Pablo Laje, MD

Pablo Laje, MD, is an attending pediatric surgeon at The Children's Hospital of Philadelphia. 

Areas of Expertise: Fetal surgery, Hyperhidrosis, Minimally invasive surgery, Neonatal Surgery
Locations: Main Campus; Specialty Care, Abington; Specialty Care & Surgery Center, King of Prussia, S. Goddard Blvd.
Appointments and Referrals: 1-800-TRY-CHOP (1-800-879-2467)

  • Background

    Dr. Pablo Laje is an attending surgeon in the Division of Pediatric General, Thoracic and Fetal Surgery at The Children’s Hospital of Philadelphia and an assistant professor of surgery at the Perelman School of Medicine at the University of Pennsylvania.

    His areas of interest include fetal surgery, neonatal surgery and minimally invasive surgery. Dr Laje earned his medical degree at the University of Buenos Aires in 1999. He completed his residency in Pediatric Surgery at the J.P. Garrahan National Pediatric Hospital in Buenos Aires, Argentina, one of the largest pediatric hospitals in the world, before continuing on to complete a fellowship in pediatric surgery.

    Dr. Laje came to CHOP in 2005 to serve as a research fellow in the Center for Fetal Research, where he worked alongside Dr. Alan W. Flake to develop innovative methods of performing gene therapy on hematopoietic stem cells for fetal transplantation. After two years as a clinical pediatric surgery fellow at CHOP, he was appointed attending surgeon in 2011. Dr. Laje performs more than 500 operations a year.

    “Working at CHOP is a privilege,” he says. “The expertise that our hospital has in every aspect of pediatric healthcare is second to none, and I know that if there is anything under the sun that can be done to help a suffering child, it can be done here at CHOP.”

    Dr. Laje has authored several pediatric surgery textbook chapters and published more than 25 articles in scientific journals, including the Journal of Pediatric Surgery, Fetal Diagnosis and Therapy, Prenatal Diagnosis, and Blood. He also serves as a fellow of the American College of Surgeons.

  • Education and Training

    Medical School

    MD - University of Buenos Aires, Buenos Aires, Argentina


    General Surgery – J.A. Fernandez Hospital, Buenos Aires, Argentina


    Pediatric Surgery – J.P. Garrahan National Pediatric Hospital, Buenos Aires, Argentina


    Pediatric Surgery – The Children’s Hospital of Philadelphia, Philadelphia, PA
    Fetal Surgery Research – The Children’s Hospital of Philadelphia, Philadelphia, PA
    Pediatric Surgery – J.P. Garrahan National Pediatric Hospital, Buenos Aires, Argentina

    Board Certification

    Pediatric Surgery

  • Titles and Academic Titles

    Attending Surgeon

    Assistant Professor, Perelman School of Medicine at the University of Pennsylvania

  • Departments and Services
  • Publications




    Laje P, Hedrick H. Operative Surgical Management of Fetuses with CHAOS: Management at Delivery. In: Sobol S, Lioy J, ed. Disorders of the Neonatal Airway. New York: Springer; 2015. p. 181-188.


    Laje P, Martinez-Ferro M. Acute abdomen. In: Sinha CK, Davenport M, editors. Handbook of pediatric surgery. London: Springer-Verlag: 2010. p. 173-76.

    Laje P, Nichol P. Laparoscopic and open small bowel resection. In: Chen H, editor. Illustrative handbook of general surgery. London: Springer-Verlag; 2010. p. 127-33.



    Laje P, Pearson EG, Simpao AF, Rehman MA, Sinclair T, Hedrick HL, Adzick NS, Flake AW. The first 100 infant thoracoscopic lobectomies: Observations through the learning curve and comparison to open lobectomy. J Pediatr Surg. 2015 Jun 3. pii: S0022-3468(15)00369-3. pii: S0022-3468(15)00369-3. doi: 10.1016. Read the abstract.

    Olive A, Moldenhauer JS, Laje P, Johnson MP, Coleman BG, Victoria T, Flake AW, Adzick NS. Axillary lymphatic malformations: Prenatal evaluation and postnatal outcomes. J Pediatr Surg. 2015 Apr 29. pii: S0022-3468(15)00312-7. doi: 10.1016. Read the abstract

    Partridge EA, Victoria T, Coleman BG, Martinez-Poyer J, Laje P, Hedrick HL, Flake AW, Adzick NS. Prenatal diagnosis of esophageal bronchus - first report of a rare foregut malformation in utero. J Pediatr Surg. 2015 Feb;50(2):306-10. Epub 2014 Nov 10. Read the abstract.


    Roybal JL, Laje P, Vrecenak JD, Flake AW. Use of manipulated stem cells for prenatal therapy. Methods Mol Biol. 2012;891:169-81. Cited in PubMed; PMID:22648772. Read the abstract

    Laje P, Johnson MP, Howell LJ, Bebbington MW, Hedrick HL, Flake AW, et al. Ex utero intrapartum treatment in the management of giant cervical teratomas. J Pediatr Surg. 2012 Jun;47(6):1208-16.Cited in PubMed; PMID:22703795 . Read the abstract

    Posters and Presentations


    Laje P, Zoltick PW, Flake AW. SLAM-enriched hematopoietic stem cells maintain long-term repopulating capacity after lentiviral transduction using an abbreviated protocol [presentation]. American Society of Gene Therapy 10th Annual Meeting; 2007 May 30 - Jun 3; Seattle, WA.