The 2021 13th Annual CHOP Global Health Conference will explore how the COVID-19 pandemic has affected global child health and the deep concerns it has revealed. The pandemic has strained, and disrupted health systems in low-, middle-, and high-income countries and children have often been the hidden victims. This conference will gather global health experts, interdisciplinary leaders from around the world, and youth to discuss the challenges that COVID-19 has imposed on children's health and wellbeing. We will also showcase strategies to mitigate its effects, highlight successes and lessons learned as we look forward to a better post-pandemic world. Attendees will leave the conference with a clear mandate, objectives and strategies to make up for lost time in child health both globally and in their local health systems.