Amanda Muir, MD

Locations: Main Hospital; Buerger Center for Advanced Pediatric Care
MD - UMDNJ - Robert Wood Johnson Medical School, New Brunswick, NJ
Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA
Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA
Gastroenterology, Hepatology and Nutrition (Chief Fellow) - The Children’s Hospital of Philadelphia, Philadelphia, PA
Research of Gastroenterology, Hepatology and Nutrition - The Children's Hospital of Philadelphia, Philadelphia, PA
Pediatric Gastroenterology – American Board of PediatricsPediatrics – American Board of Pediatrics
Attending Physician
Muir Amanda B, Jensen Elizabeth T, Wechsler Joshua B, Menard-Katcher Paul, Falk Gary W, Aceves Seema S, Furuta Glenn T, Dellon Evan S, Rothenberg Mark E, Spergel Jonathan M: Overestimation of the diagnosis of eosinophilic colitis with reliance on billing codes. The journal of allergy and clinical immunology. In practice Mar 2019.
Spergel Jonathan M, Elci Okan U, Muir Amanda B, Liacouras Chris A, Wilkins Benjamin J, Burke Deirdre, Lewis Megan O, Brown-Whitehorn Terri, Cianferoni Antonella: Efficacy of Epicutaneous Immunotherapy in Children with Milk-Induced Eosinophilic Esophagitis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association May 2019.
Pesek Robert D, Reed Craig C, Muir Amanda B, Fulkerson Patricia C, Menard-Katcher Calies, Falk Gary W, Kuhl Jonathan, Martin Ellen K, Magier Adam Z, Ahmed Faria, Demarshall Maureen, Gupta Ankur, Gross Jonathan, Ashorobi Tokunbo, Carpenter Christina L, Krischer Jeffrey P, Gonsalves Nirmala, Spergel Jonathan M, Gupta Sandeep K, Furuta Glenn T, Rothenberg Marc E, Dellon Evan S: Increasing Rates of Diagnosis, Substantial Co-Occurrence, and Variable Treatment Patterns of Eosinophilic Gastritis, Gastroenteritis, and Colitis Based on 10-Year Data Across a Multicenter Consortium. The American journal of gastroenterology 114(6): 984-994, Jun 2019.
Kasagi Yuta, Dods Kara, Wang Joshua X, Chandramouleeswaran Prasanna M, Benitez Alain J, Gambanga Fiona, Kluger Jonathan, Ashorobi Tokunbo, Gross Jonathan, Tobias John W, Klein-Szanto Andres J, Spergel Jonathan M, Cianferoni Antonella, Falk Gary W, Whelan Kelly A, Nakagawa Hiroshi, Muir Amanda B: Fibrostenotic eosinophilic esophagitis might reflect epithelial lysyl oxidase induction by fibroblast-derived TNF-α. The Journal of allergy and clinical immunology 144(1): 171-182, Jul 2019.
Kennedy Katie, Muir Amanda B, Grossman Andrew, Brown-Whitehorn Terri, Cianferoni Antonella, Spergel Jonathan M, Furuta Glenn T, Wilkins Benjamin J, Shuker Michele, Ruffner Melanie A: Modified oral enteric-coated budesonide regimens to treat pediatric eosinophilic gastroenteritis, a single center experience. The journal of allergy and clinical immunology. In practice 7(6): 2059-2061, Jul - Aug 2019.
Ruffner Melanie A, Song Li, Maurer Kelly, Shi Lihua, Carroll Margaret C, Wang Joshua X, Muir Amanda B, Spergel Jonathan M, Sullivan Kathleen E: Toll-like receptor 2 stimulation augments esophageal barrier integrity. Allergy Jul 2019.
Kijima Takashi, Nakagawa Hiroshi, Shimonosono Masataka, Chandramouleeswaran Prasanna M, Hara Takeo, Sahu Varun, Kasagi Yuta, Kikuchi Osamu, Tanaka Koji, Giroux Veronique, Muir Amanda B, Whelan Kelly A, Ohashi Shinya, Naganuma Seiji, Klein-Szanto Andres J, Shinden Yoshiaki, Sasaki Ken, Omoto Itaru, Kita Yoshiaki, Muto Manabu, Bass Adam J, Diehl J Alan, Ginsberg Gregory G, Doki Yuichiro, Mori Masaki, Uchikado Yasuto, Arigami Takaaki, Avadhani Narayan G, Basu Devraj, Rustgi Anil K, Natsugoe Shoji: Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells. Cellular and molecular gastroenterology and hepatology 7(1): 73-91, 2019.
