David A. Piccoli, MD

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David A. Piccoli, MD, is Chief of the Division of Gastroenterology, Hepatology and Nutrition, and a board-certified pediatric gastroenterologist at Children's Hospital of Philadelphia.

Areas of Expertise: Advanced, technical, endoscopic diagnostic and therapeutic procedural gastroenterology, Alagille syndrome, Congenital, metabolic, genetic and inflammatory liver diseases, Crohn's disease, General diagnostic GI and Liver diseases, Liver disease, Inflammatory bowel disease (IBD), Second opinion consultation
Locations: Main Hospital

Phone: 215-590-3630

Background

David A. Piccoli, MD, is nationally-renown pediatric gastroenterologist, Chief of the Division of Gastroenterology, Hepatology and Nutrition.

Dr. Piccoli provides individualized and compassionate care for children with liver disorders, intestinal bowel disease, and other gastrointestinal conditions. Patients from around the world are referred to him for treatment and second opinions.

“My goal as a doctor, researcher and leader at CHOP is to incorporate the newest science and best technology to improve treatments and outcomes for all children,” Dr. Piccoli says. “That translates into every aspect of my work.”

Dr. Piccoli has a special interest in treating children with complex and chronic liver and bowel disorders that are often difficult to manage.

“Some children present with such a wide variety of symptoms that finding the right treatment for that specific child can be challenging,” Dr. Piccoli says. “There are so many moving pieces; it’s like a puzzle. And it’s very satisfying to me to find the right solution for that child.”

Education and experience

Dr. Piccoli earned his bachelor’s degree from Johns Hopkins University, Baltimore, MD, and his medical degree from Harvard Medical School, Boston, MA. He was a medical resident and later chief resident at what-was-then Children’s Hospital Medical Center in Boston, MA.

Dr. Piccoli completed a one-year clinical fellowship, followed by a two-year research fellowship, in pediatric gastroenterology and nutrition at The Children’s Hospital of Philadelphia. He became an attending physician and a member of the research faculty at CHOP in 1985.

In 1990, Dr. Piccoli was named director of clinical service for the Division of Gastroenterology and Nutrition. For the following eight years, he took on positions of increasing responsibility — section chief, medical director of the Pediatric Anorectal Continence Evaluation Program, associate chairman for outreach, and acting division chief.

In 1998, he was named division chief for the newly combined Division of Gastroenterology, Hepatology and Nutrition.

Making an impact

During Dr. Piccoli’s tenure as chief, the Division has nearly tripled in size, and has vastly expanded its clinical and research mission in gastrointestinal, hepatology and nutritional disorders. Support services in the division have expanded to include psychologists, social workers, dietitians, specialty nurses and others who provide care for children’s minds and bodies. At the same time, the Division has trained more than 100 fellows — the next generation of gastroenterologists.

Along with Dr. Piccoli’s role overseeing the Division of Gastroenterology, Hepatology and Nutrition, he has been active in a number of division programs. In 2004, he was named director — and later endowed chair — of the Fred and Suzanne Biesecker Pediatric Liver Center. He is also very active in the Center for Pediatric Inflammatory Bowel Disease.

Dr. Piccoli has also been a leader at CHOP, serving as executive sponsor of EpicCare CHOPLink implementation, and associate chairman for information technology for the Department of Pediatrics at CHOP. And, for more than 20 years, he has served as a professor of pediatrics at CHOP and the Perelman School of Medicine at the University of Pennsylvania.

Dr. Piccoli is also co-director of the HUP-CHOP Joint Center for Digestive, Liver and Pancreatic Diseases, a joint venture between CHOP, the Hospital of the University of Pennsylvania, and the Perelman School of Medicine at the University of Pennsylvania.

Research and recognition

Along with Dr. Piccoli’s active clinical practice and administrative duties, he continues to pursue research about metabolic and genetic liver disease, inflammatory bowel disease and rare gastrointestinal disorders. He is a member of the group that discovered Jagged1 and NOTCH2 as the primary causes of Alagille syndrome.

