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Diva D. De León-Crutchlow, MD

Medical Director, Congenital Hyperinsulinism Center

Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania.

Abstracts

2013

Kelley J, Patel P, Li C, De León DD: Mechanisms of islet dysregulation in Beckwith-Wiedeman syndrome resulting in hyperinsulinism. Poster Presentation. Pediatric Academic Societies and Pediatric Endocrine Society Annual Meeting. Washington DC. May 4-7, 2013.

Lord K, Dzata E, Snider K, De León DD: Clinical features differentiate focal from diffuse hyperinsulinism: a review of 223 cases. Poster Presentation. American Diabetes Association's 73rd Scientific Sessions. Chicago, Il. June 21-25, 2013.

Patel P, Corbin JA, Goldfine ID, Rubin P, De León DD: A unique allosteric insulin receptor monoclonal antibody that prevents hypoglycemia in the SUR-1-/- mouse model of KATP hyperinsulinism. Oral Platform. American Diabetes Association's 73rd Scientific Sessions, Chicago, Il. June 21-25, 2013.

Stanescu DE, Hughes N, Patel P, De León DD: A novel mutation in GATA6 causes pancreatic agenesis. Poster Presentation. American Diabetes Association's 73rd Scientific Sessions. Chicago, Il. June 21-25, 2013.

2012

De León DD: GLP-1 Receptor: A Target for Treating Hyperinsulinism in Monogenic Disorders of InsulinSecretion: Congenital Hyperinsulinism and Neonatal Diabetes. Pediatric Diabetes 13(4): 344-68, June 2012.

Calabria A, Givler S, De León DD: Pilot study evaluating continuous glucose monitoring in children with postprandial hypoglycemia after fundoplasty. Poster Presentation. Pediatric Academic Societies and Pediatric Endocrine Society Annual Meeting. Boston, MA. April 27-May 1, 2012.

Lasaosa M, Spruce L, Patel P, De León DD, Seeholzer SH: Quantification of exendin-(9-39) in human neonate plasma. Poster Presentation. The American Society for Mass Spectrometry Annual Converence, Vancouver, CA. May 20-24, 2012.

Li C, Patel P, Zhang T, Chen P, Givler S, Liu C, Nissim I, Naji A, Matschinsky FM, De León DD, Stanley C: [U-13C]-glucose metabolism in islets from infants with KATP hyperinsulinism. Poster Presentation and Guided Audio Presentation. 72nd Scientific Sessions of the American Diabetes Association. Philadelphia, PA. June 8-12, 2012.

Patel P, Li C, Givler S, Matschinsky F, Stanley CA, De León DD: Functional evaluation of islets from infants with KATP hyperinsulinism. Platform Presentation. 72nd Scientific Sessions of the American Diabetes Association. Philadelphia, PA. June 8-12, 2012.

Patel P, Li C, Ruchelli E, De León DD: Inactivating mutations in the ATP-sensitive potassium channel result in increased fractional ß-cell area. Poster Presentation and Guided Audio Presentation. 72nd Scientific Sessions of the American Diabetes Association. Philadelphia, PA. June 8-12, 2012.

Peterson R, Buettger C, Patel P, Hughes N, Matschinsky F, De León DD: Effect of two novel inactivating glucokinase mutations on clinical phenotypes and enzymatic activity. Poster Presentation. Pediatric Academic Societies and Pediatric Endocrine Society Annual Meeting. Boston, MA. April 27-May 1, 2012.

Awards

2012, Fellow. Japanese American Kavil Frontiers of Science Symposium. U.S. National Academies and the Japan Society for the Promotion of Science. Irvine, California.

2011, Fellow. Arab American Frontiers of Science, Engineering, and Medicine Symposium. U.S. National Academies. Kuwait Institute for Scientific Research, Kuwait.

2010, Society for Pediatric Research, Elected Member

2004-2006: Penn Diabetes Center Pilot and Feasibility Grant

2003-2004: Center of Excellence Faculty Scholar

2002: NIH National Research Service Award

2002: Endocrine Society Travel Award

2002: GCRC Junior Clinical Investigator Award

2001: Lawson Wilkins Pediatric Endocrine Society-Eli Lilly Fellowship Grant

2001: Winner of the Philadelphia Endocrine Society Fellows Competition

2001: Winner of the NCGS Poster Competition (Fellow Category

2001: LWPES Travel Award, Advanced Post-Graduate Course in Growth and Growth Disorders, Karolinska Institute; Sigtuna Sweden

2000: Eli Lilly Travel Award, The Society of Pediatric Research Annual Meeting; Boston, Massachusetts

1999: Dr. Martin Quirk Award: Monmouth Medical Center, Long Branch, NJ 

1997: Winner of the Medical Staff Poster Competition: Crohn's Disease with Pulmonary Involvement. Monmouth Medical Center, Long Branch, NJ

1986: Guillermo Andreve Award: Department of Education, Republic of Panama

1985-1991: Institute for the Formation and Use of Human Resources Scholarship, Republic of Panama

1981-1984: Institute for the Formation and Use of Human Resources Scholarship, Republic of Panama

Books

Volume Editors: De Leon DD, Stanley CA: Monogenic Hyperinsulinemic Hypoglycemia Disorders. Frontiers in Diabetes. Karger, Basel, Switzerland, 12, Feb 2012.

