Amanda Muir, MD

Amanda Muir, MD

Amanda Muir, MD, is a pediatric gastroenterologist in the Division of Gastroenterology, Hepatology and Nutrition at Children's Hospital of Philadelphia. 

Areas of Expertise: Eosinophilic esophagitis, Eosinophilic gastroenteritis
Locations: Main Campus
Phone: 215-590-3630

Education and Training

Medical School

MD - UMDNJ - Robert Wood Johnson Medical School, New Brunswick, NJ

Internship

Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

Residency

Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA

Fellowship

Gastroenterology, Hepatology and Nutrition (Chief Fellow) - The Children’s Hospital of Philadelphia, Philadelphia, PA

Research of Gastroenterology, Hepatology and Nutrition - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Pediatric Gastroenterology
Pediatrics

Titles and Academic Titles

Attending Physician

Conditions Treated

Departments and Services

Publications

Papers

2016

Chandramouleeswaran Prasanna M, Shen Dawen, Lee Anna J, Benitez Alain, Dods Kara, Gambanga Fiona, Wilkins Benjamin J, Merves Jamie, Noah Yuliana, Toltzis Sarit, Yearley Jennifer H, Spergel Jonathan M, Nakagawa Hiroshi, Malefyt Rene deWaal, Muir Amanda B, Wang Mei-Lun: Preferential Secretion of Thymic Stromal Lymphopoietin (TSLP) by Terminally Differentiated Esophageal Epithelial Cells: Relevance to Eosinophilic Esophagitis (EoE). PloS one 11(3): e0150968, 2016 Notes: *co-corresponding author.

Muir A1, Otero H, Blinman T, Wen J: Use of Magnetic Resonance Imaging With Hepatobiliary-Specific Contrast Agent for Precise Localization of a Bile Duct Leak. Journal of Pediatric Gastroenterology and Nutrition 63(3): e36, September 2016 Notes: DOI: 10.1097/MPG.0000000000000531 

Muir AB, Dods K, Henry SJ, Benitez AJ, Lee D, Whelan KA, DeMarshall M, Hammer DA, Falk G, Wells RG, Spergel J, Hakagawa H, Wang ML: Eosinophilic Esophagitis-Associated Chemical and Mechanical Microenvironment Shapes Esophageal Fibroblast Behavior. Journal of Pediatric Gastroenterology and Nutrition 63(2), August 2016 Notes: DOI: 10.1097/MPG.0000000000001100.

Dellon Evan S, Collins Margaret H, Bonis Peter A, Leung John, Capocelli Kelley E, Dohil Ranjan, Falk Gary W, Furuta Glenn T, Menard-Katcher Calies, Gupta Sandeep K, Hirano Ikuo, Gonsalves Nirmala, Hiremath Girish S, Kagalwalla Amir F, Wershil Barry K, Liacouras Chris A, Muir Amanda B, Mukkada Vincent A, Putnam Philip E, Schoepfer Alain M, Straumann Alex, Wo John M, Yang Guang-Yu, Rothenberg Marc E: Substantial Variability in Biopsy Practice Patterns Among Gastroenterologists for Suspected Eosinophilic Gastrointestinal Disorders. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Apr 2016.

Muir A, Surrey L, Kriegermeier A, Shaikhkalil A, Piccoli DA: Severe Eosinophilic Gastroenteritis in a Crohn's Disease Patient Treated with Infliximab and Adalimumab. Am J Gastroenterol 111(3): 437-8, Mar 2016 Notes: doi: 10.1038/ajg.2015.438.

2015

Muir Amanda B, Dods Kara, Henry Steven J, Benitez Alain J, Lee Dale, Whelan Kelly A, DeMarshall Maureen, Hammer Daniel A, Falk Gary, Wells Rebecca G, Spergel Jonathan, Nakagawa Hiroshi, Wang Mei-Lun: Eosinophilic Esophagitis Associated Chemical and Mechanical Microenvironment Shapes Esophageal Fibroblast Behavior. Journal of pediatric gastroenterology and nutrition Dec 2015.

