Paul A. Offit, MD Paul A. Offit, MD, is the Director of the Vaccine Education Center and an attending physician in the Division of Infectious Diseases at Children's Hospital of Philadelphia. Areas of Expertise: Vaccines Locations: Main Campus Background Paul A. Offit, MD, is Director of the Vaccine Education Center and professor of pediatrics in the Division of Infectious Diseases at Children’s Hospital of Philadelphia. He is the Maurice R. Hilleman Professor of Vaccinology at the Perelman School of Medicine at the University of Pennsylvania. Dr. Offit is an internationally recognized expert in the fields of virology and immunology, and was a member of the Advisory Committee on Immunization Practices to the Centers for Disease Control and Prevention. He is a founding advisory board member of the Autism Science Foundation and the Foundation for Vaccine Research, a member of the Institute of Medicine and co-editor of the foremost vaccine text, Vaccines. He is a recipient of many awards including the J. Edmund Bradley Prize for Excellence in Pediatrics from the University of Maryland Medical School, the Young Investigator Award in Vaccine Development from the Infectious Disease Society of America, a Research Career Development Award from the National Institutes of Health, and the Sabin Vaccine Institute Gold Medal. Dr. Offit has published more than 150 papers in medical and scientific journals in the areas of rotavirus-specific immune responses and vaccine safety. He is also the co-inventor of the rotavirus vaccine, RotaTeq®, recommended for universal use in infants by the CDC. For this achievement, Dr. Offit received the Luigi Mastroianni and William Osler Awards from the University of Pennsylvania School of Medicine, the Charles Mérieux Award from the National Foundation for Infectious Diseases, and was honored by Bill and Melinda Gates during the launch of their Foundation’s Living Proof Project for global health. In 2009, Dr. Offit received the President’s Certificate for Outstanding Service from the American Academy of Pediatrics. In 2011, he received the Humanitarian of the Year Award from the Biologics Industry Organization (BIO), the David E. Rogers Award from the American Association of Medical Colleges, the Odyssey Award from the Center for Medicine in the Public Interest, and was elected to the Institute of Medicine of the National Academy of Sciences. In 2012, Dr. Offit received the Distinguished Medical Achievement Award from the College of Physicians of Philadelphia and the Drexel Medicine Prize in Translational Medicine from the Drexel University College of Medicine. In 2013, he received the Maxwell Finland award for Outstanding Scientific Achievement from the National Foundation for Infectious Diseases, the Distinguished Alumnus award from the University of Maryland School of Medicine, and the Innovators in Health Award from the Group Health Foundation. In 2014, he was elected to the board of trustees at the College of Physicians in Philadelphia, and in 2015, he was elected to the American Association of Physicians and the American Academy of Arts and Sciences as well as being named as a Fellow for the Pediatric Infectious Diseases Society and the American Academy for the Advancement of Science. In 2016, Dr. Offit received the Franklin Founder Award by the City of Philadelphia, The Porter Prize from the University of Pittsburgh School of Public Health, and the Jonathan E. Rhoads Medal for Distinguished Service to Medicine from The American Philosophical Society. In 2017, he received the Defensor Scientiae Award and an Honorary Doctor of Science degree from The University of the Sciences in Philadelphia. In 2018, he was named to the Alpha Omega Alpha Honor Society at the University of Maryland School of Medicine. Dr. Offit is the author of seven medical narratives which have received numerous accolades: The Cutter Incident: How America’s First Polio Vaccine Led to Today’s Growing Vaccine Crisis (Yale University Press, 2005) Vaccinated: One Man’s Quest to Defeat the World’s Deadliest Diseases (HarperCollins, 2007), for which he won an award from the American Medical Writers Association Autism’s False Prophets: Bad Science, Risky Medicine, and the Search for a Cure (Columbia University Press, 2008) Deadly Choices: How the Anti-Vaccine Movement Threatens Us All (Basic Books, 2011), which was selected by Kirkus Reviews and Booklist as one of the best non-fiction books of the year Do You Believe in Magic?: The Sense and Nonsense of Alternative Medicine (HarperCollins, 2013), which won the Robert P. Balles Prize in Critical Thinking from the Center for Skeptical Inquiry and was selected by National Public Radio as one of the best books of 2013 Bad Faith: When Religious Belief Clashes with Modern Medicine (Basic Books, 2015) Bad Advice: Or Why Celebrities, Politicians, and Activitsts Aren’t Your Best Source of Health Information (Columbia University Press, 2018) Education and Training Medical SchoolMD - University of Maryland School of Medicine, Baltimore, MD InternshipPediatrics - Children's Hospital of Pittsburgh, Pittsburgh, PA ResidencyPediatrics - Children's Hospital of Pittsburgh, Pittsburgh, PA FellowshipInfectious Diseases - The Children's Hospital of Philadelphia, Philadelphia, PA Board CertificationAmerican Board of Pediatrics Titles and Academic Titles Attending Physician, Division of Infectious DiseasesDirector, Vaccine