I'm part of a small group that focuses specifically on brain tumors. Our multidisciplinary team includes oncologists, a neurologist, neurosurgeons, a radiation oncologist, social workers and a neuropsychologist, along with skilled nurse practitioners. This is the broad spectrum of expertise that The Children's Hospital of Philadelphia brings to treating its patients with brain tumors.
Treating cancer is a team effort at Children's Hospital, and we consider patients and their families a part of the team. Since our young patients are dependent on their parents for medical decision making, I try to give them a sense of some control over their disease, communicating in an age appropriate manner. Kids do much better, even when facing death, when they are part of the treatment plan and "secrets" are not kept from them.
I do both basic science and clinical research that focuses on developmental therapeutics in tumors of the nervous system. In particular I and my colleagues are looking at signal transduction in neuroblastoma and medulloblastoma. We are evaluating the biological effects of neurotrophin receptor expression on the growth properties of these tumors. Neurotrophins are able to signal certain cells to survive, mature or grow. The Trk family of neurotrophin receptors plays a critical role in these diverse behaviors.
We recently completed a clinical trial that targeted these receptors to inhibit signaling in neuroblastoma. The results are promising that this could be a therapeutic target for high risk neuroblastoma. We also are studying the way that Trk receptor molecules located on the surface of medulloblastoma cells regulate tumor growth and development. These studies may help to identify new therapeutic targets in the Trk signaling pathways.
As part of our approach to identifying new treatments for children with brain tumors, we are members of the multi-institutional Pediatric Brain Tumor Consortium (PBTC) and the Developmental Therapeutics Children's Oncology Group. These groups are involved in early phase clinical trials for relapsing and refractory brain tumors, with a particular focus on testing new, targeted treatments in children with brain tumors.
Our Children's Hospital team has partnered with drug development groups, and we are rapidly identifying drugs that show promise in patients with brain tumors who have no other curable option. There is a sense of urgency in our group -- we don't randomly test drugs but work collaboratively with laboratory scientists and drug development companies on rational, biologically-based targets. The best example of this is a drug for medulloblastoma that was recently rapidly brought to a PBTC clinical trial.
There is huge progress in getting promising drugs to kids with cancer. Through our cooperative group consortia, the pace is much more rapid than in past years, and Children's Hospital is a major part of the effort to help bring new agents to children with brain tumors.
- Education and Training
MD - Yale University School of Medicine, New Haven, CT
Pediatrics - The Children’s Hospital, Boston, MA
Pediatrics - The Children's Hospital, Boston, MS
Hematology/Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pa.
University of Southern California (BS, psychobiology), Los Angeles, Calif.
PhD in Neurobiology - Yale University, New Haven, CT
MPhil - Yale University, New Haven, CT
- Titles and Academic Titles
Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
- Conditions Treated
- Departments and Services
Minturn JE and Fisher MJ: Brain Tumors, In: Schwartz MW (ed), The 5-Minute Pediatric Consult, 7th Edition, Philadelphia: Wolters Kluwer, 2015, p.124-125.
Zhi W, Minturn J, Rappaport E, Brodeur G, Li H: Network-based analysis of multivariate gene expression data. In: Statistical Methods for Microarray Data Analysis, vol 972, Yakovlev AY, Klebanov L, and Gaile D, (eds). Humana Press, Totowa, NJ, Pp. 121-139, 2013.
Minturn JE: Teratoma, In Schwartz MW (ed), The 5-Minute Pediatric Consult, 6th Edition, Lippincott Williams & Wilkins, Philadelphia, PA. Pp. 864-865, 2012.
Sievert AJ, Minturn JE. Brain tumors. In: Florin TA, Ludwig S, editors. Netter's pediatrics. Philadelphia: Elsevier Publishing; 2011.
Fisher MJ, Minturn J, Phillips PC. Brain tumors. In: Brodeur GM, Manno CS, editors. Pediatric hematology/oncology: the requisites in pediatrics. Philadelphia: C.V. Mosby Publishing; 2008.
Minturn JE. Teratoma. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2008. p. 840-41.
Minturn JE. Teratoma. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 834-35.
Minturn JE, Friedman DL. Teratoma. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 812-13.