Benitez Alain J, Hoffmann Christian, Muir Amanda B, Dods Kara K, Spergel Jonathan M, Bushman Frederic D, Wang Mei-Lun: Inflammation-associated microbiota in pediatric eosinophilic esophagitis. Microbiome 3: 23, 2015.

Merves J, Chandramouleeswaran PM, Benitez AJ, Muir AB, Lee AJ, Lim D,  Dods K, Mehta I, Ruchelli E, Nakagawa H, Spergel J, Wang ML: Altered esophageal histamine receptor expression in eosinophilic esophagitis (EoE): Implications on disease pathogenesis. PLOSone  10(2):e0114831, Feb 2015.

Muir, AB, Dods K, Noah Y, Toltzis S; Modayur Chandramouleeswaran P; Lee A; Bedenbaugh A; Falk GW, Wells R; Nakagawa H; Wang ML: Esophageal epithelial cells acquire functional characteristics of activated myofibroblasts after undergoing an epithelial to mesenchymal transition. Experimental Cell Research 330(1): 102-110, Jan 2015.

Muir Amanda B, Dods Kara, Noah Yuli, Toltzis Sarit, Chandramouleeswaran Prasanna Modayur, Lee Anna, Benitez Alain, Bedenbaugh Adam, Falk Gary W, Wells Rebecca G, Nakagawa Hiroshi, Wang Mei-Lun: Esophageal epithelial cells acquire functional characteristics of activated myofibroblasts after undergoing an epithelial to mesenchymal transition. Experimental cell research 330(1): 102-10, Jan 2015.

Muir AB, Otero H, Blinman T, Wen J: Use of MRI With Hepatobiliary Specific Contrast Agent For Precise Localization of A Bile Duct Leak. Journal of Pediatric Gastroenterology, Hepatology, and Nutrition Jan 2015 Notes: E-Published ahead of print. 

Abstracts

2016

Muir AB, Gambanga F, Kluger J, Tanaka K, Benitez B, Modayr P, Whelan K, Nakagawa N: Epithelial-Fibroblast interaction drives pro-fibrotic milieu in eosinophilic esophagitis.  Accepted for oral presentation at Digestive Disease Week and the 117th annual meeting of the American Gastroenterological Association 2016.

Menard-Katcher C, Benitez A, Ahmed F, Kramer R, Spergel J, Verma R, Liacouras C, Nakagawa H, Furuta G, Muir AB: Esophageal distensibility provides measure of remodeling in pediatric EoE. Digestive Disease Week and the 117th annual meeting of the American Gastroenterological Association 2016.

Godwin, B. , Whelan, K., Benitez, A., Klein-Szanto, A., Spergel, J., Falk, G., Muir, A., Nakagawa, H.: Persistent Epithelial Changes in Inactive Eosinophilic Esophagitis: Is Inactive Really Inactive? Accepted for oral presentation. Digestive Disease Week and the 117th annual meeting of the American Gastroenterological Association 2016.

2015

Whelan KA, Merves J, Muir AB, Guo A, Modayur Chandramouleeswaran P, Dods K, DeMarshall M, Que J, Spergel J, Wang ML, Falk GW, Nakagawa H: Autophagy is an epithelial cytoprotective mechanism in esophageal epithelial cells in response to Eosinophilic Esophagitis-associated inflammation. Oral Presentation: Digestive Disease Week and the 116th annual meeting of the American Gastroenterological Association, Washington, DC, May 16-19, 2015 2015.

Muir AB, Dods K, Merves J, Whelan KA, Benitez AJ, DeMarshall M, Spergel J, Falk G, Wells RG, Wang ML, Nakagawa H : Epithelial lysyl oxidase is an early mediator of fibrotic remodeling in eosinophilic esophagitis. Oral presentation: Digestive Disease Week and the 116th annual meeting of the American Gastroenterological Association, Washington, DC, May 16-19, 2015 2015.