Education CenterChairman, Therapeutic Standards CommitteeMaurice R. Hilleman Endowed Chair in VaccinologyMaurice R. Hilleman Professor of Vaccinology and Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania Adjunct Associate Professor, The Wistar Institute of Anatomy and Biology Departments and Services Division of Infectious DiseasesVaccine Education Center Publications Papers2017 Katsuta T, Miyaji Y, Offit PA, Feemster KA. Treatment with quadrivalent human papillomavirus vaccine for juvenile-onset recurrent respiratory papillomatosis: case report and review of the literature. J Pedatr Infect Dis Soc 2017; doi:10.1093/jpids/pix063 Handy L, Maroudi S, Powell M, Nfila B, Moser C, Japa I, Monyatsi N, Tzortzi E, Kouzeli I, Luberti A, Theodoridou M, Offit P, Steenhoff A, Shea JA, Feemster KA. 2017. The impact of access to immunization information on vaccine acceptance in three countries. PLOS One https://doi.org/10.137/journal.pone.0180759. 2013 Williams SE, Rothman RL, Offit PA. Schaffner W, Sullivan M, Edwards KM. A randomized trial to increase acceptance of childhood vaccines by vaccine-hesitant parents: a pilot study. Academic Pediatrics (2013) 13: 475-480. 2011 Feemster KA, Prasad P., Smith MJ, Feudtner C, Caplan A, Offit PA, Coffin SE. 2011. Health care worker support of an influenza vaccine mandate at a large pediatric tertiary care hospital. Vaccine 29: 1762-1769. 2006 Vesikari T, Clark HF, Offit PA, Dallas MJ, DiStefano DJ, Goveia MG, Ward RL, Schödel F, Karvonen A, DiNubile MJ, Heaton PM. 2006. Effects of potency and composition of the multivalent human-bovine (WC3) reassortant rotavirus vaccine on efficacy, safety and immunogenicity in healthy infants. Vaccine 24:4821-4829. Vesikari T, Matson DO, Dennehy P, Van Damme P, Santosham M, Rodriguez Z, Dallas MJ, Heyse JF, Gouveia MG, Black SB, Shinefield HR, Christie C, Ylitalo S, Itzler RF, Coia ML, Onorato MT, Adeyi BA, Marshall GS, Gothefors L, Campens D, Karvonen A, Watt JP, O’Brien KL, DiNubile MJ, Clark HF, Boslego JW, Offit PA, Heaton PM. 2006. Safety and efficacy of pentavalent human-bovine (WC3) reassortant rotavirus vaccine in preventing rotavirus gastroenteritis and associated healthcare contacts. N. Engl. J. Med 354:13-23. 2005 Offit, P.A. 2005. The Cutter Incident, 50 years later. N. Engl. J. Med. 352:1411-1412. Offit, P.A. 2005. Why are pharmaceutical companies gradually abandoning vaccines? Health Affairs Journal, 24:622-630. 2004 Clark HF, Bernstein DI, Dennehy P, Offit P, Pichichero M, Treanor J, Ward RL, Krah DL, Shaw A, Dallas MJ, Eiden JJ, Ivanoff N, Kaplan KM, Heaton P. 2004. Safety, efficacy, and immunogenicity of a live, quadrivalent human-bovine reassortant rotavirus vaccine in healthy infants. J. Pediatr. 144:184-190. Clark HF, Lawley D, Shrager D, Jean-Guillaume D, Offit P, Eiden JJ, Bennett PS, Kaplan, KM, Shaw A. 2004. Infant immune response to human rotavirus serotype G1 vaccine candidate reassortant WI79-9: Different dose response patterns to virus surface proteins vp7 and vp4. Pediatr. Infect. Dis. J. 23:206-211. 2003 Clark HF, Burke CJ, Volkin DV, Offit, P, Ward RL, Breese JS, Dennehy P, Gooch WM, Malacaman E, Matson D, Walter E, Watson B, Krah DL, Dallas MJ, Schödel F, Kaplan KM, Heaton P. 2003. Safety, immunogenicity and efficacy in healthy infants of G1 and G2 human reassortant rotavirus vaccine in a new stabilizer/buffer liquid formulation. Pediatr. Infect. Dis. J. 22:914-920. Offit, P.A. and Peter G. 2003. The meningococcal vaccine: public policy and individual choices. N. Engl. J. Med. 349:2353-2356; Offit, P.A., Peter, G. Choices about meningococcal vaccine. [correspondence] N. Engl. J. Med. 2004;350:1156. Offit, P.A. and Coffin, S.E. 2003. Communicating science to the public: MMR vaccine and autism. Vaccine 22:1-6. Offit, P.A., Jew, R.K. 2003. Addressing parents’ concerns: Do vaccines contain harmful preservatives, adjuvants, additives, or residuals? Pediatrics 112:1394-1401. Chow, A.A., Moser C.A., Speaker, T.J., and Offit, P.A. 2003. Determination of efficiency of attachment of biotinylated antibodies to avidin-linked, aqueous-based microcapsules by flow cytometry. J. Immunol. Methods 2003;277:135-139. Offit, P.A. and Hackett, C.J. 2003. Addressing parents’ concerns: Do vaccines cause allergic or autoimmune diseases? Pediatrics 111:653-659. 2002 Offit, P.A., Gerber, M.A., Hackett, C., Marcuse, E., and Gellin, B. 2002. Too many vaccines? (correspondence). Pediatrics 110:649. Offit, P.A., Quarles, J., Gerber, M.A., Hackett, C.J., Marcuse, E.K., Kollman, T.R., Gellin, B.G., and Landry, S. 2002. Addressing parents’ concerns: Do multiple vaccines overwhelm or weaken the infant’s immune system? Pediatrics 109:124-129. Brubaker, J.O., K.K. Macartney, T.J. Speaker, and P.A. Offit. 2002. Specific attachment of covalently modified aqueous-based microcapsules to macrophages, B cells, and dendritic cells. J. Microencapsulation 19:213-223. 2001 Moser, C.A. and P.A. Offit. 2001. Distribution of rotavirus-specific memory B cells in gut-associated lymphoid tissue after primary immunization. J. Gen. Virol. 82:2271-2274. Clark, HF, D. Lawley, D. Shrager, D. Jean-Guillaume, P.A. Offit, J. Eiden, and A.R. Shaw. 2001. Immune response of infants to bovine human rotavirus serotype G1 reassortant WI79-9: the dose response pattern to virus surface protein vp7 differs from that to vp4. Pediatr Infect Dis J. 2004 Mar;23(3):206-11. Kushnir, N., N.A. Bos, A.W. Zuercher, S.E. Coffin, C.A. Moser, P.A. Offit, and J.J. Cebra. 