CAR T-Cells for Severe Lupus
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Description
The purpose of this study is to test an experimental approach called cell therapy for Systemic Lupus Erythematosus (SLE).CAR T-cells have been used to treat some cancers, but these cells, known as CART19 cells, are an experimental treatment for lupus. The CAR T-cells are made by collecting T-cells from patients and changing them to find and remove B-cells, including ones that are involved in causing lupus. Participants will be given CART19 cells through an IV and then monitored for up to 24 months.
Participants will also be asked to participate in a separate, long term follow-up study to monitor their health for up to 15 years after their last CART19 treatment.
Eligibility and criteria
What to expect
This study will take place at CHOP's Philadelphia Campus.
Active participation lasts for 2 years, with most visits occurring in the first year. Study visits include Screening/Enrollment, Pre-Infusion, Day-1, Infusion (Day o), Day 1, Day 3, Day 7, Day 10, Day 14, Day 21, Day 28, Month 2, Month 3, Month 4, Month 5, Month 6, Month 9, Month 12, Month 15, Month 18, Month 21, and Month 24.
Possible procedures include:
- medical record review
- chemotherapy
- CART19 cell infusion
- blood draws
- physical exams
- imaging
- disease assessments
- genetic testing
- surveys
Related specialties
Related conditions
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