Why are we doing this study?
Babies born with congenital diaphragmatic hernia (CDH) sometimes have difficulty getting enough oxygen from the lungs to the heart and then to rest of the body.
Standard treatment for infants with CDH after birth is to place a breathing tube to open the lungs and provide oxygen to the body. Usually, the umbilical cord is clamped immediately after birth. The baby is brought to a special infant stabilization room, where the breathing tube is placed.
Some animal studies suggest that waiting to clamp the cord until after oxygen is delivered to the lungs may lead to higher blood oxygen levels and better heart function after birth. This has not yet been well studied in infants with CDH.
The purpose of the Delayed Cord Clamping for Intubation and Gentle Ventilation in Infants with CDH (DING) research study is to determine if waiting to clamp the umbilical cord until after placement of a breathing tube is safe and possible in babies with CDH.
What to expect
At Children's Hospital of Philadelphia (CHOP), babies prenatally diagnosed with CDH will be delivered in our Garbose Family Special Delivery Unit (SDU), located within our Center for Fetal Diagnosis and Treatment.
Once the baby is born, while the umbilical cord is still attached to the mother, the Neonatal Stabilization Team will place the baby on a special trolley designed for delayed cord clamping. The neonatologist will place a breathing tube and provide breaths and oxygen to gently expand and ventilate the baby's lungs. Once the baby's lungs are open, the team will cut the umbilical cord and take the baby to the infant stabilization room for ongoing care.
If you are being cared for at CHOP's Center for Fetal Diagnosis and Treatment and are interested in this trial, ask your healthcare team for more information.
For additional study details and criteria, visit clinicaltrials.gov (NCT # 03314233).