Jessica W. Wen, MD

Locations: Main Hospital; Buerger Center for Advanced Pediatric Care; Specialty Care, Bryn Mawr
MD - Baylor College of Medicine, Houston, TX
Pediatrics - Texas Children's Hospital/Ben Taub General Hospital, Houston, TX
Pediatric Gastroenterology - The Children's Hospital of Philadelphia, Philadelphia, PA (Chief GI fellow, 2009-10)
Pediatric Gastroenterology – American Board of PediatricsPediatrics – American Board of Pediatrics
BS in Biology - Massachusetts Institute of Technology, Cambridge, MA
Director, Viral Hepatitis Treatment Program
Attending Physician
Associate Professor of Clinical Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Hepatitis B and hepatitis C
Liver fibrosis
Congenital hepatic fibrosis/autosomal recessive polycystic kidney disease
Balistreri1 WF, Murray KF, Rosenthal P, Bansal S, Lin HC, Kersey K, Massetto B, Zhu Y, Kanwar B, German P, Svarovskaia E, Brainard DM, Wen J, Gonzalez-Peralta RP, Jonas MM, and Schwarz K: The safety and effectiveness of Ledipasvir-Sofosbuvir in adolescents 12 to 17 Years old with hepatitis C virus genotype 1 infection. Hepatology. 2016 Dec 20. doi: 10.1002/hep.28995. [Epub ahead of print]
Muir A, Otero H, Blinman T, Wen J: Use of MRI with hepatobiliary specific contrast agent for precise localization of bile duct leak. J Pediatr Gastroenterol Nutr 63(3): e36, September 2016 Notes: DOI: 10.1097/MPG.0000000000000531
Schwarz K. Molleston JP, Jonas MM, Wen J, Murray K, Rosenthal P, Gonzalez-Peralta RP, Lobritto SJ, Mogul D, Hooper G, Warne C, Thompson B: Durability of response in children treated with pegylated interferon alfa-2a +/- ribavirin for chronic hepatitis C. J Pediatr Gastroenterol Nutr 62(1): 93-6, Jan 2016.
Stoddard MB, Li H, Wang S, Saeed M, Andrus L, Ding W, Jiang X, Learn GH, von Schaewen M, Wen J, Goepfert PA, Hahn BH, Ploss A, Rice CM, Shaw GM.: Identification, molecular cloning, and analysis of full-length hepatitis C virus transmitted/founder genotypes 1, 3, and 4. MBio. 6(2): e02518-14, Febuary 2015.
Jonas MM, Schwarz KB, Gonzalez-Peralta R, Lobritto S, Molleston JP, Murray KF, Rosenthal P, Wen J, Wat C, Pavlovic V, Warne C: Long-term growth outcomes in children treated for chronic hepatitis C J Pediatr 165(6): 1252-4, December 2014.
Wen JW, Furth SL, Ruebner RL: Kidney and liver transplantation in children with fibrocystic liver-kidney disease: Data from the US Scientific Registry of Transplant Recipients: 1990-2010. Pediatric Transplantation 18(7): 726-32, November 2014.
Wen Jessica, Friedman Joshua R: miR-122 regulates hepatic lipid metabolism and tumor suppression. The Journal of clinical investigation 122(8): 2773-6, Aug 2012. PMCID: PMC3408753.
Wen, J.: Congenital Hepatic Fibrosis in Autosomal Recessive Polycystic Kidney Disease. Clinical and Translational Science 4(6): 460-465, December 2011.
Schwartz K, Murray KF, Rosenthal P, Bansal S, Lin HC, Ni L, Kanwar B, Fraser J, German P, Brainard DM, Wen J, Gonzalez-Peralta R, Jonas MM, Balistreri W: Ledipasvir/Sofosbuvir for 12 weeks is safe and effective in adolescents with chronic hepatitis C infection World Congress of Pediatric Gastroenterology, Hepatology and Nutrition 2016 meeting October 2016.
Malik S, Arva N, Wen J: Liver transplantation in a pediatric patient with multi-focal HCC and HCV. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) 2012 Annual Meeting 2012.
