Sarah A. Richman, MD, PhD

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Sarah A. Richman, MD, PhD, is an attending physician at the Cancer Center at Children's Hospital of Philadelphia.

Locations: Main Campus

Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Education and Training

Medical School

MD - University of Illinois at Urbana-Champaign, Champaign, IL


Pediatrics - Children’s Hospital of New York, Columbia University Medical Center, New York, NY


Hematology-Oncology - The Children’s Hospital of Philadelphia, Philadelphia, PA

Board Certification


Graduate Degree

PhD in Biochemistry - University of Illinois at Urbana-Champaign, Champaign, IL

Titles and Academic Titles

Attending Physician

Instructor, Perelman School of Medicine at the University of Pennsylvania

Departments and Services




Richman SA, Nunez-Cruz S, Moghimi B, Li LZ, Gershenson ZT, Mourelatos Z, Barrett DM, Grupp SA, Milone MC. High-Affinity GD2-Specific CAR T Cells Induce Fatal Encephalitis in a Preclinical Neuroblastoma Model. Cancer Immunol Res. 2018 Jan;6(1):36-46.

Richman SA, Milone MC. Neurotoxicity Associated with a High-Affinity GD2 CAR-Response. Cancer Immunol Res. 2018 Apr;6(4):496-497.


Zuber J, Rosen S, Shonts B, Sprangers B, Savage TM, Richman S, Yang S, Lau SP, DeWolf S, Farber D, Vlad G, Zorn E, Wong W, Emond J, Levin B, Martinez M, Kato T, Sykes M. Macrochimerism in intestinal transplantation: Association with lower rejection rates and multivisceral transplants, without GVHD. American Journal of Transplantation. 2015 Oct;15(10):2691-703.


Schmitt TM, Aggen DH, Stromnes IM, Dossett ML, Richman SA, Kranz DM, Greenberg PD.  Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection. Blood. 2013 Jul 18;122(3):348-56.


Aggen DH, Chervin AS, Schmitt TM, Engels B, Stone JD, Richman SA, Piepenbrink KH, Baker BM, Greenberg PD, Schreiber H, and Kranz DM. Single-chain VαVβ T-cell receptors function without mispairing with endogenous TCR chains. Gene Therapy. 2012 Apr;19(4):365-74.


Richman SA, Weber KS, Buonpane RA, Donermeyer DL, Dossett ML, Allen PM, Greenberg PD, and Kranz DM. Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain VαVβ fragments. Molecular Immunology. 2009 Feb; 46(5): 902-916.


Richman SA, Healan SJ, Weber KS, Donermeyer DL, Dossett ML, Greenberg PD, Allen PM, Kranz DM. Development of a novel strategy for engineering high-affinity proteins by yeast display. Protein Engineering, Design, and Selection. 2006 Jun; 19(6): 255-264.



Richman SA, Stark S and Milone MC. The impact of incorporated co-stimulatory domain on antigen-dependent cytotoxicity of chimeric antigen receptor T cells. EMBO Lymphocyte Antigen Receptor Signaling Workshop. August 25, 2018. Siena, Italy.


Richman SA, Wang S, Moon E, Albelda S, and Milone MC. Reversible regulation of chimeric antigen receptor surface expression (accepted). Young Investigators Forum for Cancer Immunotherapy, April 30-May 3, 2015, Chicago, IL.



Richman SA, Kranz DM, Stone JD. Biosensor detection systems: engineering stable, high-affinity bioreceptors by yeast surface display. In A Rasooly and KE Herold (Ed.), Methods in Molecular Biology 504: Biosensors and Biodetection: Methods and Protocols 2009. pp. 323-350. New York, NY. Humana Press.

Awards and Honors

2010, Alpha Omega Alpha Society, University of Illinois 

2001, Society of Sigma Xi, Princeton University

2010, University of Illinois College of Medicine at Urbana-Champaign Award in Pediatrics

2010, American Medical Women’s Association Glasgow-Rubin Citation for Academic Achievement, University of Illinois College of Medicine at Urbana-Champaign

2010, William E. Sorlie Award for Outstanding Clinical Core Clerkships Performance, University of Illinois College of Medicine at Urbana-Champaign

2009, P.E.O. Scholar Award.  International P.E.O. Society 

2007, School of Molecular and Cellular Biology "Teacher ranked as excellent," University of Illinois at Urbana-Champaign

2001, University of Illinois Medical Scholars Program, 2001-2010