Chapters

2013

Alves C, Constança J, De León DD, Snider K, Stanley C: A novel atypical presentation of insulin autoimmune syndrome (Hirata's disease) in a child. J Pediatr Endocrinol Metab 26(11-12): 1163-6, Jul 2013.

De León DD and Stanley CA: Hypoglycemia. Pediatric Endocrinology: A Practical Clinical Guide. Radovick S and MacGillivray MH (eds.). Springer, New York, NY. 2013.

De León DD, Stanley CA: Determination of insulin for the diagnosis of hyperinsulinemic hypoglycemia. Best Pract Res Clin Endocrinol Metab 27(6): 763-9, Dec 2013.

2012

De León DD: Role of Incretin Hormones in Hyperinsulinemic Hypoglycemia Frontiers in Diabetes: Monogenic Hyperinsulinemic Hypoglycemia Disorders. Stanley CA and De León DD (eds.). Karger, Basel, Switzerland, 21, Feb 2012.

De León DD, Stanley CA: Pathophysiology of Diffuse ATP-Sensitive Potassium Channel Hyperinsulinism. Frontiers in Diabetes: Monogenic Hyperinsulinemic Hypoglycemia Disorders. Stanley CA and De León DD (eds.). Karger, Basel, Switzerland, 21, Feb 2012.

2011

Palladino AA and De León DD: Hypoglycemia. Netter's Pediatrics (Netter Clinical Science). Florin T and Ludwig S (eds.). Saunders, Jun 2011.

2010

Weaver LA, De León DD, Borgmann-Winter K: Use of metformin to control clozapine-associated weight gain in an adolescent with schizoaffective disorder. J Child and Adolesc Psychopharmacol 20(2): 153-7, Apr 2010.

Thornton PS, Stanley CA, De Leon D, Kelly A, Sperling MA, Wolfsdorf JI, Haymond M: Research initiatives in neonatal hypoglycemia. J Pediatr 156(5): 862-3, May 2010.

Pinney SE, De León DD: Hypoglycemia. The Inpatient Pediatrics Work-Up. Shah and Frank (eds.). Lippincott Williams & Wilkins, 2010.

2008

De León DD, Stanley CA: Permanent Neonatal Diabetes Mellitus GeneReviews™ [Internet] Pagon RA, Adam MP, Bird TD, Dolan CR, Fong CT, Smith RJH, Stephens K (eds.). Copyright, University of Washington, Seattle, 1993-2014. Feb 2008 [Updated 2014 Jan 23] Notes: Available at http://www.ncbi.nlm.nih.gov/books/NBK1447/

Bamba V and De León DD: Hyperinsulinism. The 5-Minute Pediatric Consult. Schwartz, MW (eds.). Lippincott Williams & Wilkins, Philadelphia, PA, 5th edition, 2008.

De León DD, Stanley CA, Sperling MA: Hypoglycemia in Neonates and Infants. Pediatric Endocrinology Sperling, MA (eds.). Saunders, 3rd edition, 2008.

2007

Hoffman TL, Blanco E, Lane A, Galvin-Parton P, Gadi I, Santer R, De León DD, Stanley C, Wilson TA: Glucose metabolism and insulin secretion in a patient with ABCC8 mutation and Fanconi-Bickel syndrome caused by maternal isodisomy of chromosome 3. Clin Genet 71(6): 551-7, Jun 2007.

De León D, Ham N, Katz LEL: Growth Factor Regulation of Fetal Development. Fetal and Neonatal Physiology. Polin R and Fox (eds.). 4th Edition, 2007.

2006

De León D: Hyperinsulinism. The 5 Minute Pediatric Consult. Schwartz, MW (eds.). Lippincott Williams & Wilkins, Philadelphia, PA, 4th edition, 2006.

De León DD and Stanley CA: Screening for Hypoglycemia in Newborns. When to Screen in Obstetrics and Gynecology. Wildschut, Weiner and Peters (eds.). Elsevier, Philadelphia, PA, 2nd edition, 2006.

2004

De León DD and Grimberg A: Disorders of Growth. Requites in Pediatrics - Endocrinology. Moshang T Jr (eds.). Mosby Publishing, St. Louis, MO, 2004.

2003

De León DD, Cohen P, and Katz L: Growth Factor Regulation of Fetal Growth. Fetal and Neonatal Physiology. Polin, Fox and Abman (eds.). Saunders, 3rd edition, 2003.

