Optic Pathway Gliomas in Neurofibromatosis Type 1: Clinical Features, Current Management and the Importance of Functional Outcomes
Speaker(s):
Optic pathway gliomas (OPGs) are low-grade astrocytomas that occur in 15-20% of children with neurofibromatosis type 1 (NF1). Although rarely life-threatening, these tumors can cause significant vision loss. Given this, the main goal of management is to reduce the risk of permanent visual loss. Half or more of NF1-OPG are indolent with minimal tumor progression or effect on vision; thus, one of the challenges in management is identifying who to treat. In addition, there is limited data on the effectiveness of chemotherapy on visual recovery or preservation. This lecture will discuss the natural history, monitoring, and management of NF1-OPG, as well as discuss emerging therapies and novel biomarkers of vision.
Contact: Shelly Norbury, (856)397-5588, norburys@chop.edu
ACCME Accreditation Statement: Children’s Hospital of Philadelphia is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Approval of AMA PRA Category 1 Credit(s) for this lecture is pending. If approved, physicians can claim CME credit commensurate with the extent of their participation in the activity for free.