Shaverdashvili Khvaramze, Padlo Jennie, Weinblatt Daniel, Jia Yang, Jiang Wenpeng, Rao Divya, Laczkó Dorottya, Whelan Kelly A, Lynch John P, Muir Amanda B, Katz Jonathan P: KLF4 activates NFκB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF. PloS one 14(4): e0215746, 2019.
Whelan KA, Muir AB, Nakagawa H: Esophageal 3D Culture Systems as Modeling Tools in Esophageal Epithelial Pathobiology and Personalized Medicine. Cellular and molecular gastroenterology and hepatology 5(4): 461-478, Jan 2018.
Cianferoni A, Ruffner MA, Guzek R, Guan S, Brown-Whitehorn T, Muir A, Spergel JM: Elevated expression of activated T2 cells and milk-specific T2 cells in milk-induced eosinophilic esophagitis. Annals of allergy, asthma & immunology: official publication of the American College of Allergy, Asthma, & Immunology 120(2): 177-183.e2, Feb 2018.
Fahey LM, Chandramouleeswaran PM, Guan S, Benitez AJ, Furuta GT, Aceves SS, Wang M-L, Liacouras CA, Muir AB, Sleiman PMa, Hakonarson H, Spergel JM, Cianferoni A: Food allergen triggers are increased in children with the TSLP risk allele and eosinophilic esophagitis. Clinical and translational gastroenterology 9(3): 139, Mar 2018.
Kasagi Y, Chandramouleeswaran PM, Whelan KA, Tanaka K, Giroux V, Sharma M, Wang J, Benitez AJ, DeMarshall M, Tobias JW, Hamilton E, Falk GW, Spergel JM, Klein-Szanto AJ, Rustgi AK, Muir AB, Nakagawa H: The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial Changes. Cellular and molecular gastroenterology and hepatology 5(3): 333-352, Mar 2018 Notes: *co-senior author.
Muir AB: Eosinophilic Esophagitis. Current problems in pediatric and adolescent health care 48(3): 99-101, Mar 2018.
Ruffler MA, Brown-Whitehorn TF, Cianferoni A, Gober L, Shuker M, CSP, Muir AB, Liacouras CA, Spergel JM: Clinical tolerance in eosinophilic esophagitis. JACI: In Practice 6(2): 661-663, Mar-Apr 2018.
Godwin B, Liacouras C, Mehta, Eisenberg J, Agawu A, Brown-Whitehorn , Ruffner MA, Verma R, Cianferoni A, Spergel JM, Muir AB: A Review of Tertiary Referrals for Management of Pediatric Esophageal Eosinophilia. Frontiers in pediatrics 6: 173, Jun 2018.
Muir AB, Wang JX, Nakagawa H.: Epithelial-stromal crosstalk and fibrosis in eosinophilic esophagitis. J Gastroenterol. 2019 Jan;54(1):10-18. doi: 10.1007/s00535-018-1498-3. Epub 2018 Aug 12.
Whelan KA, Merves JF, Giroux V, Tanaka K, Guo A, Chandramouleeswaran PM, Benitez AJ, Dods K, Que J, Masterson JC, Fernando SD, Godwin BC, Klein-Szanto AJ, Chikwava K, Ruchelli ED, Hamilton KE, Muir AB, Wang M-L, Furuta GT, Falk GW, Spergel JM, Nakagawa H: Autophagy mediates epithelial cytoprotection in eosinophilic oesophagitis. Gut 66(7): 1197-1207, Jul 2017.
