Abdulmalik Osheiza, DVM

2026

Traxler EA, Hotan Q, Shao Y, Komar C, Chen Q, Saari MS, Thrasher AJ, Yang S, Qin K, Wang M, Peslak SA, Abdulmalik O, Giardine BM, Keller CA, Hardison RC, Minn AJ, Khandros E, Shi J, Blobel GA. Optimized CRISPR-Cas12a genome-wide screen reveals PTPA phosphatase pathway in fetal hemoglobin silencing. Blood. Jan 2026. 

Bagchi A, Billakanti S, Shehu V, Farrell KM, Cotteta SA, Godfrey BN, Alpert M, Flores Zeranski J, Budinich KA, Geng Z, Abdulmalik O, Giardine BM, Keller CA, Hardison RC, Shi J, Khandros E. Highly discriminative globin gene activation by the noncanonical BAF chromatin remodeling complex. Blood. Feb 2026;147(6):675-688. 

Kaminski PJ, Min K, Traxler EA, Khandros E, Abdulmalik O, Godfrey B, Keller CA, Giardine BM, Hardison RC, Shi J, Blobel GA. Dissecting polycomb complexes for enhanced fetal hemoglobin production. Blood. Accepted April 2026.

2025

Omar AM, El-Araby ME, Ahmed TA, Donkor AK, Opare A, Ghatge MS, Aljahdali AS, Alhashimi RT, Robinson TN, Balogun B, Macias M, Roland S, Zhang Y, Musayev FN, Abdulmalik O, Safo MK.: Potent Antisickling Furaldehyde Analogs for Acute Sickle Cell Therapy: Enhanced Efficacy and Intravenous Formulation Potential.  ChemMedChem. 2025 Nov 18;20(22) 

2024

Pavani G, Klein JG, Nations CC, Sussman JH, Tan K, An HH, Abdulmalik O, Thom CS, Gearhart PA, Willett CM, Maguire JA, Chou ST, French DL, Gadue P.: Modeling primitive and definitive erythropoiesis with induced pluripotent stem cells. Blood Adv 8: 1449-1463, Mar 2024. 

Chappell ME, Breda L, Tricoli L, Guerra A, Jarocha DJ, Castruccio Castracani C, Papp TE, Tanaka N, Hamilton N, Triebwasser MP, Ghiaccio V, Fedorky M, Gollomp K, Bochenek V, Roche AM, Everett JK, Cook EJ, Bushman FD, Teawtrakul N, Glentis S, Kattamis A Prof, Mui BL, Tam YK, Weissman D, Abdulmalik O, Parhiz H, Rivella S.: Use of HSC Targeted LNP to Generate a Mouse Model of Lethal α-Thalassemia and Treatment via Lentiviral Gene Therapy. Blood Jul 2024.

Riley JS, Berkowitz CL, Luks VL, Dave A, Cyril-Olutayo MC, Pogoriler J, Flake AW, Abdulmalik O, Peranteau WH.: Immune modulation permits tolerance and engraftment in a murine model of late-gestation transplantation. Blood Adv 8: 4523-4538, Sep 2024. 85. Dowd S, Sharo C, Abdulmalik O, Elmer J.: Optimizing the lyophilization of Lumbricus terrestris erythrocruorin. Artif Cells Nanomed Biotechnol 2024. 

2023

Peslak SA, Demirci S, Chandra V, Ryu B, Bhardwaj SK, Jiang J, Rupon JW, Throm RE, Uchida N, Leonard A, Essawi K, Bonifacino AC, Krouse AE, Linde NS, Donahue RE, Ferrara F, Wielgosz M, Abdulmalik O, Hamagami N, Germino-Watnick P, Le A, Chu R, Hinds M, Weiss MJ, Tong W, Tisdale JF, Blobel GA.: Forced enhancer-promoter rewiring to alter gene expression in animal models. Mol Ther Nucleic Acids 31: 452-465, Jan 2023. 

Xu X, Ghatge MS, Huang B, Alghamdi A, Wang H, Pierce BD, Abdulmalik O, Zhang Y, Safo MK, Venitz J.: Quantitative assessment of the in-vitro binding kinetics of antisickling aromatic aldehydes with hemoglobin A: A universal HPLC-UV/Vis method to quantitate Schiff-base adduct formation. J Pharm Biomed Anal 223: 115152, Jan 2023. 

