Sarah A. Richman, MD, PhD Sarah A. Richman, MD, PhD, is an attending physician at the Cancer Center at Children's Hospital of Philadelphia. Locations: Main Campus Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467) Education and Training Medical SchoolMD - University of Illinois at Urbana-Champaign, Champaign, IL ResidencyPediatrics - Children’s Hospital of New York, Columbia University Medical Center, New York, NY FellowshipHematology-Oncology - The Children’s Hospital of Philadelphia, Philadelphia, PA Board CertificationPediatricsGraduate DegreePhD in Biochemistry - University of Illinois at Urbana-Champaign, Champaign, IL Titles and Academic Titles Attending PhysicianInstructor, Perelman School of Medicine at the University of Pennsylvania Departments and Services Cancer Center Publications Papers2018 Richman SA, Nunez-Cruz S, Moghimi B, Li LZ, Gershenson ZT, Mourelatos Z, Barrett DM, Grupp SA, Milone MC. High-Affinity GD2-Specific CAR T Cells Induce Fatal Encephalitis in a Preclinical Neuroblastoma Model. Cancer Immunol Res. 2018 Jan;6(1):36-46. Richman SA, Milone MC. Neurotoxicity Associated with a High-Affinity GD2 CAR-Response. Cancer Immunol Res. 2018 Apr;6(4):496-497. 2015 Zuber J, Rosen S, Shonts B, Sprangers B, Savage TM, Richman S, Yang S, Lau SP, DeWolf S, Farber D, Vlad G, Zorn E, Wong W, Emond J, Levin B, Martinez M, Kato T, Sykes M. Macrochimerism in intestinal transplantation: Association with lower rejection rates and multivisceral transplants, without GVHD. American Journal of Transplantation. 2015 Oct;15(10):2691-703. 2013 Schmitt TM, Aggen DH, Stromnes IM, Dossett ML, Richman SA, Kranz DM, Greenberg PD. Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection. Blood. 2013 Jul 18;122(3):348-56. 2012 Aggen DH, Chervin AS, Schmitt TM, Engels B, Stone JD, Richman SA, Piepenbrink KH, Baker BM, Greenberg PD, Schreiber H, and Kranz DM. Single-chain VαVβ T-cell receptors function without mispairing with endogenous TCR chains. Gene Therapy. 2012 Apr;19(4):365-74. 2009 Richman SA, Weber KS, Buonpane RA, Donermeyer DL, Dossett ML, Allen PM, Greenberg PD, and Kranz DM. Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain VαVβ fragments. Molecular Immunology. 2009 Feb; 46(5): 902-916. 2006 Richman SA, Healan SJ, Weber KS, Donermeyer DL, Dossett ML, Greenberg PD, Allen PM, Kranz DM. Development of a novel strategy for engineering high-affinity proteins by yeast display. Protein Engineering, Design, and Selection. 2006 Jun; 19(6): 255-264. Abstracts2018 Richman SA, Stark S and Milone MC. The impact of incorporated co-stimulatory domain on antigen-dependent cytotoxicity of chimeric antigen receptor T cells. EMBO Lymphocyte Antigen Receptor Signaling Workshop. August 25, 2018. Siena, Italy. 2015 Richman SA, Wang S, Moon E, Albelda S, and Milone MC. Reversible regulation of chimeric antigen receptor surface expression (accepted). Young Investigators Forum for Cancer Immunotherapy, April 30-May 3, 2015, Chicago, IL. BooksChapters Richman SA, Kranz DM, Stone JD. Biosensor detection systems: engineering stable, high-affinity bioreceptors by yeast surface display. In A Rasooly and KE Herold (Ed.), Methods in Molecular Biology 504: Biosensors and Biodetection: Methods and Protocols 2009. pp. 323-350. New York, NY. Humana Press. Awards and Honors 2010, Alpha Omega Alpha Society, University of Illinois 2001, Society of Sigma Xi, Princeton University 2010, University of Illinois College of Medicine at Urbana-Champaign Award in Pediatrics 2010, American Medical Women’s Association Glasgow-Rubin Citation for Academic Achievement, University of Illinois College of Medicine at Urbana-Champaign 2010, William E. Sorlie Award for Outstanding Clinical Core Clerkships Performance, University of Illinois College of Medicine at Urbana-Champaign 2009, P.E.O. Scholar Award. International P.E.O. Society 2007, School of Molecular and Cellular Biology "Teacher ranked as excellent," University of Illinois at Urbana-Champaign 2001, University of Illinois Medical Scholars Program, 2001-2010 Patient Experience Ratings About the Patient Experience Rating System The Patient Experience Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question. Responses are measured on a scale of 1 to 5 with 5 being the best score. The comments are submitted by patients and families and reflect their views and opinions. The comments are not endorsed by and do not reflect the views of Children’s Hospital of Philadelphia.