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Monica Bessler, MD, PhD

Attending Hematologist

Director, Comprehensive Bone Marrow Failure Center

Buck Family Endowed Chair in Hematology

Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

Books

2008

Bessler M, Mason PJ, Link DC, Wilson DB. Inherited bone marrow failure syndromes. In: Orkin, SH Ginsburg, D, Nathan DG, Look, AT, Fisher, DE, Lux, SE, editors. Nathan’s and Oski’s hematology of infancy and childhood. 7th ed. Philadelphia: W.B. Saunders Co; 2008. p. 307-395.

Du HY, Bessler M, Mason PJ. Telomerase mutations and premature ageing in humans. In: Rudolf KL, editor. Telomeres and telomerase in aging, disease, and cancer. New York: Springer; 2008. p. 77-107. 

2003

Bessler M, Kulkarni S, Jasinski M, Schaefer A, Keller P, Tremml G. Mice with blood cells deficient in GPI-linked proteins — the generation of a murine model to investigate the pathogenesis and pathophysiology of paroxysmal nocturnal hemoglobinuria (PNH). Proceedings of the International Symposium on paroxysmal nocturnal hemoglobinuria and related disorders. Tokyo (Japan): Springer-Verlag; 2003. p. 27-40. 

2000

Bessler M, Atkinson JP. Paroxysmal nocturnal hemoglobinuria (PNH). In: Stamatoyannopoulos, A. Nienhuis, P. Majerus, H. Varmus, editors. The molecular basis of blood diseases. 2nd ed. Philadelphia: W. B. Saunders Company; 2000. p. 564-79.

Kinoshita T, Bessler M, Takeda J. Animal models of paroxysmal nocturnal hemoglobinuria. In: Paroxysmal nocturnal hemoglobinuria and the glycophosphoinositol-linked proteins. London: Academic Press; 2000. p. 139-55.

New Media

2012

Bessler M. From pediatric care to adult care: helping young bone marrow failure patients with making a successful transition [webinar]. Aplastic Anemia and MDS International Foundation; 2012 Sep 4.

Bessler M. PNH: Understanding the Disease and its Diagnosis [webinar]. Aplastic Anemia & MDS International Foundation; 2010 Mar 24. Available from: https://live.blueskybroadcast.com/bsb/client/CL_DEFAULT.asp?Client=680927&MA_ID=11548.

Young N, Bessler M, Casper JT, Liu J. Red cells [educational materials]. Biology and Therapy of Aplastic Anemia. American Society.

Original Papers

2012

Parikh S, Perdigones N, Paessler M, Greenbaum B, Tooke LS, Biegel JA, et al. Acquired copy number neutral loss of heterozygosity of chromosome 7 associated with clonal hematopoiesis in a patient with Shwachman-Diamond syndrome. Br J Haematol. 2012 Nov;159(4):480-2. doi: 10.1111/bjh.12032. Epub 2012 Aug 31. Cited in PubMed; PMID 22934832. No abstract available.

Pesciotta EN, Sriswasdi S, Tang HY, Mason PJ, Bessler M, Speicher DW. A label-free proteome analysis strategy for identifying quantitative changes in erythrocyte membranes induced by red cell disorders. J Proteomics. E pub 2012 Aug 29. pii: S1874-3919(12)00627-6. doi: 10.1016/j.jprot.2012.08.010. Cited in PubMed; PMID 22954596. Read the abstract

Parikh SV, Bessler M. Recent insights into inherited bone marrow failure syndromes. Curr Opin Pediatr. 2012 Feb;24(1):23-32. Cited in PubMed; PMID 22227778. Read the abstract

2011

Gu BW, Fan JM, Bessler M, Mason PJ. Accelerated hematopoietic stem cell aging in a mouse model of dyskeratosis congenita responds to antioxidant treatment. Aging Cell. 2011;10:338-348. Cited in PubMed; PMCID: PMC3238467. Read the article

Ikeda K, Mason PJ, Bessler M. 3’UTR-truncated Hmga2 cDNA causes MPN-like hematopoiesis by conferring a clonal growth advantage at the level of HSC in mice. Blood. 2011 Jun 2;117(22):5860-9. Epub 2011 Apr 1. Cited in PubMed; PMID:21460244. Read the article

Mason PJ, Bessler M. Cytokinesis failure and attenuation: new findings in Fanconi anemia. J Clin Invest. 2011 Jan 4;121(1):27-30. doi: 10.1172/JCI45619. Epub 2010 Dec 22. Cited in PubMed; PMCID: PMC3007166. Read the article

2010

Bessler M, Wilson DB, Mason PJ. Dyskeratosis congenita. FEBS Lett. 2010 Sep 10;584(17):3831-8. Epub 2010 May 21. Cited in PubMed PMCID: PMC3238451; Read the article

Ge J, Crosby SD, Heinz ME, Bessler M, Mason PJ. SnoRNA microarray analysis reveals changes in H/ACA and C/D RNA levels caused by dyskerin ablation in mouse liver. Biochem J. 2010 Jul 1;429(1):33-41. Cited in PubMed; PMID 20423331. Read the article

Hill A, Rother RP, Wang X, Morris SM Jr, Quinn-Senger K, Kelly R, et al. Effects of eculizumab on haemolysis-associated nitric oxide depletion, dyspnoea, and measures of pulmonary hypertension in patients with paroxysmal nocturnal haemoglobinuria. Br J Haematol. 2010 May;149(3):414-25. Epub 2010 Mar 8. Cited in PubMed; PMID 20423331. Read the abstract

Ge J, Rudnick DA, He J, Crimmins DL, Ladenson JH, Bessler M, et al. Dyskerin ablation in mouse liver inhibits ribosomal RNA processing and cell division. Mol Cell Biol. 2010 Jan;30(2):413-22. Epub 2009 Nov 16. Cited in PubMed; PMID 19917719. Read the article

McDonald S, Wilson DB, Pumbo E, Kulkarni S, Mason PJ, Else T, et al. Acquired monosomy 7 myelodysplastic syndrome in a child with clinical features suggestive of dyskeratosis congenita and IMAGe association. Pediatr Blood Cancer. 2010 Jan;54(1):154-7. Cited in PubMed; PMID 19760774. Read the abstract 

Posters and Presentations

2012

Bessler M. From pediatric care to adult care: helping young bone marrow failure patients with making a successful transition [webinar]. Aplastic Anemia and MDS International Foundation; 2012 Sep.

2011

Bessler M. Paroxysmal nocturnal hemoglobinuria: from bench to bedside and back to the bench [presentation]. Pediatric Grand Rounds, New York Presbyterian Hospital-Weill Cornell Medical Center: 2011 Apr; New York, NY

Bessler M. Management of adult Shwachman-Diamond syndrome patients [presentation]. Sixth International Congress on Shwachman-Diamond Syndrome; 2011 Jun; New York Academy of Sciences, New York, NY.

2010

Bessler M. AA&MDSIF National Patient & Family Conference; 2010 Jul; Washington DC.

Bessler M. Pediatric adult transition for bone marrow failure patients. Camp Sunshine for Shwachman Diamond Syndrome; 2010 Jul; Portland ME.
 
Bessler M. Camp Sunshine for families with Dyskeratosis Congenita; 2010 Sep; Portland, ME.

Bessler M. Department of Pediatrics Hematology/Oncology Seminar Series. Dana-Farber Cancer Institute/Children’s Hospital Boston Cancer Center; 2010 Sep; Boston, MA.

Bessler M. Opportunities and challenges in the laboratory and translational research [presentation]. Clinical American Society of Hematology; 2010 Dec 4-7; Orlando, FL.

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