Qin K, Lan X, Huang P, Saari MS, Khandros E, Keller CA, Giardine B, Abdulmalik O, Shi J, Hardison RC, Blobel GA.: Molecular basis of polycomb group protein-mediated fetal hemoglobin repression. Blood 141: 2756-2770, Jun 2023.

Breda L, Papp TE, Triebwasser MP, Yadegari A, Fedorky MT, Tanaka N, Abdulmalik O, Pavani G, Wang Y, Grupp SA, Chou ST, Ni H, Mui BL, Tam YK, Weissman D, Rivella S, Parhiz H.: In vivo hematopoietic stem cell modification by mRNA delivery. Science 381: 436-443, Jul 2023. 

Omar AM, Abdulmalik O, El-Say KM, Ghatge MS, Cyril-Olutayo M, Paredes S, Al-Awadh M, El-Araby ME, Safo MK.: Targeted modification of furan-2-carboxaldehydes into Michael acceptor analogs yielded long-acting hemoglobin modulators with dual antisickling activities. Chem Biol Drug Des Oct 2023. 

Alhashimi, RT,  Ahmed, TA,  Alghanem, L,  Pagare, PP,  Huang, BS,  Ghatge, MS,  Omar, AM,  Abdulmalik, O,  Zhang, Y,  Safo, MK: Design, Synthesis, and Antisickling Investigation of a Thiazolidine Prodrug of TD-7 That Prolongs the Duration of Action of Antisickling Aromatic Aldehyde. Pharmaceutics 15(11), NOV 2023. 

2022

Chow PH, Cox CD, Pei JV, Anabaraonye N, Nourmohammadi S, Henderson SW, Martinac B, Abdulmalik O, Yool AJ.: Inhibition of the Aquaporin-1 Cation Conductance by Selected Furan Compounds Reduces Red Blood Cell Sickling. Front Pharmacol 12: 794791, Jan 2022. 

Abdulmalik O, Darwish NHE, Muralidharan-Chari V, Taleb MA, Mousa SA.: Sulfated non-anticoagulant heparin derivative modifies intracellular hemoglobin, inhibits cell sickling in vitro, and prolongs survival of sickle cell mice under hypoxia. Haematologica 107: 532-540, Feb 2022. 

Xu P, Chen C, Zhang Y, Dzieciatkowska M, Brown BC, Zhang W, Xie T, Abdulmalik O, Song A, Tong C, Qi H, Roach R, Kellems RE, D'Alessandro A, Xia Y.: Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis. Cell Metab 34: 299-316, Feb 2022. 

Alhashimi RT, Ghatge MS, Donkor AK, Deshpande TM, Anabaraonye N, Alramadhani D, Danso-Danquah R, Huang B, Zhang Y, Musayev FN, Abdulmalik O, Safo MK.: Design, Synthesis, and Antisickling Investigation of a Nitric Oxide-Releasing Prodrug of 5HMF for the Treatment of Sickle Cell Disease. Biomolecules 12: 696, May 2022. 

An HH, Gagne AL, Maguire JA, Pavani G, Abdulmalik O, Gadue P, French DL, Westhoff CM, Chou ST.: The use of pluripotent stem cells to generate diagnostic tools for transfusion medicine. Blood 140: 1723-1734, Oct 2022. 

Huang B, Ghatge MS, Donkor AK, Musayev FN, Deshpande TM, Al-Awadh M, Alhashimi RT, Zhu H, Omar AM, Telen MJ, Zhang Y, McMahon TJ, Abdulmalik O, Safo MK.: Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease. Molecules 27: 6835, Oct 2022. 

Huang P, Peslak SA, Ren R, Khandros E, Qin K, Keller CA, Giardine B, Bell HW, Lan X, Sharma M, Horton JR, Abdulmalik O, Chou ST, Shi J, Crossley M, Hardison RC, Cheng X, Blobel GA.: HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription. Nat Genet 2022. 

Qin K, Huang P, Feng R, Keller CA, Peslak SA, Khandros E, Saari MS, Lan X, Mayuranathan T, Doerfler PA, Abdulmalik O, Giardine B, Chou ST, Shi J, Hardison RC, Weiss MJ, Blobel GA.: Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells. Nat Genet 2022. 