2001. B2 but not B1 B cells can contribute to CD4+ T cell-mediated clearance of rotavirus in SCID mice. J. Virol. 75:5482-5490. Moser, C.A., D.V. Dolfi, M.L. DiVietro, P.A. Offit, and H F. Clark. 2001. Hypertrophy, hyperplasia, and infectious virus in gut-associated lymphoid tissue of mice after oral inoculation with simian-human or bovine-human reassortant rotaviruses. J. Infect. Dis. 183:1108-1111. 2000 Brown, K.A., J.A. Kriss, C.A. Moser, W.J. Wenner, and P.A. Offit. 2000. Circulating rotavirus-specific antibody-secreting cells (ASC) predict the presence of rotavirus-specific ASC in the human small intestinal lamina propria. J. Infect. Dis. 182:1039-1043. Macartney, K.M., D. Baumgart, S.R. Carding, J.O. Brubaker, and P.A. Offit. 2000. Primary murine small intestinal epithelial cells, maintained in long-term culture, are susceptible to rotavirus infection. J. Virol. 74:5597-5603. Brubaker, J., R. Patel, T.J. Speaker, and P.A. Offit. 2000. A quantitative luminescence assay for measuring cell uptake of aqueous-based microcapsules in vitro. J. Immunol. Methods 237:85-93. 1999 Coffin, S.E., Moser, C.A., Cohen, S., Speaker, T.J., and Offit, P.A. 1999. Viral microencapsulation delays protection after intramuscular inoculation of mice with rotavirus. Drug Delivery 6:253-257. Coffin, S.E., Clark, S.A., Bos, N.A., Brubaker, J.O., and Offit, P.A. 1999. Migration of antigen-presenting B cells from peripheral to mucosal lymphoid tissues may induce intestinal antigen-specific IgA following parenteral immunization. J. Immunol. 163:3064-3070. 1998 Moser, C.A., Speaker, T.J., and Offit, P.A. 1998. Effect of water-based microencapsulation on protection against EDIM rotavirus challenge in mice. J. Virol. 72:3859-3862. Coffin, S.E., and Offit, P.A. 1998. Induction of rotavirus-specific memory B cells in gut-associated lymphoid tissue after intramuscular immunization. J. Virol. 72:3479-3483. Brown, K.A. and Offit, P.A. 1998. Rotavirus-specific proteins are detected in murine macrophages in both intestinal and extraintestinal lymphoid tissue. Microbial Pathogen. 24:327-331. Moser, C.A., Coffin, S.E., Cookinham, S., and Offit, P.A. 1998. Relative importance of rotavirus-specific effector and memory B cell responses in protection against challenge. J. Virol. 72:1108-1114. 1997 Coffin, S.E., Moser, C.A., Cohen, S., Clark, HF., and Offit, P.A. 1997. Immunologic correlates of protection against challenge after intramuscular immunization of mice with rotavirus. J. Virol. 71:7851-7856. Moser, C.A., Speaker, T.J., and Offit, P.A. 1997. Effect of microencapsulation on immunogenicity of a bovine herpes virus glycoprotein and inactivated influenza virus in mice. Vaccine 15: 1767-1772. Lomotan, E.A., Brown, K.A., Speaker, T.J., and Offit, P.A. 1997. Aqueous-based microcapsules are detected primarily in gut-associated dendritic cells after oral inoculation of mice. Vaccine 15:1959-1962. 1996 Moser, C.A., Speaker, T.J., Berlin, J.A., and Offit, P.A. 1996. Aqueous-based microencapsulation enhances rotavirus-specific humoral immune responses after parenteral inoculation of mice. Vaccine 14:1235-1238. 1995 Coffin, S.E., Klinek, M., and Offit, P.A. 1995. Induction of virus-specific antibody production by lamina propria lymphocytes following intramuscular inoculation with rotavirus. J. Infect. Dis. 172: 874-878. Khoury, C.A., Moser, C.A., Speaker, T.J., and Offit, P.A. 1995. Oral inoculation of mice with low doses of microencapsulated, noninfectious rotavirus induces virus-specific antibodies in gut-associated lymphoid tissue. J. Infect. Dis. 172: 870-874. Brown, K.A., Moser, C.A., Khoury, C.A., Kim, J.E., and P.A. Offit. 1995. Enhancement by microencapsulation of rotavirus-specific intestinal immune responses in mice assessed by enzyme-linked immunospot assay and intestinal fragment culture. J. Infect. Dis. 171:1334-1338. Treanor, J.J., Clark, HF., Pichichero, M., Christy, C., Gouvea, V., Shrager, D., Pallazo, S., and Offit, P.A. 1995. Evaluation of the protective efficacy of a serotype 1 bovine-human rotavirus reassortant vaccine in infants. Pediatr. Infect. Dis. J. 14:301-307. 1994 Khoury, C.A., Brown, K., Kim, J., and Offit, P.A.. 1994. Rotavirus-specific intestinal immune response in mice assessed by enzyme-linked immunospot assay and intestinal fragment culture. Clin. Diag. Lab. Immunol. 1:722-728. Offit, P.A., Khoury, C.A., Moser, C.H., Clark, HF., and Speaker T.J. 1994. Enhancement of rotavirus immunogenicity by microencapsulation. Virology 203:134-143. Santos, N., Riepenhoff-Talty, M., Clark, H.F., Offit, P, and Gouvea, V. 1994. Vp4 genotyping of human rotavirus in the USA. J. Clin. Microbiol. 32:205-208. Offit, P.A., B.E.H. Coupar, Y. M. Svoboda, R.J. Jenkins, M.A. McRae, A. Abraham, N.L. Hill, D.B. Boyle, and G.W. Both. 1994. Induction of rotavirus-specific cytotoxic T lymphocytes by vaccinia virus recombinants expressing individual rotavirus genes. Virology 198:10-16. 1993 Christy, C., P.A. Offit, H F. Clark, and J. Treanor. 1993. Evaluation of a bovine-human rotavirus reassortant vaccine in infants. J. Infect. Dis. 168:1598-1599. Offit, P.A., E.J. Hoffenberg, N. Santos, and V. Gouvea. 1993. Rotavirus-specific humoral and cellular immune response after primary, symptomatic infection. J. Infect. Dis. 167:1436-1440. 1992 Ammari, L.K., P.A. Offit, A.B. Campbell. 