He has authored more than 90 papers, 40 chapters, 130 research abstracts and edited four books on areas of pediatric gastroenterology, hepatology and nutrition. He has also presented hundreds of lectures on conditions such as Alagille syndrome, inflammatory bowel disease, liver disease and viral hepatitis.

Dr. Piccoli has received a number of awards for his clinical care, teaching, mentorship, research and work with charitable foundations. He has served on local and national boards, including the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, the American Gastroenterological Association, the National Crohn's and Colitis Foundation of America, and the American Liver Foundation.

Education and Training

Medical School

MD - Harvard Medical School, Boston, MA

Internship

Pediatrics - Children's Hospital, Boston, MA

Residency

Pediatrics - Children's Hospital, Boston, MA (Chief Resident)

Fellowship

Pediatric Gastroenterology and Nutrition (clinical and research) - The Children's Hospital of Philadelphia, Philadelphia, PA

Board Certification

Diplomate – National Board of Medical Examiners (NBME)
Pediatric Gastroenterology – American Board of Pediatrics
Pediatrics – American Board of Pediatrics

Undergraduate Degree

BA - Johns Hopkins University, Baltimore, MD

Titles and Academic Titles

Chief, Division of Gastroenterology, Hepatology and Nutrition

Associate Chair for Information Technology, Department of Pediatrics

Attending Physician

Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Research Interests

Alagille syndrome
Bile duct disorders
Inflammatory bowel diseases

 

Publications

Papers

2016

Waisbourd-Zinman O, Mamula P, Piccoli DA: Chromosome 10q23 Deletion Syndrome: An Overlap of Bannayan-Riley-Ruvalcaba Syndrome and Juvenile Polyposis Syndrome. J Paediatr Child Health 52(8), August 2016 Notes: doi:10:1111/jpc.13289.

Rajagopalan R, Grochowski CM, Gilbert MA, Falsey AM, Coleman K, Romero R, Loomes KM, Piccoli DA, Devoto M, Spinner NB: Compound heterozygous mutations in NEK8 in siblings with end-stage renal disease with hepatic and cardiac anomalies. Am J Med Genet A. doi: 10.1002/ajmg.a.37512.Epub 2015 Dec 24 (eds.). 170(3), Mar 2016.

Muir A, Surrey L, Kriegermeier A, Ahaikhkalil A, Piccoli DA: Severe Eosinophilic Gastroenteritis in a Crohn's Disease Patient Treated with Infliximab and Adalimumab. Am J Gastroenterol 111(3): 437-8, Mar 2016 Notes: doi: 10,1038/ajg.2015.438.

2015

Kelsen JR, Dawany N, Moran CJ, Petersen B-S, Sarmady M, Sasson A, Pauley-Hubbard H, Martinez A, Maurer K, Soong J, Rappaport E, Franke A, Keller A, Winter HS, Mamula P, Piccoli D, Artis D, Sonnenberg GF, Daly M, Sullivan KE, Baldassano RN, Devoto M: Exome Sequencing Analysis Reveals Variants in Primary Immunodeficiency Genes in Patients with Very Early Onset Inflammatory Bowel Disease. Gastroenterology 149(6): 1415-1424, November 2015.

Kelsen JR, Dawany N, Martinez A, Grochowski CM, Maurer K, Rappaport E, Piccoli DA, Baldassano RN, Mamula P, Sullivan KE, Devoto M: A de novo whole gene detected of XIAP detected by exome sequencing analysis in very early onset inflammatory bowel disease: a case report. BMC Gastroenterol 18(15), Nov 2015.

Mouzaki M, Bass LM, Sokol FJ, Piccoli DA, Quammie C, Loomes KM, Heubi JE, Hertel PM, Scheenstra R, Furuya K, Kutsch E, Spinner NB, Robbins KN, Venkat V, Rosenthal P, Beyene J, Baker A, Kamath BM: Early Life Predictive Markers of Liver Disease Outcome in an International, Multi-Centered Cohort of Children with Alagille Syndrome. Liver International 36(5): 755-60, July 2015.