Muir AB, Dods K, Henry S, Benitez AJ, Lee D, Whelan K, DeMarshall M, Falk G, Wells RG, Spergel J, Hammer D, Nakagawa H, Wang ML: Chemical and mechanical stimuli drive esophageal fibroblast activity: Implications for EoE Fibrosis. Oral Presentation at NASPGHAN annual meeting 2015.

Muir AB, Dods K, Henry S, Benitez AJ, DeMarshall M, Falk G, Wells RG, Hammer D, Nakagawa H, Wang ML: Matrix-stiffness enhances esophageal fibroblast activation, proliferation and contractility in pediatric and adult fibroblasts. Poster presentation at Digestive Disease Week and the 116th annual meeting of the American Gastroenterological Association, Washington, DC, May 16-19, 2015  2015.

Merves J, Whelan KA, Muir AB, Masterson J, Guo A, Benitez AJ, Blair A, Gimotty PA, Klein-Szanto A, Spergel J, Furuta GT, Wang ML, Falk GW and Nakagawa H : Autophagy-Related Gene 7 (ATG7) may serve as a biomarker of EoE disease status. Poster presentation: Digestive Disease Week and the 116th annual meeting of the American Gastroenterological Association, Washington, DC, May 16-19, 2015 2015.

Benitez AJ, Hoffmann C, Muir AB, Spergel J, Bushman F, and Wang ML: Inflammatory signature in the tissue-associated microbiota in pediatric eosinophilic esophagitis. Oral Presentation: Digestive Disease Week and the 116th annual meeting of the American Gastroenterological Association, Washington, DC, May 16-19, 2015 2015.

Books

Chapters

2015

Muir A, Markowitz JE, Liacouras CA. Allergic and Eosinophilic Gastrointestinal Disease. In: Pediatric Allergy: Principles and Practice. 3rd ed. Philadelphia: Elsevier, 2015.

2014

Muir A, Franciosi JP, Markowitz JE, Liacouras CA. Eosinophilic Esophagitis, Gastroenteritis, and Colitis. In: Metcalfe DD, Sampson HA, Simon RA, Lack G, editors. Food Allergy. 5th ed. Malden, MA: Wiley-Blackwell Publishers, 2014.

2012

Muir A, Pineiro-Carrero VM. Encopresis. In: Schwartz MW, editor. 5 Minute Pediatric Consult. 6th ed. Philadelphia, PA: Lippincott, Williams & Wilkins, 2012.

Muir A, Liacouras CA. Vomiting. In: Zorc JJ, editor. Clinical Handbook of Pediatrics. Philadelphia, PA: Lippincott, Williams & Wilkins, 2012.

2010

Kamath B, Rand E, Muir A. Nutritional considerations in pediatric liver transplantation. In: Nutrition, Diet Therapy, and the Liver. CRC Press, 2010.

Posters and Presentations

Lectures by Invitation

2017

Muir A. Detecting Early Fibrosis in Children: The EndoFlip Project [lecture]. APFED Annual meeting; 2017 Jul; San Diego, CA.

2015

Muir A. Eosinophilic Esophagitis:the role of food and the esophageal microenvironment [lecture]. Food Systems Approach to Gut Health, Penn State College of Agriculture; 2015 Oct; State College, PA.

Awards and Honors

2016, GI Fellows Faculty Honor Roll
2015, American Partnership for Eosinophilic Disorders NASPGHAN Award for Basic Science Abstract
2014, AGA Fellow Abstract Prize
2014, Komarov Research Competition - 3rd place
2014, Fellowship2Leadership Salix Travel Grant
2012, AGA Clinical Skills Travel Award
2008, NASPGHAN - Teaching and Tomorrow Award

Editorial and Academic Positions

Editorial Positions

Ad-hoc Reviewer

2015-present, Digestive Disease Sciences
2015-present, Journal of Visualized Experiments
2015-present, Journal of Allergy and Clinical Immunology
2015-present, Cellular and Molecular Gastroenterology

Institutional Committees

2014-present, REPAC, The Children's Hospital of Philadelphia

Leadership and Memberships

2010-present, American Gastroenterology Association
2010-present, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (Member, Research Committee)