Angela J. Waanders, MD, MPH

Angela J. Waanders, MD, MPH

Angela J. Waanders, MD, MPH, is an attending physician in the Neuro-Oncology Program and the Neurofibromatosis Program at Children's Hospital of Philadelphia. 

Areas of Expertise: Neuro-Oncology
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

My research focus is to develop novel therapeutic strategies and to improve the clinical outcomes for children with incurable brain tumors. As a pediatric hematology/oncology fellow, my work directly led to the discovery of an activated novel KIAA1549-BRAF fusion oncogene in the majority of pediatric low-grade gliomas (PLGGs). This genomic abnormality has since been found to be a hallmark of PLGGs.

After fellowship, I continued my research in the laboratory of Dr. Adam Resnick. Our initial findings in PNAS in March 2013 laid the foundation for understanding BRAF fusion signaling and has opened the door to several multi-institutional collaborations. Currently, I am focused on characterizing fusion gene oncogenesis in pediatric brain tumors, specifically characterizing the downstream signal activation and responsiveness to targeted inhibition of all of the fusion genes identified in pediatric gliomas.

I have also been involved in developing the phenotypic data infrastructure for the Children’s Brain Tumor Tissue Consortium (CBTTC), the first of its kind cancer database with specimens linked to prospective longitudinal clinical data collection. As the CBTTC Director of Operations, I am now helping to lead the CBTTC as we scale our efforts and make additional significant impacts through the rapid discovery and implementation of effective therapeutics for pediatric CNS tumors. I am also the Scientific Director of the new Center for Data Driven Discovery in Biomedicine (D3B) capitalizing on the research ecosystem piloted by the CBTTC.

Ultimately, my work in translational research, the CBTTC, and the Center D3B are directed at capitalizing on novel new therapeutics towards the benefit of pediatric brain tumor patients. I also have an interest in paraneoplastic neurological syndromes, specifically opsoclonus myoclonus ataxia syndrome (OMAS). This is a very rare disease that tends to afflict very young children. While the disease mechanism is not well understood, immunotherapy based approaches have proven to be effective. As the Scientific Director of the Center D3B, I plan to develop translational research programs in OMAS with focus on identifying predictive biomarkers.

Education and Training

Medical School

MD - Tulane University School of Medicine, New Orleans, LA

Residency

Pediatrics - The Children's Hospital of Philadelphia, Philadelphia, PA 

Fellowship

Pediatric Hematology-Oncology - The Children's Hospital of Philadelphia, Philadelphia, PA

Additional Training

Certificate - Wharton Executive Education, The Leadership Edge

Board Certification

Hematology-Oncology
Pediatrics

Graduate Degree

MPH - Tulane University School of Public Health & Tropical Medicine, New Orleans, LA

Titles and Academic Titles

Attending Physician

Director of Clinical Research, Center for Data Driven Discovery in Biomedicine

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Research Interests

Pediatric low grade gliomas
Opsoclonus myoclonus ataxia syndrome

Publications

Papers

2018

Jain P, Surrey LF, Straka J, Luo M, Lin F, Harding B, Resnick AC, Storm PB, Buccoliero AM, Santi M, Li MM, Waanders AJ. Acta Neuropathol. 2018 May 16. [Epub ahead of print]. PMID: 29767381.

Mackay A, Burford A, Molinari V, Jones DTW, Izquierdo E, Brouwer-Visser J, Giangaspero F, Haberler C, Pietsch T, Jacques TS, Figarella-Branger D, Rodriguez D, Morgan PS, Raman P, Waanders AJ, Resnick AC, Massimino M, Garrè ML, Smith H, Capper D, Pfister SM, Würdinger T, Tam R, Garcia J, Thakur MD, Vassal G, Grill J, Jaspan T, Varlet P, Jones C. Cancer Cell. 2018 May 14; 33 (5): 829-842. PMID: 29763623.

