David Lynch, MD, PhD

David Lynch, MD, PhD, is a pediatric neurologist at The Children's Hospital of Philadelphia and director of the Friedreich's Ataxia Program.

Areas of Expertise: Neurogenetics disease
Locations: Main Campus; Specialty Care & Surgery Center, King of Prussia, S. Goddard Blvd.
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

  • Education and Training

    Medical School

    MD - Johns Hopkins University School of Medicine, Baltimore, MD


    Internal Medicine - Hospital of the Univeristy of Pennsylvania, Philadelphia, PA


    Neurology - Hospital of the University of Pennsylvania, Philadelphia, PA


    Pharmacology and Neurology - University of Pennsylvania School of Medicine, Philadelphia, PA

    Board Certification


    Graduate Degree

    PhD in Neuroscience - Johns Hopkins University School of Medicine, Baltimore, MD

  • Titles and Academic Titles

    Attending Physician

    Professor of Neurology, Perelman School of Medicine at the University of Pennsylvania

  • Departments and Services
  • Research Interests

    Glutamate receptors

  • Publications



    Delatycki,M.B.,Tai, G., Corben, L.,Yiu, E.M. ,Evans-Galea, M. V , Stephenson,S., Gurrin, L., Allen, K. J., Lynch, D. R., Lockhart, P.J.: HFE p.C282Y heterozygosity is associated with earlier disease onset in Friedreich ataxia. Movement Disorders 29(7): 940-3, 2014. 

    Lin, H., Hsu,F-C, Baumann, B. H., Coulter, D. A., Lynch, D. R.: Cortical synaptic NMDA receptor deficits in alpha7 nicotinic acetylcholine receptor gene deletion models: Implications for neuropsychiatric diseases. Neurobiology of Disease 63: 129-140, 2014. 

    Adang,L., Lynch, D. R., Panzer, J.: Pediatric anti-NMDA receptor encephalitis is seasonal. Annals of Clinical and Translational Neurology 2014. 

    Zyskind JW, Wang Y, Cho G, Ting JH, Kolson DL, Lynch DR, Jordan-Sciutto KL.: E2F1 in neurons is cleaved by calpain in an NMDA receptor-dependent manner in a model of HIV-induced neurotoxicity. J Neurochem. 2014. 

    St John Sutton, M., Ky, B., Regner, S.R., Schadt, K.M., Plappert, T., He, J., D’Souza, B. , Lynch, D.R.: Longitudinal Strain in Friedreich Ataxia: A Potential Marker for Early Left Ventricular Dysfunction. Echocardiography 31(1): 50-7, 2014. 

    Eric C. Deutsch,Devin Oglesbee, Nathaniel R. Greeley, David R. Lynch: Utility of Frataxin Immunoassays for the diagnosis of Friedreich Ataxia. Journal of Neurology, Neurosurgery and Psychiatry 2014. 

    H. Lin, F.-C. Hsu1, B. H. Baumann, D. A. Coulter, S. A. Anderson, and D. R. Lynch: Cortical parvalbumin GABAergic deficits with ?7 nicotinic acetylcholine receptor deletion: Implications for schizophrenia. Molecular and Cellular Neuroscience 2014. 

    Gleichman, A.L., Panzer, J. A., Baumann, B., Dalmau, J., Lynch, D. R.: Antigenic and mechanistic characterization of anti-AMPA receptor encephalitis. Annals of Clinical and Translational Neurology 1(3): 180-189, 2014. 


    LA Seyer, K Galetta, J Wilson, R Sakai, S Perlman, K Mathews, GR Wilmot, CM Gomez, B Ravina, T Zesiewicz, KO Bushara, SH Subramony, T Ashizawa, MB Delatycki, A Brocht, LJ Balcer, DR Lynch: Analysis of the visual system in Friedreich ataxia. Journal of Neurology 260(9): 2362-9, 2013. 

    Devin Oglesbee; Charles Kroll, Oleksandr Gakh, Eric C. Deutsch, David R. Lynch, Ralitza Gavrilova, Silvia Tortorelli, Kimiyo Raymond, Dimitar Gavrilov, Piero Rinaldo, Dietrich Matern, and Grazia Isaya,: A High-Throughput Immunoassay for the Biochemical Diagnosis of Friedreich Ataxia in Dried Blood Spots and Whole Blood. Clinical Chemistry 59(10): 1461-9, 2013. 

    Gresa-Arribas, N., Titulaer, M.J., Torrents, A., Aguilar, E., McCracken, L. Leypoldt, F., Gleichman, A. J., Balice-Gordon, R., Rosenfeld, M.R., Lynch, D.R., Graus, F., Dalmau, J.: Diagnosis and significance of antibody titers in anti-NMDA receptor encephalitis, a retrospective study. Lancet Neurology 4422(13): 70282-5., 2013. 

    Sankha S. Basu, Eric C. Deutsch, Alec Schmaier, David R. Lynch, and Ian A. Blair: Human platelets as a platform to monitor metabolic biomarkers using stable isotopes and liquid chromatography-mass spectrometry. Bioanalysis 5(24): 3009-21., 2013. 

    Friedman, L.S., Schadt, K.A., Regner, S.R., Mark, G.E., Lin, K.Y., Sciascia, T., St John Sutton, M., Willi, S., Lynch, D.R.: Elevation of Serum Cardiac Troponin I in a Cross-Sectional Cohort of Asymptomatic Subjects with Friedreich Ataxia. International Journal of Cardiology 167(4): 1622-4, 2013.