Minturn JE. Idiopathic thrombocytopenic purpura. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 464-65.
Minturn JE, Kelly KM. Hemophilia. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 420-21.
Minturn JE, Kelly KM. Aplastic anemia. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 130-31.
Hoffman L, Bartels U, Miles L, Hawkins C, Goldman S, Leary S, Hassal T, Minturn J, Packer R, Foreman N, Warren K, Broniscer A, Broxon E, Shih C-S, Leach J, Jones B, Baugh J, Hacker B, Lerme B, Jones C, Savage S, Kirkendall J, Doughman R, Wollman M, Millett L, O’Keefe R, Bouffet E, van Vuurden D, Fouladi M. Clinical, radiographic, and biologic characteristics of long-term survivors of diffuse intrinsic pontine glioma. 3rd Biennial Conference on Pediatric Neuro-Oncology Basic and Translational Research, May 7-8, 2015. San Diego, CA.
Hollander A, Lustig RA, Tochner Z, Paltin I, Both S, Zhai H, Fisher MJ, Minturn JE, Phillips P, Hill-Kayser CE. Acute toxicities and treatment outcomes for pediatric medulloblastoma patients treated with proton-based craniospinal irradiation. 46th Congress of the International Society of Paediatric Oncology, October 22-25, 2014. Toronto, Canada.
Paltin I, Hill-Kayser CE, Lustig RA, Minturn JE, Fisher MJ. Relative differences in risk for neuropsychological late effects post proton radiation for infratentorial versus supratentorial pediatric brain tumors. 46th Congress of the International Society of Paediatric Oncology, October 22-25, 2014. Toronto, Canada.
Hill-Kayser CE, Tochner Z, Fisher M, Minturn JE, Belasco J, Bagatell R, Balamuth N, Womer R, Reilly A, Phillips P, Lustig RA. Proton radiation for treatment of children less than 18 months of age. 46th Congress of the International Society of Paediatric Oncology, October 22-25, 2014. Toronto, Canada.
Hollander A, Both S, Zhai H, Lustig RA, Tochner Z, Fisher MJ, Minturn JE, Phillips P, Hill-Kayser CE. Acute toxicities and treatment outcomes of a novel craniospinal irradiation (CSI) technique using double scattered proton therapy for medulloblastoma patients. ASTRO’s 56th Annual Meeting, September 14-17, 2014. San Francisco, CA.
Hill-Kayser CE, Lustig RA, Minturn JE, Both S, Waanders AJ, Belasco JB, Armstrong C, Phillips PC, Fisher MJ. Outcomes after proton radiotherapy (RT) for infratentorial brain tumors in infants and very young children. 16th International Symposium on Pediatric Neuro-Oncology, 28 June-02 July 2014. Singapore.Hill-Kayser CE, Paltin I, Lustig RA, Fisher MJ, Both S, Belasco JB, Cole KA, Waanders AJ, Phillips PC, Minturn JE. Proton radiation for treatment of localized ependymoma in children. 16th International Symposium on Pediatric Neuro-Oncology, 28 June-02 July 2014. Singapore.
Paltin I, Hill-Kayser CE, Lustig RA, Fisher MJ, Belasco JB, Phillips PC, Cole KA, Minturn JE. Neuropsychological functioning after proton radiation therapy for pediatric ependymoma. 12th Annual American Academy of Clinical Neuropsychology Conference, June 25-28, 2014. New York, NY.
Hill-Kayser CE, Lustig RA, Minturn JE, Both S, Waanders AJ, Belasco JB, Armstrong CA, Phillips P, Fisher MJ. Proton radiation for treatment of infratentorial brain tumors in infants and very young children. 2014 ASCO Annual Meeting, May 30-June 3, 2014. Chicago, IL.
Hill-Kayser CE, Paltin I, Lustig RA, Fisher MJ, Both S, Belasco JB, Cole KA, Waanders AJ, Phillips P, Minturn JE. Outcomes after proton radiotherapy for localized childhood ependymoma (EP). 2014 ASCO Annual Meeting, May 30-June 3, 2014. Chicago, IL.