Lee D, Albenberg L, Compher C, Baldassano R, Piccoli DA, Lewis JD, Wu GD: Diet in the Pathogenesis and Treatment of Inflammatory Bowel Disease. Gastroenterology 148(6): 1087-1106, May 2015.

Grochowski CM, Rajagopalan R, Falsey AM, Loomes KM, Piccoli DA, Krantz ID, Devoto M, Spinner NB: Exome sequencing reveals compound heterozygous mutations in ATP8B1 in a JAG1/NOTCH2 mutation-negative patient with clinically diagnosed Alagille syndrome Am J Med Genet A  167A(4): 891-3, Apr 2015 Notes: doi: 10.1002/ajmg.a.36946. Epub 2015 Mar 3.

2014

Baird LC, Smith ER, Ichord R, Piccoli DA, Bernard TJ, Spinner NB, Scott RM, Kamath BM: Moyamoya syndrome associated with Alagille syndrome: outcome after surgical revascularization. J Pediatr 166(2): 470-3, Feb 2015 Notes: doi: 10.1016/j.jpeds.2014.10.067. Epub 2014 Oct 30.

2013

Hsu E, Chugh P, Kronman M, Markowitz J, Piccoli D, Mamula P: Incidence of perforation in pediatric GI endoscopy and colonoscopy: an 11 year experience. Gastrointest Endosc 77(6): 960-966, 2013.

2012

Kamath BM, Podkameni G, Hutchinson AL, Leonard LD, Gerfen J, Krantz ID, Piccoli DA, Spinner NB, Loomes KM, Meyers K: Renal anomalies in Alagille Syndrome: A disease-defining feature. Amer J Med Gen 158A(1): 85-89, January 2012.

Kamath BM, Piccoli DA, Magee JC, Sokol RJ : Pancreatic insufficiency is not a prevalent problem in Alagille syndrome. Childhood Liver Disease Research and Education Network Journal of Pediatric Gastroenterology & Nutrition 55(5): 612-4, Nov 2012.

Kamath BM, Bauer RC, Loomes KM, Chao G, Gerfen J, Hutchinson A, Hardikar W, Hirschfield G, Jara P, Krantz ID, Lapunzina P, Leonard L, Ling S, Ng L, Hoang PL, Piccoli DA and Spinner NB: NOTCH2 Mutations in Alagille Syndrome. J Med Gen 49: 138-44, 2012.

2011

Friedlander JA, Loeben GS, Finnegan PK, Puma AE, Zhang X, de Zoeten EF, et al. A novel method to enhance informed consent: a prospective and randomised trial of form-based versus electronic assisted informed consent in paediatric endoscopy. J Med Ethics. 2011 Apr;37(4):194-200. Epub 2011 Jan 18. Cited in PubMed; PMID 21245476.

2010

Kamath BM, Loomes KM, Piccoli DA. Medical management of Alagille syndrome. J Pediatr Gastroenterol Nutr. 2010 Jun;50(6):580-6. Cited in PubMed; PMID 20479679.

Bales CB, Kamath BM, Munoz PS, Nguyen A, Piccoli DA, Spinner NB, Horn D, Shults J, Leonard MB, Grimberg A, Loomes KM. Pathologic lower extremity fractures in children with Alagille syndrome. J Pediatr Gastroenterol Nutr. 2010 Jul;51(1):66-70. Cited in PubMed; PMID 20453673.

Kamath BM, Munoz PS, Bab N, Baker A, Chen Z, Spinner NB, Piccoli DA. A longitudinal study to identify laboratory predictors of liver disease outcome in Alagille syndrome. J Pediatr Gastroenterol Nutr. 2010 May;50(5):526-30. Cited in PubMed; PMID 20421762.

Wang K, Baldassano R, Zhang H, Qu HQ, Imielinski M, Kugathasan S, et al. Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. Hum Mol Genet. 2010 May 15;19(10):2059-67. Epub 2010 Feb 22. Cited in PubMed; PMID 20176734.

2009

Kamath BM, Thiel BD, Gai X, Conlin LK, Munoz PS, Glessner J, et al. SNP array mapping of chromosome 20p deletions: genotypes, phenotypes, and copy number variation. Hum Mutat. 2009 Mar;30(3):371-8. Cited in PubMed; PMID 19058200.

