Background

Huayan Zhang, MD, is an attending neonatologist at The Children's Hospital of Philadelphia (CHOP) and the Hospital of the University of Pennsylvania. She is an associate professor of clinical pediatrics at the Perelman School of Medicine at the University of Pennsylvania.

Dr. Zhang’s clinical focus and research interests are in the prevention and management of bronchopulmonary dysplasia or infant chronic lung disease. She started the Newborn and Infant Chronic Lung Disease Program at CHOP in 2010 and currently serves as the director of the program. Dr. Zhang, together with a multidisciplinary team of colleagues, has developed this program into one of the world’s largest center dedicated to the clinical treatment and knowledge advancement for infants with severe chronic lung disease.

Dr. Zhang has been actively engaged in the care of critically ill newborns and infants, teaching of medical students, residents, fellows, and other care providers. She is a well-respected master clinician and teacher at CHOP. She initially trained and worked as a pediatrician in China, and continues to devote her time and efforts in international activities to ensure children everywhere in the world have access to quality care and the best interventions. She has been a key member of CHOP’s international collaborations in China and facilitated the training of numerous international pediatricians, neonatal fellows and medical students from Canada, Chile, China, Eastern Europe, India, Korea, and Mexico. 

Education and Training

Medical School

MD - Capital University of Medical Sciences, Beijing, China

Internship

UMDNJ-Robert Wood Johnson University Hospital, New Brunswick, NJ

Residency

Pediatrics - Beijing Children's Hospital, Beijing, China
Pediatrics - UMDNJ-Robert Wood Johnson University Hospital, New Brunswick, NJ

Fellowship

Neonatal-Perinatal Medicine - The Children's Hospital of Philadelphia, Philadelphia, PA
Pediatric Scientist Development Program (PSDP) - Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA

Board Certification

Neonatal-Perinatal Medicine

Titles and Academic Titles

Attending Neonatologist

Director, Newborn and Infant Chronic Lung Disease Program

Associate Professor of Clinical Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

Bronchopulmonary dysplasia
Neonatal and infant respiratory care

Publications

Papers

2020

Pinto E, Dori Y, Smith C, DeWitt A, Williams C, Griffis H, Escobar F, Biko DM, Krishnamurthy G, Rome J, Glatz AC, Liu M, Ravishankar C, Zhang H, Taha D. J Perinatol. Neonatal lymphatic flow disorders: impact of lymphatic imaging and interventions on outcomes. 2020 Sep 2. doi: 10.1038/s41372-020-00771-3. Online ahead of print. PMID: 32879418.

Eichenwald C, Dysart K, Zhang H, Fox W. Neonatal Partial Liquid Ventilation for the Treatment and Prevention of Bronchopulmonary Dysplasia. Neoreviews. 2020 Apr;21(4):e238-e248. doi: 10.1542/neo.21-4-e238. No abstract available. PMID: 32238486 [PubMed - in process]

Rong X, Liang F, Li YJ, Liang H, Zhao XP, Zou HM, Lu WN, Shi H, Zhang JH, Guan RL, Sun Y, Zhang H. Application of Neurally Adjusted Ventilatory Assist in Premature Neonates Less Than 1,500 Grams With Established or Evolving Bronchopulmonary Dysplasia. Front Pediatr. 2020 Mar 24;8:110. doi: 10.3389/fped.2020.00110. eCollection 2020. PMID: 32266188 [PubMed]

Xu Y, Li X, Zhu B, Liang H, Fang C, Gong Y, Guo Q, Sun X, Zhao D, Shen J, Zhang H, Liu H, Xia H, Tang J, Zhang K, Gong S. Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nat Med. 2020 Apr;26(4):502-505. doi: 10.1038/s41591-020-0817-4. Epub 2020 Mar 13. PMID: 32284613 [PubMed - in process]

2019

Hysinger E, Friedman N, Jensen EA, Zhang H, Piccione J.  Bronchoscopy in neonates with severe bronchopulmonary dysplasia in the NICU. Journal of Perinatology (2019) 39:263–268

