Joseph Piccione, DO, MS

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Joseph Piccione, DO, MS, is Co-Director of the Advanced Diagnostic and Interventional Bronchoscopy Center, and Pulmonary Co-Director for the Center for Pediatric Airway Disorders and Esophageal and Airway Treatment Program at Children's Hospital of Philadelphia.

Areas of Expertise: Advanced diagnostic and interventional bronchoscopy procedures, Pediatric airway/aerodigestive disorders (tracheomalacia, bronchial tumors, bronchial narrowing), Tracheoesophageal fistula (non-surgical repair methods), Pulmonary nodules, Minimally invasive lung biopsy procedures, Whole lung lavage (pulmonary alveolar proteinosis), Persistent air leak (pneumothorax), Airway foreign bodies, Airway cryosurgical techniques
Locations: Buerger Center for Advanced Pediatric Care

Phone: 215-590-3749

Background

Dr. Joseph Piccione, DO, MS, joined the Division of Pulmonary and Sleep Medicine in 2011 after completing his fellowship at Cincinnati Children’s Hospital where he developed a special interest in pediatric bronchology and aerodigestive disorders.

In 2014 he helped established the first pediatric Advanced Diagnostic and Interventional Bronchoscopy program in the United States and co-edited a textbook dedicated to this emerging field.  His contributions to clinical innovation have included adaptation of adult interventional bronchoscopy procedures for use in children: airway balloon dilation, tumor debulking, endobronchial valve placement for persistent air leak, cryobiopsy; and fluoroscopic, endobronchial ultrasound (EBUS) and CT navigational techniques.  While these procedures are well-developed in the care of adults, only a small handful of pediatric programs offer them in the United States.

Education and Training

Medical School

DO - New York College of Osteopathic Medicine, Old Westbury, NY

Internship

Pediatrics - Albany Medical College, Albany, NY

Residency

Pediatrics - Albany Medical College, Albany, NY

Fellowship

Pediatric Pulmonology - Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Board Certification

Pediatric Pulmonology – American Board of Pediatrics
Pediatrics – American Board of Pediatrics

Graduate Degree

MS in Clinical and Translational Research - University of Cincinnati, Cincinnati, OH

Titles and Academic Titles

Attending Physician

Pulmonary Director, Center for Pediatric Airway Disorders

Co-Director, Pulmonary Advanced Diagnostic & Interventional Bronchoscopy Center

Pulmonary Co-Director, Esophageal and Airway Treatment Program

Professor of Clinical Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Departments and Services

Research Interests

Advanced diagnostic bronchoscopy
Interventional bronchoscopy
Aerodigestive disorders

Publications

Papers

2024

Grant LMC, Hassan N, Gerber JS, Phinizy PA, Piccione J. Pediatric miliary tuberculosis diagnosed by endobronchial ultrasound-guided biopsy. Pediatr Pulmonol. 2024 Jan 19. doi: 10.1002/ppul.26878. Epub ahead of print. PMID: 38240402

Corcoran A, Foran A, Phinizy P, Biko DM, Piccione JC, Rapp JB. Dynamic airway computed tomography and flexible bronchoscopy for diagnosis of tracheomalacia in children: A comparison study. Pediatr Pulmonol. 2024 Jan 10. doi: 10.1002/ppul.26844. Epub ahead of print. PMID: 38197524.

2023

Chiotos K, Marshall D, Kellom K, Whittaker J, Wolfe H, Woods-Hill C, Stinson H, Keim G, Blumenthal J, Piccione J, Lee G, Sydney G, Gerber J.: Mixed-methods process evaluation of a respiratory-culture diagnostic stewardship intervention. Infect Control Hosp Epidemiol Page: In press, Jan 2023.

Gipsman AI, Treat JR, Piccione J.: Rare airway tumor in a previously healthy adolescent successfully treated with endoscopic resection and oral propranolol. Pediatr Pulmonol. 2023.