Wakabayashi A, Kihiu M, Sharma M, Thrasher AJ, Saari MS, Quesnel-Vallières M, Abdulmalik O, Peslak SA, Khandros E, Keller CA, Giardine BM, Barash Y, Hardison RC, Shi J, Blobel GA.: Identification and characterization of RBM12 as a novel regulator of fetal hemoglobin expression. Blood Adv 6: 5956-5968, Dec 2022. 

2021

Lan X, Ren R, Feng R, Ly LC, Lan Y, Zhang Z, Aboreden N, Qin K, Horton JR, Grevet JD, Mayuranathan T, Abdulmalik O, Keller CA, Giardine B, Hardison RC, Crossley M, Weiss MJ, Cheng X, Shi J, Blobel GA.: ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression. Mol Cell 81: 239-254, Jan 2021. 

Breda L, Ghiaccio V, Tanaka N, Jarocha D, Ikawa Y, Abdulmalik O, Dong A, Casu C, Raabe TD, Shan X, Danet-Desnoyers GA, Doto AM, Everett J, Bushman FD, Radaelli E, Assenmacher CA, Tarrant JC, Hoepp N, Kurita R, Nakamura Y, Guzikowski V, Smith-Whitley K, Kwiatkowski JL, Rivella S.: Lentiviral vector ALS20 yields high hemoglobin levels with low genomic integrations for treatment of beta-globinopathies. Mol Ther 29: 1625-1638, Apr 2021. 

Dong, A,  Ghiaccio, V,  Motta, I,  Guo, SL,  Peralta, R,  Freier, SM,  Watt, A, Damle, S,  Ikawa, Y,  Jarocha, D,  Chappell, M,  Stephanou, C,  Delbini, P, Chen, C,  Christou, S,  Kleanthous, M,  Smith-Whitley, K,  Manwani, D, Casu, C,  Abdulmalik, O,  Cappellini, MD,  Rivella, S,  Breda, L: 2′-O-methoxyethyl splice-switching oligos correct splicing from IVS2-745 β-thalassemia patient cells restoring hemoglobin A production and chain rebalance. Haematologica 106(5): 1433-1442, MAY 2021. 

Ahmed TA, El-Say KM, Abd-Allah FI, Omar AM, El-Araby ME, Muhammad YA, Pagare PP, Zhang Y, Mohmmad KA, Abdulmalik O, Safo MK.: Improving the Solubility and Oral Bioavailability of a Novel Aromatic Aldehyde Antisickling Agent (PP10) for the Treatment of Sickle Cell Disease. Pharmaceutics 13: 1148, Jul 2021. 

Pires Lourenco S, Jarocha D, Ghiaccio V, Guerra A, Abdulmalik O, La P, Zezulin A, Smith-Whitley K, Kwiatkowski JL, Guzikowski V, Nakamura Y, Raabe T, Breda L, Rivella S.: Inclusion of a short hairpin RNA targeting BCL11A into a β-globin expressing vector allows concurrent synthesis of curative adult and fetal hemoglobin. Haematologica 106: 2740-2745, Oct 2021. 

Tutwiler V, Litvinov RI, Protopopova A, Nagaswami C, Villa C, Woods E, Abdulmalik O, Siegel DL, Russell JE, Muzykantov VR, Lam WA, Myers DR, Weisel JW.: Pathologically stiff erythrocytes impede contraction of blood clots: Reply to comment. J Thromb Haemost 2021.

Tutwiler V, Litvinov RI, Protopopova A, Nagaswami C, Villa C, Woods E, Abdulmalik O, Siegel DL, Russell JE, Muzykantov VR, Lam WA, Myers DR, Weisel JW.: Pathologically stiff erythrocytes impede contraction of blood clots. J Thromb Haemost 2021. 

2020

Khandros E, Huang P, Peslak SA, Sharma M, Abdulmalik O, Giardine BM, Zhang Z, Keller CA, Hardison RC, Blobel GA.: Understanding heterogeneity of fetal hemoglobin induction through comparative analysis of F and A erythroblasts. Blood 135: 1957-1968, May 2020. 

Huang P, Peslak SA, Lan X, Khandros E, Yano JA, Sharma M, Keller CA, Giardine B, Qin K, Abdulmalik O, Hardison RC, Shi J, Blobel GA.: The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression. Blood 135: 2121-2132, Jun 2020. 