Liu J, Copetti R, Sorantin E, Lovrenski J, Rodriguez-Fanjul J, Kurepa D, Feng X, Cattaross L, Zhang H, Hwang M, Yeh TF, Lipener Y, Lodha A, Wang J, Cao H, Hu C, Lyu G, Qiu X, Jia L, Wang X, Ren X, Guo J, Gao Y, Li J, Liu Y, Fu W, Wang Y, Lu Z, Wang H, Shang L. Protocol and Guidelines for Point-of-care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus. J. Vis. Exp. (145), e58990, doi:10.3791/58990 (2019)

Bamat NA, Kirpalani H, Feudtner C, Jensen EA, Laughon MM, Zhang H, Monk HM, Passarella M, Lorch SA. Medication use in infants with severe bronchopulmonary dysplasia admitted to United States children's hospitals. J Perinatol. 2019 Jun 21. doi: 10.1038/s41372-019-0415-9. [Epub ahead of print]

Napolitano N, Jalal K, McDonough JM, Monk HM, Zhang H, Jensen E, Dysart KC, Kirpalani HM, Panitch HB. Identifying and treating intrinsic PEEP in infants with severe bronchopulmonary dysplasia. Pediatr Pulmonol. 2019 Apr 4. doi: 10.1002/ppul.24328

Brady JM, Zhang H, Kirpalani H, DeMauro SB. Living with Severe Bronchopulmonary Dysplasia-Parental Views of Their Child's Quality of Life. J Pediatr. 2019 Apr;207:117-122. doi: 10.1016/j.jpeds.2018.10.001. Epub 2018 Nov 5. PMID: 30404737 [PubMed - indexed for MEDLINE]

Degnan AJ, Zhu X, Flowers C, Fox WW, Zhang H, Saul D. Imaging Assessment of Partial Liquid Ventilation in Bronchopulmonary Dysplasia. Curr Probl Diagn Radiol. 2019 May - Jun;48(3):247-250.

Jensen EA, Zhang H, Feng R, Dysart K, Nilan K, Munson DA, Kirpalani H. Individualising care in severe bronchopulmonary dysplasia: a series of N-of-1 trials comparing transpyloric and gastric feeding. Arch Dis Child Fetal Neonatal Ed. 2019 Nov 4. pii: fetalneonatal-2019-317148. doi: 10.1136/archdischild-2019-317148. [Epub ahead of print] PMID: 31685527 [PubMed - as supplied by publisher]

DiLorenzo MP, Santo A, Rome JJ, Zhang H, Faerber JA, Mercer-Rosa L, Hopper RK. Pulmonary Vein Stenosis: Outcomes in Children With Congenital Heart Disease and Prematurity. Semin Thorac Cardiovasc Surg. 2019 Summer;31(2):266-273. doi: 10.1053/j.semtcvs.2018.09.027. Epub 2018 Sep 29. PMID: 30278272 [PubMed - indexed for MEDLINE]

2018

Zhang H, Dyart K, Kendrick DE, Li L, Das A, Hintz SR, Vohr BR, Stoll BJ, Higgins RD, Nelin L, Carlton DP, Walsh MC, Kirpalani H. Prolonged Respiratory Support of Any Type Impacts Outcomes of Extremely Low Birth Weight infants. Pediatr Pulmonol. 2018 Jul 30. doi: 10.1002/ppul.24124

Lagatta JM, Hysinger EB, Zaniletti I, Padula MA, Zhang H, Grover TR, Engle WA, Murthy K; Children's Hospital Neonatal Consortium Severe BPD Focus Group, et al. The Impact of Pulmonary Hypertension in Preterm Infants with Severe Bronchopulmonary Dysplasia through 1 Year. J Pediatr. 2018 Dec;203:218-224.e3. doi: 10.1016/j.jpeds.2018.07.035. Epub 2018 Aug 29.