Gröbner SN, Worst BC, Weischenfeldt J, Buchhalter I, Kleinheinz K, Rudneva VA, Johann PD, Balasubramanian GP, Segura-Wang M, Brabetz S, Bender S, Hutter B, Sturm D, Pfaff E, Hübschmann D, Zipprich G, Heinold M, Eils J, Lawerenz C, Erkek S, Lambo S, Waszak S, Blattmann C, Borkhardt A, Kuhlen M, Eggert A, Fulda S, Gessler M, Wegert J, Kappler R, Baumhoer D, Burdach S, Kirschner-Schwabe R, Kontny U, Kulozik AE, Lohmann D, Hettmer S, Eckert C, Bielack S, Nathrath M, Niemeyer C, Richter GH, Schulte J, Siebert R, Westermann F, Molenaar JJ, Vassal G, Witt H; ICGC PedBrain-Seq Project; ICGC MMML-Seq Project, Burkhardt B, Kratz CP, Witt O, van Tilburg CM, Kramm CM, Fleischhack G, Dirksen U, Rutkowski S, Frühwald M, von Hoff K, Wolf S, Klingebiel T, Koscielniak E, Landgraf P, Koster J, Resnick AC, Zhang J, Liu Y, Zhou X, Waanders AJ, Zwijnenburg DA, Raman P, Brors B, Weber UD, Northcott PA, Pajtler KW, Kool M, Piro RM, Korbel JO, Schlesner M, Eils R, Jones DTW, Lichter P, Chavez L, Zapatka M, Pfister SM. Nature.2018 Mar 15; 555 (7696):321-327. Epub 2018 Feb 28. PMID: 29489754.

Jones DTW, Kieran MW, Bouffet E, Alexandrescu S, Bandopadhayay P, Bornhorst M, Ellison D, Fangusaro J, Fisher MJ, Foreman N, Fouladi M, Hargrave D, Hawkins C, Jabado N, Massimino M, Mueller S, Perilongo G, Schouten van Meeteren AYN, Tabori U, Warren K, Waanders AJ, Walker D, Weiss W, Witt O, Wright K, Zhu Y, Bowers DC, Pfister SM, Packer RJ. Pediatric Low-Grade Gliomas: Next Biologically Driven Steps. Neuro-Oncol. 2018 Jan 22; 20 (2): 160-173. PMID: 29016845.

2017

Jain P, Silva A, Han HJ, Lang SS, Zhu Y, Boucher K, Smith TE, Vakil A, Diviney P, Choudhari N, Raman P, Busch CM, Delaney T, Yang X, Olow AK, Mueller S, Haas-Kogan D, Fox E, Storm PB, Resnick AC, Waanders AJ. Overcoming resistance to single-agent therapy for oncogenic BRAF gene fusions via combinatorial targeting of MAPK and PI3K/mTOR signaling pathways. Oncotarget. 2017 Sep 15; 8 (49): 84697-84713. PMIC: 29156677.

Mackay A, Burford A, Carvalho D, Izquierdo E, Salom JF, Taylor K, Bjerke L, Clarke M, Vinci M, Nandhabalan M, Temelso S, Popov S, Molinari V, Raman P, Waanders AJ, Han HJ, Gupta S, Marshall L, Zacharoulis S, Vaidya S, Mandeville HC, Bridges LR, Martin AJ, Al-Sarraj S, Chandler C, Ng HK, Li X, Mu K, Travelsi S, H’mida-Ben Brahim D, Kisljakov AN, Konovalov DM, Moore AS, Carcaboso AM, Sunoi M, de Torres C, Cruz O, Mora J, Shats LI, Stavale JN, Bidinotto LT, Reis RM, Entz-Werle N, Farrell M, Cryan J, Crimmins D, Caird J, Pears J, Monje M, Debily MA, Castel D, Grill J, Hawkins C, Nikbakht H, Jabado N, Baker SJ, Pfister SM, Jones DTW, Fouladi M, van Bueren AO, Baudis M, Resnick AC, and Jones C. Integrated molecular meta-analysis of 1000 paediatric high-grade and diffuse intrinsic pontine glioma. Cancer Cell. 2017 Oct 9; 32 (4):520-537.e5.doi: 10.1016/j.ccell.2017.08.017. Epub 2017 Sep 28. PMID: 28966033.

