Scott L. Weiss, MD, MSCE

Scott L. Weiss, MD, MSCE

Scott L. Weiss, MD, MSCE, is a pediatric intensivist at Children's Hospital of Philadelphia.

Areas of Expertise: Sepsis, Biomarkers, Microcirculatory and mitochondrial dysfunction, Multiple organ dysfunction syndrome (MODS), Epidemiology
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

Background

Dr. Weiss is a graduate of Cornell University and Harvard Medical School, and obtained a Master’s of Science in Clinical Epidemiology from the University of Pennsylvania. After pediatrics training at Children’s Hospital Boston (Harvard) and pediatric critical care fellowship at Lurie Children’s Hospital (Northwestern), Dr. Weiss came to Children’s Hospital of Philadelphia (CHOP) in 2011. He is currently an Assistant Professor of Anesthesiology and Critical Care and Pediatrics at the Perelman School of Medicine at the University of Pennsylvania and an attending physician in the pediatric intensive care unit at CHOP.

Dr. Weiss’ research focuses on epidemiology of pediatric sepsis and mitochondrial dysfunction in sepsis-associated organ injury. The driving hypothesis for his NIH-funded research is that alterations in mitochondrial bioenergetics contribute to organ injury and immune dysregulation in a subset of children with sepsis. He has several active studies evaluating risk factors, biomarkers, and mechanisms of organ dysfunction in pediatric sepsis, including changes in the intestinal microbiome. The long-term goal of Dr. Weiss’ translational research program is to identify a targeted therapeutic approach to augment mitochondrial bioenergetics and improve clinical outcomes for children with sepsis-associated immune dysregulation and organ injury.

Dr. Weiss is involved with quality improvement work for sepsis at CHOP, including leading a taskforce to develop a Hospital-wide sepsis screening alert integrated within the electronic medical record. He also serves as the Co-Vice Chair for the international Pediatric Surviving Sepsis Campaign, and has consulted for the Pennsylvania Department of Health about sepsis-related regulations.

Education and Training

Medical School

MD - Harvard Medical School, Boston, MA

Internship

Pediatrics - Children’s Hospital Boston, Boston, MA

Residency

Pediatrics - Children’s Hospital Boston, Boston, MA

Fellowship

Pediatric Critical Care Medicine - Children's Memorial Hospital (now Lurie Children’s Hospital of Chicago), Northwestern Feinberg School of Medicine, Chicago, IL

Board Certification

Pediatric Critical Care Medicine
Pediatrics

Graduate Degree

MS in Clinical Epidemiology - Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

Titles and Academic Titles

Attending Physician, Pediatric Critical Care Medicine

Assistant Professor of Anesthesiology, Critical Care and Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

Sepsis
Multiple organ dysfunction syndrome (MODS)
Mitochondrial dysfunction

Publications

Papers

2017

Lin JC, Spinella PC, Fitzgerald JC, Tucci M, Bush JL, Nadkarni VM, Thomas NJ, Weiss SL for the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. New or progressive multiple organ dysfunction syndrome (NPMODS) in pediatric severe sepsis: a sepsis phenotype with higher morbidity and mortality. Pediatric Critical Care Medicine 2017;18(1):8-16.

Weiss SL, Keele L, Balamuth F, Vendetti N, Ross R, Fitzgerald JC, Gerber JS. Crystalloid fluid choice and clinical outcomes in pediatric sepsis: a match retrospective cohort study. Journal of Pediatrics 2017;182:304-310.

Downes KJ, Weiss SL, Klieger SB, Fitzgerald JC, Balamuth F, Kubis S, Tolomeo P, Bilker W, Han X, Nachamkin I, Garrigan C, Han J, Lautenbach E. Gerber JS, Coffin S for The CDC Prevention Epicenters Program. A Pragmatic Biomarker-Driven Algorithm to Guide Antibiotic Use in the Pediatric Intensive Care Unit: the Optimizing Antibiotic Strategies in Sepsis (OASIS) Study. Journal of the Pediatric Infectious Diseases Society 2017;6:134-141.

Han M, Fitzgerald JC, Balamuth F, Keele L, Alpern ER, Lavelle J, Chilutti M, Grundmeier RW, Nadkarni VM, Thomas NJ, Weiss SL. Association of delayed antimicrobial therapy with one-year mortality in pediatric sepsis. Shock 2017 Jan 20 [Epub ahead of print].

Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald J, Checchia PA, Meyer K, Quasney M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Grunwell JR, Opoka A, Wong HR. Glucocorticoid receptor polymorphisms and outcomes in pediatric septic shock. Pediatric Critical Care Medicine 2017;18(4):299-303.

Weiss SL, Asaro LA, Flori HR, Allen GL, Wypij D, Curley MAQ. Multiple organ dysfunction in children mechanically ventilated for acute respiratory failure. Pediatric Critical Care Medicine 2017;18(4):319-329.

Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Grunwell JR, Lindsell CJ.  Improved risk stratification in pediatric septic shock using both protein and mRNA biomarkers: PERSEVERE-XP. American Journal of Respiratory and Critical Care Medicine 2017 Mar 21 [Epub ahead of print].

Balamuth F, Alpern ER, Funari MK, Hayes K, Schast A, Lavelle J, Fitzgerald JC, Weiss SL, Zorc JJ. Improving recognition of pediatric severe sepsis in the emergency department: contributions of a vital sign based electronic alert and bedside clinician identification. Annals of Emergency Medicine Annals of Emerg Med. 2017 (17)30315-3.

Weiss SL, Balamuth F, Hensley J, Fitzgerald JC, Bush J, Nadkarni VM, Thomas NJ, Hall M, Muszynski J. The epidemiology of hospital death following pediatric severe sepsis: when, why, and how children with sepsis die. Pediatric Critical Care Medicine 2017 May 25. doi: 10.1097/PCC.0000000000001222. [Epub ahead of print]

Carcillo JA, Podd B, Aneja R, Weiss SL, Hall MW, Cornell TT, Shanley TP, Doughty LA, Nguyen TC. Pathophysiology of pediatric multiple organ dysfunction syndrome. Pediatric Critical Care Medicine 2017;18:S32-S45.

Weiss, SL. Clinical trials in pediatric sepsis:  what’s the (end) point? [Invited editorial on Primary outcome measures in pediatric septic shock trials:  a systematic review] Pediatric Critical Care Medicine 2017;18(3):296-297.

Morgan R, Fitzgerald J, Weiss SL, Nadkarni V, Sutton R, Berg R. Sepsis-associated in-hospital cardiac arrest in children and adults. Journal of Critical Care 2017;40:128-135.

Davis AL, Carcillo JA, Aneja RK, Deymann AJ, Lin JC, Nguyen TC, Okhuysen-Cawley RS, Relvas MS, Rozenfeld RA, Skippen PW, Stojadinovic BJ, Williams EA, Yeh TS, Balamuth F, Brierley J, de Caen AR, Cheifetz IM, Choong K, Conway E, Cornell T, Doctor A, Dugas M, Feldman JD, Fitzgerald JC, Flori HR, Fortenberry JD, Braciano AL, Greenwald BM, Hall MW, Han YY, Hernan LK, Irazuzta JE, Iselin E, van der Jagt WE, Jeffries HE, Kache S, Katyal C, Kissoon N, Kon AA, Jutko MC, MacLaren G, Maul T, Mehta R, Odetola F, Parbuoni K, Paul R, Peters MJ, Ranjit S, Reuter-Rice KE, Schnitzler EJ, cott H, Torees A, Weingarten-Abrams J, Weiss SL, Zimmerman JJ, Zuckerberg AL.  American College of Critical Care Medicine clinical practice parameters for hemodynamic support of pediatric and neonatal shock. Critical Care Medicine 2017;45:1061-1093.

2016

Klieger SB, Fitzgerald JC, Weiss SL, Balamuth F, Teszner E, Sammons JS, Coffin SE. Pediatric Severe Sepsis/Septic Shock Associated with Healthcare-Associated Infections. Infect Control Hosp Epidemiol 2016;37(4):483-5.

Giuliano JS, Jr, Markovitz BP, Brierley J, Levin R, Williams G,  Lum LC, Dorofaeff T, Cruces P, Bush JL, Keele L, Nadkarni VM, Thomas NJ, Fitzgerald JC, Weiss SL for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Variability in pediatric severe sepsis managed in USA and European intensive care units. Pediatric Critical Care Medicine 2016;17(6):522-30.

Balamuth F, Weiss SL, Fitzgerald JC, Hayes K, Centkowski S, Chilutti M, Grundmeier R, Lavelle J, Alpern ER. Protocolized treatment is associated with decreased organ dysfunction in pediatric severe sepsis. Pediatric Critical Care Medicine 2016; 17(9):817-822.

Halstead ES, Rajasekaran S, Fitzgerald JC, Weiss SL. Hyperferritinemic sepsis:  an opportunity for earlier diagnosis and intervention. Front Pediatr. 2016:4:77.

Fitzgerald JC, Weiss SL, Kissoon N. 2016 Update for the Rogers’ Textbook of Pediatric Intensive Care:  Recognition and initial management of shock. Pediatric Critical Care Medicine 2016;17(11):1073-1079.

Teachey DT, Lacey SF, Shaw PA, Melenhorst JJ, Maude SL, Frey N, Pequignot E, Gonzalez VE, Chen F, Finklestein J, Barrett DM, Weiss SL, Fitzgerald JC, Berg RA, Aplenc R, Callahan C, Rheingold SR, Zheng Z, Rose-John S, Nazimuddin F, Wertheim G, Levine BL,  June CH, Porter DL, Grupp SA. Identification of predictive biomarkers for cytokine release syndrome after chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia. Cancer Discovery 2016;6(6):664-679.