Luo J, Shepard S, Nilan K, Wood A, Monk HM, Jensen EA, Harrington AT, Maschhoff K, Kirpalani H, Feng Z, Zhang H. Improved growth and developmental activity post tracheostomy in preterm infants with severe BPD. Pediatr Pulmonol. 2018 Jul 3. doi: 10.1002/ppul.24087. [Epub ahead of print]

DiLorenzo MP, Santo A, Rome JJ, Zhang H, Faerber JA, Mercer-Rosa L, Hopper RK. Pulmonary Vein Stenosis: Outcomes in Children with Congenital Heart Disease and Prematurity. Semin Thorac Cardiovasc Surg. 2018 Sep 29. pii: S1043-0679(18)30295-8

Milet B, Chuo J, Nilan K, Warren K, McKenna K, Carroll JM, Evans J and Zhang H. Increasing Immunization Rates in Hospitalized Infants with Severe Chronic Lung Disease Through A Quality Improvement Initiative. Hosp Pediatr. 2018 Nov;8(11):693-698

Degnan AJ, Fox WW, Zhang H, Saul D. Partial liquid ventilation for bronchopulmonary dysplasia: Visualizing ventilation patterns on chest radiographs. Pediatr Neonatol. 2018 Nov 1. pii: S1875-9572(18)30432-7

2017

Tkach EK, White AM, Dysart KC, Waber B, Nawab US, Zhang H, Jensen EA. Comparison of Intact Parathyroid Hormone, Alkaline Phosphatase, Phosphate Levels for Diagnosing Severe Metabolic

Bone Disease in Infants with Severe Bronchopulmonary Dysplasia. Am J Perinatol. 2017 Apr 21. doi: 10.1055/s-0037-1602419. [Epub ahead of print]

Tramper J, Zhang H, Foglia EE, Dysart KC, Padula MA, Sullivan KV, Jensen EA. The association between positive tracheal aspirate cultures and adverse pulmonary outcomes in preterm infants with severe bronchopulmonary dysplasia. Am J Perinatol. 2017;34(1):96-104.

Hysinger EB, Friedman NL, Padula MA, Shinohara RT, Zhang H, Panitch HB, Kawut SM. Tracheobronchomalacia is associated with increased morbidity in bronchopulmonary dysplasia. Ann Am Thorac Soc. 2017 Jun 16. doi: 10.1513/AnnalsATS.201702-178OC. [Epub ahead of print]

2016

Jensen EA, White AM, Liu P, Yee K, Waber B, Monk HM, Zhang H. Determinants of severe metabolic bone disease in very low-birth-weight infants with severe bronchopulmonary dysplasia admitted to a tertiary referral center. Am J Perinatol. 2016;33(1):1011-7.

2015

Jensen EA, Munson DA, Zhang H, Blinman TA, Kirpalani H. Anti-gastroesophageal reflux surgery in infants with severe bronchopulmonary dysplasia. Pediatr Pulmonol. 2015;50(6):584-587.

2014

Murthy K, Savani RC, Lagatta JM, Zaniletti I, Wadhawan R, Truog W, Grover TR, Zhang H, Asselin JM, Durand DJ, Short BL, Pallotto EK, Padula MA, Dykes FD, Reber KM, Evans JR. Predicting death or tracheostomy placement in infants with severe bronchopulmonary dysplasia. J Perinatol. 2014 Mar 20. [Epub ahead of print]

Jensen EA, Munson DA, Zhang H, Blinman TA, Kirpalani H. Anti-gastroesophageal reflux surgery in infants with severe bronchopulmonary dysplasia. Pediatr Pulmonol. 2014 Apr 21. [Epub ahead of print]

2013

Flibotte JJ, Lee GE, Buser GL, Feja KN, Kreiswirth BN, McSherry GD, Nolan SM, Tolan RW Jr, Zhang H. Infertility, in vitro fertilization and congenital tuberculosis. J Perinatol. 2013 Jul;33(7):565-8. doi: 10.1038/jp.2012.146.

Books

Chapters

2018

Jensen EA, Zhang H, Kirpalani H. Bronchopulmonary Dysplasia in Rudolph’s Pediatrics, 23th edition. McGraw-Hill Education 2018

2016

Zhang H, William Fox. Management of the infant with BPD in Assisted Ventilation of the Neonate, 6th edition. Elsevier 2016

2014

Zhang H, Jason Gien, and Kevin Dysart. Effects of Prematurity, Prolonged Intubation and Ventilation on Acquired Airway Disorders in Disorders of the Neonatal Airway: Fundamentals of Practice. Springer Publishing Group December 2014.