Schiff E, Propst EJ, Balakrishnan K, Johnson K, Lounsbury DW, Brenner MJ, Tawfik MM...Yang CJ. : Pediatric Tracheostomy Emergency Readiness Workgroup; Pediatric Tracheostomy Emergency Readiness Assessment Tool: International Consensus Recommendations. Laryngoscope 2023.

Jacobs IN, Giordano T, Soaper A, Din TF, Faig W, de Alarcon A, Balakrishnan K, Prager JD, Michael R, Douglas S, Piccione J. A multicenter study analyzing the impact of pre-existing comorbidities on laryngotracheal reconstruction (LTR) outcomes. Int J Pediatr Otorhinolaryngol. 2023 Sep;172:111631. doi: 10.1016/j.ijporl.2023.111631. Epub 2023 Jun 23. PMID: 37567085.

Corcoran A, Senthil K, Stinson H, Phinizy PA, Piccione JC. Endobronchial valve and fibrin sealant placement for successful control of pulmonary hemorrhage in a pediatric patient. Pediatr Pulmonol. 2023 Aug 18. doi: 10.1002/ppul.26639. Epub ahead of print. PMID: 37594146

Gipsman AI, Feld L, Johnson B, Needleman JP, Boas H, Lin N, DePasquale B, Pogoriler J, McDowell KM, Piccione JC. Eosinophilic plastic bronchitis: Case series and review of the literature. Pediatr Pulmonol. 2023 Aug 22. doi: 10.1002/ppul.26650. Epub ahead of print. PMID: 37606213

Corcoran A, Phinizy P, Piccione J. Stridor in a 7-month-old Girl. Pediatr Rev. 2023 Oct 1;44(S1):S66-S68. doi: 10.1542/pir.2022-005577. PMID: 37777226

Corcoran A, Franklin S, Hysinger E, Goldfarb S, Phinizy P, Pogoriler J, Tran S, DiBardino DM, Haas AR, Piccione JC. Diagnostic yield of endobronchial ultrasound and virtual CT navigational bronchoscopy for biopsy of pulmonary nodules, mediastinal lymph nodes, and thoracic tumors in children. Pediatr Pulmonol. 2023 Nov 17. doi: 10.1002/ppul.26756. Epub ahead of print. PMID: 37975500

Grant LMC, Hassan N, Gerber JS, Phinizy PA, Piccione J. Pediatric miliary tuberculosis diagnosed by endobronchial ultrasound-guided biopsy. Pediatr Pulmonol. 2024 Jan 19. doi: 10.1002/ppul.26878. Epub ahead of print. PMID: 38240402

Corcoran A, Foran A, Phinizy P, Biko DM, Piccione JC, Rapp JB. Dynamic airway computed tomography and flexible bronchoscopy for diagnosis of tracheomalacia in children: A comparison study. Pediatr Pulmonol. 2024 Jan 10. doi: 10.1002/ppul.26844. Epub ahead of print. PMID: 38197524.

2022

Boesch RP, de Alarcon A, Piccione J, Prager J, Rosen R, Sidell DR, Wootten C, Balakrishnan K; Aerodigestive Research Collaborative: Consensus on Triple Endoscopy Data Elements Preparatory to Development of an Aerodigestive Registry. Laryngoscope 132(11): 2251-2258, February  2022.

Franklin SD, Fierro J, Hysinger EB, Phinizy PA, Piccione J.: Hemosiderin Laden Macrophages in BAL samples of Children with Bronchopulmonary Dysplasia. J Pediatr Page: doi: 10.1016, Sep 2022 Notes: epub.

Tsukahara K, Johnson, B, Chiotos K, Jensen EA, Planet P, Phinizy P, Piccione J.: Comparison of tracheal aspirate and bronchoalveolar lavage samples in the microbiological diagnosis of lower respiratory tract infection in pediatric patients. Pediatr Pulmonol. 57(10):2405-2410, Oct 2022.

