John Maris Laboratory

Led by John M. Maris, MD, researchers in the Maris Laboratory are focused on understanding the underlying molecular and genetic mechanisms that contribute to the development and progression of pediatric neuroblastoma. Also, efforts in the Maris Laboratory are dedicated to the development of new molecular diagnostic tests and less toxic, targeted cancer therapies to treat relapsed or refractory neuroblastoma. The long-term goal of the work in this laboratory is to use a multidisciplinary approach to improve existing cure rates for children with neuroblastoma.

CHOP Researchers Identify Potential Target in Treating High-risk Childhood Cancers

Selected Publications

MYCN controls an alternative RNA splicing program in high-risk metastatic neuroblastoma. Cancer Lett. 2015 Dec 10. pii: S0304-3835(15)00735-1. doi: 10.1016/j.canlet.2015.11.045. [Epub ahead of print] PMID: 26683771. 
Zhang S, Wei JS, Li SQ, Badgett TC, Song YK, Agarwal S, Coarfa C, Tolman C, Hurd L, Liao H, He J, Wen X, Liu Z, Thiele CJ, Westermann F, Asgharzadeh S, Seeger RC, Maris JM, Guidry Auvil JM, Smith MA, Kolaczyk ED, Shohet J, Khan J. 


Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism. Nature. 2015 Dec 17;528(7582):418-21. doi: 10.1038/nature15540. Epub 2015 Nov 11. PMID: 26560027. 
Oldridge DA, Wood AC, Weichert-Leahey N, Crimmins I, Sussman R, Winter C, McDaniel LD, Diamond M, Hart LS, Zhu S, Durbin AD, Abraham BJ, Anders L, Tian L, Zhang S, Wei JS, Khan J, Bramlett K, Rahman N, Capasso M, Iolascon A, Gerhard DS, Guidry Auvil JM, Young RA, Hakonarson H, Diskin SJ, Look AT, Maris JM. 


A LIN28B-RAN-AURKA signaling network promotes neuroblastoma tumorigenesis. Cancer Cell. 2015 Nov 9;28(5):599-609. 
Schnepp RW, Khurana P, Attiyeh EF, Raman P, Chodosh SE, Oldridge DA, Gagliardi ME, Conkrite KL, Asgharzadeh S, Seeger RC, Madison BB, Rustgi AK, Maris JM, Diskin SJ.