Amrom Obstfeld, MD, PhD

Amrom Obstfeld, MD, PhD
Amrom Obstfeld, MD, PhD, is Director of the Hematology and Coagulation Laboratories at Children's Hospital of Philadelphia and a member of the DBHi faculty.

Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - College of Physicians and Surgeons, Columbia University


Pathology and Laboratory Medicine - Hospital of the University of Pennsylvania, Philadelphia, PA

Board Certification

Clinical Pathology

Graduate Degree

PhD in Physiology - Columbia University, New York, NY

Titles and Academic Titles

Director, Hematology and Coagulation Laboratories

Faculty, DBHi

Assistant Professor of Clinical Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania

Departments and Services




Obstfeld AE, Frey NV, Mansfield K, Lacey SF, June CH, Porter DL, Melenhorst JJ, Wasik MA: Cytokine release syndrome associated with chimeric-antigen receptor T-cell therapy: clinicopathological insights. Blood 23(130): 2569-2572, December 2017.

Mehr CR, Obstfeld AE, Barrett AC, Montone KT, Schwartz LE: Surgical Pathology Resident Rotation Restructuring at a Tertiary Care Academic Center. Acad Pathol. eCollection (eds.). Jan-Dec 2017.

Cedeno-Laurent F, Wysocka M, Obstfeld AE, Novoa RA, Vittorio CC, Kim EJ, Weng WK, Rook AH: Gain of CD26 expression on the malignant T-cells in relapsed erythrodermic leukemic mycosis fungoides. J Cutan Pathol 44(5), January 13 2017 Notes: doi: 10.1111/cup.12899.


Bhoj VG, Arhontoulis D, Wertheim G, Capobianchi J, Callahan CA, Ellebrecht CT, Obstfeld AE, Lacey SF, Melenhorst JJ, Nazimuddin F, Hwang WT, Maude SL, Wasik MA, Bagg A, Schuster S, Feldman MD, Porter DL, Grupp SA, June CH, Milone MC: Persistence of long-lived plasma cells and humoral immunity in individuals responding to CD19-directed CAR T-cell therapy. Blood 128(3): 360-370, July 2016.

Cedeno-Laurent F, Obstfeld A E, Boni A, Lipoff J B: Lupus-like eruption as the presenting sign of acute myeloblastic leukemia. Lupus 3: 312-4, Mar 2016 Notes: Epub 2015 Oct 13.


Meykler S, Obstfeld A, Jhala N, Vergara N, Gupta PK: Pleural mass forming extramedullary hematopoiesis masquerading as a malignant neoplasm. Diagnostic Cytopathology 43(12): 996-9, Dec 2015 Notes: Epub 2015 Aug 25.


Obstfeld AE1, Sugaru E, Thearle M, Francisco AM, Gayet C, Ginsberg HN, Ables EV, Ferrante AW Jr: C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis. Diabetes 59(4): 916-925, April 2010 Notes: Epub 2010 Jan 26.


Jordan MS1, Maltzman JS, Kliche S, Shabason J, Smith JE, Obstfeld A, Schraven B, Koretzky GA: In vivo disruption of T cell development by expression of a dominant-negative polypeptide designed to abolish the SLP-76/Gads interaction. Eur J Immunol 37(10): 2961-72, Oct 2007.


Seimon TA, Obstfeld A, Moore KJ, Golenbock DT, Tabas I: Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages. Proc Natl Acad Sci U S A. 103(52): 19794-9, Dec 2006 Notes: Epub 2006 Dec 13.


Singer AL1, Bunnell SC, Obstfeld AE, Jordan MS, Wu JN, Myung PS, Samelson LE, Koretzky GA.: Roles of the proline-rich domain in SLP-76 subcellular localization and T cell function. J Biol Chem 279(15), April 2004.


Husemann J1, Obstfeld A, Febbraio M, Kodama T, Silverstein SC: CD11b/CD18 mediates production of reactive oxygen species by mouse and human macrophages adherent to matrixes containing oxidized LDL. Arterioscler Thromb Vasc Biol 21(8): 1301-5, Aug 2001.



Paessler M, Doshi B, Obstfeld AE, Helfrich M, Lambert MP: A case report of catastrophic thrombosis, acquired sitosterolemia and hereditary xerocytosis in a 2 year-old girl after tumor resection.  Annual Meeting of the International Society of Laboratory Hematology 2017 2017.