2021

Karen I. Ramirez-Suarez, Christian A. Barrera; Hansel J. Otero; David M. Biko; Lisa J. States; Sabah Servaes, MD; Xiaowei Zhu; James C. Davis; Joseph Piccione; Jordan B. Rapp: Pilot Study for comparative assessment of Dual-energy CT and SPECT-CT V/Q scanning for lung perfusion evaluation in infants. Pediatr Pulmonol 57(3): 702-710, March 2021.

Maier P, Silvestro E, Goldfarb SB, Piccione J, Phinizy PA, Andronikou S.: Three-dimensional printed realistic pediatric static and dynamic airway models for bronchoscopy and foreign body removal training. Pediatr Pulmonol. 56(8): 2654-2659, May 2021.

Wertz A, Ryan M, Jacobs I, Piccione J: Impact of Pre-operative Multidisciplinary Evaluation on Laryngotracheal Reconstruction Outcomes. Laryngoscope 131(7): E2356-E2362, July 2021.

Mattos C, Phinizy P, Duffy KL, Sobol S, Piccione J.: Clinical predictors of laryngotracheoesophageal clefts and tracheoesophageal fistulae in children with dysphagia. Pediatr Pulmonol. 56(12): 3792-3795, Dec 2021.

2020

Bouso JM, Yendur O, Hysinger E, Planet PJ, Haas A, Goldfarb S, Piccione J.: Endobronchial Ultrasound-guided Biopsy Is Feasible, Safe, and Improves Diagnostic Yields in Immunocompromised Children. Am J Respir Crit Care Med 201(3): 384-386, February 2020.

Fierro J, Piccione J, Lorch S.: Clinical Factors Influencing Time to Decannulation in Children with Tracheostomy and Ventilator Dependence Secondary to Bronchopulmonary Dysplasia. J Pediatr. 228(1): 31-35, August 2020.

2019

Quinlan C, Piccione J, Kim JY, Beck SE, Brooks L, Chandy-Patel R, Escobar E,Afolabi-Brown O.: The role of polysomnography in tracheostomy decannulation of children with bronchopulmonary dysplasia. Pediatr Pulmonol 54(11): 676-1683, November 2019.

2018

Erik Hysinger, Nicholas Friedman, Erik Jensen, Huayan Zhang, Joseph Piccione: Bronchoscopy in neonates with severe bronchopulmonary dysplasia in the NICU. Journal of Perinatology 39(2): 263-268, October 2018.

2012

Piccione Joseph C, McPhail Gary L, Fenchel Matthew C, Brody Alan S, Boesch Richard P: Bronchiectasis in chronic pulmonary aspiration: risk factors and clinical implications. Pediatric pulmonology 47(5): 447-452, May 2012.

Books

2020

S. Goldfarb & J. Piccione (Editors): Diagnostic and Interventional Bronchoscopy in Children. Textbook. S. Goldfarb & J. Piccione (Editors) (eds.). Springer, 1, November 2020.

Chapters

2022

Johnson, B., Franklin, S., Jacobs, I.N., Goldfarb, S., Piccione, J. (2022). Bronchoscopy and Airway Disorders. In: Mattei, P. (eds) Fundamentals of Pediatric Surgery. Springer, Cham. https://doi.org/10.1007/978-3-031-07524-7_29

2017

Alexiou, S & Piccione, J: Long Term Ventilator Dependency in Infants without Lung Disease. Manual of Neonatal Respiratory Care  Donn & Sinha (eds.). Springer, 4th Ed. : 729-731, 2017 Notes: Textbook Chapter.

2016

Clemmons, C & Piccione, J: Airway evaluation: Bronchoscopy, laryngoscopy, and tracheal aspirates. Goldsmith's Mechanical Ventilation of the Neonate. Elsevier, 6th Ed., 2016.

2010

Piccione J, Cicchino N. Acute chest syndrome. In: Jeanmonod R, editor. Case studies in emergency medicine. Cambridge (England): Cambridge University Press; 2010.