1992. Unusual presentation of group B streptococcus osteomyelitis. Pediatr. Infect. Dis. J. 11:1066-1067. Offit, P.A., E.J. Hoffenberg, E.S. Pia, P.A. Panackal, and N.L. Hill. 1992. Rotavirus-specific helper T cell response in newborns, infants, children, and adults. J. Infect. Dis. 165:1107-1111. Nadel, S., P.A. Offit, R. Hodinka, R. Gesser, and L.M. Bell. 1992. Upper airway obstruction in perinatally-acquired herpes simplex virus infection. J. Pediatr. 120:127-129. 1991 Brussow, H., P.A. Offit, J. Sidoti. 1991. Neutralizing antibodies to heterologous animal rotavirus serotypes 5, 6, 7, and 10 in sera from Ecuadorian children. J. Clin. Microbiol. 29:869-873. Offit, P.A., D.B. Boyle, G.W. Both, N.L. Hill, Y.M. Svoboda, S.L. Cunningham, R.J. Jenkins, and M.A. McCrae. 1991. Surface glycoprotein vp7 is recognized by crossreactive rotavirus-specific cytotoxic T lymphocytes. Virology 184:563-568. Offit, P.A., S.L. Cunningham, and K.I. Dudzik. 1991. Memory and distribution of virus-specific cytotoxic T lymphocytes (CTLs) and CTLp after rotavirus infection. J. Virol. 65:1318-1324. Offit, P.A. and K.I. Dudzik. 1990. Rotavirus-specific cytotoxic T lymphocytes passively protect against gastroenteritis in suckling mice. J. Virol. 64:6325-6328. 1990 Matsuda Y., O. Nakagomi, and P.A. Offit. 1990. Presence of three P types (vp4 serotypes) and two G types (vp7 serotypes) among bovine rotavirus strains. Arch. Virol. 115:199-207. Brussow H., P.A. Offit, G. Gerna, A. Bruttin, and J. Sidoti. 1990. Polypeptide specificity of anti-viral serum antibodies in children naturally infected with human rotavirus. J. Virol. 64:4130-4136. 1989 Offit, P.A. and Y.M. Svoboda. 1989. Rotavirus-specific cytotoxic T lymphocyte response of mice after oral inoculation with candidate rotavirus vaccine strains RRV or WC3. J. Infect. Dis. 160:783-788. Offit, P.A., H.B. Greenberg, and K.I. Dudzik. 1989. Rotavirus-specific protein synthesis is not necessary for recognition of infected cells by virus-specific cytotoxic T lymphocytes. J. Virol. 63: 3279-3283. Offit, P.A., and K.I. Dudzik. 1989. Rotavirus-specific cytotoxic T lymphocytes appear at the intestinal mucosal surface after rotavirus infection. J. Virol. 63: 3507-3512. Matsui, S., P.A. Offit, P.T. Vo, E.R. Mackow, D.A. Benfield, R.D. Shaw, L. Padilla-Noriega, and H.B. Greenberg. 1989. Passive protection against rotavirus-induced diarrhea by monoclonal antibodies to the heterotypic neutralization domain of vp7 and the vp8 fragment of vp4. J. Clin. Microbiol. 27: 780-782. Offit, P.A., and K.I. Dudzik. 1989. Noninfectious rotavirus (strain RRV) induces and immune response which protects against rotavirus challenge. J. Clin. Microbiol. 27: 885-888. Offit, P.A., and K.I. Dudzik. 1988. Rotavirus-specific cytotoxic T lymphocytes cross-react with target cells infected with different rotavirus serotypes. J. Virol. 62:127-131. 1988 Liu, M., P.A. Offit, and M.K. Estes. 1988. Identification of the simian rotavirus SA11 genome segment 3 product. Virology 163: 26-32. 1987 Clark, H.F., Y. Hoshino, L.M. Bell, J. Groff, P. Bachman, and P.A. Offit. 1987. A rotavirus isolate WI61 representing a presumptive new human serotype. J. Clin. Microbiol. 25: 1757-1762. Bell, L.M., H.F. Clark, E.A. O'Brien, M.J. Kornstein, S.A. Plotkin, and P.A. Offit. 1987. Gastroenteritis caused by human rotaviruses (serotype 3) in a suckling mouse model. Proc. Soc. Exp. Biol. Med. 184: 127-132. Bell, L.M., H.F. Clark, P.A. Offit, P.H. Slight, A.M. Arbeter, and S.A. Plotkin. 1987. Rotavirus serotype-specific neutralizing activity in human milk. Am. J. Dis. Child. 142: 275-278. 1986 Offit, P.A., G. Blavat, H.F. Clark, and H.B. Greenberg. 1986. Reassortant rotaviruses containing structural proteins vp3 and vp7 from different parents induce antibodies protective against each parental serotype. J. Virol. 60: 491-496. Shaw, R.D., T.V. Phuoc, P.A. Offit, B.S. Coulson, and H.B. Greenberg. 1986. Antigenic mapping of the surface proteins of rhesus rotavirus. Virology 155: 434-451. Clark, H.F., T. Furukawa, L.M. Bell, P.A. Offit, P.A. Parrella, and S.A. Plotkin. 1986. Immune response of infants and children to low-passage bovine rotavirus (strain WC-3). Am J. Dis. Child. 140:350-356. Clark, H.F., P.A. Offit, K.T. Dolan, A. Tezza, K. Gogalin, E.M. Twist, and S.A. Plotkin. 1986. Response of adult human volunteers to oral administration of bovine and bovine/human reassortant rotaviruses. Vaccine 4: 25-31. Offit, P.A., R. Shaw, and H.B. Greenberg. 1986. Protection against rotavirus-induced gastroenteritis in newborn mice by monoclonal antibodies to surface proteins vp3 and vp7. J. Virol. 58: 700-703. Offit, P.A., and G. Blavat. 1986. Identification of the two rotavirus genes determining neutralization specificities. J. Virol. 57: 376-378. 10. Offit, P.A., G. Blavat, H.B. Greenberg, and H.F. Clark. 1986. Molecular basis of rotavirus virulence: role of gene segment 4. J. Virol. 57: 46-49. 1985 Clark, H.F., P.A. Offit, K. Dolan, T. Furukawa, L. Bell, and S.A. Plotkin. 1985. Rotavirus (RV) of bovine and human origin: immune response of adults and children following oral administration. Pediatr. Res. 19: 290 A. Offit, P.A., and H.F. Clark. 1985. Maternal antibody-mediated protection against gastroenteritis due to rotavirus in neonatal mice is dependent on both serotype and titer of antibody. J. Infect. Dis. 152: 1152-1158. Offit, P.A., and H.F. Clark. 