Wang K, Zhang H, Kugathasan S, Annese V, Bradfield JP, Russell RK, et al. Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease. Am J Hum Genet. 2009 Mar;84(3):399-405. Epub 2009 Feb 26. Cited in PubMed; PMID 19249008.

Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V, Dubinsky M, et al. Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet. 2009 Dec;41(12):1335-40. Epub 2009 Nov 15. Cited in PubMed; PMID 19915574.

Colletti RB, Baldassano RN, Milov DE, Margolis PA, Bousvaros A, Crandall WV. Variation in care in pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2009 Sep;49(3):297-303. Cited in PubMed; PMID 19590456.

Abstracts

2016

Conrad MA, Dawany N, Bittinger K, Baldassano RN, Piccoli D, Bushman FD, Devoto M, Kelsen JR: Characterization of the Intestinal Microbiome in Very Early Onset Inflammatory Bowel Disease  Digestive Disease Week Annual Meeting, San Diego, CA May 2016.

Kelsen J, Dawany N, Conrad M, Martinez A, Mamula P, Piccoli D, Artis D, Sonnenberg G, Baldassano R, Sullivan K, Devoto M: 0-003 Understanding the Relevance of Whole Exome Sequencing Identified Variants in Patients with Very Early-Onset IBD. Inflamm Bowel Dis Suppl 1:S1-2, Mar 2016 Notes: doi: 10.1097/01.MIB0000480041.81008.d2.

2015

Stein RE, Conrad M, Maxwell EC, Albenberg L, Baldassano R, Dawany N, Grossman AB, Mamula P, Piccoli D, Kelsen JR: Vedolizumab therapy in severe pediatric inflammatory bowel disease. North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Annual Meeting, Washington, DC October 2015.

Conrad M, Stein R, Maxwell EC, Albenberg L, Baldassano R, Grossman AB, Mamula P, Piccoli D, Kelsen JR: The Use of Vedolizumab for Treatment of Severe Pediatric Inflammatory Bowel Disease. Digestive Disease Week May 2015 Notes: Oral presentation by collaborator Stein R.

2014

Kelsen JR, Moran CJ, Sasson A, Sarmady M, Gupta K, Pauly-Hubbard H, Rappaport E, Stolle C, Mamula P, Grossman AB, Piccoli D, Winter H, Baldassano R, Devoto M: Exome Sequencing Analysis of Candidate Genes in Very Early Onset IBD. Gastroenterology 146(5): s27, 2014.

2013

Jump C, Loomes KM, Piccoli DA, Blinman TA, Rosh J, Anupindi S, Smith-Whitley K, and Kelsen JR : "Role of Colectomy to Treat Life-Threatening Thrombotic Storm in Pediatric IBD" North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Annual Meeting, Chicago, IL October 2013.

Waisbourd-Zinman O, Mamula P, Friedman J and Piccoli DA: "Severe Bannayan-Riley-Ruvalcaba Syndrome caused by a deletion encompassing both the BMPR1A and PTEN genes," North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Annual Meeting October 2013.

2011

Mouzaki M, Piccoli DA: Modeling liver disease outcome in an international multi-center cohort of Alagille Syndrome patients. AASLD, Anaheim, CA November 2011.

2009

Kamath BM. Loomes KM, Pidkameni G, Munoz, Piccoli DA, Spinner NB, et al. Renal anomalies in Alagille syndrome: prevalence and characterization [abstract]. 60th Annual Meeting of the American Association for the Study of Liver Diseases; 2009 Oct 30-Nov 3; Boston, MA.

Mamula P, Markowitz JE, Piccoli DA, Liacouras CA. Incidence of perforation in pediatric gastrointestinal endoscopy: 11 year experience in a series of 30,177 procedures performed at a tertiary care center [abstract]. 23rd Annual Meeting of the American Gastroenterological Association; 2009 May; Chicago, IL. 