Menard-Katcher C, Benitez AJ, Pan Z, Ahmed FN, Wilkins BJ, Capocelli KE, Liacouras CA, Verma R, Spergel JM, Furuta GT, Muir AB: Influence of Age and Eosinophilic Esophagitis on Esophageal Distensibility in a Pediatric Cohort. The American journal of gastroenterology 112(9): 1466-1473, Sep 2017 Notes: See editorial on this paper by Carlson:Widening the Use of the Functional Lumen Imaging Probe to Kids With Eosinophilic Esophagitis: Esophageal Narrowing is not Just an Adult Problem.
Dellon ES, Collins MH, Bonis PA, Leung J, Capocelli KE, Dohil R, Falk GW, Furuta GT, Menard-Katcher C, Gupta SK, Hirano I, Hiremath GS, Kagalwalla AF, Wershil BK, Liacouras CA, Muir AB, Mukkada VA, Putnam PE, Schoepfer AM, Straumann A, Wo JM, Yang G-Y, Rothenberg ME, Gonsalves N: Substantial Variability in Biopsy Practice Patterns Among Gastroenterologists for Suspected Eosinophilic Gastrointestinal Disorders. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association 14(12): 1842-1844, Dec 2016.
Chandramouleeswaran Prasanna M, Shen Dawen, Lee Anna J, Benitez Alain, Dods Kara, Gambanga Fiona, Wilkins Benjamin J, Merves Jamie, Noah Yuliana, Toltzis Sarit, Yearley Jennifer H, Spergel Jonathan M, Nakagawa Hiroshi, Malefyt Rene deWaal, Muir Amanda B, Wang Mei-Lun: Preferential Secretion of Thymic Stromal Lymphopoietin (TSLP) by Terminally Differentiated Esophageal Epithelial Cells: Relevance to Eosinophilic Esophagitis (EoE). PloS one 11(3): e0150968, 2016 Notes: *co-corresponding author.
Muir A1, Otero H, Blinman T, Wen J: Use of Magnetic Resonance Imaging With Hepatobiliary-Specific Contrast Agent for Precise Localization of a Bile Duct Leak. Journal of Pediatric Gastroenterology and Nutrition 63(3): e36, September 2016 Notes: DOI: 10.1097/MPG.0000000000000531
Muir AB, Benitez AJ, Dods K, Spergel JM, Fillon SA: Microbiome and its impact on gastrointestinal atopy. Allergy 71(9): 1256-63, Sep 2016 Notes: *co-corresponding author.
Muir AB, Dods K, Henry SJ, Benitez AJ, Lee D, Whelan KA, DeMarshall M, Hammer DA, Falk G, Wells RG, Spergel J, Hakagawa H, Wang ML: Eosinophilic Esophagitis-Associated Chemical and Mechanical Microenvironment Shapes Esophageal Fibroblast Behavior. Journal of Pediatric Gastroenterology and Nutrition 63(2), August 2016 Notes: DOI: 10.1097/MPG.0000000000001100.
Dellon Evan S, Collins Margaret H, Bonis Peter A, Leung John, Capocelli Kelley E, Dohil Ranjan, Falk Gary W, Furuta Glenn T, Menard-Katcher Calies, Gupta Sandeep K, Hirano Ikuo, Gonsalves Nirmala, Hiremath Girish S, Kagalwalla Amir F, Wershil Barry K, Liacouras Chris A, Muir Amanda B, Mukkada Vincent A, Putnam Philip E, Schoepfer Alain M, Straumann Alex, Wo John M, Yang Guang-Yu, Rothenberg Marc E: Substantial Variability in Biopsy Practice Patterns Among Gastroenterologists for Suspected Eosinophilic Gastrointestinal Disorders. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Apr 2016.
Muir A, Surrey L, Kriegermeier A, Shaikhkalil A, Piccoli DA: Severe Eosinophilic Gastroenteritis in a Crohn's Disease Patient Treated with Infliximab and Adalimumab. Am J Gastroenterol 111(3): 437-8, Mar 2016 Notes: doi: 10.1038/ajg.2015.438.
Muir AB, Merves J, Liacouras CA: Role of Endoscopy in Diagnosis and Management of Pediatric Eosinophilic Esophagitis. Gastrointestinal endoscopy clinics of North America 26(1): 187-200, Jan 2016.