Posters and Presentations

2018

Geanacopoulos, A; Dori, Y; Itkin, M; Pinto, E; Johnstone, J; Piccione, J; Goldfarb, S: Characterizing Bronchoalveolar Lavages and Bronchial Casts in Patients with Congenital Heart Disease and Plastic Bronchitis at Time of Percutaneous Lymphatic Intervention. American Thoracic Society International Conference, San Diego, CA May 2018 Notes: Oral Poster Presentation presented by a Penn Medical Student who was first author on the poster.

2017

Zhang, H; Hysinger, E; Piccione, J.: Tracheobronchomalacia may contribute to cardiopulmonary instability in infants with severe bronchopulmonary dysplasia (Poster). Pediatric Academic Societies (PAS) 2017 National Meeting, San Francisco, CA. May 2017 Notes: Abstract presented by collaborator.

Hysinger, E; Zhang, H; Piccione, J: Flexible Bronchoscopy Is Safe and Changes Management in Neonates with Severe Bronchopulmonary Dysplasia in the NICU (Poster). American Thoracic Society International Meeting, Washington, DC May 2017 Notes: Poster presented by a former fellow whom I mentored.

Gerardo A. Vazquez Garcia, Teresa Giordano, Kevin Moran, Joseph Piccione: The Role of Flexible Bronchoscopy with Bronchoalveolar Lavage in Pre-operative Evaluation for Laryngotracheal Reconstruction in Children (Poster). American Thoracic Society International Conference, Washington, DC May 2017 Notes: Poster presented by a fellow I mentored.

Friedman, N.; Hysinger, E.; Jensen, E.; Piccione, J.: Tracheal Aspirates Do Not Correlate with Bronchoalveolar Lavage Cultures or Cell Counts in Pre-Term Neonates with Bronchopulmonary Dysplasia (Poster). Eastern Society for Pediatric Research Annual Meeting, Philadelphia, PA March 2017 Notes: Abstract presented by a fellow whom I mentored

2016

Giordano T, Piccione J, Ryan M: Esophagogastroduoendoscopy and impedance monitoring in patients undergoing laryngotracheal reconstruction (Poster). American Society for Pediatric Otorhinolaryngology National Meeting, Chicago, IL 2016.

Zur, K; Piccione, J; Mamula, P, Ryan, M: Ectopic Gastric Mucosa and a Persistent Dry Cough (Poster). World Congress of Pediatric Gastroenterology, Hepatology and Nutrition, Montreal, QC October 2016.

Piccione, J; Kofmehl, E; Facey, H; Giordano, T; Panitch, H.: Bethanechol Improves Respiratory Symptoms in Young Children with Tracheomalacia (Poster). American Thoracic Society International Conference, San Francisco, CA May 2016 Notes: Poster presented by myself.

Lectures by Invitation
2018

Piccone JC. Evaluation and Medical Management of Tracheomalacia - American Thoracic Society International Conference Aerodigestive Post-Graduate Course, San Diego, CA. May, 2018.

2017

Piccone JC. "Asthma and Small Airway Disease" - American Academy of Pediatrics National Conference & Exhibition, Chicago, IL. Sep, 2017.

Piccone JC. "Diagnosis and Management of Chronic Cough in Children" Key Essentials for Optimizing Patient Care CME Series - Pediatrics, Rowan School of Medicine, Stratford, NJ. Sep, 2017.

Piccone JC. "Chronic Pulmonary Aspiration in Children" PCOM Family Medicine Weekend, Hershey, PA. Jun, 2017.

Piccone JC. "The role of flexile bronchoscopy in children undergoing laryngotracheal reconstruction" - Pediatric Aerodigestive Disorders Post-Graduate Course, American Thoracic Society International Conference, Washington, DC. May, 2017.

Piccone JC. "Aerodigestive Clinical Case Presentation" Pediatric Aerodigestive Disorders Post-Graduate Course, American Thoracic Society International Conference, Washington, DC. May, 2017.

