Jordan S. Orange, MD, PhD, FAAP

Jordan S. Orange, MD, PhD, FAAP

Areas of Expertise: NEMO, NK Cell Deficiencies, Wiskott-Aldrich Syndrome
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

Brown University, Providence, RI

Internship

The Children's Hospital of Philadelphia, Philadelphia, PA

Residency

The Children's Hospital of Philadelphia, Philadelphia, PA

Fellowship

Children's Hospital, Boston, MA

Board Certification

Allergy and Immunology
Pediatrics

Titles and Academic Titles

Attending Physician

Publications

Papers

Yatherajam G, Banerjee PP, McCorkell KA, Solt LA, Hanson EP, Madge LA, Kang S, Worley PF, Orange JS, May MJ. Cutting edge: association with IkappaB kinase beta regulates the subcellular localization of Homer3. J Immunol. 2010 Sep 1;185(5):2665-9. Epub 2010 Aug 6. Read abstract.

Yu D, dos Santos CO, Zhao G, Jiang J, Amigo JD, Khandros E, Dore LC, Yao Y, D'Souza J, Zhang Z, Ghaffari S, Choi J, Friend S, Tong W, Orange JS, Paw BH, Weiss MJ. miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta. Genes Dev. 2010 Aug 1;24(15):1620-33. Read abstract.

Orange JS, Grossman WJ, Navickis RJ, Wilkes MM. Impact of trough IgG on pneumonia incidence in primary immunodeficiency: A meta-analysis of clinical studies. Clin Immunol. 2010 Jul 30. [Epub ahead of print] Read abstract.

Roy-Ghanta S, Orange JS. Use of cytokine therapy in primary immunodeficiency. Clin Rev Allergy Immunol. 2010 Feb;38(1):39-53. Review. Read abstract

Banerjee PP, Orange JS. Quantitative measurement of F-actin accumulation at the NK cell immunological synapse. J Immunol Methods. 2010 Apr 15;355(1-2):1-13. Epub 2010 Feb 19. Read abstract

Wang HY, Gopalan V, Aksentijevich I, Yeager M, Ma CA, Mohamoud YA, Quinones M, Matthews C, Boland J, Niemela JE, Torgerson TR, Giliani S, Uzel G, Orange JS, Shapiro R, Notarangelo L, Ochs HD, Fleisher T, Kastner D, Chanock SJ, Jain A. A custom 148 gene-based resequencing chip and the SNP explorer software: new tools to study antibody deficiency. Hum Mutat. 2010 Sep;31(9):1080-8. Read abstract.

Pien GC, Basner-Tschakarjan E, Hui DJ, Mentlik AN, Finn JD, Hasbrouck NC, Zhou S, Murphy SL, Maus MV, Mingozzi F, Orange JS, High KA. Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors. J Clin Invest. 2009 Jun;119(6):1688-95. doi: 10.1172/JCI36891. Epub 2009 May 11. Read abstract.

Devora GA, Sun L, Chen Z, van Oers NS, Hanson EP, Orange JS, de la Morena MT. A Novel Missense Mutation in the Nuclear Factor-kappaB Essential Modulator (NEMO) Gene Resulting in Impaired Activation of the NF-kappaB Pathway and a Unique Clinical Phenotype Presenting as MRSA Subdural Empyema. J Clin Immunol. 2010 Jul 23. [Epub ahead of print] Read abstract.

Orange JS. Latent herpesviruses: aligning human and murine NK cells. Blood. 2010 Jun 3;115(22):4321-2. No abstract available.

Hagan JB, Fasano MB, Spector S, Wasserman RL, Melamed I, Rojavin MA, Zenker O, Orange JS. Efficacy and Safety of a New 20% Immunoglobulin Preparation for Subcutaneous Administration, IgPro20, in Patients With Primary Immunodeficiency. J Clin Immunol. 2010 Sep;30(5):734-45. Epub 2010 May 8. Read abstract.

Mentlik AN, Sanborn KB, Holzbaur EL, Orange JS. Rapid lytic granule convergence to the MTOC in natural killer cells is dependent on dynein but not cytolytic commitment. Mol Biol Cell. 2010 Jul;21(13):2241-56. Epub 2010 May 5. Read abstract.

Yong PL, Orange JS, Sullivan KE. Pediatric common variable immunodeficiency: immunologic and phenotypic associations with switched memory B cells. Pediatr Allergy Immunol. 2010 Aug;21(5):852-8. Epub 2010 Mar 19. Read abstract.

Sanborn KB, Orange JS. Navigating barriers: the challenge of directed secretion at the natural killer cell lytic immunological synapse. J Clin Immunol. 2010 May;30(3):358-63. Epub 2010 Feb 27. Read abstract.

Banerjee PP, Orange JS. Quantitative measurement of F-actin accumulation at the NK cell immunological synapse. J Immunol Methods. 2010 Apr 15;355(1-2):1-13. Epub 2010 Feb 19. Read abstract.

Sanborn KB, Rak GD, Mentlik AN, Banerjee PP, Orange JS. Analysis of the NK cell immunological synapse. Methods Mol Biol. 2010;612:127-48. Read abstract.

Sleiman PM, Flory J, Imielinski M, Bradfield JP, Annaiah K, Willis-Owen SA, Wang K, Rafaels NM, Michel S, Bonnelykke K, Zhang H, Kim CE, Frackelton EC, Glessner JT, Hou C, Otieno FG, Santa E, Thomas K, Smith RM, Glaberson WR, Garris M, Chiavacci RM, Beaty TH, Ruczinski I, Orange JM, Allen J, Spergel JM, Grundmeier R, Mathias RA, Christie JD, von Mutius E, Cookson WO, Kabesch M, Moffatt MF, Grunstein MM, Barnes KC, Devoto M, Magnusson M, Li H, Grant SF, Bisgaard H, Hakonarson H. Variants of DENND1B associated with asthma in children. N Engl J Med. 2010 Jan 7;362(1):36-44. Epub 2009 Dec 23. Erratum in: N Engl J Med. 2010 Sep 2;363(10):994. Read abstract.