Although the majority of children and adults with diabetes (DM) are diagnosed with type 1 diabetes mellitus (T1D) or type 2 diabetes mellitus (T2D), a significant number of patients with DM do not meet T1D or T2D diagnostic criteria or have atypical manifestations of their DM. Monogenic diabetes is estimated to 1-5% of the pediatric diabetes population,mostly among those classified as “T1D” but without evidence of pancreatic islet autoimmunity. However, 8% of patients clinically diagnosed with T2D carry mutations in genes associated with monogenic diabetes in one study. Other rare forms of diabetes related to mitochondrial defects, severe insulin resistance syndromes, and lipodystrophy also contribute to the population of patients with atypical forms of diabetes. Collectively, patients who do not have clear presentations of either T1D or T2D may represent a unique population enriched in both known and as of yet undefined monogenic causes of diabetes.
- To define Atypical Diabetes
- To define Monogenic Diabetes
- To review clinical characteristics of monogenic forms of diabetes
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AMA Credit Designation Statement: Children's Hospital of Philadelphia designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Disclosure Statement: Sara Pinney, MD (Speaker), Meghan Craven, MD (Speaker), Lisa Biggs, MD (CHOP Talks Course Director) and Monica S. Williams (CME Planner) and others as appropriate have no relevant financial relationship with a commercial interest to disclose.