Friedlander JA, Loeben G, Finnegan K, Puma A, Piccoli DA, Mamula P. Improving informed consent in pediatric endoscopy. 23rd Annual Meeting of the American Gastroenterological Association; 2009 May; Chicago, IL. 

2008

Kamath BM, Munoz PS, Chen Z, Zhao H, Spinner NB, Piccoli DA. A Longitudinal study to identify biochemical predictors of liver disease outcome in Alagille syndrome [abstract  oral presentation]. 59th Annual Meeting of the American Association of the Study of Liver Diseases, 2008 Oct 31-Nov 4; San Francisco, CA.

Bales CB, Kamath BM, Munoz PS, Piccoli DA, Spinner NB, Grimberg A, et al.  Fracture risk in Alagille syndrome [abstract]. 59th Annual Meeting of the American Association of the Study of Liver Diseases, 2008 Oct 31-Nov 4; San Francisco, CA.

Books

2014

Russo P, Ruchelli ED, Piccoli DA: Pathology of Pediatric Gastrointestinal and Liver Disease. Springer 2014.

2008

Kamath BM, Piccoli DA: Alagille Syndrome. Pediatric Gastroenterology, The Requisites. Liacouras CA, Piccoli DA (eds.). Saunders/Churchill/Mosby, Philadelphia, Page: 227-232, 2008.

Liacouras CA, Piccoli DA. Pediatric gastroenterology and nutrition: the requisites. Philadelphia: Saunders/Churchill/Mosby; 2008.

2004

Russo P, Ruchelli E, Piccoli DA, editors. Pathology of pediatric gastrointestinal and liver disease. New York: Springer-Verlag; 2004.

Chapters

2015

Lin HC, Piccoli DA: Ascites. Pediatric Gastrointestinal and Liver Disease, Chapter 17. Wyllie R, Hyams JS, Kay M (eds.). 2015.

2014

Kamath BM, Piccoli DA: Alagille Syndrome. Diseases of the Liver in Children. Murray KF, Horslen S (eds.). Springer, 2014.

2010

Kamath BM, Loomes KM, Piccoli DA: JAGGED1/NOTCH2 Sequence in Alagille Syndrome. Fibrocystic Disease of the Liver. Murray K (eds.). Humana Press, 2010.

2008

Kamath BM, Piccoli DA. Alagille syndrome. In: Liacouras CA, Piccoli DA, editors. Pediatric gastroenterology: the requisites. Philadelphia: Saunders/Churchill/Mosby; 2008. p. 227-232. 

2007

Kamath BM, Spinner NB, Piccoli DA. Alagille syndrome. In: Suchy F, Balistreri W, Sokol RJ, editors. Liver disease in children. 3rd ed. New York: Cambridge University Press; 2007. p. 326-345.

2005

Graham-Maar RC, Piccoli DA. Gastroenterology (10), esophagus and stomach. In: Frank G, Shah SS, Catallozzi M, Zaoutis LB, editors. The Philadelphia guide: inpatient pediatrics. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 102-109.

Graham-Maar RC, Piccoli DA. Esophagus and stomach. In: Frank G, Shah SS, Catallozzi M, Zaoutis LB, editors. The Philadelphia guide: inpatient pediatrics. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 100-102.

Graham-Maar RC, Piccoli DA. Hepatobiliary system. In: Frank G, Shah SS, Catallozzi M, Zaoutis LB, editors. The Philadelphia guide: inpatient pediatrics. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 102-109.

Graham-Maar RC, Piccoli DA. Small and large intestine. In: Frank G, Shah SS, Catallozzi M, Zaoutis LB, editors. The Philadelphia guide: inpatient pediatrics. Philadelphia: Lippincott Williams & Wilkins; 2005.

2004

Piccoli DA. Disorders of the biliary tract: intrahepatic bile ducts. In: Walker WA, Kleinman RE, Sherman PM, Schneider BL, Sanderson IR, editors. Pediatric gastrointestinal disease. Shelton: PMPH USA; 2004.

2003

Kamath BM, Piccoli DA. Alagille syndrome. In: Grand RI, editor. Encyclopedia of pediatric gastroenterology. Philadelphia: Elsevier; 2003.

