Stephen A. Zderic, MD

Stephen A. Zderic, MD, is an attending urologist in the Division of Urology at The Children's Hospital of Philadelphia.

Areas of Expertise: Hypospadias, Molecular mechanisms of bladder wall hypertrophy, Obstructive uropathies, Reconstructive urology, Stress induced changes in bladder function, Voiding function and dysfunction
Locations: Main Campus; Specialty Care, Atlantic County; Specialty Care & Surgery Center, Brandywine Valley; Specialty Care & Surgery Center, Voorhees; Specialty Care, Exton
Phone: 215-590-2754

  • Background

    Approach to Care

    The practice of medicine is a wonderful combination of strong scientific principles applied in the care of our fellow human beings. While we are guided by many quality scientific and clinical studies, at some point the art of medicine must be acknowledged. Care must be individualized and tailored to the individual; one size does not fit all. The art of medicine comes in understanding which option among several works best for a child and family.

  • Education and Training

    Medical School

    MD - University of California at Los Angeles School of Medicine, Los Angeles, CA


    Surgery - Hospital of the University of Pennsylvania, Philadelphia, PA


    Surgery and Urologic Surgery - Hospital of the University of Pennsylvania, Philadelphia, PA


    Pediatric Urology - The Children's Hospital of Philadelphia, Philadelphia, PA

    Board Certification

    Pediatric Urology

  • Titles and Academic Titles

    Attending Urologist

    Professor of Urology in Surgery, Perelman School of Medicine at the University of Pennsylvania

  • Departments and Services
  • Publications


    Zderic SA, Kirk, J (eds): Pediatric Urology for the Primary Care Provider. Slack Incorporated, 2008

    Zderic SA, Carr MC, Canning DA, Snyder HM (eds.): Pediatric Gender Assignment: A Critical Reappraisal. New York: Kluwer-Plenum Press, 2002

    Zderic SA (ed.): Muscle Matrix and Bladder Function. New York: Plenum Press, 1995

    Zderic, SA. Donor Nephrectomy. In Baskin, LS, Hinman, F. Atlas of Pediatric Urologic Surgery, Philadelphia, Elsevier, 2008, 201-207.

    Zderic, SA. Ureteral Tailoring Techniques. In Baskin, LS, Hinman, F. Atlas of Pediatric Urologic Surgery, Philadelphia, Elsevier, 2008, 265-266.



    Hypolite JA, Lei Q, Chang S, Zderic SA, Butler S, Wein AJ, Malykhina AP, Chacko S. Spontaneous and evoked contractions are regulated by PKC-mediated signaling in detrusor smooth muscle: involvement of BK channels. Am J Physiol Renal Physiol. 2013 Mar;304(5):F451–62. doi: 10.1152/ajprenal.00639.2011. Epub 2012 Dec 26. Cited in PubMed; PMID 23269650. Read the abstract

    Boopathi E, Hypolite JA, Zderic SA, Gomes CM, Malkowicz B, Liou HC, Wein AJ, Chacko S. GATA-6 and NF-κB activate CPI-17 gene transcription and regulate Ca2+ sensitization of smooth muscle contraction. Mol Cell Biol. 2013 Mar;33(5):1085–102. doi: 10.1128/MCB.00626-12. Epub 2012 Dec 28. Cited in PubMed; PMID 23275439. Read the abstract

    Christman MS, Kraft KH, Tasian GE, Zderic SA, Kolon TF. Reproducibility and reliability of semen analyses in youths at risk for infertility. J Urol. 2013 Feb 19. doi:pii: S0022-5347(13)00299-1. 10.1016/j.juro.2013.02.030. [Epub ahead of print]. Cited in PubMed; PMID 23434946. Read the abstract

    Christman MS, Zderic SA, Kolon TF. Comparison of semen analyses amongst youths with a history of cryptorchidism or varicocele. J Urol. 2013 Feb 14. doi:pii: S0022-5347(13)00286-3. 10.1016/j.juro.2013.02.017. [Epub ahead of print]. Cited in PubMed; PMID 23416638. Read the abstract

    Lei Q, Pan XQ, Villamor AN, Asfaw TS, Chang S, Zderic SA, Malykhina AP. Lack of transient receptor potential vanilloid 1 channel modulates the development of neurogenic bladder dysfunction induced by cross-sensitization in afferent pathways. J Neuroinflammation. 2013 Jan 11;10:3. doi: 10.1186/1742-2094-10-3. Cited in PubMed; PMID 23305398. Read the article


    Chang AY, Sliwoski J, Butler S, Hearn G, Lassmann J, Chacko S, et al. Calcineurin mediates bladder wall remodeling secondary to partial outlet obstruction. Am J Physiol Renal Physiol. 2011 Oct;301(4):F813-22. Epub 2011 Jul 20. Cited in PubMed; PMID 21775483. Read the abstract

    Posters and Presentations

    “Pediatric Urologic Emergencies.” A Course in Pediatric Emergency Medicine, The Alfred I. DuPont Institute of the Nemours Foundation, Orlando, Fla.

    “Pediatric Urology for the general urologist. R.I.P. by C.A.Q.?” Special Topic Lecture, Mid-Atlantic Section of The American Urological Association.

    Surgeon Scientists at the Starting Line, Applying Kleiner’s Laws, Section on Urology, American Academy of Pediatrics, Section on Urology, San Francisco, Calif.

    A Clinical Urologist’s View of Bladder Function = NIH Symposium on

    Surgeon Scientists at the Starting Line, Applying Kleiner’s Laws, University of Michigan, Ann Arbor, Mich.

  • Editorial and Academic Positions

    Editorial Positions
    British Journal of Urology
    Journal of Endourology
    Journal of Urology
    Pediatric Emergency Care
    Wound Repair and Regeneration
    Asian Journal of Andrology
    American Journal of Physiology Renal
    Molecular and Cellular Biochemistry
    Pediatric Nephrology
    Pediatric Research

    Academic Committees
    Physician’s Health Committee