Wong HR, Atkinson SJ, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Lindsell CJ. Combining prognostic and predictive enrichment strategies to identify children with septic shock responsive to corticosteroids. Critical Care Medicine 2016;44(10)e1000-10003.

Lautz AJ, Dziorny AC, Denson AR, O’Connor KA, Chilutti MR, Ross RK, Gerber JS, Weiss SL. Value of procalcitonin measurement for early evidence of severe bacterial infections in the pediatric intensive care unit. Journal of Pediatrics 2016;179:74-81.

Fitzgerald JC, Basu R, Akcan-Arikan A, Izquierdo LM, Pineres Olave BE, Hassinger AB, Szczepanski M, Deep A, Williams D, Sapru A, Roy JA, Nadkarni VM, Thomas NJ, Weiss SL, Furth S for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Acute kidney injury in pediatric severe sepsis: an independent risk for death and new disability. Critical Care Medicine 2016;44(12):2241-2250.

Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald J, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Howard K, Harmon K, Lahni P, Frank E, Hart KW, Nguyen TC, Lindsell CJ. Pediatric sepsis biomarker risk model-II:  Redefining the pediatric sepsis biomarker risk model with septic shock phenotype. Crit Care Med 2016;44(11):2010-2017

Fitzgerald JC, Weiss SL, Maude S, Barrett D, Lacey S, Melenhorst J, Shaw P, Berg R, June C, Porter D, Frey N, Grupp S, Teachey D. Cytokine release syndrome after chimeric antigen receptor T-cell therapy for leukemia. Critical Care Medicine 2016 Sept 14 [Epub ahead of print].

2015

Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Checchia PA, Meyer K, Shanley TP, Quasney M, Hall M, Gedeit R, Freishstat RJ, Nowak J, Shekhar RS, Gertz S, Dawson E, Howard K, Harmon K, Beckman E, Frank E, Lindsell CJ. Developing a clinically feasible theragnostic approach to pediatric septic shock. Am J Respir Crit Care Med. 2015;191(3):309-15.

Weiss SL, Selak MA, Tuluc F, Perales-Villarroel JP, Nadkarni VM, Deutschman CS, Becker, LB. Mitochondrial dysfunction in peripheral mononuclear cells in pediatric septic shock. Pediatric Critical Care Medicine. 2015;16(1):e4-e12.

Weiss SL*, Fitzgerald JC*, Pappachan J, Wheeler D, Jaramillo-Bustamante JC, Salloo A,  Singhi SC, Erickson S, Roy JA, Bush JL, Nadkarni VM, Thomas NJ for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Global epidemiology of pediatric severe sepsis: the Sepsis PRevalence, OUtcomes, and Therapies (SPROUT) study. Am J Respir Crit Care Med 2015;191(10):1147-57.  (*contributed equally)

Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Checchia PA, Meyer K, Shanley TP, Quasney M, Hall M, Gedeit R, Freishstat RJ, Nowak J, Shekhar RS, Gertz S, Dawson E, Howard K, Harmon K, Lahni P, Beckman E, Frank E, Hart KW, Lindsell CJ. A multi-biomarker-based model for estimating the risk of septic acute kidney injury. Crit Care Medicine 2015;43(8):1646-1653.

Martin K, Weiss SL. Initial resuscitation and management of pediatric septic shock. Minerva Pediatrica 2015;67(2):141-58.

Balamuth F, Alpern ER, Weiss SL, Grundmeier R, Chilutti M, Fitzgerald JC, Hayes K, Bilker W, Lautenbach E. Comparison of Two Sepsis Recognition Methods in a Pediatric Emergency Department. Academic Emergency Medicine 2015;22(11):1298-306.

Grunwell JR, Weiss SL, Cvijanovich NZ, Allen GL, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Cecchia PA, Shanley TP, Bigham MT, Fitzgerald JC, Howard K, Frank E, Harmon K, Wong HR. Differential expression of the Nrf2-linked genes in pediatric septic shock. Critical Care 2015;19:327.

Weiss SL, Fitzgerald JC, Maffei F, Kane JM, Rodriguez-Nunez A, Hsing DD, Franzon D, Ying Kee S, Bush JL, Roy JA, Thomas, NJ, Nadkarnin VM for the SPROUT Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Discordant Identification of Pediatric Severe Sepsis by Research and Clinical Definitions in the SPROUT International Point Prevalence Study. Critical Care 2015;19:325.

