Lymphatic Leakage in Protein-losing Enteropathy (PLE)

In children and adults with protein-losing enteropathy (PLE), lymphatic channels originating from the liver and connecting to the intestine, or channels originating in the intestine, create leaks in the intestinal wall, leading to an abnormally low level of albumin (a protein made by the liver), electrolytes, coagulants and even T-cells.

The world-renowned experts in the Jill and Mark Fishman Center for Lymphatic Disorders developed a specialized imaging technique — dynamic contrast magnetic resonance lymphangiography (DCMRL) — that is used to pinpoint the exact source of lymphatic leaks. During this procedure, an MRI contrast agent (a safe, injectable dye) is injected directly into the lymphatic system and tracked by MRI. In some cases, a special blue dye injected into lymphatic channels can further aid localization of lymphatic leaks.

Related Centers and Programs: Jill and Mark Fishman Center for Lymphatic Disorders