Find a Doctor

Diva D. De León-Crutchlow, MD

Medical Director, Congenital Hyperinsulinism Center

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania.

Abstracts

Desai B, Farzad C, De León DD, Guoping S, Leach S, Stoffers D. Mature Pancreatic Acinar cells do not transdifferentiate into islet endocrine cells after partial pancreatectomy or pancreatic duct ligation in mice.  American Diabetes Association's 65th Scientific Sessions, San Diego, CA 228-OR, June 2005.

Hoe FM, Reeves GD, De León DD. Diabetes associated with novel mutation R271P in hepatic nuclear factor (HNF)-1alpha. American Diabetes Association's 65th Scientific Sessions, San Diego, CA 2785-PO , June 2005.

Kapadia CR, Levitt Katz L, Stanley CA, De León DD. Role of GLP-1 in post-prandial hypoglycemia after Nissen fundoplication. Poster Presentation Pediatric Academic Societies' Meeting. San Francisco, CA 3514.107: 105, April 2006.

Ham JYN, De León DD. Maturity onset diabetes of the young associated with missense mutation in two genes. Poster Presentation American Diabetes Association 66th Scientific Sessions. Washington, DC June 2006.

Penn M, Koren D, Hughes N, Kelly A, De León DD. Neonatal Diabetes Due to KCNJ11 Gene Mutations Poster Presentation Pediatric Academic Societies' Meeting. Honolulu, Hawaii. May 2008.

De León DD,Li C, Delson MI, Matschinsky FM, Stanley CA, Stoffers DA. Exendin-(9-39) corrects fasting hypoglycemia in SUR-1-/- mice by lowering cAMP in pancreatic beta-cells and inhibiting insulin secretion Oral presentation at The Endocrine Society's 90th Annual Meeting, San Francisco, CA. June 2008.

Palladino AA, Sayed S, Levitt Katz LE, Gallagher PR, De León DD. Increased Glucagon-like Peptide-1 Secretion and Post-prandial Hypoglycemia in Children After Nissen Fundoplication Poster presentation at The Endocrine Society's 90th Annual Meeting, San Francisco, CA. June 2008.

Pinney SE, Ernst LM, Hughes N, Russo P, De León DD. Congenital Diabetes and Congenital Malabsorptive Diarrhea Attributable to a Mutation in the Human Neurogenin-3 Coding Sequence. Poster presentation at The Endocrine Society's 90th Annual Meeting, San Francisco, CA. June 2008.

Awards

1981-1984: Institute for the Formation and Use of Human Resources Scholarship, Republic of Panama

1985-1991: Institute for the Formation and Use of Human Resources Scholarship, Republic of Panama
 
1986: Guillermo Andreve Award: Department of Education, Republic of Panama
 
1997: Winner of the Medical Staff Poster Competition: Crohn's Disease with Pulmonary Involvement. Monmouth Medical Center, Long Branch, NJ
 
1999: Dr. Martin Quirk Award: Monmouth Medical Center, Long Branch, NJ
 
2000: Eli Lilly Travel Award, The Society of Pediatric Research Annual Meeting; Boston, Massachusetts
 
2001: Lawson Wilkins Pediatric Endocrine Society-Eli Lilly Fellowship Grant
 
2001: Winner of the Philadelphia Endocrine Society Fellows Competition
 
2001: Winner of the NCGS Poster Competition (Fellow Category)
 
2001: LWPES Travel Award, Advanced Post-Graduate Course in Growth and Growth Disorders, Karolinska Institute; Sigtuna Sweden
 
2002: NIH National Research Service Award
 
2002: Endocrine Society Travel Award
 
2002: GCRC Junior Clinical Investigator Award
 
2003-2004: Center of Excellence Faculty Scholar
 
2004-2006: Penn Diabetes Center Pilot and Feasibility Grant

Books

De León D, De León F, De León S, et al. Aterosclerosis: Detección de los factores de riesgo en la edad pediátrica Aterosclerosis:Detection of risk factors in pediatrics]. Revista Medico-Cientifica 6(1): 46-53, 1991.

