David Lynch, MD, PhD

David Lynch, MD, PhD, is an attending neurologist in the Division of Neurology at The Children's Hospital of Philadelphia and director of the Friedreich's Ataxia Program.

Areas of Expertise: Neurogenetics disease
Locations: Main Campus
Appointments and Referrals: 1-800-TRY-CHOP

  • Education and Training

    Medical School

    MD - Johns Hopkins University School of Medicine, Baltimore, MD


    Internal Medicine - Hospital of the Univeristy of Pennsylvania, Philadelphia, PA


    Neurology - Hospital of the University of Pennsylvania, Philadelphia, PA


    Pharmacology and Neurology - University of Pennsylvania School of Medicine, Philadelphia, PA

    Board Certification


    Graduate Degree

    PhD in Neuroscience - Johns Hopkins University School of Medicine, Baltimore, MD

  • Titles and Academic Titles

    Attending Physician

    Professor of Neurology, Perelman School of Medicine at the University of Pennsylvania

  • Centers and Programs
  • Research Interests

    Glutamate receptors

  • Publications



    Delatycki,M.B.,Tai, G., Corben, L.,Yiu, E.M. ,Evans-Galea, M. V , Stephenson,S., Gurrin, L., Allen, K. J., Lynch, D. R., Lockhart, P.J.: HFE p.C282Y heterozygosity is associated with earlier disease onset in Friedreich ataxia. Movement Disorders 29(7): 940-3, 2014. 

    Lin, H., Hsu,F-C, Baumann, B. H., Coulter, D. A., Lynch, D. R.: Cortical synaptic NMDA receptor deficits in alpha7 nicotinic acetylcholine receptor gene deletion models: Implications for neuropsychiatric diseases. Neurobiology of Disease 63: 129-140, 2014. 

    Adang,L., Lynch, D. R., Panzer, J.: Pediatric anti-NMDA receptor encephalitis is seasonal. Annals of Clinical and Translational Neurology 2014. 

    Zyskind JW, Wang Y, Cho G, Ting JH, Kolson DL, Lynch DR, Jordan-Sciutto KL.: E2F1 in neurons is cleaved by calpain in an NMDA receptor-dependent manner in a model of HIV-induced neurotoxicity. J Neurochem. 2014. 

    St John Sutton, M., Ky, B., Regner, S.R., Schadt, K.M., Plappert, T., He, J., D’Souza, B. , Lynch, D.R.: Longitudinal Strain in Friedreich Ataxia: A Potential Marker for Early Left Ventricular Dysfunction. Echocardiography 31(1): 50-7, 2014. 

    Eric C. Deutsch,Devin Oglesbee, Nathaniel R. Greeley, David R. Lynch: Utility of Frataxin Immunoassays for the diagnosis of Friedreich Ataxia. Journal of Neurology, Neurosurgery and Psychiatry 2014. 

    H. Lin, F.-C. Hsu1, B. H. Baumann, D. A. Coulter, S. A. Anderson, and D. R. Lynch: Cortical parvalbumin GABAergic deficits with ?7 nicotinic acetylcholine receptor deletion: Implications for schizophrenia. Molecualr and Cellular Neuroscience 2014. 

    Gleichman, A.L., Panzer, J. A., Baumann, B., Dalmau, J., Lynch, D. R.: Antigenic and mechanistic characterization of anti-AMPA receptor encephalitis. Annals of Clinical and Translational Neurology 1(3): 180-189, 2014. 


    LA Seyer, K Galetta, J Wilson, R Sakai, S Perlman, K Mathews, GR Wilmot, CM Gomez, B Ravina, T Zesiewicz, KO Bushara, SH Subramony, T Ashizawa, MB Delatycki, A Brocht, LJ Balcer, DR Lynch: Analysis of the visual system in Friedreich ataxia. Journal of Neurology 260(9): 2362-9, 2013. 

    Devin Oglesbee; Charles Kroll, Oleksandr Gakh, Eric C. Deutsch, David R. Lynch, Ralitza Gavrilova, Silvia Tortorelli, Kimiyo Raymond, Dimitar Gavrilov, Piero Rinaldo, Dietrich Matern, and Grazia Isaya,: A High-Throughput Immunoassay for the Biochemical Diagnosis of Friedreich Ataxia in Dried Blood Spots and Whole Blood. Clinical Chemistry 59(10): 1461-9, 2013. 

    Gresa-Arribas, N., Titulaer, M.J., Torrents, A., Aguilar, E., McCracken, L. Leypoldt, F., Gleichman, A. J., Balice-Gordon, R., Rosenfeld, M.R., Lynch, D.R., Graus, F., Dalmau, J.: Diagnosis and significance of antibody titers in anti-NMDA receptor encephalitis, a retrospective study. Lancet Neurology 4422(13): 70282-5., 2013. 

    Sankha S. Basu, Eric C. Deutsch, Alec Schmaier, David R. Lynch, and Ian A. Blair: Human platelets as a platform to monitor metabolic biomarkers using stable isotopes and liquid chromatography-mass spectrometry. Bioanalysis 5(24): 3009-21., 2013. 

    Friedman, L.S., Schadt, K.A., Regner, S.R., Mark, G.E., Lin, K.Y., Sciascia, T., St John Sutton, M., Willi, S., Lynch, D.R.: Elevation of Serum Cardiac Troponin I in a Cross-Sectional Cohort of Asymptomatic Subjects with Friedreich Ataxia. International Journal of Cardiology 167(4): 1622-4, 2013.