Timm B, Abdulmalik O, Chakrabarti A, Elmer J.: Purification of Lumbricus terrestris erythrocruorin (LtEc) with anion exchange chromatography. J Chromatogr B Analyt Technol Biomed Life Sci 1150: 122162, Aug 2020. 

Peslak SA, Khandros E, Huang P, Lan X, Geronimo CL, Grevet JD, Abdulmalik O, Zhang Z, Giardine BM, Keller CA, Shi J, Hardison RC, Blobel GA.: HRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation. Blood Adv 4: 4560-4572, Sep 2020. 

Abdulmalik O, Pagare PP, Huang B, Xu GG, Ghatge MS, Xu X, Chen Q, Anabaraonye N, Musayev FN, Omar AM, Venitz J, Zhang Y, Safo MK.: VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions. Sci Rep 10: 20277, Nov 2020. 

Omar AM, Abdulmalik O, Ghatge MS, Muhammad YA, Paredes SD, El-Araby ME, Safo MK.: An Investigation of Structure-Activity Relationships of Azolylacryloyl Derivatives Yielded Potent and Long-Acting Hemoglobin Modulators for Reversing Erythrocyte Sickling. Biomolecules 10: 1508, Nov 2020. 

Jaffey JA, Reading NS, Abdulmalik O, Kreisler R, Bullock G, Wiest A, Villani NA, Mhlanga-Mutangadura T, Johnson GS, Cohn LA, Isaza N, Harvey JW, Giger U.:Clinical, metabolic, and molecular genetic characterization of hereditary methemoglobinemia caused by cytochrome b(5) reductase deficiency in 30 dogs. Sci Rep 10: 21399, Dec 2020. 

Pagare PP, Ghatge MS, Chen Q, Musayev FN, Venitz J, Abdulmalik O, Zhang Y, Safo MK.: Exploration of Structure-Activity Relationship of Aromatic Aldehydes Bearing Pyridinylmethoxy-Methyl Esters as Novel Antisickling Agents. J Med Chem 63: 14724-14739, Dec 2020.

2019

Dong A, Ghiaccio V, Motta I, Guo S, Peralta R, Freier SM, Watt A, Damle S, Ikawa Y, Jarocha D, Chappell M, Stephanou C, Delbini P, Chen C, Christou S, Kleanthous M, Smith-Whitley K, Manwani D, Casu C, Abdulmalik O, Cappellini MD, Rivella S, Breda L.: 2'-O-methoxyethyl splice-switching oligos correct splicing from IVS2-745 β-thalassemia patient cells restoring HbA production and chain rebalance. Haematologica 106: 1433-1442, May 2019. 

Lan X, Khandros E, Huang P, Peslak SA, Bhardwaj SK, Grevet JD, Abdulmalik O, Wang H, Keller CA, Giardine B, Baeza J, Duffner ER, El Demerdash O, Wu XS, Vakoc CR, Garcia BA, Hardison RC, Shi J, Blobel GA.: The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells. Blood Adv 3: 1586-1597, May 2019. 

Omar AM, David T, Pagare PP, Ghatge MS, Chen Q, Mehta A, Zhang Y, Abdulmalik O, Naghi AH, El-Araby ME, Safo MK.: Structural modification of azolylacryloyl derivatives yields a novel class of covalent modifiers of hemoglobin as potential antisickling agents. Medchemcomm 10: 1900-1906, Aug 2019. 

Jaffey JA, Reading NS, Giger U, Abdulmalik O, Buckley RM, Johnstone S, Lyons LA; 99 Lives Cat Genome Consortium.: Clinical, metabolic, and genetic characterization of hereditary methemoglobinemia caused by cytochrome b(5) reductase deficiency in cats. J Vet Intern Med 2019. 

Mejaddam AY, Hornick MA, McGovern PE, Baumgarten HD, Lawrence KM, Rossidis AC, Hwang G, Young K, Abdulmalik O, Partridge EA, Peranteau WH, Davey MG, Flake AW.: Erythropoietin Prevents Anemia and Transfusions in Extremely Premature Lambs Supported by an EXTrauterine Environment for Neonatal Development (EXTEND). Fetal Diagn Ther 2019. 