Piccone JC. Expert Discussant for Pediatric Clinical Chest Rounds, American Thoracic Society International Conference, Washington, D.C. May, 2017.

Piccone JC. Annual Pediatric Airway Foreign Body Course Instructor - The Children's Hospital of Philadelphia, Division of Otolaryngology - Attendees are Otolaryngology Residents & Fellows from programs throughout the eastern U.S. Mar, 2017.

2016

Piccone JC. "Lung Disease Across the Lifespan", Salzburg Weill Cornell Seminar in Pediatric Pulmonology American-Austrian Foundation Salzburg, Austria. Nov, 2016.

Piccone JC. "Invasive Mechanical Ventilation in Chronic Lung Disease". Salzburg Weill Cornell Seminar in Pediatric Pulmonology American-Austrian Foundation. Salzburg, Austria. Nov, 2016.

Piccone JC. "Chronic Pulmonary Aspiration in Children". Salzburg Weill Cornell Seminar in Pediatric Pulmonology American-Austrian Foundation. Salzburg, Austria. Nov, 2016.

Piccone JC. "Chronic Pulmonary Aspiration & Dynamic Airway Disorders in Children": Short Course: Multi-disciplinary Management of Pediatric Aerodigestive Disorders.  American Speech Language & Hearing Association National Conference, Philadelphia, PA. Nov, 2016.

Piccone JC. Annual Pediatric Airway Foreign Body Course Instructor - The Children's Hospital of Philadelphia, Division of Otolaryngology, Philadelphia, PA. Attendees are Otolaryngology Residents & Fellows from programs throughout the eastern U.S. Mar, 2016.

Awards and Honors

2021, Alan R. Cohen Master Clinician Award, Children's Hospital of Philadelphia
2021, American Thoracic Society Fellow
2013-2018, Early Career Faculty Teaching Honor Roll, Pediatric Residency Program, Children's Hospital of Philadelphia
2009-2010, Full Tuition Scholarship for M.S. Degree, University of Cincinnati
1997-2001, Full Tuition Scholarship for B.S. Degree, Towson University

Editorial and Academic Positions

Editorial Positions

2017-present, Peer Reviewer, Pediatric Pulmonology
2017-present, Peer Reviewer, Pediatric Allergy, Immunology, and Pulmonology
2015-present, Peer Reviewer, Annals of the American Thoracic Society
2013-present, Peer Reviewer, Pediatrics

Academic and Institutional Committees

2017-present, Home Care Strategic Planning Committee
2016-present, Internal Review Committee, Accreditation Council for Graduate Medical Education (ACGME)
2015-present, Quality Measures Committee
2015-present, Department of Pediatrics Quality Improvement Committee
2014-present, Graduate Education Committee
2014-present, ABP/ABMS Maintenance of Certification (MOC) Steering Committee
2014-present, Chair, Croup Clinical Pathway Committee
2014-present, Quality Improvement Champion, Division of Pulmonary and Sleep Medicine
2013-present, Pediatric Residency Program, Intern Selection Committee
2011-present, EPIC Superuser, Division of Pulmonary and Sleep Medicine
2011-present, Fellowship Curriculum Committee, Division of Pulmonary and Sleep Medicine

Leadership and Memberships

Memberships in Professional Organizations

2023-present, American Association for Bronchology and Interventional Pulmonology
 - Membership Committee
 - Pediatrics Chapter Lead
2019-present, American Society for Pediatric Otolaryngology
 - Ad Hoc Committee on "The Role of the Otolaryngologist in Contemporary Landscape of Pediatric Aerodigestive Disorders"
2018-present, The Aerodigestive Society
2018-present, Aerodigestive Research Collaborative
 - Executive Board Member, National Registry
2010-present, American Thoracic Society
 - Co-Founder, Pediatric Bronchoscopy Library
 - 2023-2024, Pediatrics Assembly Nominating Committee
 - 2022, 2024, Course Co-Director, Pediatric Advanced Diagnostic and Interventional Bronchoscopy Post-Graduate Course