1985. Protection against rotavirus-induced gastroenteritis in a murine model by passively-acquired gastrointestinal but not circulating antibodies. J. Virol. 54: 58-64. 1984 Offit, P.A., H.F. Clark, A.H. Taylor, R.G. Hess, P.A. Bachman, and S.A. Plotkin. 1984. Rotavirus-specific antibodies in fetal bovine serum and commercial preparations of serum albumin. J. Clin. Microbiol. 20: 266-270. Offit, P.A., Clark, H.F., M. Kornstein, and S.A. Plotkin. 1984. A murine model for oral infection with a primate rotavirus (simian strain SA-11). J. Virol. 51: 233-236. Offit, P.A., H.F. Clark, and S.A. Plotkin. 1983. Experimental analysis of the immune response to rotaviruses of bovine or primate origin assessed by radioimmunoassay, radioimmunoprecipitation, and plaque-reduction neutralization. Infect. Immun. 42: 293-300. 1983 Offit, P.A., H.F. Clark, W.G. Stroop, E.M. Twist, and S.A. Plotkin. 1983. The cultivation of human rotavirus, strain 'WA', to high titer in cell culture and characterization of the viral structural polypeptides. J. Virol. Methods 7: 29-40. 1982 Offit, P.A., S. Starr, P. Zolnick, and S.A. Plotkin. 1982. Acyclovir treatment in neonatal herpes simplex virus infection. Ped. Infect. Dis. 1: 253-255. Offit, P.A., J. Campos, and S.A. Plotkin. 1982. Ampicillin-resistant, beta-lactamase negative, Haemophilus influenza type b. Pediatrics 69: 230-232. 1981 Offit, P.A., G.B. Fleischer, N. Koven, and S.A. Plotkin. 1981. Severe pneumonia in Epstein-Barr virus infection. J. Adol. Health Care 2: 121-125. Books2018 Offit, P.A., 2018. Bad Advice: Or Why Celebrities, Politicians, and Activitsts Aren’t Your Best Source of Health Information, Columbia University Press, New York, NY. 2017 Offit, P. A., 2017. Pandora’s Lab: Seven Stories of Science Gone Wrong. National Geographic Press, Washington, D.C. Plotkin, S.A., Orenstein, W.A., Offit, P.A., Edwards, K. (eds.). 2017. Plotkin’s Vaccines. Saunders/Elsevier. London, UK. 2015 Offit, P. A., 2015. Bad Faith: When Religious Belief Clashes with Modern Medicine. Basic Books, New York, N.Y. 2014 Offit, P. A., 2015. Bad Faith: When Religious Belief Clashes with Modern Medicine. Basic Books, New York, N.Y. 2013 Offit, P. A. 2013. Killing Us Softly: The Sense and Nonsense of Alternative Medicine. HarperCollins UK, London, England. Offit, P.A. 2013. Do You Believe in Magic? The Sense and Nonsense of Alternative Medicine. HarperCollins, New York, N.Y. 2012 Plotkin, S.A., Orenstein, W.A., Offit, P.A. (eds.). 2012. Vaccines. Saunders/Elsevier. London, UK. 2011 Offit, P.A. 2011. Deadly Choices: How the Anti-Vaccine Movement Threatens Us All. Basic Books, New York, N.Y. Offit, P.A., Moser, C.A. 2011. Vaccines and Your Child: Separating Fact from Fiction. Columbia University Press, New York, N.Y. 2008 Plotkin, S.A., Orenstein, W.A., Offit, P.A. (eds.). 2008. Vaccines. Saunders/Elsevier. London, UK. Offit, P.A. 2008. Autism’s False Prophets: Bad Science, Risky Medicine, and the Search for a Cure. Columbia University Press, New York, N.Y. 2007 Offit, P.A. 2007. Vaccinated: One Man’s Quest to Defeat the World’s Deadliest Diseases. Smithsonian Books, New York, N.Y. 2005 Offit, P.A. 2005. The Cutter Incident: How America’s First Polio Vaccine Led to a Growing Vaccine Crisis. Yale University Press, New Haven, CT 2004 Marshall, GS, Dennehy PH, Greenberg DP, Offit PA, Tan TQ. 2004. The Vaccine Handbook: A Practical Guide for the Clinician, Lippincott Williams & Wilkens, Philadelphia, PA. 2003 Offit, P.A., and L.M. Bell. 2003. Vaccines: What You Should Know. 3rd edition. John Wiley & Sons, New York, N.Y. 1999 Offit, P.A., and L.M. Bell. 1999. Vaccines: What Every Parent Should Know. 2nd edition, Hungry Minds, New York, N.Y. Offit, P.A., Fass-Offit, B., and Bell, L.M. 1999. Breaking the Antibiotic Habit: A Parent’s Guide to Coughs, Colds, Ear Infections, and Sore Throats. John Wiley & Sons, New York, N.Y. 1998 Offit, P.A., and L.M. Bell. 1998. What Every Parent Should Know about Vaccines. Macmillan Press, New York, N.Y. Chapters 2018 Offit, P.A., Challenges to developing a rotavirus vaccine, In Viral Immunology 31 (2); March 2018 2014 Offit, P. A., “Fear of Vaccines,” In: CDC: Health Information for the International Traveler: The Yellow Book, 2014. G. W. Brunette (ed.) Oxford: Oxford University Press, 2014. 2013 Feemster, K. A., P. A. Offit, “‘Compassionate Use’ for Public Health,” Annals of Internal Medicine December 24, 2013, doi: 10.7326/M13-2927. 2012 Plotkin, S. A., P. A. Offit, F. Murphy. In Memoriam: Dr. H Fred Clark (1937-2012), Hum Vaccin Immunother 2012: 1:8. Offit, P. A. “A Look at Complementary and Alternative Medicine,” Infectious Diseases in Children, 2012;25:3. Offit, P. A. “Fear of Vaccines,” In: CDC Health Information for International Travel: The Yellow Book 2012, G. W. Brunette (ed.), Oxford: Oxford University Press, 2012. 2011 Offit, P. A., H F. Clark. Rotavirus Vaccines Part II: Raising the Bar for Vaccine Safety, in History of Vaccine Development, S. A. Plotkin (ed.), New York: Springer, 2011. 2009 Gerber, J. Offit, P.A. Vaccines and autism: a tale of shifting hypotheses, Clinical Infectious Diseases 2009;48:456-461 2008 Offit, P.A. Vaccines. 2008. In: J. M. Bergelson, S. S. Shah, and T. E. Zaoutis (eds.): Pediatric Infectious Diseases, pp. 373-384. Mosby Elsevier, Philadelphia, PA. 2006 Offit, P.A., Clark HF. A multivalent bovine-human reassortant rotavirus vaccine (RotaTeq). Pediatr Annals 2006; 35: 29-34. 