Rab MAE, van Oirschot BA, Bos J, Merkx TH, van Wesel ACW, Abdulmalik O, Safo MK, Versluijs BA, Houwing ME, Cnossen MH, Riedl J, Schutgens REG, Pasterkamp G, Bartels M, van Beers EJ, van Wijk R.: Rapid and reproducible characterization of sickling during automated deoxygenation in sickle cell disease patients. Am J Hematol 2019. 

Vasiliadou E, Karakitsou V, Kazakos G, Oikonomidis IL, Tsouloufi TK, Kosmas P, Abdulmalik OY, Koutinas C, Giger U, Mylonakis ME.: Hereditary methemoglobinemia in a cyanotic cat presented for ovariohysterectomy. Can Vet J 2019. 

2018

Nakagawa A, Ferrari M, Schleifer G, Cooper MK, Liu C, Yu B, Berra L, Klings ES, Safo RS, Chen Q, Musayev FN, Safo MK, Abdulmalik O, Bloch DB, Zapol WM.: A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells. Mol Pharm 15: 1954-1963, May 2018. 

Pagare PP, Ghatge MS, Musayev FN, Deshpande TM, Chen Q, Braxton C, Kim S, Venitz J, Zhang Y, Abdulmalik O, Safo MK.: Rational design of pyridyl derivatives of vanillin for the treatment of sickle cell disease. Bioorg Med Chem 26: 2530-2538, May 2018. 

Grevet JD, Lan X, Hamagami N, Edwards CR, Sankaranarayanan L, Ji X, Bhardwaj SK, Face CJ, Posocco DF, Abdulmalik O, Keller CA, Giardine B, Sidoli S, Garcia BA, Chou ST, Liebhaber SA, Hardison RC, Shi J, Blobel GA.: Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells. Science 361: 285-290, Jul 2018. 

Deshpande TM, Pagare PP, Ghatge MS, Chen Q, Musayev FN, Venitz J, Zhang Y, Abdulmalik O, Safo MK.: Rational modification of vanillin derivatives to stereospecifically destabilize sickle hemoglobin polymer formation. Acta Crystallogr D Struct Biol 74: 956-964, Oct 2018. 

Casu C, Presti VL, Oikonomidou PR, Melchiori L, Abdulmalik O, Ramos P, Rivella S.: Short-term administration of JAK2 inhibitors reduces splenomegaly in mouse models of β-thalassemia intermedia and major. Haematologica 2018. 

Muzzelo C, Neely C, Shah P, Abdulmalik O, Elmer J.: Prolonging the shelf life of Lumbricus terrestris erythrocruorin for use as a novel blood substitute. Artif Cells Nanomed Biotechnol 2018. 

Rajesh A, Zimmerman D, Spivack K, Abdulmalik O, Elmer J.: Glutaraldehyde cross-linking increases the stability of Lumbricus terrestris erythrocruorin. Biotechnol Prog 2018. 

Rodríguez-Soto AE, Abdulmalik O, Langham MC, Schwartz N, Lee H, Wehrli FW.: T(2) -prepared balanced steady-state free precession (bSSFP) for quantifying whole-blood oxygen saturation at 1.5T. Magn Reson Med 2018. 

Rodríguez-Soto AE, Langham MC, Abdulmalik O, Englund EK, Schwartz N, Wehrli FW.: MRI quantification of human fetal O(2) delivery rate in the second and third trimesters of pregnancy. Magn Reson Med 2018. 

Spivack K, Tucker M, Zimmerman D, Nicholas M, Abdulmalik O, Comolli N, Elmer J.: Increasing the stability of Lumbricus terrestris erythrocruorin via poly(acrylic acid) conjugation. Artif Cells Nanomed Biotechnol 2018. 

2017

Zimmerman D, DiIusto M, Dienes J, Abdulmalik O, Elmer JJ.: Direct comparison of oligochaete erythrocruorins as potential blood substitutes. Bioeng Transl Med 2: 212-221, Jul 2017. 

Xu GG, Pagare PP, Ghatge MS, Safo RP, Gazi A, Chen Q, David T, Alabbas AB, Musayev FN, Venitz J, Zhang Y, Safo MK, Abdulmalik O.: Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease. Mol Pharm 14: 3499-3511, Oct 2017. 

