Jessica W. Wen, MD

Jessica W. Wen, MD

Jessica W. Wen, MD, is Director of the Viral Hepatitis Treatment Program and a board certified pediatric gastroenterologist at Children's Hospital of Philadelphia. She also works with CHOP's Liver Transplant Program and the Biesecker Pediatric Liver Center.

Areas of Expertise: Viral hepatitis, Biliary atresia, ARPKD/congenital hepatic fibrosis, Liver disease
Locations: Main Campus
Phone: 215-590-3630

Education and Training

Medical School

MD - Baylor College of Medicine, Houston, TX

Residency

Pediatrics - Texas Children's Hospital/Ben Taub General Hospital, Houston, TX

Fellowship

Pediatric Gastroenterology - The Children's Hospital of Philadelphia, Philadelphia, PA (Chief GI fellow, 2009-10)

Board Certification

Pediatric Gastroenterology
Pediatrics

Undergraduate Degree

BS in Biology - Massachusetts Institute of Technology, Cambridge, MA

Graduate Degree

MSc in Translational Research - University of Pennsylvania, Philadelphia, PA

Titles and Academic Titles

Director, Viral Hepatitis Treatment Program

Attending Physician

Assistant Professor of Clinical Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Conditions Treated

Departments and Services

Research Interests

Hepatitis B and hepatitis C
Liver fibrosis
Congenital hepatic fibrosis/autosomal recessive polycystic kidney disease

Publications

Papers

2016

Balistreri1 WF, Murray KF, Rosenthal P, Bansal S, Lin HC, Kersey K, Massetto B, Zhu Y, Kanwar B, German P, Svarovskaia E, Brainard DM, Wen J, Gonzalez-Peralta RP, Jonas MM, and Schwarz K: The safety and effectiveness of Ledipasvir-Sofosbuvir in adolescents 12 to 17 Years old with hepatitis C virus genotype 1 infection. Hepatology. 2016 Dec 20. doi: 10.1002/hep.28995. [Epub ahead of print]

Muir A, Otero H, Blinman T, Wen J: Use of MRI with hepatobiliary specific contrast agent for precise localization of bile duct leak. J Pediatr Gastroenterol Nutr 63(3): e36, September 2016 Notes: DOI: 10.1097/MPG.0000000000000531 

Schwarz K. Molleston JP, Jonas MM, Wen J, Murray K, Rosenthal P, Gonzalez-Peralta RP, Lobritto SJ, Mogul D, Hooper G, Warne C, Thompson B: Durability of response in children treated with pegylated interferon alfa-2a +/- ribavirin for chronic hepatitis C. J Pediatr Gastroenterol Nutr 62(1): 93-6, Jan 2016.

2015

Stoddard MB, Li H, Wang S, Saeed M, Andrus L, Ding W, Jiang X, Learn GH, von Schaewen M, Wen J, Goepfert PA, Hahn BH, Ploss A, Rice CM, Shaw GM.: Identification, molecular cloning, and analysis of full-length hepatitis C virus transmitted/founder genotypes 1, 3, and 4. MBio.  6(2): e02518-14, Febuary 2015.

2014

Jonas MM, Schwarz KB, Gonzalez-Peralta R, Lobritto S, Molleston JP, Murray KF, Rosenthal P, Wen J, Wat C, Pavlovic V, Warne C: Long-term growth outcomes in children treated for chronic hepatitis C J Pediatr 165(6): 1252-4, December 2014.

Wen JW, Furth SL, Ruebner RL: Kidney and liver transplantation in children with fibrocystic liver-kidney disease: Data from the US Scientific Registry of Transplant Recipients: 1990-2010. Pediatric Transplantation 18(7): 726-32, November 2014.

2012

Wen Jessica, Friedman Joshua R: miR-122 regulates hepatic lipid metabolism and tumor suppression. The Journal of clinical investigation 122(8): 2773-6, Aug 2012. PMCID: PMC3408753.

2011

Wen, J.: Congenital Hepatic Fibrosis in Autosomal Recessive Polycystic Kidney Disease. Clinical and Translational Science 4(6): 460-465, December 2011.

Abstracts

2016

Schwartz K, Murray KF, Rosenthal P, Bansal S, Lin HC, Ni L, Kanwar B, Fraser J, German P, Brainard DM, Wen J, Gonzalez-Peralta R, Jonas MM, Balistreri W: Ledipasvir/Sofosbuvir for 12 weeks is safe and effective in adolescents with chronic hepatitis C infection  World Congress of Pediatric Gastroenterology, Hepatology and Nutrition 2016 meeting October  2016.