Jain P, Fierst TM, Han HJ, Smith TE, Vakil A, Storm PB, Resnick AC, Waanders AJ. CRAF gene fusions in pediatric low-grade gliomas define a distinct drug response based on dimerization profiles. Oncogene. 2017 Aug 14. [Epub ahead of print]. PMID: 28806393

2016

Olow A, Mueller S, Yang X, Hashizume R, Meyerowitz J, Weiss W, Resnick AJ, Waanders AJ, Stalpers LJ, Berger MS, Gupta N, James CD, Petritsch CK, Haas-Kogan DA. BRAF status in personalizing treatment approaches for pediatric gliomas. Clin Cancer Res. 2016 Nov1; 22 (21):5312-5321. Epub 2016 May 23. PMID: 27217440

Roth JJ, Fierst TM, Waanders AJ, Li Yimei, Biegel JA, Santi M. Whole chromosome 7 gain predicts higher risk of recurrence in pediatric pilocytic astrocytomas independently from KIAA1549-BRAF fusion status. J Neuropathol Exp Neurol. 2016 Mar 4. Pil: nlw001. [Epub ahead of print]. PMID 26945035

Bandopadhayay P, Ramkissoon LA, Jain P, Bergthold G, et al. MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism. Nat Genet. 2016 March; 48 (3):273-82. Doi: 10.1038/ng.3500. Epub 2016 Feb 1. PMID: 26829751.

2015

Shah AC, Minturn JE, Li Y, Belasco JB, Phillips PC, Kang TI, Cole KA, Waanders AJ, Pollack R, Didomenico C, Wildes C, Fisher MJ. Carboplatin rechallenge after hypersensitivity reactions in pediatric patients with low-grade glioma. Pediatr Blood Cancer. 2015 Jul 31. Doi: 10.1002/pbc.25697. [Epub ahead of print]. PMID: 26235452.

Jones CL, Gearheart CM, Fosmire S, Delgado-Martin C, Evensen NA, Waanders AJ, Pais F, Wang J, Bhatia T, Bitterman DS, de Rijk SR, Bourgeois W, Dandekar S, Park E, Burleson TM, Madhusoodhan PP, Teachey DT, Raetz EA, Hermiston ML, Muschen M, Loh ML, Hunger SP, Zhang J, Garabedian MJ, Porter CC, Carroll WL. MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia. Blood. 2015 Nov 5; 126 (19): 2202-12. Doi:10.1182/blood-2015-04-639138. Epub 2015 Aug 31. PMID: 26324703.

2014

Karajannis MA, Legault G, Fisher MJ, Milla SS, Cohen KJ, Wisoff JH, Harter DH, Goldbery JD, Hochman T, Merkelson A, Bloom MC, Sievert AJ, Resnick AC, Dhall G, Jones DTW, Korshunov A, Pfister SM, Eberhart CG, Zagzag D, and Allen JC. Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas. Neuro Oncol. 2014 May 6. [Epub ahead of print]. PMID: 24803676

Goldberg EM, Titulaer M, de Blank PM, Sievert A, Ryan N. Anti-N-methyl-D aspartate receptor-mediated encephalitis in infants and toddlers: case report and review of literature. Pediatr Neurol 2014 Feb; 50(2): 181-4. Doi: 10.1016/j.pediatrneurol.2013.10.002. Epub 2013 Oct 14. 