Sun K, D'Alessandro A, Ahmed MH, Zhang Y, Song A, Ko TP, Nemkov T, Reisz JA, Wu H, Adebiyi M, Peng Z, Gong J, Liu H, Huang A, Wen YE, Wen AQ, Berka V, Bogdanov MV, Abdulmalik O, Han L, Tsai AL, Idowu M, Juneja HS, Kellems RE, Dowhan W, Hansen KC, Safo MK, Xia Y.: Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease. Sci Rep 7: 15281, Nov 2017. 

2016

Breda L, Motta I, Lourenco S, Gemmo C, Deng W, Rupon JW, Abdulmalik OY, Manwani D, Blobel GA, Rivella S.: Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers. Blood 128: 1139-43, Aug 2016. 

Omar AM, Mahran MA, Ghatge MS, Bamane FH, Ahmed MH, El-Araby ME, Abdulmalik O, Safo MK.: Aryloxyalkanoic Acids as Non-Covalent Modifiers of the Allosteric Properties of Hemoglobin. Molecules 21: 1057, Aug 2016. 30. Ghatge MS, Ahmed MH, Omar AS, Pagare PP, Rosef S, Kellogg GE, Abdulmalik O, Safo MK.: Crystal structure of carbonmonoxy sickle hemoglobin in R-state conformation. J Struct Biol 2016.

Zimmerman D, Dienes J, Abdulmalik O, Elmer JJ.: Purification of diverse hemoglobins by metal salt precipitation. Protein Expr Purif 2016. 

2015

Omar AM, Mahran MA, Ghatge MS, Chowdhury N, Bamane FH, El-Araby ME, Abdulmalik O, Safo MK.: Identification of a novel class of covalent modifiers of hemoglobin as potential antisickling agents. Org Biomol Chem 13: 6353-70, Jun 2015. 

Peranteau WH, Hayashi S, Abdulmalik O, Chen Q, Merchant A, Asakura T, Flake AW.: Correction of murine hemoglobinopathies by prenatal tolerance induction and postnatal nonmyeloablative allogeneic BM transplants. Blood 126: 1245-54, Sep 2015. 

Xu GG, Deshpande TM, Ghatge MS, Mehta AY, Omar AS, Ahmed MH, Venitz J, Abdulmalik O, Zhang Y, Safo MK.: Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Prodrugs as Drug Candidates for the Treatment of Ischemic Disorders: Insights into NO-Releasing Prodrug Biotransformation and Hemoglobin-NO Biochemistry. Biochemistry 54: 7178-92, Dec 2015.

2014

Nakagawa A, Lui FE, Wassaf D, Yefidoff-Freedman R, Casalena D, Palmer MA, Meadows J, Mozzarelli A, Ronda L, Abdulmalik O, Bloch KD, Safo MK, Zapol WM.: Identification of a small molecule that increases hemoglobin oxygen affinity and reduces SS erythrocyte sickling. ACS Chem Biol 9: 2318-25, Oct 2014. 

Zhang Y, Berka V, Song A, Sun K, Wang W, Zhang W, Ning C, Li C, Zhang Q, Bogdanov M, Alexander DC, Milburn MV, Ahmed MH, Lin H, Idowu M, Zhang J, Kato GJ, Abdulmalik OY, Zhang W, Dowhan W, Kellems RE, Zhang P, Jin J, Safo M, Tsai AL, Juneja HS, Xia Y.: Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression. J Clin Invest 2014.

2013

Safo MK, Ko TP, Abdulmalik O, He Z, Wang AH, Schreiter ER, Russell JE.: Structure of fully liganded Hb ζ2β2s trapped in a tense conformation. Acta Crystallogr D Biol Crystallogr 2013. 

2012

Abdulmalik, O,  Lombardi, AA,  Russell, JE: A Reverse Time-Course Method for Transcriptional Chase Analyses of mRNA Half-Lives in Cultured Cells. Plos One 7(7), JUL 13 2012. 

Abdulmalik O, Lombardi AA, Russell JE.: A reverse time-course method for transcriptional chase analyses of mRNA half-lives in cultured cells. PLoS One 2012. 20. Gultekin GI, Raj K, Foureman P, Lehman S, Manhart K, Abdulmalik O, Giger U.: Erythrocytic pyruvate kinase mutations causing hemolytic anemia, osteosclerosis, and secondary hemochromatosis in dogs. J Vet Intern Med 2012. 

Jain V, Abdulmalik O, Propert KJ, Wehrli FW.: Investigating the magnetic susceptibility properties of fresh human blood for noninvasive oxygen saturation quantification. Magn Reson Med 2012. 