2012

Malik S, Arva N, Wen J: Liver transplantation in a pediatric patient with multi-focal HCC and HCV. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) 2012 Annual Meeting 2012.

Wen J, Ruebner R, Kaplan B, Furth S: The natural history of fibrocystic liver disease in pediatric organ transplant recipients North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) 2012 Annual Meeting 2012.

Books

Chapters

2015

Wen J, Liacouras C: Chapters on peritonitis and chylous ascites   Nelson Textbook of Pediatrics, 20th Ed  Kliegman RM (eds.). Elsevier, May 2015.

2014

Ruchelli E, Wen J, Rand E : Hepatitis and liver failure in infancy and childhood. Pathology of Pediatric Gastrointestinal and Liver Disease, 2nd Edition. Russo P, Ruchelli E, Piccoli D (eds.). Springer, June 2014.

2012

Wen, J. & Fernando del Rosairo, J.: Chapter on Congenital Hepatic Fibrosis. 5 Minute Pediatric Consult, 6th ed. M. William Schwartz (eds.). Lippincott Williams & Wilkins, Page: 214-215, 2012.

2011

Wen, J. & Liacouras, C: Chapters on Peritonitis and Chylous Ascites. Nelson Textbook of Pediatrics, 19th Ed. Kliegman, R.M. et al. (eds.). Elsevier, Page: 1416-1418, 2011.

Wen, J. & Graham R.: Chapter on Inflammatory Bowel Disease. Netter's Pediatrics Florin, T. & Ludwig, S. (eds.). Elsevier, Page: 698-703, June 2011.

Wen, J. & Piccoli, D.: Biliary Tree- Normal Anatomy, Development, Physiology, and Microanatomy The NASPGHAN Fellows Concise Review of Pediatric Gastroenterology, Hepatology and Nutrition. Sondheimer, J. & Waasdorp Hurtado, C. (eds.). Castle Connolly Graduate Medical Publishing, Ltd, Page: 207-208, 2011.

Posters and Presentations

Posters and Oral Presentations

2017

Murray, K.F.,Balistreri, W., Bansal, S., Whitworth, M., Evans, H., Gonzalez-Peralta R., Wen, J., Kersey, K., Massetto, B., Brainard, D.M., Zhu, Y., Arnon, R., Gillis, L., Jonas, M.M., Lin, C-H., Narkewicz, M., Schwarz, K., Rosenthal, P.: Ledipasvir/Sofosbuvir ± Ribavirin for 12 or 24 Weeks is safe and effective in children 6-11 years old with chronic hepatitis C infection. EASL-The International Liver Congress 2017 April 2017 Notes: Oral presentation.

Murray, K.F.,Balistreri, W., Bansal, S., Whitworth, M., Evans, H., Gonzalez-Peralta R., Wen, J., Kersey, K., Massetto, B., Brainard, D.M., Zhu, Y., Arnon, R., Gillis, L., Jonas, M.M., Lin, C-H., Narkewicz, M., Schwarz, K., Rosenthal, P.: Ledipasvir/Sofosbuvir ± Ribavirin for 12 or 24 Weeks is safe and effective in children 6-11 years old with chronic hepatitis C infection. EASL-The International Liver Congress 2017 April 2017 Notes: Oral presentation.

2016

Garrison K, Mathias A, Kersey K, Kanwar, B, Ni L, Jain A, Ling J, Gonzalez-Peralta RP, Murray KF, Lin CH, Whitworth MS,  Wen J, Schwarz KB, Balistreri W: Pharmacokinetics of once daily Sofosbuvir and Ledipasvir/Sofosbuvir in HCV infected pediatrics aged 6 to <12 years old, Poster Presentation. AASLD 2016 Annual Meeting November 2016.

Mitchel EB, Fisher BT, Wen J: Retrospective study of pediatric liver transplant patients with post-transplant lymphoproliferative disease, Poster Presentation  World Congress of Pediatric Gastroenterology, Hepatology and Nutrition, Montreal, Canada  October 2016.

Brownell JN, Wehrman, A, and Wen J: Giant cell hepatitis with autoimmune hemolytic anemia treated successfully with rituximab, Poster Presentation. World Congress of Pediatric Gastroenterology, Hepatology and Nutrition, Montreal, Canada October 2016.