2013

Sievert AJ, Lang SS, Boucher KL, Madsen PJ, Slaunwhite E, Choudhari N, Kellet M, Storm PB, and Resnick AC. Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas. PNAS 2013 April; 110 (15): 5957-5962. Epub 2013 Mar 26. PMID: 23533272

Abstracts

2015

Mueller S, Dik R, Yang X, Olow A, Gustafson C, DuBois S, Weiss W, Waanders AJ, Resnick, AC, and Haas-Kogan D. Effects of TORC1/2 inhibitor MLN0128 alone and in combination with MEK inhibition in BRAF mutated glioma cells. Neuro-Oncology. 17:iii1-iii40, 2015. Doi:10.1093/neuonc/nov061.75.

Waanders AJ, Silva A, Chen SS, Han H, Zhu Y, Boucher K, Jain P, Fierst T, Choudhari N, Mueller S, Haas-Kogan D, Storm PB, Resnick AC. Combinatorial pathway targeting approaches for BRAF-fusions associated with pediatric low-grade gliomas. Neuro-Oncology. 17:iii1-iii40, 2015. Doi:10.1093/neuonc/nov061.151.

Olow AK, Mueller S, Yang X, Hashizume R, Meyerowitz J, Weiss W, Resnick AC, Waanders AJ, Berger MS, Gupta N, James CD, Haas-Kogan DA. Targeted combinatorial approach for treatment of pediatric low-grade gliomas in the context of BRAF V600E and KIAA1549:BRAF mutations. Neuro-Oncology. 17:iii1-iii40, 2015. Doi:10.1093/neuonc/nov061.153.

2013

Sievert AJ, Lang SS, Silva A, Brewington D, Mueller S, Haas-Kogan DA, Storm PB, Resnick AC. Rationale for combinatorial therapeutics to inhibit BRAF fusion activation. Mol Cancer Ther. Nov 2013. 12:B272, doi:10.1158/1535-7163.

Books

Chapters

Waanders AJ, Minturn JE, Fisher MJ. Pediatric Low-Grade Gliomas: Diagnosis, Treatment, and Future Directions. In: Hayat MA, ed. Tumors of the Central Nervous System,Volume 14: Glioma, Meningioma, Neuroblastoma, and Spinal Tumors, New York: Springer, 2015, p.13-24.

Minturn JE, Sievert AJ. Pediatric brain tumors. In: Florin T, Ludwig S. Netter's pediatrics. Philadelphia: Saunders; 2011.

Posters and Presentations

2018

Madsen PJ, Zhang B, Wang K, Waanders AJ, Storm PB, Resnick AC. In silico identification of neo-antigens in a high-grade pediatric brain tumor cohort utilizing next-generation sequencing: pilot study of a discovery pipeline for immunotherapy targets. 2018 Meeting of the American Association of Neurological Surgeons. Oral presentation. AANS/CNS Tumor Section, Columbia Softball Charity Award.

Madsen PJ, Han HJ, Liu G, Sonawane P, Menschik AI, Raman P, Waanders AJ, Storm PB, Resnick AC. ACVR1-mutant DIPGs are characterized by aberrant activin-mediated BMP signaling but may lack cytotoxic response to targeted ACVR1-receptor inhibition. 2018 Meeting of the American Association of Neurological Surgeons. Poster presentation.

2017

Payal Jain, Tamara Fierst, Harry Han, Tiffany Smith, Phillip B Storm, Angela Waanders,and Adam Resnick. Pediatric low-grade gliomas with CRAF gene fusions are therapeutically distinct from BRAF-fusions based on dimerization mediated by N-terminal fusion partner. Neuro-Oncology. Vol 19 (suppl_4), 1 June 2017, pages iv35. https://doi.org/10.1093/neunco/nox083.142 (Poster)

Felmeister A, Lulla R, Waanders AJ, Raman P, Santi M, Lilly JV, Mason J, Nazarian J, and Resnick AC. The Children’s Brain Tumor Tissue Consortium (CBTTC) infrastructure facilitates collaborative research in pediatric central nervous system tumors. Neuro-Oncology. Vol 19 (suppl_4), 1 June 2017, pages iv20-iv21. https://doi.org/10.1093/neunco/nox083.0863 (Poster)