2011

Crowley MA, Mollan TL, Abdulmalik OY, Butler AD, Goodwin EF, Sarkar A, Stolle CA, Gow AJ, Olson JS, Weiss MJ.: A hemoglobin variant associated with neonatal cyanosis and anemia. N Engl J Med 364: 1837-43, May 2011. 

Crowley, MA,  Mollan, TL,  Abdulmalik, OY,  Butler, AD,  Goodwin, EF, Sarkar, A,  Stolle, CA,  Gow, AJ,  Olson, JS,  Weiss, MJ: A Hemoglobin Variant Associated with Neonatal Cyanosis and Anemia. New England Journal Of Medicine 364(19): 1837-1843, MAY 12 2011. 

Abdulmalik O, Ghatge MS, Musayev FN, Parikh A, Chen Q, Yang J, Nnamani I, Danso-Danquah R, Eseonu DN, Asakura T, Abraham DJ, Venitz J, Safo MK.: Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin. Acta Crystallogr D Biol Crystallogr 2011. 

Abdulmalik, O,  Ghatge, MS,  Musayev, FN,  Parikh, A,  Chen, QK,  Yang, JS, Nnamani, I,  Danso-Danquah, R,  Eseonu, DN,  Asakura, T,  Abraham, DJ, Venitz, J,  Safo, MK: Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin (vol D67, pg 920, 2011). Acta Crystallographica Section D-biological Crystallography 67: 1076, DEC 2011. 

Guest EM, Neville KA, Hoyer JD, Safo MK, Garg U, Saunders CJ, Abdulmalik O, Zwick DL.: Hb Lake Tapawingo [α46(CE4)Pheu8594Ser; HBA2:c.140T>C]: a new unstable α chain hemoglobin variant associated with low systemic arterial saturation. Hemoglobin 2011. 

Guest, EM,  Neville, KA,  Hoyer, JD,  Safo, MK,  Garg, U,  Saunders, CJ, Abdulmalik, O,  Zwick, DL: Hb LAKE TAPAWINGO [α46(CE4)Pheu8594Ser; HBA2:c.140T>C]: A NEW UNSTABLE α CHAIN HEMOGLOBIN VARIANT ASSOCIATED WITH LOW SYSTEMIC ARTERIAL SATURATION. Hemoglobin 35(4): 411-416, 2011.

2010

Abdulmalik, O,  Safo, MK,  Seeholzer, SH,  Asakura, T,  Hasbrouck, NC, Russell, JE: Hb Baden: Structural and functional characterization. American Journal Of Hematology 85(11): 848-852, NOV 2010. 11. Abdulmalik O, Safo MK, Seeholzer SH, Asakura T, Hasbrouck NC, Russell JE.: Hb Baden: structural and functional characterization. Am J Hematol 2010. 

2008

Nnamani IN, Joshi GS, Danso-Danquah R, Abdulmalik O, Asakura T, Abraham DJ, Safo MK.: Pyridyl derivatives of benzaldehyde as potential antisickling agents. Chem Biodivers 2008.

2007

Yu X, Kong Y, Dore LC, Abdulmalik O, Katein AM, Zhou S, Choi JK, Gell D, Mackay JP, Gow AJ, Weiss MJ.: An erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis. J Clin Invest 2007. 

2005

Abdulmalik O, Safo MK, Chen Q, Yang J, Brugnara C, Ohene-Frempong K, Abraham DJ, Asakura T.: 5-hydroxymethyl-2-furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cells. Br J Haematol 2005. 

Safo MK, Abdulmalik O, Lin HR, Asakura T, Abraham DJ.: Structures of R- and T-state hemoglobin Bassett: elucidating the structural basis for the low oxygen affinity of a mutant hemoglobin. Acta Crystallogr D Biol Crystallogr 2005. 

2004

Safo MK, Abdulmalik O, Danso-Danquah R, Burnett JC, Nokuri S, Joshi GS, Musayev FN, Asakura T, Abraham DJ.: Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds. J Med Chem 47: 4665-76, Sep 2004. 

Abdulmalik, O,  Safo, MK,  Lerner, NB,  Ochotorena, J,  Daikhin, E,  Lakka, VG, Santacroce, R,  Abraham, DJ,  Asakura, T: Characterization of hemoglobin Bassett (α94Aspu8594Ala), a variant with very low oxygen affinity. American Journal Of Hematology 77(3): 268-276, NOV 2004. 