Posters and Presentations

2019

Gibbs K, Fox W, Dysart K, Kleinman S, Nilan K, Morris H, Napolitano N, Alexiou S, Bamat N, McKenna K, Jensen E, Maschhoff K, Peterside I, Munson D, Panitch H and Zhang H. Patterns of PEEP Use in Infants Referred to the NeoCLD Program at CHOP: Characteristics and Outcome Prediction. Presented at PAS  2019

Taha D, Dori Y, McKenna KJ, Zhang H, Warren K, Gibbs K. Central Lymphatic Flow Disorder is Associated with Worse Outcomes in Infants with Severe Bronchopulmonary Dysplasia. Presented at PAS 2019

Wang Y, Pogoriler J, Laje P, Nilan K, Kirpalani H and Zhang H. Utility of Lung Biopsy in the Management of Preterm Infants with Severe Chronic Lung Disease. Presented at PAS 2019

Zhang H, Kleinman S, Morris H, Dysart K, Munson D, Jensen E, Napolitano N, Peterside I, McKenna K, Gibbs K, Maschhoff K, Nilan K, Devine M, and Fox W. Partial Liquid Ventilation (PLV) in Infants with  Severe Bronchopulmonary Dysplasia- A Pilot Randomized Controlled Trial. Presented at PAS 2019

2018

Vyas-Read S, Wymore E, Murthy K, Padula M, Truog WE, Engle WA, Savani RC, Yallapragada S, Zhang H, Hysinger EB, Grover TR, Natarajan G, Nelin LD, Porta N, Potoka K, DiGeronimo R, Lagatta JM. Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia: Findings from the Children's Hospitals Neonatal Consortium.Platform presentation at the Pediatric Academic Societies Meeting, Toronto, Canada, May 8, 2018.

Zhang H, Nilan K, Luo J, Jensen E. Duration of tracheostomy and ventilation support in infants with severe Bronchopulmonary Dysplasia. Platform presentation at the Pediatric Academic Societies Meeting, Toronto, Canada, May 7, 2018.

Wu KY, Jensen EA, White A, Wang Y, Biko DM, Zhang H, Fraga MV, Mercer-Rosa L, Kirpalani HM. Phenotypes of Severe Bronchopulmonary Dysplasia. Poster presentation at the Pediatric Academic Societies Meeting, Toronto, Canada, May 6, 2018.

Avitabile CM, Ansems S, Wang Y, Fraga MV, Kirpalani HM, Zhang H, Mercer-Rosa L, Jensen EA. Accuracy of brain natriuretic peptide as compared to a reference standard of echocardiogram for diagnosing pulmonary hypertension in severe bronchopulmonary dysplasia. Platform presentation at the Pediatric Academic Societies Meeting, Toronto, Canada, May 5, 2018.

Degnan, A, Daul D, Fox W, Zhang H. Partial Liquid Ventilation with Perfluorooctylbromide Highlights Heterogeneous Ventilation Patterns in Severe Bronchopulmonary Dysplasia. Poster presentation at the Pediatric Academic Societies Meeting, Toronto, Canada, May 5, 2018.

Yallaparagada SG, Savani RC, Porta NFM, Lagatta J, Zhang H, Truog MK. Exploring Potential Indications for Tracheostomy and Chronic Mechanical Ventilation in Patients with Severe Bronchopulmonary Dysplasia. Poster presentation at the Pediatric Academic Societies Meeting, Toronto, Canada, May 5, 2018.

Degnan, A, Daul D, Fox W, Zhang H. Partial Liquid Ventilation with Perfluorooctylbromide Highlights Heterogeneous Ventilation Patterns in Severe Bronchopulmonary Dysplasia. Platform presentation at the Eastern Society for Pediatric Research Annual Meeting, Philadelphia, PA, March 2018.