Balamuth F, Weiss SL, Hall M, Neuman MI, Scott H, Brady PW, Paul R, Farris RWD, McClead R, Centkowski S, Baumer S, Weiser J, Hayes K, Shah SS, Alpern ER.  Identifying pediatric severe sepsis and septic shock:  accuracy of diagnosis codes.  Journal of Pediatrics 2015;167(6):1295-1300.

Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishstat RJ, Nowak J, Shekhar RS, Gertz S, Howard K, Harmon K, Lahni P, Frank E, Hart KW, Lindsell CJ.  Prospective testing and redesign of a temporal biomarker based risk model for patients with septic shock: implications for septic shock biology. EBioMedcine 2015:2(12);2087-93.

2014

Abulebda K, Cvijanovich N, Thomas N, Allen G, Anas N, Bingham M, Hall M, Freishtat R, Sen A, Meyer K, Checchia P, Shanley T, Nowak J, Quasney M, Weiss SL, Chopra A, Banschbach S, Beckman E, Lindsell C, Wong HR. Post-intensive care unit admission fluid balance and pediatric septic shock outcomes: A risk-stratified analysis. Critical Care Medicine. 2014;42(2):397-403.

Wong HR, Weiss SL, Giuliano JS, Wainwright M, Cvijanovich NZ, MD, Thomas NJ, Allen GL, Anas N, Bigham MT, Hall M, Freishtat RJ, Sen A, Meyer K, Checchia PA, Shanley TP,  Nowak J, Quasney M, Chopra A, Fitzgerald JC, Gedeit R, Banschbach S, Beckman E, Lahni P, Hart K, Lindsell CJ. Testing the Prognostic Accuracy of the Pediatric Sepsis Biomarker Risk Model. PLoS One. 2014; 2014;9(1):e86242.

Wong HR, Weiss SL, Giuliano JS, Wainwright M, Cvijanovich NZ, MD, Thomas NJ, Allen GL, Anas N, Bigham MT, Hall M, Freishtat RJ, Sen A, Meyer K, Checchia PA, Shanley TP,  Nowak J, Quasney M, Chopra A, Fitzgerald JC, Gedeit R, Banschbach S, Beckman E, Lahni P, Hart K, Lindsell CJ. The temporal version of the pediatric sepsis biomarker risk model. PLoS One. 2014;9(3):e92121.

Wong HR, Cvijanovich N, Allen G, Thomas N, Freishtat R, Anas N, Meyer K Checchia P, Weiss SL, Shanley T, Bigham MT, Banschbach S, Beckman E, Harmon K, Zimmerman J. Corticosteroids are associated with repression of adaptive immunity gene programs in pediatric septic shock. Am J Respir Crit Care Med. 2014 Apr 15;189(8):940-6.

Weiss SL, Fitzgerald JC, Faustino EV, Festa MS, Fink EL, Jouvet P, Bush JL, Kissoon N, Marshall J, Nadkarni VM, Thomas NJ.  Understanding the global epidemiology of pediatric critical illness:  the power, pitfalls, and practicalities of point prevalence studies. Pediatric Critical Care Medicine. 2014;15(7):660-6.

Weiss SL, Fitzgerald JC, Balamuth F, Alpern ER, Lavelle J, Chilutti M, Grundmeier R, Nadkarni VM, Thomas NJ. Delayed antimicrobial therapy increases mortality and organ dysfunction duration in pediatric sepsis. Critical Care Medicine 2014;42(11):2409-2417.

Balamuth F, Weiss SL, Neuman MI, Scott H, Brady PW, Paul R, Farris RWD, McClead R, Hayes K, Gaieski D, Hall M, Shah SS, Alpern ER. Pediatric Severe Sepsis in US Children's Hospitals. Pediatric Critical Care Medicine. 2014;15(9):798-805.

Atkinson S, Cvijanovich N, Thomas N, Allen G, Anas N, Bigham M, Hall M, Freishtat R, Sen A, Meyer K, Checchia P, Shanley T, Nowak J, Quasney M, Weiss SL, Banschbach S, Beckman E, Howard K, Frank E, Harmon Kelli, Lahni P, Lindsell C, Wong H. Corticosteroids and Pediatric Septic Shock Outcomes: A Risk Stratified Analysis. PLoS One. 2014;9(11):e112702.

Weiss SL, Cvijanovich NZ, Allen GA, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Checchia PA, Shanley TP, Bigham MT, Fitzgerald J, Banschbach S, Beckman E, Howard K, Frank E, Harmon K, Wong HR. Differential expression of the nuclear-encoded mitochondrial transcriptome based on genome-wide expression profiling in pediatric septic shock. Critical Care. 2014;18(6):623.

2013

Karamercan MA, Weiss SL, Villarroel JP, Guan Y, Werlin EC, Figueredo R, Becker LB, Sims CA. Can peripheral blood mononuclear cells be used as a proxy for mitochondrial dysfunction in vital organs during hemorrhagic shock and resuscitation? Shock. 2013;40(6):476-84.