Stephens M, Batres LA, Ng D (De León D), Baldassano R. Growth failure in the child with inflammatory bowel disease. Semin in Gastrointes Dis 12(4): 253-62, Oct 2001.

Ng D (De León D), Weinzimer S: Hyperinsulinism. The 5 Minute Pediatric Consult. Schwartz, M.W. (eds.). Lippincott Williams & Wilkins, Philadelphia, PA  3: 1057, 2002.

De León D, Cohen P, and Katz L. Growth Factor Regulation of Fetal Growth. Fetal and Neonatal Physiology. Polin,Fox and Abman (eds.). Saunders, 3rd edition, 2003.

De León D, Grimberg A. Disorders of Growth. Requites in Pediatrics -Endocrinology. Moshang T Jr. (eds.). Mosby Publishing, St. Louis, MO, 2004.

De León D. Hyperinsulinism. The 5 Minute Pediatric Consult. Schwartz, MW (eds.). Lippincott Williams & Wilkins, Philadelphia, PA, 4th edition, 2006.

De León D, Stanley C. Screening for Hypoglycemia in Newborns. When to Screen in Obstetrics and Gynecology. Wildschut, Weiner and Peters (eds.). Elsevier, Philadelphia, PA, 2nd edition, 2006.

Bamba V, De León DD. Hyperinsulinism. The 5-Minute Pediatric Consult. Schwartz, MW (eds.). Lippincott Williams & Wilkins, Philadelphia, PA, 5th edition, 2008.

De León DD, Stanley CA, Sperling MA. Hypoglycemia in Neonates and Infants. Pediatric Endocrinology.   Sperling, MA  (eds.). Saunders, 3rd edition, 2008.

Editorial and Academic Positions

2003-present: Assistant Professor of Pediatrics at the Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine
 
2006-present: Course Director University of Pennsylvania School of Medicine, Pediatric Endocrinology (PED 394)

Leadership

National

American Diabetes Association

Lawson Wilkins Pediatric Endocrine Society

The Endocrine Society

Local

Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania

Institute for Translational Medicine and Therapeutics, University of Pennsylvania

Philadelphia Endocrine Society

The Joseph Stokes Jr. Research Institute, The Children's Hospital of Philadelphia

New Media

De León DD, Stanley CA. Permanent Neonatal Diabetes Mellitus GeneReviews at GeneTests: Medical Genetics Information Resource [database online]. Copyright, University of Washington, Seattle, 1997-2008. February 2008 Notes: Available at http://www.genetests.org.
 

Original Papers

Weaver LA, De León DD, Borgmann-Winter K, Coffey BJ. Use of metformin to control clozapine-associated weight gain in an adolescent with schizoaffective disorder. J Child Adolesc Psychopharmacol. 2010 Apr;20(2):153-7. No abstract available

De León DD, Li C, Delson MI, Matschinsky FM, Stanley CA, Stoffers DA. Exendin-(9-39) corrects fasting hypoglycemia in sur-1- mice by lowering cAMP in pancreatic beta -cells and inhibiting insulin secretion. J Biol Chem July 2008.

Hoffman TL, Blanco E, Lane A, Galvin-Parton P, Gadi I, Santer R, De León D, Stanley C, Wilson TA. Glucose metabolism and insulin secretion in a patient with ABCC8 mutation and Fanconi-Bickel syndrome caused by maternal isodisomy of chromosome 3. Clin Genet 71(6): 551-7, June 2007.

Masia R, De León DD, MacMullen C, McKnight H, Stanley CA, Nichols CG. A mutations in the TMD0-L0 region of SUR1 (L225P) causes permanent neonatal diabetes mellitus (PNFM).  Diabetes 56(5): 1357-62, May 2007.

Desai B, Oliver-Krasinski J, De León DD, Farzad C, Hong N, Leach SD, Stoffers DA. Preexisting acinar cells contribute to acinar, but not ß cell, regeneration. The Journal of Clinical Investigation 117(4): 971-7, April 2007.

« Back to Previous Page
  • Print
  • Share

Contact Us