Abdulmalik O, Safo MK, Lerner NB, Ochotorena J, Daikhin E, Lakka V, Santacroce R, Abraham DJ, Asakura T.: Characterization of hemoglobin bassett (alpha94Asp-->Ala), a variant with very low oxygen affinity. Am J Hematol 2004. 

Zhang C, Li X, Lian L, Chen Q, Abdulmalik O, Vassilev V, Lai CS, Asakura T.: Anti-sickling effect of MX-1520, a prodrug of vanillin: an in vivo study using rodents. Br J Haematol 2004. 

2003

Hayashi S, Abdulmalik O, Peranteau WH, Ashizuka S, Campagnoli C, Chen Q, Horiuchi K, Asakura T, Flake AW.: Mixed chimerism following in utero hematopoietic stem cell transplantation in murine models of hemoglobinopathy. Exp Hematol 2003. 

2025

Fleischman, A., D. Light, K. Gollomp, C. Field, B. Balogun, T. Ruggiero, M. Macias, S. Ismail, S. Sun, C. Brown, M. Safo and O. Abdulmalik (2025). Direct hemoglobin S polymerization inhibitor MCP435 completely halts ongoing disease pathophysiology in transgenic sickle cell disease mice. 67th ASH Annual Meeting and Exposition. Blood 146(Supplement 1): 2932-2932. 

2024

Abdulmalik, Osheiza; Safo, Martin, Light, David; Balogun, Benita; Cyril-Olutayo, Mojisola; El-Araby, Moustafa; Omar, Abdelsattar; Fleischman, Andrew: ILX-002 - A Direct HbS Polymerization Inhibitor for the Treatment of Sickle Cell Disease. 18th Annual Sickle Cell Disease Research and Educational Symposium and 47th National Sickle Cell Disease Scientific Meeting June 2024. 

Abdulmalik, Osheiza; Gollomp, Kandace; Bochenek, Veronica; Field, Conroy; Safo, Martin; Omar, Abdelsattar; Light, David; Brown, Clark; Fleischman, Andrew: A Novel Direct Hemoglobin S Polymerization Inhibitor for the Treatment of Sickle Cell Disease - In Vivo Efficacy of Ilx-002 in Humanized Mice.  66th ASH Annual Meeting and Exposition. Blood. 144((Supplement 1)): 173, December 2024. 

Elizabeth A. Traxler, Chad Komar, Megan Saari, Quynn Hotan, A Josephine Thrasher, Eugene Khandros, Kunhua Qin, Osheiza Abdulmalik, Claire Shao, Qingzhou Chen, Andy J. Minn, Cheryl A. Keller, Junwei Shi, Gerd A. Blobel: A Novel Genome-Scale CRISPR-Cas12a Screen Identifies Ptpa As a Fetal Hemoglobin Regulator Via BCL11A. 66th ASH Annual Meeting and Exposition. Blood. 144 ((Supplement 1)): 412, December 2024. 

Zheng, S., A. Bagchi, K. Li, P. Huang, J. Hines, M. Krone, A. Butrin, M. Bond, B. Giardine, C. Keller, Z. Geng, B. Godfrey, S. Cotteta, O. Abdulmalik, R. Hardison, G. Burslem, E. Khandros, C. Crews and G. Blobel (2025). A novel LRF degrader induces fetal hemoglobin expression in adult erythroblasts. 67th ASH Annual Meeting and Exposition. Blood 146(Supplement 1): 836-836. 

2026

Donkor, A. K., Opare, A., Thomas, W., Abdulmalik, O., Zhang, Y., Safo, M. K. Haemoglobin - A Target for Sickle Cell Disease Drug Discovery. In Engineering Approaches to Sickle Cell Disease: Innovations, Applications, and Future Prospects. Barabino, G. A.; Green, M. D.; Wood, D. K., Eds.; Springer Nature: Cham, Switzerland. 2026; pp 225-249. 

2021

Safo MK, Aljahdali A, Burnett J, Abraham DJ, Abdulmalik O.: Therapeutic Strategies for the Treatment of Sickle Cell Disease. In Burger's Medicinal Chemistry, Drug Discovery and Development, 8th Edition. Abraham, DJ (eds.). 4: 221-252, 2021.