2012

Weiss SL, Haymond S, Ralay Ranaivo H, De Jesus V, Chace DH, Wainwright MS. Evaluation of asymmetric dimethylarginine, arginine, and carnitine metabolism in pediatric sepsis. Pediatric Critical Care Medicine. 2012 July;13(4):e210-8.

Weiss SL, Parker B, Bullock ME, Swartz S, Price C, Wainwright MS, Goodman DM. Defining pediatric sepsis by different criteria: discrepancies in populations and implications for clinical practice. Pediatric Critical Care Medicine. 2012 July;13(4):e219-26.

Weiss SL, Yu M, Jennings L, Haymond S, Zhang G, Wainwright MS. Pilot Study of the Association of the DDAH2 -449G polymorphism with asymmetric dimethylarginine and hemodynamic shock in pediatric sepsis. PLoS One. 2012 March;7(3):e33355.

2011

Weiss SL, Gossett JG, Kaushal S, Wang D, Backer CL, Wald EL. Comparison of gastrointestinal morbidity after Norwood and hybrid palliation for complex heart defects. Pediatric Cardiology. 2011;32(4):391-398.

2010

Weiss SL, Alexander J, Agus, M. Extreme stress hyperglycemia during acute illness in a pediatric emergency department. Pediatric Emergency Care. 2010;26(9):626-632.

2008

Maniaci V, Dauber A, Weiss S, Nylen E, Becker KL, Bachur R. Procalcitonin in young febrile infants for the detection of serious bacterial infection. Pediatrics. 2008;122:701-710.

Dauber A, Weiss S, Maniaci V, Nylen E, Becker KL, Bachur R. Procalcitonin levels in febrile infants after recent immunization. Pediatrics. 2008;122:e1119-e1122.

2007

Robertson SS, Johnson SL, Masnick AM, Weiss SL. Robust coupling of body movement and gaze in young infants. Developmental psychobiology. 2007;49:208-215.

Books

Chapter

2017

Weiss SL, Deutschman CS, Becker LB. Chapter 80: “Cellular Respiration”. In Fuhrman and Zimmerman’s Pediatric Critical Care, 5th Edition. Bradley P. Fuhrman and Jerry J. Zimmerman, Editors. Elsevier, Philadelphia PA. 2017, pgs 1131-1144.

2016

Weiss SL, Levy RL, Deutschman CS. Chapter 49: “Is Sepsis-Induced Organ Dysfunction an Adaptive Response?”. In Evidence-Based Practice of Critical Care, 2nd Edition. Clifford S. Deutschman and Patrick J. Neligan, Editors. Elsevier, Philadelphia PA. 2016, pgs 335-340.

Balamuth F, Fitzgerald JC, Weiss SL. Chapter 5: “Shock”. In Fleisher and Ludwig’s Textbook of Emergency Medicine, 7th Edition. Richard Bachur, Kathy Shaw, James Chamberlain, Jane Lavelle, Josh Nagler, and Joan Shook, Editors. Wolters Kluwer, Philadelphia PA. 2016, pgs 55-68.

Thomas NJ, Tamburro RF, Rajasekaran S, Fitzgerald JC, Weiss SL, Hall MW. Chapter 87: “Bacterial sepsis”. In Rogers’ Textbook of Pediatric Intensive Care 5th Edition. David G. Nichols, MD and Donald H. Shaffner, MD, Editors. Wolters Kluwer, Philadelphia PA. 2016, pgs 1377-1396.

Weiss SL, Han YY, Shanley TP, Carcillo JA. Chapter 23: “Multiple organ dysfunction syndrome”. In Rogers’ Textbook of Pediatric Intensive Care 5th Edition. David G. Nichols, MD and Donald H. Shaffner, MD, Editors. Wolters Kluwer, Philadelphia PA. 2016, pgs 287-302.

2012

Florin TA, Balamuth F, Rizkalla N, Weiss SL, Davis K, Gaspers M, Nathanang D, Lockman J. Chapter 73: “Environmental Exposures and Intoxications: Poisonings”. In Comprehensive Critical Care: Pediatric. Jana Stockwell, M.D. and Catherine (Katy) Preissig, M.D., Editors. pp 1009-1028, 2012.

2008

Weiss S. “Abdominal mass; Acute abdominal pain; Chronic abdominal pain; Chest pain; Cyanosis; Murmur in the newborn”. In: Sectish: Chief Complaints in Pediatrics. Theodore C. Sectish, M.D. and Amanda S. P. Growdon, M.D., Editors. New York, NY: PocketMedicine.com, Inc., 2008.