2002

De León DD, Lange BJ, Walterhouse D, Moshang T: Long-term (15 years) outcome in an infant with metastatic adrenocortical carcinoma. J Clin Endocrinol Metab 87(10): 4452-6, Oct 2002.

Ng D (De León DD), Weinzimer S: Hyperinsulinism. The 5 Minute Pediatric Consult. Schwartz MW (eds.). Lippincott Williams & Wilkins, Philadelphia, PA 3: 1057, 2002.

2001

Stephens M, Batres LA, Ng D (De León DD), Baldassano R: Growth failure in the child with inflammatory bowel disease. Semin in Gastrointes Dis 12(4): 253-62, Oct 2001.

1994

Rivas de La Lastra E, Lasso Bonilla M, De León DD: Cellulitis periorbiaria por Dermatobia Hominis [Periorbital cellulitis caused by Dermatobis Hominis] Boletin de al Sociedad Panameña de Pediatria 23(1): 43-8, 1994.

1991

De León DD, De León F, De León S, et al. : Aterosclerosis: Detección de los factores de riesgo en la edad pediátrica Aterosclerosis:Detection of risk factors in pediatrics]. Revista Medico-Cientifica 6(1): 46-53, 1991.

Editorial and Academic Positions

Editorial positions

2013-present, International Journal of Endocrinology, ad hoc reviewer
2012-present, Journal of Pediatrics, ad hoc reviewer
2012-present, Journal of Neonatal-Perinatal Medicine, ad hoc reviewer
2012-present, Endocrinology, ad hoc reviewer
2011-present, Journal of Clinical Endocrinology and Metabolism, ad hoc reviewer
2011-present, Diabetes Care, ad hoc reviewer
2006-present, Pediatric Diabetes, ad hoc reviewer
2006-present, American Journal of Physiology, ad hoc reviewer
2005-present, Diabetes, ad hoc reviewer
2003-present, Physiologic Genomics, ad hoc reviewer

Academic and institutional committees

2009-present, Chair, Division of Endocrinology Scientific Review Committee
2005-present, CHOP Endocrine Fellowship Advisory Committee

Leadership

American Diabetes Association
Endocrine Society
Lawson Wilkins Pediatric Endocrine Society

  • 2012-2013, Program Committee

Pediatric Endocrine Society
Society for Pediatric Research

New Media

De León DD, Stanley CA. Permanent Neonatal Diabetes Mellitus GeneReviews at GeneTests: Medical Genetics Information Resource [database online]. Copyright, University of Washington, Seattle, 1997-2008. February 2008 Notes: Available at http://www.genetests.org.
 

Original Papers

2014

Stanescu DE, Hughes N, Patel P, De León DD: A novel mutation in GATA6 causes pancreatic agenesis. Pediatr Diabetes Jan 17 2014 [Epub ahead of print]

Browning E, Wang H, Hong N, Yu K, Buerk DG, DeBolt K, Gonder D, Sorokina EM, Patel P, De León DD, Feinstein SI, Fisher AB and Chatterjee S: Mechanotransduction drives post ischemic revascularization through KATP channel closure and production of reactive oxygen species. Antioxidants & Redox Signaling 20(6): 872-86, Feb 2014.

Lasaosa M, Patel P, Givler S, De León DD, Seeholzer SH: A liquid chromatography-mass spectrometry assay for quantification of Exendin [9-39] in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci 947-948: 186-91, Feb 2014.

2013

Lord K, Dzata E, Snider KE, Gallagher PR, De León DD: Clinical presentation and management of children with diffuse and focal hyperinsulinism: a review of 223 cases. J Clin Endocrinol Metab 98(11): E1786-9, Nov 2013.

Lord K, De León DD: Monogenic hyperinsulinemic hypoglycemia: current insights into the pathogenesis and management. Int J Pediatr Endocrinol 1: 3, Feb 2013.

2012

Lin YW, Akrouh A, Hsu YC, Hughes N, Nichols CG, De León DD: Compound heterozygous mutations int eh SUR1 (ABCC 8) subunit of pancreatic K(ATP) channels cause neonatal diabetes by perturbing the coupling between Kir6.2 and SUR1 subunits. Channels (Austin) 6(2): 133-8, March-April 2012.

Calabria AC, Li C, Gallagher PR, Stanley CA, De León DD: GLP-1 receptor antagonist exendin-(9-39) elevates fasting blood glucose levels in congenital hyperinsulinism due to inactivating mutations in the ATP-sensitive K+ channel. Diabetes 61(10): 2585-91, Oct 2012.

Stanescu DE, Hughes N, Kaplan B, Stanley CA, De León DD: Novel presentations of congenital hyperinsulinism due to mutations in the MODY genes: HNF1A and HNF4A. J Clin Endocrinol Metab 97(10): E2026-30, Oct 2012.

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