2001

Piccoli DA. Alagille syndrome. In: Suchy F, editor. Liver disease in children. 2nd ed. Philadelphia: WB Saunders; 2001. p. 327-342.

2000

Piccoli DA. Disorders of the biliary tract: extrahepatic bile ducts. In: Walker WA, editors. Pediatric gastrointestinal disease: pathophysiology, diagnosis, management. 3rd ed. Philadelphia: BC Decker, Inc.; 2000. p. 915-927.

Piccoli DA. Disorders of the biliary tract: intrahepatic bile ducts. In: Walker WA, editors. Pediatric gastrointestinal disease: pathophysiology, diagnosis, management. 3rd ed. Philadelphia: BC Decker, Inc.; 2000. p. 915-927.

Mamula P, Markowitz, Baldassano RN, Piccoli DA, Liacouras CA. Gastroenterology. In: Polin R, editor. Pediatric secrets. 3rd ed. Philadelphia: Hanley & Belfus, Inc.; 2000.

1999

Wenner WJ, Piccoli DA. Viral hepatitis. In: Altschuler SM, Liacouras CA, editors. Clinical pediatric gastroenterology. London: Churchill Livingstone; 1998. p. 445-450.

Piccoli DA, Peck SN. Inflammatory bowel disease in children and adolescents. In: Stein SH, Rood RP, editors. Inflammatory bowel disease: a guide for patients and their families. Philadelphia: Lippincott-Raven; 1998. p. 79-92.

Piccoli DA. Hepatic fibrosis. In: Altschuler SM, Liacouras CA, editors. Clinical pediatric gastroenterology. London: Churchill Livingstone; 1998. p. 391-396.

Piccoli DA. Hirschsprung disease. In: Altschuler SM, Liacouras CA, editors. Clinical pediatric gastroenterology. London: Churchill Livingstone; 1998. p. 1399-1403. 

Piccoli DA. Breath testing. In: Altschuler SM, Liacouras CA, editors. Clinical pediatric gastroenterology. London: Churchill Livingstone; 1998. p. 567-574.

Gibson J, Piccoli DA, Berry G. Pathophysiology of metabolic disease of the liver. In: Polin R, Fox W, editors. Fetal and neonatal physiology. 2nd ed. Philadelphia: WB Saunders; 1998. p. 1514-20.

1997

Piccoli DA. Rectal bleeding. In: Schwartz MW, Curry TA, Sargent AJ, Blum NJ, Fein J, editors. Pediatric primary care: a problem-oriented approach. 3rd ed. Philadelphia: Mosby-Year Book, Inc.; 1997. p. 346-354.

Posters and Presentations

Poster Presentations

Conrad M, Darwany N, Bittinger K, Baldassano RN, Piccoli DA, Bushman F, Devoto M, Kelsen J: "Characterization of the Intestinal Microbiome of Very Early Onset Inflammatory Bowel Disease" Poster Presentation at the World Congress of Pediatric Gastroenterology, Hepatology and Nutrition Meeting, Montreal, Canada October 2016.

Kelsen J, Dawany N, Conrad M, Piccoli D, Giraudo C, Behrens E, Sullivan K, Devoto M: "The role of the Hyperinflammatory Pathway in Very Early-Onset Inflammatory Bowel Disease. Poster Presentation at the World Congress of Pediatric Gastroenterology, Hepatology and Nutrition Meeting, Montreal, Canada October 2016.

Itkin M, Piccoli DA, Dori Y: "Protein-Losing Enteropathy:  Redefining the Anatomy and Pathophysiology and Providing Novel Therapy" Poster Presentation at the World Congress of Pediatric Gastroenterology, Hepatology and Nutrition Meeting, Montreal, Canada October 2016.

Lectures by Invitation

2016

Piccoli DA. Differential diagnosis and clinical evaluation of infantile liver disorders with clinic-pathologic discussion [lecture]. Society for Pediatric Pathology; 2016  Mar; Seattle, WA.