Posters and Presentations

2017

Downes KJ, Schriver E, Russo M, Weiss SL, Fitzgerald JC, Balamuth F, Tolomeo P, Bilker WB, Han JH, Lautenbach E, Coffin SE, Gerber JS for the CDC Prevention Epicenters Program. Implementation of a pragmatic biomarker-driven algorithm to guide antibiotic use in the pediatric intensive care unit: the optimizing antibiotic strategies in sepsis (OASIS) II study. Poster presentation at the IDWeek 2017 Conference, 2017 Oct 4-8, San Diego, CA.

Gu H, Keele L, Hayes K, Fitzgerald J, Weiss SL, Balamuth F. Machine learning predictive modeling for organ dysfunction in children with suspected sepsis in the emergency department. Oral presentation at the American Academy of Pediatrics Annual Meeting, 2017 September, Chicago, Illinois.

Hall M, Steele L, Hanson-Huber L, Agan A, Anushay M, Mourani P, Loftis L, Weiss SL, Paden M, Higgerson R, Hartman M, Randolph A. Longitudinal innate immune function and outcomes from pediatric critical influenza. Platform Presentation, Pediatric Academic Societies’ Annual Meeting, 2017 May 6-9, San Francisco, California.

Glau C, Conlon T, Weiss SL, Yehya N, Himebauch, Nishisaki A. Progressive diaphragm atrophy is present in pediatric acute respiratory failure. Research Presentation at the 46th Critical Care Congress, January 22-25, 2017, Honolulu, Hawaii.

Weiss SL, Balamuth F, Fitzgerald J, Hensley J, Bush J, Thomas N, Hall M, Muszynski J. Epidemiology of death following pediatric sepsis: when, why, and how septic kids die. Research Snapshot Presentation at the 46th Critical Care Congress, January 22-25, 2017, Honolulu, Hawaii.

Weiss SL, Zhang D, Graham K, Deutschman CS, Kilbaugh T, McGowan F, Becker L, Wallace D. Reduced mitochondrial mass underlays decreased respiration in septic immune cells. Star Research Presentation at the 46th Critical Care Congress, January 22-25, 2017, Honolulu, Hawaii.

***Star Research Achievement Award

***Pediatrics Section Travel Grant Award

2016

Lacey SF, Shaw PA, Teachey DT, Weiss SL, Chen F, Gonzalez V, Frey N, Porter DL, Maude SL, Grupp SA, Pequignot E, June CH, Melenhorst JJ. Biomarker profiling to differentiate sepsis from cytokine release syndrome in chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia. Poster Presentation at the American Society of Hematology 58th Annual Meeting and Exposition, December 3-6, 2016, San Diego, California.

Ballantine A, DiTaranto S, Roberts K, Balamuth F, Weiss SL, Fitzgerald J, Hadley S, Minich C, Rigby V, Keren R. Improving response to suspected sepsis: results of a hospital-wide quality improvement initiative. Poster presentation, American Academy of Pediatrics National Conference & Exhibition, October 22-25, 2016, San Francisco, CA.

Abaya R, Weiss SL, Fitzgerald JC, Balamuth F. Utility of procalcitonin to predict intensive care unit admission and identify bacterial illness in the ED resuscitation of pediatric sepsis. Poster presentation, Pediatric Academic Societies’ Annual Meeting, April 30-May 3, 2016, Baltimore, Maryland.

Alqahtani M, Dawson S, Ralay Ranaivo H, Smith CM, Weiss SL, Wainwright M. Biomarkers in pediatric sepsis: MMP-9, TIMP-1, MRPROANP, and adipocyte fatty-acid binding protein. Research Snapshot Presentation at the 45th Critical Care Congress, February 21-24, 2016, Orlando, Florida.

Han M, Fitzgerald J, Balamuth F, Chilutti M, Grundmeier R, Nadkarni V, Thomas N, Weiss SL. Hourly delays to antimicrobial therapy do not increase one-year mortality in pediatric severe sepsis. Critical Care Medicine 2015;43(12) Suppl:A272-273. [Research Snapshot Presentation at the 45th Critical Care Congress, February 21-24, 2016, Orlando, Florida].

Signoff J, Fitzgerald F, Teachey D, Balamuth F, Weiss SL. Hypofibrinogenemia is associated with poor outcome and secondary HLH in pediatric severe sepsis. Critical Care Medicine 2015;43(12) Suppl:A260 [Research Snapshot Presentation at the 45th Critical Care Congress, February 21-24, 2016, Orlando, Florida].

2015

Downes KJ, Weiss SL, Klieger SB, Fitzgerald JC, Balamuth F, Kubis S, Tolomeo P, Bilker W, Han X, Nachamkin I, Garrigan C, Han J, Lautenbach E. Gerber JS, Coffin S for The CDC Prevention Epicenters Program. Developing a Biomarker-Driven Algorithm to Improve Antibiotic Use in the Pediatric Intensive Care Unit: the Optimizing Antibiotic Strategies in Sepsis (OASIS) Study. Oral presentation, IDWeek 2015, San Diego, CA, Octobter 9, 2015.