2005 McMillan, J.A., Abramson, J.S., Katz, S.L., and Offit, P.A. Reducing the risk of pediatric influenza: Prevention strategies help both the young and old. Contemporary Pediatrics [in press] 2004 Ward RL, HF Clark, PA Offit, and RI Glass. 2004. Live vaccine strategies to prevent rotavirus disease. In: M.M. Levine, J.B. Kaper, R. Rappuoli, M. Liu, and M.F. Good (eds.): New Generation Vaccines, pp. 607-620. Marcel Dekker, Inc., New York, NY. 2003 Offit, P.A. 2003. The power of 'box a'. Expert Rev Vaccines 2003;2:1-3. Offit P.A., and C.J. Hackett. Multiple vaccines and the immune system. In: S.A. Plotkin and W. Orenstein (eds): Vaccines, 2003, pp. 1583-1589, 4th Edition, W.B. Saunders. Clark, H F., P.A. Offit, R.I. Glass, and RM Ward. Rotavirus vaccines. In: S.A. Plotkin and W. Orenstein (eds): Vaccines, 2003; pp. 1327-1345, 4th Edition, W.B. Saunders. Offit, PA, HF Clark, and RL Ward. Current state of development of human rotavirus vaccines. In: U. Desselberger and J. Gray (eds.): Viral Gastroenteritis, 2003; pp. 345-356, Elsevier Science BV, Amsterdam, The Netherlands. 2002 Offit, P.A. 2002. The future of rotavirus vaccines. Sem Pediatr Infect Dis 2002;13: 190-195. 2001 Macartney, K.K., and P.A. Offit. How vaccine safety is monitored before and after licensure. Pediatric Annals 2001;30:392-399. Offit, P.A. 2001. Correlates of protection against rotavirus infection and disease. In Gastroenteritis viruses. Novartis Foundation Symposium 238, pp. 106-124, Wiley, Chichester. 2000 Offit, P.A. 2000. Withdrawal of rotavirus vaccine in the USA. Vaccines: Children and Practice 3:2-3. Macartney, K.K., and P.A. Offit. 2000. Immunologic methods and correlates of protection. In: Gray, J., and Desselberger, U. (eds.): Methods in Molecular Medicine: Rotaviruses, Humana Press Inc., Totawa, New Jersey. 1999 Offit, P.A., and H F. Clark. 1999. Rotavirus vaccines, pp. 171-195. In: Ellis, R. (ed.): Combination Vaccines, 1st Edition, Humana Press, Totowa, New Jersey. Clark, H F., R.I. Glass, and P.A. Offit. 1999. Rotavirus vaccines. In: S.A. Plotkin and W. Orenstein (eds): Vaccines, pages 987-1005, 3rd Edition, W.B. Saunders. 1998 Offit, P.A., and H.F. Clark. 1998. The rotavirus vaccine. Current Opinion in Pediatrics, Lippincott, Williams and Wilkins. Offit, P.A. 1998. Rotavirus, In: F.D. Burg, J.R. Ingelfinger, and E.R. Wald, R.A. Polin (eds.): Gellis and Kagan's Current Pediatric Therapy, pages 132-133, 14th Edition, W.B. Saunders. 1997 Coffin, S.E., and P.A. Offit. 1997. New vaccines against mucosal pathogens: rotavirus and respiratory syncytial virus. Adv. Pediatr. Infect. Dis. 13: 333-348. Offit, P.A., Kapikian, A.Z., and Clark, HF. 1997. Vaccines against rotavirus. In: M.M. Levine, G.C. Woodrow, J.B. Kaper, and G.S. Cobon (eds.): New Generation Vaccines, Marcel Dekker, Inc., New York, NY, pages 659-671. 1996 Clark, HF., Offit, P.A., Ellis, R.W., Krah, D., Shaw, A.R., Eiden, J.J., Pichichero, M., and Treanor, J.J. 1996. WC3 reassortant vaccines in children: brief review. Arch. Virol. [Suppl] 12: 187-198. Conner, M.E., Estes, M.K., Offit, P.A., Clark, HF., Franco, M., Feng, N., and Greenberg, H.B. 1996. Development of a mucosal rotavirus vaccine. In: H. Kiyono, P.L. Ogra, and J.R. McGhee (eds.): Mucosal Vaccines: New Trends in Immunization, Academic Press, pp. 325-344. Offit, P.A. Viral gastroenteritis. 1996. In: A.M. Rudolph, J.I.E. Hoffman, and C.D. Rudolph (eds.): Rudolph's Pediatrics, 20th Edition, Appleton and Lange, pp. 642-643. 1995 Offit, P.A. and Clark, H.F. 1995. Vaccines for enteric viral pathogens. pp. 1471-8, In: Blaser, M.J., Smith, P.D., Ravdin, J.I., Greenberg, H.B., and Guerrant, R.L. (eds.). Infections of the Gastrointestinal Tract. Raven Press, New York, N.Y. 1994 Offit, P.A., and Clark, HF. 1994. Rotaviruses. In: Mandell, G.L., Bennett, J.E., and Dolin, R. (eds.). Principles and Practice of Infectious Diseases, pp. 1448-1455. 4th Edition, Churchill Livingstone. Offit, P.A. 1994. Rotaviruses: immunological determinants of protection against infection and disease. Advances in Virus Research 44: 161-202. Offit, P.A. 1994. Virus-specific cellular immune response to intestinal infection. pp. 89-100. In: D.A.J. Tyrell and A.Z. Kapikian (eds.): Virus infections of the gastrointestinal tract, 2nd Edition, Marcel Dekker, Inc. Clark, H F., and P.A. Offit. 1994. Rotavirus vaccines. pp. 809-822. In: S.A. Plotkin and E.A. Mortimer, Jr. (eds): Vaccines, 2nd Edition, W.B. Saunders. 1993 Offit, P.A. 1994. Immunologic determinants of protection against rotavirus challenge. Current Topics in Microbiology and Immunology, 1993;185:229-254, Springer-Verlag Publishers, Berlin, West Germany. Greenberg H.B., H.F. Clark, and P.A. Offit. 1994. Rotavirus pathology and pathophysiology. Current Topics in Microbiology and Immunology, 1993;255-283, Springer-Verlag Publishers, Berlin, West Germany. Offit, P.A. 1993. Rotavirus. In: F.D. Burg, J.R. Ingelfinger, and E.R. Wald (eds.): Gellis and Kagan's Current Pediatric Therapy, pages 652-653. 14th Edition, W.B. Saunders. 1991 Offit, P.A. 1991. Viral gastroenteritis. In: A.M. Rudolph and J.I.E. Hoffman (eds.): Rudolph's Pediatrics, 19th Edition, Appleton and Lange, 1991: 670-671. 1988 Greenberg, H.B., P.A. Offit, and R.D. Shaw. 1988. Neutralization of rotaviruses in vitro and in vivo: molecular determinants of protection and role of local immunity. pp. 319-330, In: W. Strober, M.E. Lamm, J.R. McGhee, and S.P. James (eds.): Mucosal Immunity and Infections at Mucosal Surfaces. 