Muir Amanda B, Dods Kara, Henry Steven J, Benitez Alain J, Lee Dale, Whelan Kelly A, DeMarshall Maureen, Hammer Daniel A, Falk Gary, Wells Rebecca G, Spergel Jonathan, Nakagawa Hiroshi, Wang Mei-Lun: Eosinophilic Esophagitis Associated Chemical and Mechanical Microenvironment Shapes Esophageal Fibroblast Behavior. Journal of pediatric gastroenterology and nutrition Dec 2015.
Benitez Alain J, Hoffmann Christian, Muir Amanda B, Dods Kara K, Spergel Jonathan M, Bushman Frederic D, Wang Mei-Lun: Inflammation-associated microbiota in pediatric eosinophilic esophagitis. Microbiome 3: 23, 2015.
Merves J, Chandramouleeswaran PM, Benitez AJ, Muir AB, Lee AJ, Lim D, Dods K, Mehta I, Ruchelli E, Nakagawa H, Spergel J, Wang ML: Altered esophageal histamine receptor expression in eosinophilic esophagitis (EoE): Implications on disease pathogenesis. PLOSone 10(2):e0114831, Feb 2015.
Muir, AB, Dods K, Noah Y, Toltzis S; Modayur Chandramouleeswaran P; Lee A; Bedenbaugh A; Falk GW, Wells R; Nakagawa H; Wang ML: Esophageal epithelial cells acquire functional characteristics of activated myofibroblasts after undergoing an epithelial to mesenchymal transition. Experimental Cell Research 330(1): 102-110, Jan 2015.
Muir Amanda B, Dods Kara, Noah Yuli, Toltzis Sarit, Chandramouleeswaran Prasanna Modayur, Lee Anna, Benitez Alain, Bedenbaugh Adam, Falk Gary W, Wells Rebecca G, Nakagawa Hiroshi, Wang Mei-Lun: Esophageal epithelial cells acquire functional characteristics of activated myofibroblasts after undergoing an epithelial to mesenchymal transition. Experimental cell research 330(1): 102-10, Jan 2015.
Muir AB, Otero H, Blinman T, Wen J: Use of MRI With Hepatobiliary Specific Contrast Agent For Precise Localization of A Bile Duct Leak. Journal of Pediatric Gastroenterology, Hepatology, and Nutrition Jan 2015 Notes: E-Published ahead of print.
Muir AB, Gambanga F, Kluger J, Tanaka K, Benitez B, Modayr P, Whelan K, Nakagawa N: Epithelial-Fibroblast interaction drives pro-fibrotic milieu in eosinophilic esophagitis. Accepted for oral presentation at Digestive Disease Week and the 117th annual meeting of the American Gastroenterological Association 2016.
Menard-Katcher C, Benitez A, Ahmed F, Kramer R, Spergel J, Verma R, Liacouras C, Nakagawa H, Furuta G, Muir AB: Esophageal distensibility provides measure of remodeling in pediatric EoE. Digestive Disease Week and the 117th annual meeting of the American Gastroenterological Association 2016.
Godwin, B. , Whelan, K., Benitez, A., Klein-Szanto, A., Spergel, J., Falk, G., Muir, A., Nakagawa, H.: Persistent Epithelial Changes in Inactive Eosinophilic Esophagitis: Is Inactive Really Inactive? Accepted for oral presentation. Digestive Disease Week and the 117th annual meeting of the American Gastroenterological Association 2016.
Whelan KA, Merves J, Muir AB, Guo A, Modayur Chandramouleeswaran P, Dods K, DeMarshall M, Que J, Spergel J, Wang ML, Falk GW, Nakagawa H: Autophagy is an epithelial cytoprotective mechanism in esophageal epithelial cells in response to Eosinophilic Esophagitis-associated inflammation. Oral Presentation: Digestive Disease Week and the 116th annual meeting of the American Gastroenterological Association, Washington, DC, May 16-19, 2015 2015.
Muir AB, Dods K, Merves J, Whelan KA, Benitez AJ, DeMarshall M, Spergel J, Falk G, Wells RG, Wang ML, Nakagawa H : Epithelial lysyl oxidase is an early mediator of fibrotic remodeling in eosinophilic esophagitis. Oral presentation: Digestive Disease Week and the 116th annual meeting of the American Gastroenterological Association, Washington, DC, May 16-19, 2015 2015.