Balamuth F, Hayes K, Centkowski S, Gagel A, Fitzgerald JC, Weiss SL, Chilutti M, Grundmeier R, Lavelle J, Alpern ER. Decreased organ failure in pediatric sepsis treated according to a bundled treatment guideline. Poster presentation, Pediatric Academic Societies’ Annual Meeting, 2015 April 25-28, San Diego, California.

Balamuth F, Funari MK, Hayes K, Schast A, Lavelle J, Fitzgerald JC, Weiss SL, Alpern ER, Zorc, JJ. Improved emergency department recognition of pediatric severe sepsis/septic shock with an electronic alert. Platform presentation, Pediatric Academic Societies’ Annual Meeting, 2015 April 25-28, San Diego, California.

Dziorny A, Lautz A, Densen A, O’Connor K, Weiss SL. Procalcitonin for Early Recognition of Severe Bacterial Infections in the Pediatric Intensive Care Unit. Platform presentation, Pediatric Academic Societies’ Annual Meeting, 2015 April 25-28, San Diego, California.

Klieger SB, Fitzgerald JC, Weiss SL, Balamuth F, Teszner E, Sammons JS & Coffin SE. Pediatric Severe Sepsis/Septic Shock Attributable to Healthcare-Associated Infections. The Society for Healthcare Epidemiology of America (SHEA) annual meeting. May 2015, Orlando, Florida.

Balamuth F, Caplan I, Scott H, Weiss SL, Fitzgerald J, Kubis S, Chilutti M, Grundmeier R, Alpern ER. Increased risk of one-year all-cause mortality after pediatric severe sepsis. Critical Care Medicine 2014;42(12) Suppl:A1606 [Poster Presentation at the 44th Critical Care Congress, January 2015, Phoenix, Arizona].

2014

Balamuth F, Weiss SL, Fitzgerald JC, Hayes K, Chilutti M, Grundmeier R, Myers S, Lautenbach E, Alpern ER. Comparison of two sepsis recognition methods in a pediatric Emergency Department. Platform Presentation at the Pediatric Academic Societies Annual Meeting, May 2014, Vancouver, BC, Canada.

Invited Lectures

2017

Weiss S. “Management of Pediatric Sepsis and the Role Clinically-Available Biomarkers May Play in More Complex Cases”, Invited panelist for Medscape video-conference, New York, New York, June 30, 2017.

Weiss S. “Role of the Intestinal Microbiome in Mitochondrial-Induced Immune Dysregulation in Pediatric Sepsis”, PennCHOP Microbiome Lab Meeting, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, June 14, 2017.

Weiss S. “Mortality Post-Discharge from Sepsis”, 28th Annual Meeting of The European Society of Pediatric and Neonatal Intensive Care, Lisbon, Portugal, June 8, 2017.

Weiss S. “Which Antibiotics to Use in Sepsis? The Use and Misuse of Antibiotics”, 28th Annual Meeting of The European Society of Pediatric and Neonatal Intensive Care, Lisbon, Portugal, June 7, 2017.

Weiss S. “Can We Prevent Development of Multiple Organ Dysfunction Syndrome?”, Pre-meeting Sepsis Workshop at the 28th Annual Meeting of The European Society of Pediatric and Neonatal Intensive Care, Lisbon, Portugal, June 6, 2017.

Weiss S. “Mitochondrial Energy Metabolism and the Immune Response in Sepsins”, 40th Annual Conference on Shock, The Shock Society, Ft. Lauderdale, Florida, June 3, 2017

Weiss S. “Global Epidemiology of Pediatric Severe Sepsis: The SPROUT Study”, Pediatric Academic Societies’ Annual Meeting, San Francisco, California, May 8, 2017.

Weiss S. “Definitions, Epidemiology, and Guidelines (Oh My!) for Pediatric Sepsis”, Emergency Medicine Special Interest Group, Pediatric Academic Societies’ Annual Meeting, San Francisco, California, May 7, 2017.

Weiss S. “Resuscitating the Resuscitation Algorithm for Pediatric Septic Shock: Can We Do Better”, 8° Congreso Argentino de Emergencias y Cuidados Criticos en Pediatria (8th Argentina Congress for Pediatric Emergency and Critical Care), Buenos Aires, Argentina, April 28, 2017.

Weiss S. “Mitochondrial Dysfunction in Pediatric Sepsis: Should We Be Resuscitating Our Patients’ Ch’i”, 8° Congreso Argentino de Emergencias y Cuidados Criticos en Pediatria (8th Argentina Congress for Pediatric Emergency and Critical Care), Buenos Aires, Argentina, April 28, 2017.

Weiss S. “Global Epidemiology of Pediatric Severe Sepsis: Lessons Learned from the SPROUT Study”, 8° Congreso Argentino de Emergencias y Cuidados Criticos en Pediatria (8th Argentina Congress for Pediatric Emergency and Critical Care), Buenos Aires, Argentina, April 27, 2017.