Zhang H, Nilan K, Luo J, Jensen E. Duration of tracheostomy and ventilation support in infants with severe Bronchopulmonary Dysplasia. Platform presentation at the Eastern Society for Pediatric Research Annual Meeting, Philadelphia, PA, March 2018.

Wu KY, Jensen EA, White A, Wang Y, Biko DM, Zhang H, Fraga MV, Mercer-Rosa L, Kirpalani HM. Phenotypes of Severe Bronchopulmonary Dysplasia. Platform presentation at the Eastern Society for Pediatric Research Annual Meeting, Philadelphia, PA, March 2018.

Nilan K, Hasiuk ML, Morris H, Warren K, Patykula J, Zhang H. Establishing an Education Plan for Families and Staff Caring for Infants with Severe Bronchopulmonary Dysplasia. Poster presentation at the Eastern Society for Pediatric Research Annual Meeting, Philadelphia, PA, March 2018.

Bamat NA, Kirpalani H, Feudtner C, Jensen EA, Laughon M, Zhang H, Monk HM, Passarella M, Lorch S. Medication Use and Polypharmacy in Infants with Severe Bronchopulmonary Dysplasia Admitted to United States Children’s Hospitals. Poster presentation at the Eastern Society for Pediatric Research Annual Meeting, Philadelphia, PA, March 2018.

Invited Lectures

2019

Zhang H. In-hospital interdisciplinary care of the infant with sBPD: Who, Where and When. BPD Workshop at American Thoracic Society 2019 Conference, Dallas, TX. May 2019.

Zhang H. When is CLD Not BPD. Chinese Pediatric Critical Care Physician Association Annual Conference, Beijing, China. April 2019.

Zhang H. BPD Management. Shengjing Pediatric Forum, Shenyang, China. April 2019.

Zhang H. Chronic Respiratory Support for Infants with BPD, Chinese Neonatologist Association Annual Conference, Beijing China. March 2019.

Zhang H. Neo-OB Collaboration, Jinsui Obstetrics International Forum, Guangzhou, China. March 2019.

Zhang H. Neonatal ECMO: Now and Future Perspectives, Fudan ECMO forum, Shanghai, China. January 2019.

2018

Zhang H. 1) BPD Management Strategies; 2) Respiratory Care and Neurodevelopmental Outcomes, 2nd International Symposium of Asia, Shanghai, China. November 2018.

Zhang H. All About PEEP. Chengdu Neonatology Forum, Chengdu, China. October 2018.

Zhang H. Neonatal-Perinatal Medicine Fellowship in the US, Chinese Neonatal Fellowship Teacher’s training course, Shenzhen, China. September 2018.

Zhang H. Practical Problems in Neonatal Mechanical Ventilation, Neonatal Respiratory Care Conference, Fujian, China. September 2018.

Zhang H. Infant Interstitial Lung Disease, Yangzi Pediatric Forum, Wuhan, China. September 2018.

Zhang H. Progress in Diagnosis and Treatment of Infant Chronic Lung Disease, Yuying Respiratory Forum, Zhejiang, China. August 2018.

Zhang H. Caring for Infants with Severe Chronic Lung Disease: Not a One-person or a One-day Job. Cincinnati Children’s Hospital Neonatology Grand Round. Cincinnati, OH, USA. June 2018.

Zhang H. Management of BPD Associated Pulmonary Hypertension. Foshan Hospital for Maternal and Child Health Care. Guangdong, China. April 2018.

Zhang H. Partial Liquid Ventilation for Neonatal Respiratory Diseases: Difficulty and Prospective. The 1st Global Chinese Neonatal Medicine Summit. Fujian, china. April 2018.

Zhang H. 1) VLBW Infection Prevention; 2) Management of Infants with Severe BPD. Bayi Children’s Hospital, Beijing, China. March 2018.

Zhang H. Pathophysiology-based Mechanical Ventilation for Preterm Infants: From BPD Prevention to Treatment. The 8th National Conference of Chinese Neonatologist Association. Beijing, China. March 2018.

2017

Zhang H. Severe BPD management workshop. Children’s Hospital of Montefiore, Bronx, NY. December 2017.