1986 Offit, P.A., G. Blavat, H.F. Clark, R. Shaw, and H.B. Greenberg. 1986. Role of gene segments 4 and 9 in determining rotavirus virulence and protection against rotavirus challenge. pp. 267-273, In: R.M. Chanock and R.M. Lerner (eds.): Vaccines '86: New Approaches to Immunization. Greenberg, H.B., and P.A. Offit. 1986. Gene coding assignments for rotavirus surface proteins. pp. 221-225. In: Development of Vaccines and Drugs against Diarrheal Diseases, Studentlitteratur, Lund, Sweden. 1985 Greenberg, H.B., P.A. Offit, C. Tran, A. Kapikian, W. Robinson, R. Shaw, R. Gaeta, and R. Bellamy. 1985. Vaccine strategies for the prevention of rotavirus diarrhea. pp. 447-455. In: S. Tzipori (ed.), Infectious diarrhea in the young: strategies for control in humans and animals. Elsevier Science Publishers, Amsterdam, The Netherlands. 1982 Offit, P.A., and D. Rubin. 1982. Viral diseases: infections of the gastrointestinal tract. Comprehensive Therapy 8: 21-26. Awards and Honors 2018, Theodore R. Woodward Lecture, University of Maryland School of Medicine 2018, Joseph Wiley, MD Lectureship, Sinai Hospital, Baltimore, MD 2017, Sixteenth J. Neal and Louis Middelkamp Lecture, Washington University School of Medicine 2017, Harry Wollman Lecture, Department of Anesthesia, Perelman School of Medicine at the University of Pennsylvania 2017, Roselyn Payne Epps, MD Lecture in Pediatrics and Child Health, Howard University Hospital and School of Medicine 2017, Third Annual Julius Youngner Lectureship, University of Pittsburgh School of Medicine 2016, Jonathan E. Rhoads Medal for Distinguished Service to Medicine, The American Philosophical Society 2016, 10th Annual Children’s Hospital Distinguished Lecture, Children’s Hospital of San Antonio 2016, The Porter Prize, University of Pittsburgh School of Public Health 2016, American Democracy Project Distinguished Speaker Series, SUNY Brockport, Brockport, NY 2016, S. Rexford Kennamer Distinguished Lecture Series, University of Alabama at Birmingham, Montgomery Regional Medical Campus, Montgomery, AL 2016, Emil Stratton Lectureship, University of Oklahoma Health Sciences Center, Oklahoma City, OK 2015, Eighth Annual Leo M. Evers Lecture, NYU-Langone Medical Center 2015, The Joseph B. Bilderback Lecture, Oregon Health and Science University, Portland, Oregon 2015, Christian R. and Mary F. Lindback Award for Distinguished Teaching, University of Pennsylvania 2014, 13th Annual Donald Schaffner Lecture, Children’s Healthcare of Atlanta at Scottish Rite, Atlanta, GA 2014, 7th Annual Sheldon C. Siegel Lectureship, Department of Pediatrics, UCLA School of Medicine 2014, Robert P. Balles Prize in Critical Thinking, The Committee for Skeptical Inquiry and Skeptical Inquirer Magazine 2014, Honoree, Autism Science Foundation, 5th Anniversary Celebration 2014, Visiting Professor, Department of Biology, Haverford College 2014, Visiting Professor, Department of Biology, University of Richmond 2013, Innovators in Health Award, Group Health Foundation 2013, Honor Award and Gold Key, Distinguished Alumnus Award, University of Maryland School of Medicine 2013, Maxwell Finland Award for Scientific Achievement, National Foundation for Infectious Diseases 2012, Elected to the John Morgan Society, University of Pennsylvania 2012, Drexel Medicine Prize in Translational Medicine, Drexel University College of Medicine 2012, Jonathan M. Mann Memorial Lecture, Council of State and Territorial Epidemiologists 2012, Distinguished Medical Achievement Award, The College of Physicians of Philadelphia 2012, The CSL Behring Visiting Professor, A. I. Dupont Nemours Hospital for Children 2012, Fellow, American Academy of Microbiology 2011, Inducted into the Institute of Medicine of the National Academies 2011, Board Member, The Franklin Institute 2011, Odyssey Award, Center for Medicine in the Public Interest 2011, David E. Rogers Award, American Association of Medical Colleges 2011, Humanitarian of the Year Award, Biotechnology Industries Organization (BIO) 2010, Lawrence T. Taft Memorial Lecture, Robert Wood Johnson School of Medicine 2010, 35th Hattie Alexander Memorial Lecture, Columbia University College of Physicians and Surgeons 2010, Ashley Weech Visiting Professor, Children’s Hospital of Cincinnati 2010, Ralph D. Feigin Award for Excellence, 2010, for “Outstanding Advocacy for Immunizations,” 2010, 37th Lori Haker Visiting Professor, Medical College of Wisconsin 2009, Honored by Bill and Melinda Gates at the Bill and Melinda Gates Foundation’s Living Proof Project for Global Health 2009, 16th Annual Frontiers in Vaccinology Lecture, Center for Vaccine Development, University of Maryland School of Medicine 2009, Fiser Lecturer, University of Arkansas Medical Sciences 2009, President’s Certificate for Outstanding Service, American Academy of Pediatrics 2009, William Osler Patient Oriented Research Award, University of Pennsylvania School of Medicine for the co-invention of the RotaTeq and for the creation of the Vaccine Education Center at the Children’s Hospital of Philadelphia 2009, Humanitarian of the Year Award, National Meningitis Association 2009, Dr. Charles Mérieux Award for Achievement in Vaccinology and Immunology from the National Foundation for Infectious Diseases 2008, Saul Krugman Memorial Lectureship, “The Rotavirus Vaccine: From Bench to Bedside,” New York University School of Medicine 2008, Luigi Mastroianni Clinical Innovator