Meany HJ, Dome J, Hinds PS, Bagatell R, Shusterman S, Widemann BC, Stern E, London WB, Kim A, Fox E, Rodriguez-Galindo C, Minturn JE. Phase 1 study of sorafenib and irinotecan in pediatric patients with relapsed or refractory solid tumors. 2014 ASCO Annual Meeting, May 30-June 3, 2014. Chicago, IL.
Doolin E, Redden RA, Brodeur GM, Minturn JE, Iyer R. Use of a microgravity culture system to assess biological behavior in neuroblastoma (NB) cell lines. 99th Clinical Congress, American College of Surgeons, October 6-10, 2013. Washington, D.C.
Paltin I, Minturn J, Fisher M, Barakat L. Prospective case study of two 2 year olds with posterior fossa ependymoma treated with proton radiation therapy. American Academy of Clinical Neuropsychology, June 19-22, 2013. Chicago, IL.
Shah AC, Cole KA, Waanders AJ, Minturn JE, Fisher MJ, Hill-Kayser C. Proton radiation therapy effect mimicking radiologic relapse in two young adults with pure CNS germinoma. Pediatric Blood and Cancer, 2015 (in review).
Frick M, Minturn JE, Li Y, Hill-Kayser CE. Radiotherapy-related outcomes in pediatric patients with atypical teratoid rhabdoid tumor of the central nervous system. Journal of Pediatric Hematology/Oncology, 2015 (in review).
Shah AC, Minturn JE, Li Y, Belasco JB, Phillips PC, Kang TI, Cole KA, Waanders AJ, Pollack R, Didomenico C, Wildes C, Fisher MJ. Carboplatin rechallenge after hypersensitivity reactions in pediatric patients with low-grade glioma. Pediatric Blood and Cancer, 2015 (in press).
Posters and Presentations
From the Office through Treatment and Survivorship: Pediatric Brain Tumors. CME Lecture Series in Pediatric Oncology, Bridgewater NJ, March 2015.
Neurocognitive effects of brain tumor therapy in children. Pediatric Brain Tumor Foundation, Valley Forge Christian College, Phoenixville, PA, September 2014.
Advances in Precision Medicine for Pediatric Brain Tumors. Pediatric Brain Tumor Foundation Annual Ride for Kids Program, Valley Forge Christian College, Phoenixville, PA, September 2013.
- Awards and Honors
2010, Hyundai Hope on Wheels, Hope Grant Award Winner
2010, Advances in Neuroblastoma Research Annual Meeting: Best Clinical Poster Award, Stockholm, Sweden
2006-2009, American Cancer Society Mentored Research Scholar Grant
2004-2006, Wolfson Scholar in Neuroblastoma Research
2003-2006, American Society of Clinical Oncology Career Development Award
2003, Florence R.C. Murray Program Fund Award
2002-2003, American Society of Clinical Oncology Young Investigator Award
2000, Selected Participant, American Association for Cancer Research Workshop, Molecular Biology in Clinical Oncology, The Given Institute, Aspen, CO
1989-1996, Pre-doctoral Fellowship, Howard Hughes Medical Institute
1988, Medical Student Research Fellowship, American Heart Association
1986, 1986 Phi Kappa Phi, University of Southern California
1986, 1986 Phi Beta Kappa, University of Southern California
1986, 1986 Summa Cum Laude, University of Southern California
- Editorial and Academic Positions
Clinical Cancer Research
Journal of Neuro-Oncology
Pediatric Blood & Cancer
Neuropsychiatric Disease and Treatment
Academic and Institutional Committees
2015-present, Oncology Liaison, International Medicine
2013-present, Clinical Competency Committee
2011-present, Targeted Therapy Glioma Group
2010-present, Proton Therapy Triage Committee
2008-present, Pediatric Protocol Review Committee
2006-present, Pediatric Residency Program Faculty Interviewer
Memberships in Professional Organizations
American Association for Cancer Research
American Society of Clinical Oncology
American Society of Pediatric Hematology/Oncology
Children’s Oncology Group (COG)
Pediatric Brain Tumor Consortium
Institutional Principal Investigator
Society for Neuro-Oncology
Pacific Pediatric Neuro-Oncology Consortium
- Institutional Principal Investigator
- Awards and Honors