Raman P, Waanders AJ, Storm PB, Lilly JV, Mason J, Heath AP, Felmeister AS, Cros, A, Zhu Y, Sender L, Prados M, Mueller S, Lulla R, Nazarian AC. Cavatica- a pediatric genomic cloud empowering data discovery through the pediatric brain tumor atlas. Neuro-Oncology. Vol 19 (suppl_4), 1 June 2017, pages iv21. https://doi.org/10.1093/neunco/nox083.086  (Poster)

Mueller S, Dirk R, Yang X, DuBois S, Waanders AJ, Resnick AC, Weiss W, Haas-Kogan D. Effects of TORC1/2 inhibition and alone and in combination with MEK inhibition in BRAF mutated glioma cells. Neuro-Oncology. Vol 19 (suppl_4), 1 June 2017, pages iv58. https://doi.org/10.1093/neunco/nox083.241  (Poster)

Christini, A.B., Waanders, A.J., Wagenaar, J.B., Felmeister, A.S., Mason, J.L., Lilly, J.V., Pennington J.W., Resnick, A.C., Lulla, R.R. [ on behalf of the Children’s Brain Tumor Tissue Consortium] Accelerating pediatric brain tumor research through team science solutions. AACR Annual Meeting, April 2017, Washington DC. (Poster)

Resnick AC, Storm PB, Waanders AJ, Lilly LV, Lulla RR, MD, Mueller S, Prados M, Sender LS, Heath A, Felmeister AS, Cros A, Zhu Y, and Raman P. The Pediatric Brain Tumor Atlas: building an integrated, multi-platform data-rich ecosystem for collaborative discovery in the cloud. AACR Annual Meeting, April 2017, Washington DC. (Poster)

2016

Payal Jain, Tamara Fierst, Harry Han, Angela J Waanders, Adam Resnick. Pediatric low-grade gliomas with CRAF fusions respond differentially to targeted therapeutics based on their dimerization profiles. Poster presentation. 28th EORTC-NCI-AACR Symposium, AACR-NCI-EORTC, Nov29-Dec2, 2016; Munich, Germany.

Paltin, I., Hill-Kayser, C. E., Lustig, R., Minturn, J. E., Belasco, J., Cole, K. A., Phillips, P. C., Waanders, A. J., Fisher, M. J., Zebrowski, C., & Barakat, L. P. The importance of baseline data for children receiving cranial proton radiation therapy.  (Oral Presentation by collaborator).  48th Annual Congress of the International Society of Paediatric Oncology, October 2016, Dublin, Ireland.

Paltin I, Zembrowski C, Hill-Kayser CE, Lustig RA, Belasco J, Waanders AJ, Cole K, Kang T, Phillips P, Green A, Fisher MJ, Minturn JE, and Barakat LP. Neuropsychological Functioning at Baseline and at least 2 Years Post Cranial Proton Radiation Therapy. Poster presentation. Annual Meeting of the International Neuropsychological Society, 2016, Boston, Massachusetts.

Raman P, Felmeister AS, Storm PB, Lulla, RR, Waanders AJ, and Resnick AC. Cavatica: Empowering the Pediatric Cancer Genome, CAC2 Cold Springs Harbor Laboratory Pediatric Research Conference, Sept 2016, Cold Spring Harbor, NY. Selected as Best Poster (Presenter: Waanders AJ).