2016

Weiss S. “Decreased Mitochondrial Respiration and Content in Pediatric Sepsis”, The 6th Regional Translational Research in Mitochondria, Aging, and Disease Symposium, The Children's Hospital of Philadelphia, PA, October 29, 2016.

Weiss S. “PRoMPT BOLUS: Pragmatic Pediatric Trial of Balanced vs Normal Saline Fluid in Sepsis”, PECARN Meeting, Cincinnati, Ohio, September 16, 2016.

Weiss S. “Utility of Procalcitonin to Augment Care in Pediatric Illness", Grand Rounds, Department of Pediatrics, Jersey Shore Medical Center, Neptune City, NJ, August 30, 2016.

Weiss S. “Mitochondrial Dysfunction in Pediatric Sepsis and Cardiovascular Disease: Should We Be Resuscitating the Ch’i?”, Division of Cardiac Critical Care Medicine, The Children’s Hospital of Philadelphia, PA, June 24, 2016.

Weiss S. “Late Breakers: Comparison of Pediatric Severe Sepsis Managed in USA and European Intensive Care Units”, 8th World Congress on Pediatric Intensive and Critical Care, Toronto, Canada, June 8, 2016.

Weiss S. “Pediatrics Year-In-Review: Clinical and Translational Science”, Society of Critical Care Medicine Annual Congress, Orlando, Florida, February 23, 2016.

2015

Weiss S. “Mitochondrial Dysfunction in Pediatric Multi-Organ Dysfunction Syndrome”, Eunice Kennedy Shriver National Institute of Child Health and Human Development Pediatric Multiple Organ Dysfunction Syndrome Workshop, National Institute of Health, Bethesda, MD, March 27, 2015.

2014

Weiss S. “Pediatric Sepsis: A Growing Problem with Potential Solutions”, Pediatric Infectious Disease Consortium, September 5, 2014.

Awards and Honors

2017, Fellow of the American College of Critical Care Medicine (FCCM)

2017, Editor’s commendation for authorship in Emergency Medicine, UpToDate

2017, Presidential Citation, Society of Critical Care Medicine

2017, Pediatric Section Travel Grant Award, Society of Critical Care Medicine Annual Congress

2017, Star Research Achievement Award, Society of Critical Care Medicine Annual Congress

2015, Patient-Oriented Research Track Award, CHOP Research Poster Day

2014, Sepsis Specialty Research Award, Society of Critical Care Medicine Annual Congress

2010, Pediatric Critical Care Colloquium Travel Award

2000, Golden Key International Honor Society, Cornell University

2000, Phi Kappa Phi Honor Society, Cornell University (top 5% of class)

2000, Merrill Presidential Scholar, Cornell University (top 1% of class)

1999, Alpha Epsilon Delta Pre-Medical Honor Society

1999, Merit Scholarship, Boston University Study Abroad

1999, Quill & Dagger Senior Honor Society, Cornell University

1998, Sophomore Academic Achievement Award, Cornell University

1996-2000, Dean’s List, Cornell University

1996-2000, Robinson Award for Academic Excellence, Cornell University

Editorial and Academic Positions

Editorial Positions

2015-present, Journal of Pediatric Intensive Care, Editorial Board

Ad hoc Reviewer

2017, The Lancet Infectious Diseases

2017, BMJ Open

2017, Seminars in Arthritis and Rheumatism

2016, Jornal de Pediatria

2016, Pediatric Infectious Disease Journal

2016, BMC Anesthesiology

2015, The Journal of Pediatrics

2015, BMC Pediatrics

2015, American Journal of Respiratory and Critical Care Medicine

2015, PLoS One

2015, Journal of Clinical Trials

2015, BMC Medicine

2014, Respiratory Care

Academic and Institutional Committees

2017-present, Scholarly Oversight Committee, PCCM Fellows 2017-2020, Chair

2016-present, Evaluation and Feedback Improvement Committee

2014-2016, Selection Committee for the Clinical Research Coordinator Research Excellence @ CHOP (CRC RE@CH) Award

2014-present, CHOP Sepsis Governance Committee

2012-present, PICU Sepsis Management Guideline Development Committee

2012-present, Interactive Continuing Education (ICE) for RNs, Founder and Co-chair

Leadership and Memberships

Memberships in Professional Organizations

International

2008-present, Society of Critical Care Medicine

 - 2017-present, Basic and Translational Science Subcommittee, Research Section, Chair

 - 2016-present, Pediatric Surviving Sepsis Campaign Task Force, Co-Vice Chair

National

2012-present, Shock Society

2008-present, American Academy of Pediatrics, Section of Critical Care

2007-present, American Medical Association

2004-present, American Academy of Pediatrics