mulberg AE (eds.). Philadelphia:  Lippincott Williams and Wilkins, Page: 272-3, 2000.

1999

Loomes KM and Mulberg AE : The infant with cholestasis. Clinical Practice of Gastroenterology. Brandt, LJ (eds.). Philadelphia:  Current Medicine, Page: 1403-9, 1999.

Posters and Presentations

2011

Loomes KM. Academic careers in pediatrics [roundtable discussion]. Hopitaux Universitaires de Geneve, 2011 Mar; Geneva, Switzerland.

Loomes KM. Alagille syndrome: bench to bedside [presentation]. Grand Rounds, Department of Pediatrics, Hopitaux Universitaires de Geneve, 2011 Mar; Geneva, Switzerland.

Loomes KM.  The role of Jag1 in bile duct development and remodeling [presentation]. Department of Pediatrics Research Seminar, Monroe Carell Jr. Children's Hospital at Vanderbilt; 2011 Feb; Nashville, TN.

2010

Loomes KM. Neonatal cholestasis [presentation]. American Austrian Foundation, Course in Pediatric Gastroenterology; 2010 Oct; Salzburg, Austria.

Loomes KM. Viral and autoimmune hepatitis [presentation]. American Austrian Foundation, Course in Pediatric Gastroenterology; 2010 Oct; Salzburg, Austria.

Loomes KM. Metabolic liver disease [presentation]. American Austrian Foundation, Course in Pediatric Gastroenterology; 2010 Oct; Salzburg, Austria.

Loomes KM. Liver failure [presentation]. American Austrian Foundation, Course in Pediatric Gastroenterology; 2010 Oct; Salzburg, Austria.

Invited Lectures

2016

Loomes KM. Genetic Diagnostics in Pediatric Liver Disease. Presented at: World Congress of Pediatric Gastroenterology, Hepatology and Nutrition; 2016 Oct; Montreal, Canada.

Loomes KM. Thrombospondin 2 is a candidate genetic modifier of liver disease severity in Alagille syndrome. Presented at: Division of Gastroenterology Grand Rounds, Morgan Stanley Children's Hospital of New York-Presbyterian; 2016 May; New York, NY.

Loomes KM. Autoimmune Liver Disease and PSC. Presented at: Open Medical Institute - The Children's Hospital of Philadelphia Seminar in Gastroenterology; 2016 Apr; Salzburg, Austria.

Loomes KM. Metabolic Liver Disease. Presented at: Open Medical Institute - The Children's Hospital of Philadelphia Seminar in Gastroenterology; 2016 Apr; Salzburg, Austria.

Loomes KM. Pediatric Liver Transplantation. Presented at: Open Medical Institute - The Children's Hospital of Philadelphia Seminar in Gastroenterology; 2016 Apr; Salzburg, Austria.

Loomes KM. Pediatric Acute Liver Failure. Presented at: Open Medical Institute - The Children's Hospital of Philadelphia Seminar in Gastroenterology; 2016 Apr; Salzburg, Austria.

2015

Loomes KM. Biliary Tree Diseases: Lessons from Congenital Cholangiopathies. Presented at: Early Morning Workshop at the American Association for the Study of Liver Disease Annual Meeting; 2015 Nov; San Francisco, CA.

Loomes KM. How to Choose a Mentor. Presented at: Nestle First Year Pediatric GI Fellows' Conference; 2015 Jan; Ft. Lauderdale, FL.

Awards and Honors

2012-2013, Pediatric Residency Faculty Honor Roll, The Children's Hospital of Philadelphia

2012, Master Clinician Award, The Children's Hospital of Philadelphia

2003, Researcher of the Year, American Liver Foundation, Delaware Valley Chapter

1999, Philadelphia Gastroenterological Research Forum, 37th Annual Komarov Prize Competition-3rd Prize

1997, Fellows' Teacher of the Year Award, The Children's Hospital of Philadelphia

1992, Alpha Omega Alpha, University of Texas Southwestern Medical School

1988, Phi Beta Kappa, Rice University, Houston, TX

Editorial and Academic Positions

Editorial Positions

2015-present, Cellular and Molecular Gastroenterology and Hepatology, Editorial Board
2009-present, PLOS Genetics, Ad hoc Reviewer
2008-present, Journal of Pediatrics, Ad hoc Reviewer
2007-present, Hepatology, Ad hoc Reviewer
2007-present, Pediatric Gastroenterology, Clinical Handbook of Pediatrics, Associate Editor
2006-present, Gastroenterology, Ad hoc Reviewer
2006-present, Pediatric Gastroenterology, 5 Minute Pediatric Consult Textbook, Associate Editor
2004-present, Journal of Pathology, Ad hoc Reviewer
2003-present, Human Molecular Genetics, Ad hoc Reviewer

Academic and Institutional Committees

2016-present, Space Committee, Children's Hospital of Philadelphia
2014-present, GI Division Mentorship Steering Committee, Children's Hospital of Philadelphia
2014-present, Faculty Senate Nominating Committee, University of Pennsylvania
2014-present, Faculty Senate Committee on Academic Freedom and Responsibility, University of Pennsylvania
2014-present, GI Research Steering Committee, Chair, Children's Hospital of Philadelphia
2013-present, Formulary Committee, Children's Hospital of Philadelphia
2012-present, GI Division Scientific Review Committee, Chair, Children's Hospital of Philadelphia
2012-present, Clinical Competency Committee, Children's Hospital of Philadelphia
2008-present, Institutional Animal Care and Use Committee, Children's Hospital of Philadelphia
2007-present, GI Division Scholarship Oversight Committee, Chair, Children's Hospital of Philadelphia
2006-present, Graduate Medical Education Committee, Children's Hospital of Philadelphia

Leadership and Memberships

Memberships in professional organizations

International

1996-present, North American Society for Pediatric Gastroenterology and Nutrition

- 2016-present, Research Committee

- 2012-2016, Training Committee

National

2006-present, National Institutes of Health

- 2016-2020, Hepatobiliary Pathophysiology Study Section

1996-present, American Gastroenterological Association

- 2009-present, Growth, Development and Aging Section Nominating Committee

1996-present, American Association for the Study of Liver Disease

- 2007-present, Pediatric Interest Group Steering Committee