Vakil A, Silva A, Han HJ, Choudhari N, Storm PB, Resnick AC, Davare MA, and Waanders AJ. Combinatorial targeting of oncogenic FGFR 1 gene rearrangements in pediatric gliomas. Neuro-Oncology. 18 (suppl_3) 1 June 2016, pages iii93. https://doi.org/10.1093/neuonc/now075.64 (Poster)

Bergthold G, Bandopadhayay P, Ramkissoon L, Jain P, Wala J, Schumacher S, Ramkissoon S, Varlet P, et al, Angela Waanders, Phillip Storm, Mark Kieran, Adam Resnick, Keith Ligon, Rameen Beroukhim. MYB-QKI rearrangements in angiocentric glioma drive tumorigeneicity through a tripartite mechanism. Neuro-Oncology. 18 (suppl_3) 1 June 2016, pages iii78. https://doi.org/10.1093/neuonc/now075.02 (Oral Presentation)

Payal Jain, Tamara Fierst, Amanda Silva, Jake Budlow, Angela J Waanders, Adam Resnick. Pediatric low-grade gliomas with CRAF fusions respond differentially to targeted therapeutics based on their dimerization profiles. Neuro-Oncology. 18 (suppl_3) 1 June 2016, pages iii84. https://doi.org/10.1093/neuonc/now075.25 (Poster)

Yadavilli S, Yang X, Kilburn L, Magge S, Kambhampati M, Waanders AJ, Han H, Mueller S, Resnick AC, Packer R, and Nazarian J. Development of robust in vitro and in vitro preclinical models for diffuse intrinsic pontine glioma. Neuro-Oncology. 18 (suppl_3) 1 June 2016, pages iii65. https://doi.org/10.1093/neuonc/now073.70 (Poster)

Meuller S, Liang W, Gupta, N, Kuhn J, Kilburn L, Crawford J, Banerjee A, Nazemi K, Packer R, Nazarian J, Petritsch C, et al., Angela Waanders, Adam Resnick, David Craig John Carpten, Sara Byron, Michael Berens, Michael Prados. Precision medicine approach for children with diffuse intrinsic pontine glioma. Neuro-Oncology. 18 (suppl_3) 1 June 2016, pages iii75. https://doi.org/10.1093/neuonc/now073.111 (Oral presentation by collaborator)

Pichai Raman, Alex S Felmeister, Phillip B Storm, Rishi R.Lulla, Angela J Waanders, and Adam C Resnick, on behalf of the complete team membership of the Children’s Brain Tumor Tissue Consortium (CBTTC). “Cavatica: Empowering Research with a Pediatric Genomic Cloud.” Poster presentation. 2016 MidAtlantic Bioinformatics Conference: Computational Challenges for Precision Medicine by The Children's Hospital of Philadelphia DBHi. Philadelphia, PA.

Payal Jain* (presenter), Tamara Fierst, Amanda Silva, Jake Budlow, Angela J Waanders, Adam Resnick. Pediatric low-grade gliomas with CRAF fusions respond differentially to targeted therapeutics based on their dimerization profiles. National oral presentation at AACR Annual Meeting 2016, April 16-20, 2016; New Orleans, La.

Lectures by Invitation

2018

Waanders AJ. “CBTTC Empowering Discovery”, 2016 WHO CNS Classification Sunrise Session, International Symposium on Pediatric Neuro-Oncology 2018, Denver, CO. July 2018.

Waanders AJ. “NonProfit Collaborative Panel”, NonProfit Symposium, International Symposium on Pediatric Neuro-Oncology 2018, Denver, CO. June 2018.

Waanders AJ. “Open Sourcing of Tissue Data Empowered by CBTTC”, Family Day, International Symposium on Pediatric Neuro-Oncology 2018, Denver, CO. June 2018.

Waanders AJ. “Current Landscape: CBTTC International Pediatric Brain Tumor Collaborative Research Consortia,” Brain Tumors 2018 From Biology to Therapy, Warsaw, Poland. June 2018.

Waanders AJ. “Identification of Predictive Biomarkers in OMAS,” OMS International Workshop, Abingdon, UK. March 2018.

Waanders AJ. “Innovation through Collaboration”, Hudson Institute of Medical Research Childhood Cancer Research Symposium, Melbourne, VIC, Australia. February 2018.

Waanders AJ. “Introduction to CBTTC”, AI Dupont Hospital, Wilmington, Delaware. January 2018.

