Areas of Expertise:
Hypospadias, Molecular mechanisms of bladder wall hypertrophy, Obstructive uropathies, Reconstructive urology, Stress induced changes in bladder function, Voiding function and dysfunction
Locations: Main Campus; Specialty Care, Atlantic County; Specialty Care & Surgery Center, Brandywine Valley; Specialty Care & Surgery Center, Voorhees; Specialty Care, Exton
Approach to Care
The practice of medicine is a wonderful combination of strong scientific principles applied in the care of our fellow human beings. While we are guided by many quality scientific and clinical studies, at some point the art of medicine must be acknowledged. Care must be individualized and tailored to the individual; one size does not fit all. The art of medicine comes in understanding which option among several works best for a child and family.
- Education and Training
MD - University of California at Los Angeles School of Medicine, Los Angeles, CA
Surgery - Hospital of the University of Pennsylvania, Philadelphia, PA
Surgery and Urologic Surgery - Hospital of the University of Pennsylvania, Philadelphia, PA
Pediatric Urology - The Children's Hospital of Philadelphia, Philadelphia, PA
- Titles and Academic Titles
Professor of Urology in Surgery, Perelman School of Medicine at the University of Pennsylvania
- Departments and Services
Zderic SA, Kirk, J (eds): Pediatric Urology for the Primary Care Provider. Slack Incorporated, 2008
Zderic SA, Carr MC, Canning DA, Snyder HM (eds.): Pediatric Gender Assignment: A Critical Reappraisal. New York: Kluwer-Plenum Press, 2002
Zderic SA (ed.): Muscle Matrix and Bladder Function. New York: Plenum Press, 1995
Zderic, SA. Donor Nephrectomy. In Baskin, LS, Hinman, F. Atlas of Pediatric Urologic Surgery, Philadelphia, Elsevier, 2008, 201-207.
Zderic, SA. Ureteral Tailoring Techniques. In Baskin, LS, Hinman, F. Atlas of Pediatric Urologic Surgery, Philadelphia, Elsevier, 2008, 265-266.
Hypolite JA, Lei Q, Chang S, Zderic SA, Butler S, Wein AJ, Malykhina AP, Chacko S. Spontaneous and evoked contractions are regulated by PKC-mediated signaling in detrusor smooth muscle: involvement of BK channels. Am J Physiol Renal Physiol. 2013 Mar;304(5):F451–62. doi: 10.1152/ajprenal.00639.2011. Epub 2012 Dec 26. Cited in PubMed; PMID 23269650. Read the abstract
Boopathi E, Hypolite JA, Zderic SA, Gomes CM, Malkowicz B, Liou HC, Wein AJ, Chacko S. GATA-6 and NF-κB activate CPI-17 gene transcription and regulate Ca2+ sensitization of smooth muscle contraction. Mol Cell Biol. 2013 Mar;33(5):1085–102. doi: 10.1128/MCB.00626-12. Epub 2012 Dec 28. Cited in PubMed; PMID 23275439. Read the abstract
Christman MS, Kraft KH, Tasian GE, Zderic SA, Kolon TF. Reproducibility and reliability of semen analyses in youths at risk for infertility. J Urol. 2013 Feb 19. doi:pii: S0022-5347(13)00299-1. 10.1016/j.juro.2013.02.030. [Epub ahead of print]. Cited in PubMed; PMID 23434946. Read the abstract
Christman MS, Zderic SA, Kolon TF. Comparison of semen analyses amongst youths with a history of cryptorchidism or varicocele. J Urol. 2013 Feb 14. doi:pii: S0022-5347(13)00286-3. 10.1016/j.juro.2013.02.017. [Epub ahead of print]. Cited in PubMed; PMID 23416638. Read the abstract
Lei Q, Pan XQ, Villamor AN, Asfaw TS, Chang S, Zderic SA, Malykhina AP. Lack of transient receptor potential vanilloid 1 channel modulates the development of neurogenic bladder dysfunction induced by cross-sensitization in afferent pathways. J Neuroinflammation. 2013 Jan 11;10:3. doi: 10.1186/1742-2094-10-3. Cited in PubMed; PMID 23305398. Read the article
Chang AY, Sliwoski J, Butler S, Hearn G, Lassmann J, Chacko S, et al. Calcineurin mediates bladder wall remodeling secondary to partial outlet obstruction. Am J Physiol Renal Physiol. 2011 Oct;301(4):F813-22. Epub 2011 Jul 20. Cited in PubMed; PMID 21775483. Read the abstract
Posters and Presentations
“Pediatric Urologic Emergencies.” A Course in Pediatric Emergency Medicine, The Alfred I. DuPont Institute of the Nemours Foundation, Orlando, Fla.
“Pediatric Urology for the general urologist. R.I.P. by C.A.Q.?” Special Topic Lecture, Mid-Atlantic Section of The American Urological Association.
Surgeon Scientists at the Starting Line, Applying Kleiner’s Laws, Section on Urology, American Academy of Pediatrics, Section on Urology, San Francisco, Calif.
A Clinical Urologist’s View of Bladder Function = NIH Symposium on
Surgeon Scientists at the Starting Line, Applying Kleiner’s Laws, University of Michigan, Ann Arbor, Mich.
- Editorial and Academic Positions
British Journal of Urology
Journal of Endourology
Journal of Urology
Pediatric Emergency Care
Wound Repair and Regeneration
Asian Journal of Andrology
American Journal of Physiology Renal
Molecular and Cellular Biochemistry
Physician’s Health Committee
- Editorial and Academic Positions