This symposium hosted by the CHOP Multidisciplinary Immune Dysregulation Team is intended for clinicians, researchers and those who care for patients with complex multi-organ immune disease. It precedes the Clinical Immunology Society meeting in Philadelphia to synergize with common activities and themes. This symposium will explore immune dysregulation driven by infection; review knowledge on disease pathogenesis and best practices for therapeutics; and include cutting-edge talks, a debate on therapeutic decision-making, provocative cases and more.