2017

Waanders AJ. “Pediatric cancer clinical trial and research consortia landscape,” Cancer Informatics for Cancer Centers (CI4CC) Fall 2017 Symposium, La Jolla, CA.

2016

Waanders, AJ. “Therapeutic targeting of fusion genes activating MAP kinase and other pathways,” Johns Hopkins Medical Center, Baltimore, MD. March 2016.

Waanders, AJ. “CBTTC New Initiatives: Enriching the Clinical Data to Empower the Genomic Data," CBTTC Investigator Meeting, New Orleans, LA. May 2016.

Waanders, AJ. “Cavatica: Empowering the Pediatric Cancer Genome,” CAC2 Cold Springs Harbor Laboratory Pediatric Research Conference, Cold Spring Harbor, NY. Sept 2016.

Waanders AJ. “PedcBioPortal: A cancer data visualization tool for integrative pediatric cancer analyses,” Society of NeuroOncology Annual Meeting, Scottsdale, AZ. (Invited oral presentation but unavailable to speak and 2nd author presented on my behalf). November 2016.

Awards and Honors

2015-2016, Alex’s Lemonade Stand Center of Excellence Scholar Award
2015-2017, Damon Runyon Dale F Frey Breakthrough Scientist Award
2014-2016, Sanford Endowed Chair for Pediatric Oncology Research
2009,  Prize- CHOP Research Poster Day 
1999-2003, Adopt-A-Student Scholarship, Tulane University SOM
1996,  Philosophy Department Senior Student Award
1992-1996, Alpha Lambda Delta Honorary Society
1992-1996, Medallion and HEIS Scholarships for Academic Excellence

Editorial and Academic Positions

Editorial Positions

2017-present, Perspectives in Pediatrics, Editorial Board
2017-present, Journal of the National Comprehensive Cancer Network, reviewer
2013-present, Molecular Cancer Therapeutics, reviewer
2012-present, Journal of Neuro-Oncology, reviewer
2011-present, Pediatric Blood and Cancer, reviewer

Academic and Institutional Committees

2018-present, Executive Board Chair, Institutional Principal Investigator, The Children’s Brain Tumor Tissue Consortium
2017-present, Site Co-Principal Investigator, Pacific Pediatric Neuro-Oncology Consortium
2017-present, Director of Clinical Research, Center for Data Driven Discovery in Biomedicine (D3b), Children’s Hospital of Philadelphia
2017-present, Bear Necessities Pediatric Cancer Foundation, Grant Review Committee
2016-present, Director of Operations, University of Pennsylvania Brain Tumor Banking Program (NTTB)
2016-present, Institutional Review Board, Children’s Hospital of Philadelphia
2016-2018, Institutional Principal Investigator, Director of Operations, The Children’s Brain Tumor Tissue Consortium (CBTTC)
2015-present, Pediatric Oncology Precision Medicine Tumor Board series, Division of Oncology (monthly 1-hour education series), Children’s Hospital of Philadelphia
2014-present,  St. Baldrick’s Foundation, Grant Review Committee
2014-present, Tumor Board, Division of Oncology (Pediatric Brain Tumor lecture series), Children’s Hospital of Philadelphia
2011-present, Pediatric Protocol Review Committee, Division of Oncology, Children’s Hospital of Philadelphia

Leadership and Memberships

Memberships in Professional Organizations
International

2017-present, International Society of Pediatric Oncology
 - 2018-present, Annual Meeting 2018, abstract reviewer

National

2016 NIH Blueprint Neurotherapeutics Network Grant Review Committee
2013- present, Co-Scientific Investigator, Pacific Pediatric Neuro-Oncology Consortium
2009- 2012, Pediatric Brain Tumor Consortium
2008- present, American Association for Cancer Research
2007- present, Society of Neuro-Oncology
2007- present, Children’s Oncology Group
2006- present, American Society of Pediatric Hematology/Oncology
2006-present, American Society of Clinical Oncology