Award, University of Pennsylvania School of Medicine for the co-invention of RotaTeq 2008, AMWA (American Medical Writers Association) Medical Book Award, Public/Healthcare Consumer Category for “Vaccinated: One Man’s Quest to Defeat the World’s Deadliest Diseases” 2008, 16th Annual Dorothy Horstmann Lecture, Yale University School of Medicine 2008, Stanley A. Plotkin Award for Outstanding Achievement in Vaccines, Pediatric Infectious Diseases Society 2008, Stevens Distinguished Visiting Professor, LeBonheur Children’s Hospital and the University of Tennessee Medical Center 2007, Canon Ely Distinguished Professor, Boston Children’s Hospital 2006, Jonas Salk Bronze Medal from the Association for Professionals in Infection Control and Epidemiology for the co-invention of RotaTeq 2006, Gold Medal Award from the Children’s Hospital of Philadelphia for the co-invention of RotaTeq 2006, The Joseph W. Mountin Lecturer, CDC 2006, Howard Mermelstein Lecture, Children’s Hospital of Pittsburgh 2006, Jeryl Lynn Hilleman Lecture, CDC Foundation 2006, John H. Erskine Lecture in Infectious Diseases, St. Jude Children’s Research Hospital 2004, Recipient of the Maurice R. Hilleman Chair in Vaccinology from the University of Pennsylvania School of Medicine 2003, Fellow, College of Physicians of Philadelphia 2001, “Excellence in Service” Award from the Delaware Valley Immunization Coalition 1998, Elected to the Executive Committee of the Joseph Stokes, Jr. Research Institute 1997, Recipient of the Werner and Gertrude Henle Chair in Pediatric Immunologic and Infectious Diseases at the Children’s Hospital of Philadelphia 1997, Elected to the council of the Society of Pediatric Research 1991, Research Achievement Award, The Children’s Hospital of Philadelphia 1988, The University of Pennsylvania Research Foundation Award 1988, Lederle Young Investigator Award in Vaccine Development 1981, Fellow's Annual Teaching Award, The Children's Hospital of Philadelphia 1977, J. Edmund Bradley Prize for Excellence in Pediatrics, University of Maryland Medical School Editorial and Academic Positions Editorial positions 2018, Philadelphia Inquirer, Regular Contributor 2017, The Daily Beast, Weekly Columnist 2007-present, American Baby Magazine, Advisory Board 2006-present, American Council on Science and Health, Advisory Board 2006-present, Every Child By Two, Advisory Board 2005-present, Clinical and Diagnostic Laboratory Immunology, Editorial Board 2003-present, Infectious Diseases in Children, Associate Editor 1990-present, Virology, Editorial Board 1999-present, Child Magazine, Advisory Board 1999-present, Immunization Action Coalition, Advisory Board 1999-present, PKIDS, Advisory Board National Scientific Committees 2005-present, Allergy/Asthma Data Safety Monitoring Board, National Institutes for Health, National Institute for Allergy and Infectious Diseases 2018-present, Vaccine-Related Biologicals Approval Committee, Food and Drug Administration 1998-2003, Advisory Committee on Immunization Practices, Centers for Disease Control and Prevention Academic and institutional committees 2018-present, Vaccine-Related Biologicals Approval Committee, Food and Drug Administration 2008-present, The Center for Vaccine Ethics and Policy, Co-Director 2006-present, Cell and Molecular Biology Graduate Group 2005-present, Allergy/Asthma Data Safety Monitoring Board, National Institutes for Health, National Institute for Allergy and Infectious Diseases 2005-present, Graduate Program in Public Health Studies 1989-present, Molecular Biology Graduate Group 1989-present, Immunology Graduate Group Leadership and Memberships Memberships in professional organizations American Academy of Pediatrics American Association of Immunologists American Gastroenterological Association American Pediatric Society American Society for Microbiology American Society for the Advancement of Science American Society for Virology Association for the Prudent Use of Antibiotics GAVI Campaign, Board of Directors International Society for Vaccines Institute for Science in Medicine Pediatric Infectious Disease Society Philadelphia Childhood Immunization Coalition Philadelphia County Medical Society Philadelphia Pediatric Society Society for Experimental Biology and Medicine Society for Mucosal Immunology Society for Pediatric Research Union of Concerned Scientists Patient Experience Ratings About the Patient Experience Rating System The Patient Experience Rating is an average of all responses to the care provider related questions shown above from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question. Responses are measured on a scale of 1 to 5 with 5 being the best score. We are committed to true transparency. However, to ensure the comments are fair and correctly attributed, we review each one before posting to the website. We exclude entire comments that disclose patient's protected health information, are off-topic, or include other confidential or inappropriate content. Comments will appear on provider bios only if providers have a minimum number of comments. Comments are shared internally for education purposes to ensure that we are doing our very best for the patients and families for whom we are privileged to care. The comments are submitted by patients and families and reflect their views and opinions. The comments are not endorsed by and do not reflect the views of Children’s Hospital of Philadelphia.