2015

Piccoli DA. Mission, Money, Midas and Magic [lecture]. NASPGHAN; 2015 Oct; Washington, DC.

Awards and Honors

2022, Philadelphia Magazine's Top Doctors in Gastroenterology, Hepatology and Nutrition

2016, Master Clinician, Academy of Master Clinicians, University of Pennsylvania

2012-2013, Pediatric Residency Faculty Honor Roll, The Children's Hospital of Philadelphia

2007, Faculty Mentor Award - The Children's Hospital of Philadelphia

2006, Beverly Mandell Physician Mentorship Award - APGNN

2006, Leadership Award, American Liver Foundation, Delaware Valley Chapter

2005-2012, Best Doctors, Philadelphia Magazine

2005, Outstanding Leadership Award, Crohn's and Colitis Foundation of America

2005, The Fred and Suzanne Biesecker Endowed Chair in Pediatrics

2004-2012, Castle Connolly America's Top Doctors

1999, Jean A. Cortner Divisional Teaching Award, The Children's Hospital of Philadelphia

1999, Klaus and Mary Hummeler Endowed Research Prize

1998, Komarov Research Prize (mentor), Philadelphia Gastrointestinal Research Forum

1996, The Best Doctors in America, American Health Magazine, Reader's Digest

1996, Christian R. and Mary F. Lindback Foundation Award for Distinguished Teaching, University of Pennsylvania

1996, Physician of the Year, Crohn's and Colitis Foundation, Delaware Valley Chapter

1994-1998, The Best Doctors in America Directory, Woodward White, Inc.

1994, Physician of the Year, American Liver Foundation, Delaware Valley Chapter

1993, Class of 1992 Teaching Award, University of Pennsylvania School of Medicine

1993, Faculty Teaching Award, The Children's Hospital of Philadelphia

1992, Blockley-Osler Award for Teaching Clinical Medicine, Blockley Section, College of Physicians of Philadelphia, University of Pennsylvania School of Medicine

1988, Komarov Research Prize (mentor), Philadelphia Gastrointestinal Research Forum

1986, Komarov Research Prize, Philadelphia Gastrointestinal Research Forum

1984, Fellows' Teacher of the Year Award, The Children's Hospital of Philadelphia

1983, Sidney Farber House Staff Award, The Children's Hospital, Boston, MA

1980, American Academy of Pediatrics Residency Fellowship

1975, High Honors, Departmental Honors (Biology), Johns Hopkins University

1974, Phi Beta Kappa, Johns Hopkins University

Editorial and Academic Positions

Academic committees

2014-2019, Internal Advisory Committee, Center for Molecular Studies in Digestive and Liver Diseases, Perelman School of Medicine, University of Pennsylvania
2012-present, Compensation Committee, Department of Pediatrics, The Children's Hospital of Philadelphia
2012-present, Perioperative IS Design Executive Sponsor Committee
2012-2013, Department of Medicine Review Committee, University of Pennsylvania Perelman School of Medicine
2012-2013, NIH-TAC Final Task Force Summit, University of Pennsylvania School of Medicine
2011-present, Optimization Management Group, Epic IS, Chair
2009-present, HUP CHOP Joint Center for Digestive, Liver and Pancreatic Disease, Co-Director
2008-present, Epic Care CHOPlink implementation, Ambulatory Advisory Team, The Children's Hospital of Philadelphia
2008-present, Bollig Provider Committee
2008-2009, Leader, IMO Implementation, Epic Care CHOPlink Committee
2008-2009, Department of Pediatrics Compensation Committee, University of Pennsylvania
2006-2008, EpicCare, CHOPlink Implementation, Executive Sponsor, Ambulatory, The Children's Hospital of Philadelphia
2004-present, Biesecker Liver Center Internal Scientific Advisory Committee, The Children's Hospital of Philadelphia

Leadership and Memberships

Memberships in professional organizations

American Association for the Study of Liver Diseases

American Gastroenterological Association

American Liver Foundation

National Alagille Syndrome Alliance

National Crohn's and Colitis Foundation of America

North American Society for Pediatric Gastroenterology, Hepatology and Nutrition