Wen J, Ruebner R, Kaplan B, Furth S: The natural history of fibrocystic liver disease in pediatric organ transplant recipients North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) 2012 Annual Meeting 2012.
Wen J, Liacouras C: Chapters on peritonitis and chylous ascites Nelson Textbook of Pediatrics, 20th Ed Kliegman RM (eds.). Elsevier, May 2015.
Ruchelli E, Wen J, Rand E : Hepatitis and liver failure in infancy and childhood. Pathology of Pediatric Gastrointestinal and Liver Disease, 2nd Edition. Russo P, Ruchelli E, Piccoli D (eds.). Springer, June 2014.
Wen, J. & Fernando del Rosairo, J.: Chapter on Congenital Hepatic Fibrosis. 5 Minute Pediatric Consult, 6th ed. M. William Schwartz (eds.). Lippincott Williams & Wilkins, Page: 214-215, 2012.
Wen, J. & Liacouras, C: Chapters on Peritonitis and Chylous Ascites. Nelson Textbook of Pediatrics, 19th Ed. Kliegman, R.M. et al. (eds.). Elsevier, Page: 1416-1418, 2011.
Wen, J. & Graham R.: Chapter on Inflammatory Bowel Disease. Netter's Pediatrics Florin, T. & Ludwig, S. (eds.). Elsevier, Page: 698-703, June 2011.
Wen, J. & Piccoli, D.: Biliary Tree- Normal Anatomy, Development, Physiology, and Microanatomy The NASPGHAN Fellows Concise Review of Pediatric Gastroenterology, Hepatology and Nutrition. Sondheimer, J. & Waasdorp Hurtado, C. (eds.). Castle Connolly Graduate Medical Publishing, Ltd, Page: 207-208, 2011.
Murray, K.F.,Balistreri, W., Bansal, S., Whitworth, M., Evans, H., Gonzalez-Peralta R., Wen, J., Kersey, K., Massetto, B., Brainard, D.M., Zhu, Y., Arnon, R., Gillis, L., Jonas, M.M., Lin, C-H., Narkewicz, M., Schwarz, K., Rosenthal, P.: Ledipasvir/Sofosbuvir ± Ribavirin for 12 or 24 Weeks is safe and effective in children 6-11 years old with chronic hepatitis C infection. EASL-The International Liver Congress 2017 April 2017 Notes: Oral presentation.
Murray, K.F.,Balistreri, W., Bansal, S., Whitworth, M., Evans, H., Gonzalez-Peralta R., Wen, J., Kersey, K., Massetto, B., Brainard, D.M., Zhu, Y., Arnon, R., Gillis, L., Jonas, M.M., Lin, C-H., Narkewicz, M., Schwarz, K., Rosenthal, P.: Ledipasvir/Sofosbuvir ± Ribavirin for 12 or 24 Weeks is safe and effective in children 6-11 years old with chronic hepatitis C infection. EASL-The International Liver Congress 2017 April 2017 Notes: Oral presentation.
Garrison K, Mathias A, Kersey K, Kanwar, B, Ni L, Jain A, Ling J, Gonzalez-Peralta RP, Murray KF, Lin CH, Whitworth MS, Wen J, Schwarz KB, Balistreri W: Pharmacokinetics of once daily Sofosbuvir and Ledipasvir/Sofosbuvir in HCV infected pediatrics aged 6 to <12 years old, Poster Presentation. AASLD 2016 Annual Meeting November 2016.
Mitchel EB, Fisher BT, Wen J: Retrospective study of pediatric liver transplant patients with post-transplant lymphoproliferative disease, Poster Presentation World Congress of Pediatric Gastroenterology, Hepatology and Nutrition, Montreal, Canada October 2016.
Brownell JN, Wehrman, A, and Wen J: Giant cell hepatitis with autoimmune hemolytic anemia treated successfully with rituximab, Poster Presentation. World Congress of Pediatric Gastroenterology, Hepatology and Nutrition, Montreal, Canada October 2016.