Schwartz K, Murray KF, Rosenthal P, Bansal, S, Lin CH, Ni L, Kanwar B, Fraser J, German P, Brainard DM, Wen J, Gonzalez-Peralta R, Jonas MM, Balistreri W: High rates of SVR12 in adolescents treated with the combination of ledipasvir/sofosbuvir, Poster Presentation. European Association for the Study of Liver Disease Annual Meeting Apr 2016 Notes: Oral presentation given by collaborator.

2015

Chan P, Mould DR, AbuTarif M, Wen J, Mei-Hwei Chang M-H, Emerick K, Reynolds L, Bertz R, Bifano M: Population pharmacokinetic and pharmacodynamic analyses of entecavir in pediatric subjects, Poster Presentation. International Society of Pharmacometrics - 6th American Conference on Pharmacometrics 2015.

Wen J, Jiang XP, Li H, Honegger J, Learn GH, Shaw GM: Identification and quantification of transmitted/founder virus in mother to child transmission of hepatitis C virus by single genome sequencing, Poster Presentation  NASPGHAN annual meeting Oct 2015.

Lectures by Invitation

2015

Wen WW. Chronic hepatitis B infection for healthcare providers. Presented to: Asian Pacific American Medical Student Association (APAMSA); 2015 Dec; Philadelphia, PA.

Wen WW. Chronic hepatitis C infection in children, a primer for pediatricians. Presented to: Philadelphia Department of Public Health City Health Centers Pediatric CME; 2015 Feb; Philadelphia, PA.

2014

Wen WW. Chronic Viral Hepatitis in Children. Invited lecture. Presented to: American Liver Foundation. 8th Annual Hepatology and Liver Transplantation Conference; 2014 Nov; Philadelphia PA.

Wen WW. Chronic hepatitis C: What is it and what to do about it? Presented to: The Children's Hospital of Philadelphia Thalassemia Program Annual Patient and Family Meeting; 2014 Jul; Philadelphia, PA.

Awards and Honors

2015, Fellows Faculty Honor Roll, Children's Hospital of Philadelphia, Division of Gastroenterology, Hepatology & Nutrition

2014, Fellows Faculty Honor Roll, Children's Hospital of Philadelphia, Division of Gastroenterology, Hepatology & Nutrition

2013, Fellows Faculty Honor Roll, Children's Hospital of Philadelphia, Division of Gastroenterology, Hepatology & Nutrition

2012-2014, University of Pennsylvania Master of Translational Research Fellowship

2012, Young Faculty Clinical Investigator Award/ North American Society for Pediatric Gastroenterology, Hepatology and Nutrition

2011, American Association for the Study of Liver Disease(AASLD)/American Liver Foundation(ALF) Liver Scholar Award

2011, Studies of Pediatric Liver Transplantation (SPLIT) Annual Meeting Young Faculty Travel Award

2010, North American Society for Pediatric Gastroenterology, Hepatology & Nutrition (NASPGHAN) Annual Meeting 2010 Poster of Distinction

2010, AASLD Annual Meeting Young Investigator Travel Award

2009-2011, NIH NRSA F32 Individual Research Training Fellowship

2009-2010, Chief Fellow, The Children's Hospital Pediatric GI Fellowship Program

2008-2012, NIH Loan Repayment Program

2008-2009, NIH NRSA T32 Institution Training Fellowship

1999-2000, MIT Undergraduate Research Opportunities Program Direct Research Funding with Howard Hughes Medical Institute

Editorial and Academic Positions

Editorial Positions

Peer Reviewer

2012-present, Hepatology
2012-present, World Journal of Pediatrics

Academic and Institutional Committees

2017-present, Chair of Data Monitoring Committee for study "A Randomized, Double-Blind Evaluation of the Pharmacokinetics, Safety, and Antiviral Efficacy of Tenofovir Alafenamide (TAF) in Adolescents with Chronic Hepatitis B Virus Infection."

2016-present, Member, The Children's Hospital of Philadelphia GI division Research Interest Steering Committee.

2014-present, Member, The Children's Hospital of Philadelphia GI Division Education Committee

2013, Consultant Reviewer, The Children's Hospital of Philadelphia Institutional Review Board

2013-2016, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) Hepatology Committee

2009-present, Member, The Children's Hospital of Philadelphia GI Division Quality and Safety Committee

Leadership and Memberships

Memberships in professional organizations

2016-present, American Medial Association
2015-present, American Society of Transplantation
2007-present, American Association For The Study of Liver Disease (AASLD)
2007-present, American Gastroenterological Association (AGA)