Infants display a wide range of liver problems ranging from age appropriate differences in laboratory values to both hepatocellular and cholestatic liver diseases and frank liver failure. Achieving a specific hepatology diagnosis can be challenging, as infants with disparate types of liver disease may present with overlapping clinical symptoms and nonspecific radiologic findings. Treatment and prognosis varies based on disease etiology, underscoring the importance of accurate diagnosis. This seminar will review the clinical presentations of liver abnormalities seen in the NICU along with diagnostic methodologies including routine labs/imaging, genetic testing, and liver biopsy. Management options and outcomes will be presented including liver transplant in infancy.
- Identify blood testing useful to distinguish categories of liver disease in infants
- Identify liver imaging useful in the assessment of neonatal cholestasis
- Describe the outcome of liver transplant in young infants
ACCME Accreditation Statement: Children’s Hospital of Philadelphia is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
AMA Credit Designation Statement: Children's Hospital of Philadelphia designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Disclosure Statement: Elizabeth Rand, MD (Speaker), Amit Shah, MD (Speaker), Lisa Biggs, MD (CHOP Talks Course Director) and Monica S. Williams (CME Planner) and others as appropriate have no relevant financial relationship with a commercial interest to disclose.
Related specialties: neonatology, gastroenterology, hepatology and nutrition, transplant