Schwartz K, Murray KF, Rosenthal P, Bansal, S, Lin CH, Ni L, Kanwar B, Fraser J, German P, Brainard DM, Wen J, Gonzalez-Peralta R, Jonas MM, Balistreri W: High rates of SVR12 in adolescents treated with the combination of ledipasvir/sofosbuvir, Poster Presentation. European Association for the Study of Liver Disease Annual Meeting Apr 2016 Notes: Oral presentation given by collaborator.
Chan P, Mould DR, AbuTarif M, Wen J, Mei-Hwei Chang M-H, Emerick K, Reynolds L, Bertz R, Bifano M: Population pharmacokinetic and pharmacodynamic analyses of entecavir in pediatric subjects, Poster Presentation. International Society of Pharmacometrics - 6th American Conference on Pharmacometrics 2015.
Wen J, Jiang XP, Li H, Honegger J, Learn GH, Shaw GM: Identification and quantification of transmitted/founder virus in mother to child transmission of hepatitis C virus by single genome sequencing, Poster Presentation NASPGHAN annual meeting Oct 2015.
Wen WW. Chronic hepatitis B infection for healthcare providers. Presented to: Asian Pacific American Medical Student Association (APAMSA); 2015 Dec; Philadelphia, PA.
Wen WW. Chronic hepatitis C infection in children, a primer for pediatricians. Presented to: Philadelphia Department of Public Health City Health Centers Pediatric CME; 2015 Feb; Philadelphia, PA.
Wen WW. Chronic Viral Hepatitis in Children. Invited lecture. Presented to: American Liver Foundation. 8th Annual Hepatology and Liver Transplantation Conference; 2014 Nov; Philadelphia PA.
Wen WW. Chronic hepatitis C: What is it and what to do about it? Presented to: The Children's Hospital of Philadelphia Thalassemia Program Annual Patient and Family Meeting; 2014 Jul; Philadelphia, PA.
2015, Fellows Faculty Honor Roll, Children's Hospital of Philadelphia, Division of Gastroenterology, Hepatology & Nutrition
2014, Fellows Faculty Honor Roll, Children's Hospital of Philadelphia, Division of Gastroenterology, Hepatology & Nutrition
2013, Fellows Faculty Honor Roll, Children's Hospital of Philadelphia, Division of Gastroenterology, Hepatology & Nutrition
2012-2014, University of Pennsylvania Master of Translational Research Fellowship
2012, Young Faculty Clinical Investigator Award/ North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
2011, American Association for the Study of Liver Disease(AASLD)/American Liver Foundation(ALF) Liver Scholar Award
2011, Studies of Pediatric Liver Transplantation (SPLIT) Annual Meeting Young Faculty Travel Award
2010, North American Society for Pediatric Gastroenterology, Hepatology & Nutrition (NASPGHAN) Annual Meeting 2010 Poster of Distinction
2010, AASLD Annual Meeting Young Investigator Travel Award
2009-2011, NIH NRSA F32 Individual Research Training Fellowship
2009-2010, Chief Fellow, The Children's Hospital Pediatric GI Fellowship Program
2008-2012, NIH Loan Repayment Program
2008-2009, NIH NRSA T32 Institution Training Fellowship
1999-2000, MIT Undergraduate Research Opportunities Program Direct Research Funding with Howard Hughes Medical Institute
2012-present, Hepatology
2012-present, World Journal of Pediatrics
2017-present, Chair of Data Monitoring Committee for study "A Randomized, Double-Blind Evaluation of the Pharmacokinetics, Safety, and Antiviral Efficacy of Tenofovir Alafenamide (TAF) in Adolescents with Chronic Hepatitis B Virus Infection."
2016-present, Member, The Children's Hospital of Philadelphia GI division Research Interest Steering Committee.
2014-present, Member, The Children's Hospital of Philadelphia GI Division Education Committee
2013, Consultant Reviewer, The Children's Hospital of Philadelphia Institutional Review Board
2013-2016, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) Hepatology Committee
2009-present, Member, The Children's Hospital of Philadelphia GI Division Quality and Safety Committee
2016-present, American Medial Association
2015-present, American Society of Transplantation
2007-present, American Association For The Study of Liver Disease (AASLD)
2007-present, American Gastroenterological Association (AGA)