Holly L. Hedrick, MD, FACS

Holly Hedrick, MD, is an attending pediatric and fetal surgeon at The Children’s Hospital of Philadelphia.

Areas of Expertise: Clinical applications of fetal diagnosis and therapy, ECMO, Laparoscopy and thoracoscopy, Neonatal Surgery, Oncology, Thoracic Surgery
Locations: Main Campus
Phone: 215-590-2730

  • Background

    Dr. Holly Hedrick is an attending surgeon in the Division of Pediatric General, Thoracic and Fetal Surgery at The Children’s Hospital of Philadelphia (CHOP) and the Louise Schnaufer Endowed Chair in Pediatric Surgery. She is also the surgical director of the Extracorporeal Membrane Oxygenation (ECMO) Program, co-director of the Neonatal Surgery Team and director of the Pulmonary Hypoplasia Program. In addition, she is an investigator in the Center for Fetal Research and an associate professor of surgery at the University of Pennsylvania School of Medicine.

    Dr. Hedrick completed her pediatric surgery fellowship at CHOP and joined the staff as an attending surgeon 1999. “I felt grateful and honored to be trained at CHOP,” she says. “It is a dream come true to work here.” Dr. Hedrick’s areas of interest include neonatal surgery, ECMO, thoracic surgery, and minimally invasive techniques including laparoscopy and thoracoscopy.

    Her clinical specialty is treating children with congenital diaphragmatic hernia (CDH), a birth defect in which a hole in the diaphragm allows abdominal organs to migrate into the chest, restricting development of the lungs. Concerned with improving outcomes after surgical repair for these fragile infants, who suffer long-term complications including pulmonary hypoplasia, Dr. Hedrick sought to create a specialized program offering the most complete and current care tailored to the specific needs of patients with compromised lung function. The result was the Hospital’s unique Pulmonary Hypoplasia Program (PHP), founded in 2004, which unites specialists from various disciplines including neonatology, cardiology, pulmonology, audiology and gastroenterology, to provide comprehensive care for CDH patients well into school age. Today, more than 230 patients are followed in the PHP Program.

    “It’s been thrilling to work with this truly interdisciplinary team,” she says. “We are very challenged by these diagnoses, but we find it rewarding to see these babies through. It’s not enough to deliver a survivor. We want to give them a high quality of life.”

    Dr. Hedrick earned her bachelor’s degree from Indiana University and her medical degree from Duke University School of Medicine. She completed her general surgery residency at Brigham & Women’s Hospital/Harvard Medical School and her residency and fellowship in pediatric surgery at The Children’s Hospital of Philadelphia. Dr. Hedrick also completed research fellowships at Duke University School of Medicine and Harvard Medical School.

    To contact the Center for Fetal Diagnosis and Treatment, call 1-800-468-8376 (1-800-IN-UTERO).

  • Education and Training

    Medical School

    MD - Duke University School of Medicine, Durham, NC


    General Surgery - Brigham and Women's Hospital, Boston, MA


    Pediatric Surgery - The Children's Hospital of Philadelphia, Philadelphia, PA


    Research - Indiana University School of Medicine Biomedical Research Program, Krannert Institute of Cardiology, Bloomington, IN
    Research - Duke University School of Medicine, Surgical Oncology Research Facility, Durham, NC
    Research - Department of P

    Board Certification

    Pediatric Surgery

  • Titles and Academic Titles

    Attending Surgeon

    Surgical Director, ECMO Program

    Co-director, Neonatal Surgery Team

    Director, Pulmonary Hypoplasia Program

    Louise Schnaufer Endowed Chair in Pediatric Surgery

    Associate Professor of Surgery, Perelman School of Medicine at the University of Pennsylvania

  • Conditions Treated
  • Departments and Services
  • Publications




    Laje P, Hedrick HL. Operative Surgical Management of Fetuses with CHAOS: Management at Delivery. In: Sobol S, Lioy J, ed. Disorders of the Neonatal Airway. New York: Springer; 2015. p. 181-188.



    Partridge EA, Victoria T, Coleman BG, Martinez-Poyer J, Laje P, Hedrick HL, Flake AW, Adzick NS. Prenatal diagnosis of esophageal bronchus - first report of a rare foregut malformation in utero. J Pediatr Surg. 2015 Feb;50(2):306-10. Epub 2014 Nov 10.  Read the abstract.

    Danzer E, Gerdes M, D'Agostino JA, Bernbaum J, Hoffman C, Herkert L, Rintoul NE, Peranteau WH, Flake AW, Adzick NS, Hedrick HL. Neurodevelopmental outcome at one year of age in congenital diaphragmatic hernia infants not treated with extracorporeal membrane oxygenation. J Pediatr Surg. 2015 Jun;50(6):898-903. doi: 10.1016. Read the abstract.

    Laje P, Pearson EG, Simpao AF, Rehman MA, Sinclair T, Hedrick HL, Adzick NS, Flake AW. The first 100 infant thoracoscopic lobectomies: Observations through the learning curve and comparison to open lobectomy. J Pediatr Surg. 2015 Jun 3. pii: S0022-3468(15)00369-3. pii: S0022-3468(15)00369-3. doi: 10.1016. Read the abstract.

    Partridge EA, Peranteau WH, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL. Timing of repair of congenital diaphragmatic hernia in patients supported by extracorporeal membrane oxygenation (ECMO). J Pediatr Surg. 2015 Feb;50(2):260-2. Read the abstract.

    Partridge EA, Hanna BD, Rintoul NE, Herkert L, Flake AW, Adzick NS, Hedrick HL, Peranteau WH. Brain-type natriuretic peptide levels correlate with pulmonary hypertension and requirement for extracorporeal membrane oxygenation in congenital diaphragmatic hernia. J Pediatr Surg. 2015 Feb;50(2):263-6. Read the abstract.

    Peranteau WH, Scott Adzick N, Boelig MM, Alan W F, Hedrick HL, Howell LJ, Moldenhauer JS, Khalek N, Martinez-Poyer J, Johnson MP. Thoracoamniotic shunts for the management of fetal lung lesions and pleural effusions: a single-institution review and predictors of survival in 75 cases. J Pediatr Surg. 2015 Feb;50(2):301-5. Read the abstract.

    Danzer E, Gerdes M, D'Agostino JA, Bernbaum J, Hoffman C, Rintoul NE, Herkert LM, Flake AW, Adzick NS, Hedrick HL. Patient characteristics are important determinants of neurodevelopmental outcome during infancy in giant omphalocele. Early Hum Dev. 2015 Feb 9;91(3):187-193. Read the abstract.

    Peranteau WH, Tharakan SJ, Partridge E, Herkert L, Rintoul NE, Flake AW, Adzick NS, Hedrick HL. Systemic hypertension in giant omphalocele: An underappreciated association. J Pediatr Surg. 2015 Feb 23. pii: S0022-3468(15)00131-1. doi: 10.1016. Read the abstract


    Danzer E, Zarnow D, Gerdes M, D'Agostino JA, Siegle J, Bebbington MW, et al. Abnormal brain development and maturation on magnetic resonance imaging in survivors of severe congenital diaphragmatic hernia. J Pediatr Surg. 2012 Mar;47(3):453-61. Cited in PubMed; PMID:22424337. Read the abstract

    Laje P, Johnson MP, Howell LJ, Bebbington MW, Hedrick HL, Flake AW, et al. Ex utero intrapartum treatment in the management of giant cervical teratomas. J Pediatr Surg. 2012 Jun;47(6):1208-16. Cited in PubMed; PMID:22703795. Read the abstract