Muir AB, Dods K, Henry S, Benitez AJ, Lee D, Whelan K, DeMarshall M, Falk G, Wells RG, Spergel J, Hammer D, Nakagawa H, Wang ML: Chemical and mechanical stimuli drive esophageal fibroblast activity: Implications for EoE Fibrosis. Oral Presentation at NASPGHAN annual meeting 2015.
Muir AB, Dods K, Henry S, Benitez AJ, DeMarshall M, Falk G, Wells RG, Hammer D, Nakagawa H, Wang ML: Matrix-stiffness enhances esophageal fibroblast activation, proliferation and contractility in pediatric and adult fibroblasts. Poster presentation at Digestive Disease Week and the 116th annual meeting of the American Gastroenterological Association, Washington, DC, May 16-19, 2015 2015.
Merves J, Whelan KA, Muir AB, Masterson J, Guo A, Benitez AJ, Blair A, Gimotty PA, Klein-Szanto A, Spergel J, Furuta GT, Wang ML, Falk GW and Nakagawa H : Autophagy-Related Gene 7 (ATG7) may serve as a biomarker of EoE disease status. Poster presentation: Digestive Disease Week and the 116th annual meeting of the American Gastroenterological Association, Washington, DC, May 16-19, 2015 2015.
Benitez AJ, Hoffmann C, Muir AB, Spergel J, Bushman F, and Wang ML: Inflammatory signature in the tissue-associated microbiota in pediatric eosinophilic esophagitis. Oral Presentation: Digestive Disease Week and the 116th annual meeting of the American Gastroenterological Association, Washington, DC, May 16-19, 2015 2015.
Muir A, Markowitz JE, Liacouras CA. Allergic and Eosinophilic Gastrointestinal Disease. In: Pediatric Allergy: Principles and Practice. 3rd ed. Philadelphia: Elsevier, 2015.
Muir A, Franciosi JP, Markowitz JE, Liacouras CA. Eosinophilic Esophagitis, Gastroenteritis, and Colitis. In: Metcalfe DD, Sampson HA, Simon RA, Lack G, editors. Food Allergy. 5th ed. Malden, MA: Wiley-Blackwell Publishers, 2014.
Muir A, Pineiro-Carrero VM. Encopresis. In: Schwartz MW, editor. 5 Minute Pediatric Consult. 6th ed. Philadelphia, PA: Lippincott, Williams & Wilkins, 2012.
Muir A, Liacouras CA. Vomiting. In: Zorc JJ, editor. Clinical Handbook of Pediatrics. Philadelphia, PA: Lippincott, Williams & Wilkins, 2012.
Kamath B, Rand E, Muir A. Nutritional considerations in pediatric liver transplantation. In: Nutrition, Diet Therapy, and the Liver. CRC Press, 2010.
Benitez AJ, Turco R, Ahmed F, Gross J, Li C, Lynch K, Verma R, Menard-Katcher C, Muir A: Esophagogastric junction distensibility is decreased in eosinophilic esophagitis: Results from a multicenter pediatric cohort Digestive Disease Week, Washington, DC Poster Presentation. 2018.
Benitez AJ, Turco R, Muir A, Lynch K, Verma R, Mamula P : Esophagogastric junction distensibility in pediatric achalasia: a useful tool during pneumatic dilation. Digestive Disease Week, Washington, DC 2018 Notes: Poster Presentation.
Kennedy K, Grossman A, Ruffner M, Spergel J, Wilkins B, Muir A,Furuta G, Ruchelli E, Cianferoni A, Brown-Whitehorn T: Treatment of Eosinophilic Gastroenteritis: A multiphasic approach American Academy of Allery, Asthma, and Immunology Annual Meeting, Orlando, FL 2018 Notes: Poster presentation.
Pesek RD, Reed CC, Muir AB, Fulkerson PP,Menard-Katcher C,Falk G,Kuhl J, Ahmed F, Demarshall M, Gupta A, Gross J, Ashorobi T, Carpenter CL, Krischer JP, Spergel JM, Sandeep GK,Furuta GT,Rothenberg ME, Dellon ES: Treatment patterns for eosinophilic gastritis, enteritis and colitis vary across sites in a multi-center consortium. Digestive Disease Week, Washington, DC 2018 Notes: Poster Presentation.