Zhang H. Management of Severe BPD, Neonatology Grand Rounds, Yale. November 2017.

Zhang H. Chronic Lung Disease of Infancy, Grand Rounds, Department of Pediatrics, Yale University School of Medicine. November 2017.

Zhang H. Pulmonary Hypertension in Infants with Severe BPD. AAP Chapter 2 District 2, Long Island, NY. November 2017.

Zhang H. 1) BPD: General Information; 2) Update information in BPD; 3) Long term impact of BPD; 4) Management of Severe BPD, Chang Gung Memorial Hospital Grand Rounds and Regional BPD Forum, Taiwan. October 2017.

Zhang H. Prevention and Management of Chronic Lung Disease After Premature Birth: Current Status and Future Perspectives. United Family Hospital, Beijing, China. October 2017.

Zhang H. 1) Airway Disorder in Infants with Bronchopulmonary Dysplasia; 2) Nutritional Care in Infants with Severe BPD, 2017 International Neonatal Forum, Henan, China. October 2017.

Zhang H. Progress in Neonatal Respiratory Care and Prevention of BPD. 2017 Changzhou Pediatric Association Annual Conference, Jiangsu, China. October 2017.

Zhang H. Nutritional Care for Infants with Severe BPD. PAS 2017 workshop: The care of the infant with severe bronchopulmonary dysplasia: current state of the art and future directions, San Francisco, CA. May 2017.

Zhang H. Achieving Optimum Lung Volumes During Mechanical Ventilation, Dongguan Maternity and Child Health Care Hospital. May 2017.

Zhang H. Respiratory Care for Preterm Infants with Congenital Heart Disease. Shenzhen Children’s Hospital, Shenzhen, China. May 2017.

Zhang H. Preventing Infections in the Very Low Birth Weight Infants. Guangdong Medical Association 6th Neonatal Academic Conference. Guangzhou, China. May 2017.

Zhang H. Comprehensive Evaluation for Infants with Severe Bronchopulmonary Dysplasia: Crucial for Successful Treatment, Third Annual Chronic Lung Disease Conference: A Multidisciplinary Approach, Philadelphia, PA. March 2017.

Zhang H. Prevention and Management of Chronic Lung Disease after Premature Birth: Current Status and Future Perspectives, the 7th National Conference of Chinese Neonatologist Association, Beijing, China. March 2017.

Awards and Honors

2018, Department of Pediatrics Alan R. Cohen Master Clinician Award
2016, Best Care Community Award, Chaim Medical Resource, New York, NY
2007, Perinatal Research Society Young Investigator Award, Savannah, GA
2006, Travel award, Society of Pediatric Research annual meeting, San Francisco, CA
2006, Young investigator award, Eastern Society of Pediatric Research, 18th annual meeting, Greenwich, CT
2004-2006, Pediatric Scientist Development Award
2003, Professionalism Award, Department of Pediatrics, UMDNJ-Robert Wood Johnson Medical Schoo
2003, David H. Carver Teaching Award, Department of Pediatrics, UMDNJ-Robert Wood Johnson Medical Schoo

Editorial and Academic Positions

Editorial Positions

2018-present, Reviewer, Journal of Perinatal Medicine
2017-present, Editorial board member, Pediatric Investigation
2017-present, Reviewer, Journal of Pediatrics
2015-present, Reviewer, Archives of Disease in Childhood
2014-present, Reviewer, Journal of Perinatology
2014-present, Reviewer, Pediatric Pulmonology
2013-present, Reviewer, Respiratory Research
2012-present, Reviewer, Open Journal of Respiratory Diseases
2007-present, Reviewer, Experimental Lung Research

Academic and Institutional Committees

2014-present, Neonatology Fellow Clinical Competency Committee
2012-present, Global Neonatology Committee, Division of Neonatology

Leadership and Memberships

Memberships in Professional Organizations

2018-present, American Medical Association
2016-present, Eastern Society of Pediatric Research
2015-present, Society of Pediatric Research
2009-present, Philadelphia Perinatal Society
2000-present, American Academy of Pediatrics