Zachary B.R. McClain, MD

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Zachary B.R. McClain, MD, is an attending physician in the Gender and Sexuality Development Clinic and Medical Director of the Young Men’s Clinic at Children's Hospital of Philadelphia.

Phone: 215-590-3537


Dr. Zachary McClain is a pediatrician specializing in Adolescent Medicine at Children’s Hospital of Philadelphia (CHOP) and an Assistant Professor of Pediatrics at the University of Pennsylvania. Dr. McClain’s love for caring for adolescents started over a decade ago as a middle school teacher in New York City. From there, his life’s work, research and passion have focused on positive youth development and caring for marginalized youth.

In Dr. McClain’s adolescent medicine practice, he cares for a wide variety of medical conditions, while simultaneously addressing adolescent behavioral issues. He practices social adolescent medicine —medicine with special attention to prevention and the recognition that social context and stressors affect both physical and emotional health.

At Children’s Hospital of Philadelphia, Dr. McClain is a leader in promoting the health and well-being of lesbian, gay, bisexual, and transgender (LGBT) youth. He is a medical provider for the Adolescent Initiative, which provides high-quality medical care for adolescents living with or at risk of HIV. He is also a lead medical provider for the Gender and Sexuality Clinic, where he provides medical care for gender-variant and transgender youth.

Beyond medical care, Dr. McClain is a tireless advocate for LGBTQ youth, educating parents, community members, and medical providers on their unique healthcare needs and resilience on local and national levels. He has published multiple book chapters and original articles on the care for LGBTQ youth.

In addition to his work with LGBTQ youth, Dr. McClain is the Medical Director of the Young Men’s Clinic, which supports the healthy development and growth for young men and provides a place where boys and young men can talk about their body, mind, emotions and relationships. Dr. McClain knows that boys and young men frequently face barriers to get the care they need and deserve, so he aims to provide high-quality, male-friendly medical care to boys and young men throughout the adolescent years. He focuses on respecting individuality, supporting physical and emotional growth and development, and educating and empowering young men to ultimately take ownership of their healthcare and life decisions.

Dr. McClain had the distinct honor to serve as the youngest member on the Society for Adolescent Health and Medicine Board of Directors, and continues to work with the society on a national level to advocate for marginalized youth.

The theme that ties together his clinical practice, teaching, research and advocacy efforts is that of building on the strength of teenagers by fostering their internal resilience. He works to translate the best of what is known from research and practice into practical approaches parents, professionals and communities can use to build resilience.   

Education and Training

Medical School

MD - Icahn School of Medicine at Mount Sinai, New York, NY


Pediatrics - Comer Children's Hospital at The University of Chicago, Chicago, IL


Pediatrics - Comer Children's Hospital at The University of Chicago, Chicago, IL


Adolescent Medicine - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Adolescent Medicine

Titles and Academic Titles

Attending Physician

Medical Director, Young Men’s Clinic

Assistant Professor of Clinical Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services




McClain, Z, Peebles, R: Body Image and Disordered Eating among LGBT Youth. Pediatric Clinics of North America. Pediatr Clin North Am. 2016 Dec;63(6):1079-1090. doi: 10.1016/j.pcl.2016.07.008. Epub 2016 Oct 12.

McClain Z., Hawkins L., Yehia, B., : Creating Welcoming Spaces for Lesbian, Gay, Bisexual, and Transgender (LGBT) patients: An Evaluation of the Healthcare Environment. Journal of Homosexuality. Routledge, 63(3): 387-393, March 2016.


McKay MM., Alicea S, Elwyn L, McClain Z., Parker G., Small L., Mellins CA.: The development and implementation of theory-driven programs capable of addressing poverty-impacted children's health, mental health, and prevention needs: CHAMP and CHAMP+, evidence-informed, family-based interventions to address HIV risk and care.:   CHAMP and CHAMP+. Journal of Clinical Child and Adolescent Psychology. Routledge, 43(3): 428-441, May 2014.



McClain Z., Reirden DH., Schwarz D., Peebles R.: Eating Disorders  Comprehensive Pediatric Hospital Medicine, 2nd ed. 2016.


McClain Z., Bell D: Adolescent Emergencies:  Adolescent Male GU Emergencies. In:  Goyal M. Adolescent Emergencies of AM:STARS.Elks Grove Village, IL; American  Academy of Pediatrics  Monika K. Goyal, MD, MSCE; John D. Rowlett, MD; Donald E. Greydanus, MD, DrHC  (eds.). American Academy of Pediatrics, 26(3): 486-492, December 2015.


McClain Z., Ginsburg KR.: Bullying In:  Ginsburg KR and Kinsman SB. Reaching Teens: Wisdom from Adolescent Medicine. American Academy of Pediatrics. A Textbook and Video Product (eds.). 2014.

McClain Z, Reirden DH, Schwarz D, Peebles R: Eating Disorders. In: Zaoutis LB and Chiang VW. Comprehensive Pediatric Hospital Medicine, 2nd ed. New York, NY: McGraw-Hill; 2013

Posters and Presentations


Sala-Humara C., McClain Z., Dowshen N., Caroslon J., Lock J., Peebles R.: Media Influences by gender and Sexual Orientation Among Adolescents with Eating Disorders  Accepted for poster presentation at the Annual Meeting for the Society of Adolescent Health and Medicine, Los Angeles, CA 2015.

Invited Lectures


McClain Z. "Medical Care for Gender Variant and Transgender Youth," Drexel University School of Medicine LGBTQI Symposium, Philadelphia, PA. Jul, 2017.

McClain Z. CME Lecture "Communicating with Teenagers," Main Line Health, Bryn Mawr, PA, May, 2017.


McClain Z. "Advocating for your Health" at the Achieving Independence Center, Department of Human Services, City of Philadelphia, Dec, 2015.

McClain Z. "Primary Care for the Adolescent Male," University of Pennsylvania School of Nursing, Jun, 2015.

Awards and Honors

2017, Children's Hospital of Philadelphia Early Career Faculty Honor Roll

2014-2016, Trainee Representative to the Board of Directors for the Society of Adolescent Health and Medicine

2013, Honored Speaker, Older Youth Summit, City of Philadelphia Department of Human Services

2012, Senior Resident of the Year

2011, La Rabida Resident of the Year

2011, 2010, University of Chicago Department of Pediatrics Resident of the Month (Winter 2011, Fall 2010)

2006, Patricia S. Levinson Summer Fellowship in Interdisciplinary and Community Research and Service

Leadership and Memberships

Memberships in Professional Organizations

2008-present, American Academy of Pediatrics 

2010-present, Society for Adolescent Health and Medicine

 - 2014-present, Committee for Youth and Families