Pesek RD, Reed CC, Muir AB, Fulkerson PP,Menard-Katcher C,Falk G,Kuhl J, Ahmed F, Demarshall M, Gupta A, Gross J, Ashorobi T, Carpenter CL, Krischer JP, Spergel JM, Sandeep GK,Furuta GT,Rothenberg ME,4 and Dellon ES: Histologic Characterization of a Large Cohort of Patients with Eosinophilic Gastrointestinal Disorders: 10 Years of Data from a Multi-Center Consortium. Digestive Disease Week, Washington, DC 2018 Notes: Poster Presentation.
Pesek RD, Reed CC, Muir AB, Fulkerson PP,Menard-Katcher C,Falk G,Kuhl J, Ahmed F, Demarshall M, Gupta A, Gross J, Ashorobi T, Carpenter CL, Krischer JP, Spergel JM, Sandeep GK,Furuta GT,Rothenberg ME,4 and Dellon ES: High rates of overlap and increasing rates of diagnosis for eosinophilic gastritis, enteritis and colitis: 10 years of data from a multi-center consortium. Digestive Disease Week, Washington, DC 2018 Notes: Poster Presentation.
Whelan K, Chandramouleeswaran P, Sharma M, Benitez A, DeMarshall M, Klein-Szanto A, Spergel J, Falk G, Muir A, Nakagawa H. : Rapamycin-mediated autophagy activation ameliorates EoE-associated alterations in epithelial tissue architecture, Oral presentation by colleague. Digestive Disease Week, Washington, DC 2018.
Godwin B, Wehrman A, Fulkerson P, Muir A, and Lin H : Clinical Features and Management of Eosinophilic Gastrointestinal Disease in Pediatric Liver Transplant Recipients: A Longitudinal Case Series Digestive Disease Week, Chicago, IL 2017 Notes: Poster Presentation.
Kasagi Y, Gambanga F, Whelan KA, Benitez AJ, Gross, J, Kluger J, Chandramouleeswaran P, DeMarshall M, Cianferoni A, Spergel J, Falk G, Nakagawa H, Muir AB: Lysyl oxidase is a novel fibrostenotic indicator in eosinophilic esophagitis induced via the TNFα-TGFβ axis in the epithelial-fibroblast crosstalk. Digestive Disease Week, Chicago, IL 2017 Notes: Poster Presentation.
Lynch KL, Benitez AJ, Kluger J, DeMarshall M, Falk GW, Muir AB: Esophageal Distensibility in Proton Pump Inhibitor Responsive Esophageal Eosinophilia Is Decreased Compared to Controls. Digestive Disease Week, Chicago, IL 2017 Notes: Poster Presentation.
Menard-Katcher C, Benitez A, Ahmed F, Kramer R, Spergel J, Verma R, Liacouras C, Nakagawa H, Furuta G, Muir AB: Esophageal distensibility provides measure of remodeling in pediatric EoE. Digestive Disease Week and the 117th annual meeting of the American Gastroenterological Association, Anaheim, CA 2016 Notes: Oral presentation by colleague.
Muir A. Detecting Early Fibrosis in Children: The EndoFlip Project [lecture]. APFED Annual meeting; 2017 Jul; San Diego, CA.
2016, GI Fellows Faculty Honor Roll
2015, American Partnership for Eosinophilic Disorders NASPGHAN Award for Basic Science Abstract
2014, AGA Fellow Abstract Prize
2014, Komarov Research Competition - 3rd place
2014, Fellowship2Leadership Salix Travel Grant
2012, AGA Clinical Skills Travel Award
2008, NASPGHAN - Teaching and Tomorrow Award
2015-present, Digestive Disease Sciences
2015-present, Journal of Visualized Experiments
2015-present, Journal of Allergy and Clinical Immunology
2015-present, Cellular and Molecular Gastroenterology
2014-present, REPAC, The Children's Hospital of Philadelphia
2010-present, American Gastroenterology Association
2010-present, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (Member, Research Committee)