Obstfeld AE, Velu P, Sadigh S, Raess PW, Bagg A: Predicting the Diagnosis of a Myelodysplastic Syndrome Using Complete Blood Count and Cell Population Data Prior To Bone Marrow Biopsy. MDS Foundation Meeting 2017 2017.

Obstfeld AE, Lim D, Lambert MP, Paessler M: Classification of Hypochromic Microcytic Anemia Using Machine Learning Techniques. Annual Meeting of the International Society of Laboratory Hematology 2017 2017

Obstfeld AE, Lim D, Lambert MP, Paessler M: Manual Gating of Sysmex XN Scattergram Data for Accurate Reticulocyte and WBC Count Determinations. Annual Meeting of the International Society of Laboratory Hematology 2017 2017.

Obstfeld AE, Lambert MP: Prediction of Partial Thromboplastin Time (PTT) and Prothrombin Time (PT) on the Basis of Factor Assay Activities Using Data from a Clinical Data Warehouse. XXVI Congress of the International Society on Thrombosis and Haemostasis and 63rd Annual Scientific and Standardization Committee (SSC) Meeting. 2017.

Obstfeld A, Helfrich M, Paessler M: The morphologic spectrum of cells in peripheral blood in CART T-cell therapy for refractory B lymphoblastic leukemia. International Society for Laboratory Hematology 2017.


Obstfeld AE, Raess PW, Master SR, Bagg A: Comparison of Applied Machine Learning Tools for The Prediction Of Myelodysplastic Syndromes Using Complete Blood Count Parameters. Association for Pathology Informatics Annual Meeting 2016.

Obstfeld AE, Lim D, Lambert MP, Paessler M. Utility of Extended Reticulocyte Indices in the Diagnosis of Parvovirus Infection Induced Red Cell Aplasia in Sickle Cell Disease. Annual Meeting of the International Society of Laboratory Hematology 2016.

Obstfeld AE, Raess PW, Master SR, Bagg A: Predictive capacity of complete blood count and cell population data parameters in in the diagnosis of myelodysplastic syndromes. 5th International Conference on Myelodysplastic Syndromes 2016.

Mehr C, Obstfeld A, LiVolsi V, Furth E, Litzky L, Montone K and Schwartz L.,: The Creation and Implementation of a Points-Based System for Distributing Specimens to Residents at a Tertiary Care Academic Residency Program. The United States and Canadian Academy of Pathology National Meeting 2016.

Posters and Presentations

Invited Lectures


Obstfeld A. "Bumps, Bruises and Bleeds:  Review of Coagulation and Thrombosis using Case studies"  American Society for Clinical Laboratory Science-Pennsylvania Pennsylvania State Society of American Medical Technologists Annual Spring Meeting; Plymouth Meeting, PA. May 2017.

Awards and Honors

2016, Penn Institute of Biomedical Informatics Junior Faculty Travel Award

2015, Leonard Berwick Resident Teaching Award

2012, Doctor Harold Lee Meierhof Memorial Prize for outstanding achievement in Pathology, Columbia University

2010, Student Research Day MD/PhD Award, Columbia University

2008, Immunology Retreat 2nd Place Poster Prize, Columbia University 

2007, MD/PhD Symposium Award, Columbia University

2003, Magna Cum Laude, University of Pennsylvania

Editorial and Academic Positions

Editorial Positions

2017-present, Ad hoc Reviewer, The Journal of the American Medical Association Pediatrics
2015-present, Ad hoc Reviewer, Clinical Chemistry

Institutional and Academic Committees

2017-present, Pathology Resident Steering Committee
2016-present, Laboratory Information System Operations Meeting
2016-present, Vice Chair, LIS Governance Committee
2015-present, Clinical Informatics Council
2013-present, Institutional Review Board, University of Pennsylvania

Leadership and Memberships

Memberships in Professional Organizations


2018-present, International Council for Standardization in Haematology (ICSH)
 - 2018-present, Chair, Standardization of the Immature Reticulocyte Fraction
2018-present, College of American Pathologists
 - 2018-present, Liaison-Inbound Hematology and Clinical Microscopy Resource Committee
2016-present, International Society for Laboratory Hematology (ISLH)